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12The Central Nervous System
Brain
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Central Nervous System (CNS)
CNS – composed of the brain and spinal cord
Cephalization
Elaboration of the anterior portion of the CNS
Increase in number of neurons in the head
Highest level is reached in the human brain
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The Brain
Composed of wrinkled, pinkish gray tissue
Surface anatomy includes cerebral hemispheres, cerebellum, and brain stem
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Embryonic Development
During the first 26 days of development:
Ectoderm thickens along dorsal midline to form the neural plate
The neural plate invaginates, forming a groove flanked by neural folds
The neural groove fuses dorsally and forms the neural tube
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Surface ectoderm
(a) 19 days
(b) 20 days
(c) 22 days
(d) 26 days
Neural folds
Neural crest
Surface ectoderm
Neural groove
Neural tube
Anterior (rostral) end
Embryonic Development
Figure 12.1
Level of section
Neural plate
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Primary Brain Vesicles
The anterior end of the neural tube expands and constricts to form the three primary brain vesicles
Prosencephalon – the forebrain
Mesencephalon – the midbrain
Rhombencephalon – hindbrain
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Neural Tube and Primary Brain Vesicles
Figure 12.2a, b
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Secondary Brain Vesicles
In week 5 of embryonic development, secondary brain vesicles form
Telencephalon and diencephalon arise from the forebrain
Mesencephalon remains undivided
Metencephalon and myelencephalon arise from the hindbrain
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Secondary Brain Vesicles
Figure 12.2c
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Adult Brain Structures
Fates of the secondary brain vesicles:
Telencephalon – cerebrum: cortex, white matter, and basal nuclei
Diencephalon – thalamus, hypothalamus, and epithalamus
Mesencephalon – brain stem: midbrain
Metencephalon – brain stem: pons
Myelencephalon – brain stem: medulla oblongata
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Adult Neural Canal Regions
Figure 12.2c, d
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Adult Neural Canal Regions
Adult structures derived from the neural canal
Telencephalon – lateral ventricles
Diencephalon – third ventricle
Mesencephalon – cerebral aqueduct
Metencephalon and myelencephalon – fourth ventricle
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Adult Neural Canal Regions
Figure 12.2c, e
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Space Restriction and Brain Development
Figure 12.3
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Basic Pattern of the Central Nervous System
Spinal Cord
Central cavity surrounded by a gray matter core
External to which is white matter composed of myelinated fiber tracts
Brain
Similar to spinal cord but with additional areas of gray matter
Cerebellum has gray matter in nuclei
Cerebrum has nuclei and additional gray matter in the cortex
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Basic Pattern of the Central Nervous System
Figure 12.4
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Ventricles of the Brain
Arise from expansion of the lumen of the neural tube
The ventricles are:
The paired C-shaped lateral ventricles
The third ventricle found in the diencephalon
The fourth ventricle found in the hindbrain dorsal to the pons
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Ventricles of the Brain
Figure 12.5
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Cerebral Hemispheres
Form the superior part of the brain and make up 83% of its mass
Contain ridges (gyri) and shallow grooves (sulci)
Contain deep grooves called fissures
Are separated by the longitudinal fissure
Have three basic regions: cortex, white matter, and basal nuclei
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Deep sulci divide the hemispheres into five lobes:
Frontal, parietal, temporal, occipital, and insula
Central sulcus – separates the frontal and parietal lobes
Major Lobes, Gyri, and Sulci of the Cerebral Hemisphere
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Parieto-occipital sulcus – separates the parietal and occipital lobes
Lateral sulcus – separates the parietal and temporal lobes
The precentral and postcentral gyri border the central sulcus
Major Lobes, Gyri, and Sulci of the Cerebral Hemisphere
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Cerebral Cortex
The cortex – superficial gray matter; accounts for 40% of the mass of the brain
It enables sensation, communication, memory, understanding, and voluntary movements
Each hemisphere acts contralaterally (controls the opposite side of the body)
Hemispheres are not equal in function
No functional area acts alone; conscious behavior involves the entire cortex
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The three types of functional areas are:
Motor areas – control voluntary movement
Sensory areas – conscious awareness of sensation
Association areas – integrate diverse information
Functional Areas of the Cerebral Cortex
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Functional Areas of the Cerebral Cortex
Figure 12.8a
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Functional Areas of the Cerebral Cortex
Figure 12.8b
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Cerebral Cortex: Motor Areas
Primary (somatic) motor cortex
Premotor cortex
Broca’s area
Frontal eye field
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Located in the precentral gyrus
Composed of pyramidal cells whose axons make up the corticospinal tracts
Allows conscious control of precise, skilled, voluntary movements
Motor homunculus – caricature of relative amounts of cortical tissue devoted to each motor function
Primary Motor Cortex
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Primary Motor Cortex
