1 3.3 - dna structure
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DP Biology 11DP Biology 11Unit 3.3DNA Structure
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DNA StructureDNA Structure
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DNA StructureDNA Structure
Nucleotide structure Sugar◦ Deoxyribose
Phosphate group◦ PO4
-3 group
Nitrogenous base◦ 4 different kinds of ring-based structures
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DNA StructureDNA Structure
Nucleotide structure Nitrogenous base◦ C Cytosine◦ G Guanine◦ A Adenine◦ T Thymine
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DNA StructureDNA Structure
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DNA StructureDNA Structure
General structure Backbone:◦ Phosphate group of one nucleotide attaches to the
third (3’) carbon of the deoxyribose in the next◦ Deoxyribose - Phosphate - Deoxyribose –
Phosphate - etc...
Nitrogenous base attached to deoxyribose
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DNA StructureDNA Structure
General structure
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DNA StructureDNA Structure
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DNA StructureDNA Structure
Formation of the DNA double helix Complementary base paring:◦ A = T Adenine forms two hydrogen bonds with its
complementary base, thymine
◦ G = C: Guanine forms three hydrogen bonds with its
complementary base, cytosine
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DNA StructureDNA Structure
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DNA StructureDNA Structure
Formation of the DNA double helix Hydrogen bonds:◦ Hydrogen bonds between A = T and G = C hold
the two strands of DNA together◦ Each strand forms a helix, the two strands
together form a double helix
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DNA StructureDNA Structure
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DNA StructureDNA Structure
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DNA StructureDNA Structure
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DNA StructureDNA StructureThis is image shows: Two polynucleotide chains Two anti-parallel chains◦ The two chains are in
opposite directions
A uniform distance (2nm) between the backbones
Complementary base pairs:◦ Adenine hydrogen binds to
Thymine◦ Cytosine hydrogen bonds to
Guanine
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DNA StructureDNA StructureThis is image shows: DNA is double-stranded, ◦ The strands are antiparallel,
The strands are wound round each other to form a double helix (not a spiral)
The two strands are joined together by hydrogen bonds between the bases◦ Follow commplementarity◦ Sequence on one strand
complementary to the other
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TOK QUESTION:TOK QUESTION:
PLAGIARISM in science!
To what extent was Watson and Crick’s “discovery” of the three dimensional
structure of DNA dependent on the use of data generated by Rosalind Franklin,
which was shared without her knowledge or consent?
Do they deserve full credit?
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MAJOR SOURCESMAJOR SOURCESThank you to my favorite sources of information when making these lectures!
John Burrell (Bangkok, TH)www.click4biology.info
Dave Ferguson (Kobe, JA)
http://canada.canacad.ac.jp/High/49
Stephen Taylor (Bandung, IN)
www.i-biology.net
Andrew Allott – Biology for the IB DiplomaC. J.Clegg – Biology for the IB DiplomaWeem, Talbot, Mayrhofer – Biology for the International BaccalaureateHoward Hugh’s Medical Institute – www.hhmi.org/biointeractiveMr. Hoye’s TOK Website – http://mrhoyestokwebsite.com And all the contributors at www.YouTube.com