1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti...

32
1. Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential (Cardiac Muscle Cell) Tufts OpenCourseWare © 2008 Tufts University Anti Arrhythmic Drugs and Miscellaneous Topics OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 1

Transcript of 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti...

Page 1: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

1. Anti Arrhythmic Drugs and Miscellaneous Topics

2. Monophasic Action Potential (Cardiac Muscle Cell)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 1

Page 2: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

3. Monophasic Action Potential (Cardiac Muscle Cell)

4. The Monophasic Action Potential (MAP)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 2

Page 3: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

5. Conduction of Electrical Impulses

6. Monophasic Action Potential (Cardiac Pacemaker Cell)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 3

Page 4: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

7. Monophasic Action Potential (Cardiac Pacemaker Cell)

8. The Monophasic Action Potential

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 4

Page 5: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

9. The Cardiac Cycle

10. Arrhythmogenesis

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 5

Page 6: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

11. Reentry

12. Reentry

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 6

Page 7: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

13. Reentry

14. Early Afterdepolarization (EAD)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 7

Page 8: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

15. Delayed Afterdepolarization (DAD)

16. Mechanism of Action of Antiarrhythmic Drugs

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 8

Page 9: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

17. Drug Types

18. Drug Types, cont.

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 9

Page 10: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

19. Anti Arrhythmic Drugs and Miscellaneous Topics: Slide 19

20. The Vaughan Williams Classification of Anti Arrhythmic Drugs...

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 10

Page 11: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

21. The Vaughan Williams Classification of Anti Arrhythmic Drugs...

22. Monophasic Action Potential

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 11

Page 12: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

23. The Vaughan Williams Classification of Anti Arrhythmic Drugs...

24. Monophasic Action Potential (Effect of Potassium Channel Blo...

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 12

Page 13: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

25. Torsade de Pointe

26. Mechanism of Action of Anti Arrhythmic Drugs in a Model of R...

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 13

Page 14: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

27. Preliminary Report

28. Proarrhythmia

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 14

Page 15: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

29. Tachy Brady Syndrome (Sick Sinus Syndrome)

30. Mobitz I 2° AV Block (Wenckebach)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 15

Page 16: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

31. Mobitz II 2° AV Block

32. Complete (3° AV Block)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 16

Page 17: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

33. High Grade AV Block

34. Sick Sinus Syndrome

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 17

Page 18: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

35. Atrial Fibrillation

36. Atrial Flutter

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 18

Page 19: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

37. Atrial Flutter with 1:1 Conduction

38. Paroxysmal Supra Ventricular Tachycardia

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 19

Page 20: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

39. Paroxysmal Supra Ventricular Tachycardia

40. Accessory Bypass Tract

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 20

Page 21: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

41. AF and WPW

42. Ventricular Tachycardia

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 21

Page 22: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

43. Ventricular Fibrillation

44. Anti Arrhythmic Drugs and Miscellaneous Topics: Slide 44

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 22

Page 23: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

45. AV Wenckebach

46. Sinus Bradycardia

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 23

Page 24: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

47. Polymorphic VT

48. Atrial Flutter

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 24

Page 25: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

49. PSVT

50. Mobitz II – 2° AV Block

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 25

Page 26: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

51. Atrial Fibrillation

52. Complete AV Block

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 26

Page 27: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

53. Ventricular Flutter

54. 1° AV Block

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 27

Page 28: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

55. Mobitz I 2º AV Block Wenckebach Block

56. Valvular Heart Sounds and Hemodynamic Tracings

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 28

Page 29: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

57. Heart Sounds

58. Heart Sounds (Mitral Stenosis)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 29

Page 30: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

59. Mitral Stenosis

60. Heart Sounds (Mitral Regurgitation)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 30

Page 31: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

61. Mitral Regurgitation

62. Heart Sounds (Aortic Stenosis)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 31

Page 32: 1. Anti Arrhythmic Drugs and Miscellaneous Topicsocw.tufts.edu/data/50/634401.pdf · Anti Arrhythmic Drugs and Miscellaneous Topics 2. Monophasic Action Potential ... Mechanism of

63. Aortic Stenosis

64. Heart Sounds (Aortic Regurgitation)

Tufts OpenCourseWare © 2008 Tufts University

Anti Arrhythmic Drugs and Miscellaneous Topics

OCW: Cardiovascular Pathophysiology (M. Homoud) Page - 32