Figure 12.9.1
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Premotor Cortex
Located anterior to the precentral gyrus
Controls learned, repetitious, or patterned motor skills
Coordinates simultaneous or sequential actions
Involved in the planning of movements
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Broca’s Area
Broca’s area
Located anterior to the inferior region of the premotor area
Present in one hemisphere (usually the left)
A motor speech area that directs muscles of the tongue
Is active as one prepares to speak
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Frontal Eye Field
Frontal eye field
Located anterior to the premotor cortex and superior to Broca’s area
Controls voluntary eye movement
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Sensory Areas
Primary somatosensory cortex
Somatosensory association cortex
Visual and auditory areas
Olfactory, gustatory, and vestibular cortices
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Sensory Areas
Figure 12.8a
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PrImary Somatosensory Cortex
Located in the postcentral gyrus, this area:
Receives information from the skin and skeletal muscles
Exhibits spatial discrimination
Somatosensory homunculus – caricature of relative amounts of cortical tissue devoted to each sensory function
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Primary Somatosensory Cortex
Figure 12.9.2
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Somatosensory Association Cortex
Located posterior to the primary somatosensory cortex
Integrates sensory information
Forms comprehensive understanding of the stimulus
Determines size, texture, and relationship of parts
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Visual Areas
Primary visual (striate) cortex
Seen on the extreme posterior tip of the occipital lobe
Most of it is buried in the calcarine sulcus
Receives visual information from the retinas
Visual association area
Surrounds the primary visual cortex
Interprets visual stimuli (e.g., color, form, and movement)
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Auditory Areas
Primary auditory cortex
Located at the superior margin of the temporal lobe
Receives information related to pitch, rhythm, and loudness
Auditory association area
Located posterior to the primary auditory cortex
Stores memories of sounds and permits perception of sounds
Wernicke’s area
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Association Areas
Prefrontal cortex
Language areas
General (common) interpretation area
Visceral association area
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Association Areas
Figure 12.8a
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Prefrontal Cortex
Located in the anterior portion of the frontal lobe
Involved with intellect, cognition, recall, and personality
Necessary for judgment, reasoning, persistence, and conscience
Closely linked to the limbic system (emotional part of the brain)
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12The Central Nervous System
Part B
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Language Areas
Located in a large area surrounding the left (or language-dominant) lateral sulcus
Major parts and functions:
Wernicke’s area – involved in sounding out unfamiliar words
Broca’s area – speech preparation and production
Lateral prefrontal cortex – language comprehension and word analysis
Lateral and ventral temporal lobe – coordinate auditory and visual aspects of language
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General (Common) Interpretation Area
Ill-defined region including parts of the temporal, parietal, and occipital lobes
Found in one hemisphere, usually the left
Integrates incoming signals into a single thought
Involved in processing spatial relationships
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Visceral Association Area
Located in the cortex of the insula
Involved in conscious perception of visceral sensations
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Lateralization of Cortical Function
Lateralization – each hemisphere has abilities not shared with its partner
Cerebral dominance – designates the hemisphere dominant for language
Left hemisphere – controls language, math, and logic
Right hemisphere – controls visual-spatial skills, emotion, and artistic skills
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Cerebral White Matter
Consists of deep myelinated fibers and their tracts
It is responsible for communication between:
The cerebral cortex and lower CNS center, and areas of the cerebrum
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Cerebral White Matter
Types include:
Commissures – connect corresponding gray areas of the two hemispheres
Association fibers – connect different parts of the same hemisphere
Projection fibers – enter the hemispheres from lower brain or cord centers
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Fiber Tracts in White Matter
Figure 12.10a
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Fiber Tracts in White Matter
Figure 12.10b
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Basal Nuclei
Masses of gray matter found deep within the cortical white matter
The corpus striatum is composed of three parts
Caudate nucleus
Lentiform nucleus – composed of the putamen and the globus pallidus
Fibers of internal capsule running between and through caudate and lentiform nuclei
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Basal Nuclei
Figure 12.11a
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Basal Nuclei
Figure 12.11b
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Functions of Basal Nuclei
Though somewhat elusive, the following are thought to be functions of basal nuclei
Influence muscular activity
Regulate attention and cognition
Regulate intensity of slow or stereotyped movements
Inhibit antagonistic and unnecessary movement
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Diencephalon
Central core of the forebrain
Consists of three paired structures – thalamus, hypothalamus, and epithalamus
Encloses the third ventricle
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Diencephalon
Figure 12.12
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Thalamus
Paired, egg-shaped masses that form the superolateral walls of the third ventricle
Connected at the midline by the intermediate mass
Contains four groups of nuclei – anterior, ventral, dorsal, and posterior
Nuclei project and receive fibers from the cerebral cortex
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Thalamus
Figure 12.13a
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Thalamic Function
Afferent impulses from all senses converge and synapse in the thalamus
Impulses of similar function are sorted out, edited, and relayed as a group
All inputs ascending to the cerebral cortex pass through the thalamus
Plays a key role in mediating sensation, motor activities, cortical arousal, learning, and memory
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Hypothalamus
Located below the thalamus, it caps the brainstem and forms the inferolateral walls of the third ventricle
Mammillary bodies
Small, paired nuclei bulging anteriorly from the hypothalamus
Relay station for olfactory pathways
Infundibulum – stalk of the hypothalamus; connects to the pituitary gland
Main visceral control center of the body
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Hypothalamic Nuclei
Figure 12.13b
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Hypothalamic Function
Regulates blood pressure, rate and force of heartbeat, digestive tract motility, rate and depth of breathing, and many other visceral activities
Is involved with perception of pleasure, fear, and rage
Controls mechanisms needed to maintain normal body temperature
Regulates feelings of hunger and satiety
Regulates sleep and the sleep cycle
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Endocrine Functions of the Hypothalamus
Releasing hormones control secretion of hormones by the anterior pituitary
The supraoptic and paraventricular nuclei produce ADH and oxytocin
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Epithalamus
Most dorsal portion of the diencephalon; forms roof of the third ventricle
Pineal gland – extends from the posterior border and secretes melatonin
Melatonin – a hormone involved with sleep regulation, sleep-wake cycles, and mood
Choroid plexus – a structure that secretes cerebral spinal fluid (CSF)
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Epithalamus
Figure 12.12
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Brain Stem
Consists of three regions – midbrain, pons, and medulla oblongata
Similar to spinal cord but contains embedded nuclei
Controls automatic behaviors necessary for survival
Provides the pathway for tracts between higher and lower brain centers
Associated with 10 of the 12 pairs of cranial nerves
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Brain Stem
Figure 12.15c
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Midbrain
Located between the diencephalon and the pons
Midbrain structures include:
Cerebral peduncles – two bulging structures that contain descending pyramidal motor tracts
Cerebral aqueduct – hollow tube that connects the third and fourth ventricles
Various nuclei
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Midbrain Nuclei
Nuclei that control cranial nerves III (oculomotor) and IV (trochlear)
Corpora quadrigemina – four domelike protrusions of the dorsal midbrain
Superior colliculi – visual reflex centers
Inferior colliculi – auditory relay centers
Substantia nigra – functionally linked to basal nuclei
Red nucleus – largest nucleus of the reticular formation; red nuclei are relay nuclei for some descending motor pathways
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Midbrain Nuclei
Figure 12.16a
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Pons
Bulging brainstem region between the midbrain and the medulla oblongata
Forms part of the anterior wall of the fourth ventricle
Fibers of the pons:
Connect higher brain centers and the spinal cord
Relay impulses between the motor cortex and the cerebellum
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Pons
Origin of cranial nerves V (trigeminal), VI (abducens), and VII (facial)
Contains nuclei of the reticular formation
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Pons
Figure 12.16b
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Medulla Oblongata
Most inferior part of the brain stem
Along with the pons, forms the ventral wall of the fourth ventricle
Contains a choroid plexus on the ventral wall of the fourth ventricle
Pyramids – two longitudinal ridges formed by corticospinal tracts
Decussation of the pyramids – crossover points of the corticospinal tracts
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Medulla Oblongata
Figure 12.16c
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Medulla Nuclei
Inferior olivary nuclei – gray matter that relays sensory information
Cranial nerves X, XI, and XII are associated with the medulla
Vestibular nuclear complex – synapses that mediate and maintain equilibrium
Ascending sensory tract nuclei, including nucleus cuneatus and nucleus gracilis
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Medulla Nuclei
Cardiovascular control center – adjusts force and rate of heart contraction
Respiratory centers – control rate and depth of breathing
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The Cerebellum
Located dorsal to the pons and medulla
Protrudes under the occipital lobes of the cerebrum
Makes up 11% of the brain’s mass
Provides precise timing and appropriate patterns of skeletal muscle contraction
Cerebellar activity occurs subconsciously
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The Cerebellum
Figure 12.17b
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Anatomy of the Cerebellum
Two bilaterally symmetrical hemispheres connected medially by the vermis
Folia – transversely oriented gyri
Each hemisphere has three lobes – anterior, posterior, and flocculonodular
Neural arrangement – gray matter cortex, internal white matter, scattered nuclei
Arbor vitae – distinctive treelike pattern of the cerebellar white matter
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Cerebellar Peduncles
Three paired fiber tracts that connect the cerebellum to the brain stem
All fibers in the cerebellum are ipsilateral
Superior peduncles connect the cerebellum to the midbrain
Middle peduncles connect the pons to the cerebellum
Inferior peduncles connect the medulla to the cerebellum
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Cerebellar Processing
Cerebellum receives impulses of the intent to initiate voluntary muscle contraction
Proprioceptors and visual signals “inform” the cerebellum of the body’s condition
Cerebellar cortex calculates the best way to perform a movement
A “blueprint” of coordinated movement is sent to the cerebral motor cortex
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Cerebellar Cognitive Function
Plays a role in language and problem solving
Recognizes and predicts sequences of events
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12The Central Nervous System
Functional Brain Systems
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Functional Brain System
Networks of neurons working together and spanning wide areas of the brain
The two systems are:
Limbic system
Reticular formation
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Limbic System
Structures located on the medial aspects of cerebral hemispheres and diencephalon
Includes the rhinencephalon, amygdala, hypothalamus, and anterior nucleus of the thalamus
Parts especially important in emotions:
Amygdala – deals with anger, danger, and fear responses
Cingulate gyrus – plays a role in expressing emotions via gestures, and resolves mental conflict
Puts emotional responses to odors – e.g., skunks smell bad
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Limbic System
Figure 12.18
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Limbic System: Emotion and Cognition
The limbic system interacts with the prefrontal lobes, therefore:
One can react emotionally to conscious understandings
One is consciously aware of emotion in one’s life
Hippocampal structures – convert new information into long-term memories
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Reticular Formation
Composed of three broad columns along the length of the brain stem
Raphe nuclei
Medial (large cell) group
Lateral (small cell) group
Has far-flung axonal connections with hypothalamus, thalamus, cerebellum, and spinal cord
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Reticular Formation
Figure 12.19
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Reticular Formation: RAS and Motor Function
RAS – reticular activating system
Sends impulses to the cerebral cortex to keep it conscious and alert
Filters out repetitive and weak stimuli
Motor function
Helps control coarse motor movements
Autonomic centers regulate visceral motor functions – e.g., vasomotor, cardiac, and respiratory centers
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Brain Waves
Normal brain function involves continuous electrical activity
An electroencephalogram (EEG) records this activity
Patterns of neuronal electrical activity recorded are called brain waves
Each person’s brain waves are unique
Continuous train of peaks and troughs
Wave frequency is expressed in Hertz (Hz)
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Types of Brain Waves
Alpha waves – regular and rhythmic, low-amplitude, slow, synchronous waves indicating an “idling” brain
Beta waves – rhythmic, more irregular waves occurring during the awake and mentally alert state
Theta waves – more irregular than alpha waves; common in children but abnormal in adults
Delta waves – high-amplitude waves seen in deep sleep and when reticular activating system is damped
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Types of Brain Waves
Figure 12.20b
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Brain Waves: State of the Brain
Brain waves change with age, sensory stimuli, brain disease, and the chemical state of the body
EEGs can be used to diagnose and localize brain lesions, tumors, infarcts, infections, abscesses, and epileptic lesions
A flat EEG (no electrical activity) is clinical evidence of death
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Epilepsy
A victim of epilepsy may lose consciousness, fall stiffly, and have uncontrollable jerking, characteristic of epileptic seizure
Epilepsy is not associated with, nor does it cause, intellectual impairments
Epilepsy occurs in 1% of the population
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Epileptic Seizures
Absence seizures, or petit mal – mild seizures seen in young children where the expression goes blank
Grand mal seizures – victim loses consciousness, bones are often broken due to intense convulsions, loss of bowel and bladder control, and severe biting of the tongue
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Control of Epilepsy
Epilepsy can usually be controlled with anticonvulsive drugs
Valproic acid, a nonsedating drug, enhances GABA and is a drug of choice
Vagus nerve stimulators can be implanted under the skin of the chest and can keep electrical activity of the brain from becoming chaotic
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Consciousness
Encompasses perception of sensation, voluntary initiation and control of movement, and capabilities associated with higher mental processing
Involves simultaneous activity of large areas of the cerebral cortex
Is superimposed on other types of neural activity
Is holistic and totally interconnected
Clinical consciousness is defined on a continuum that grades levels of behavior – alertness, drowsiness, stupor, coma
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Types of Sleep
There are two major types of sleep:
Non-rapid eye movement (NREM)
Rapid eye movement (REM)
One passes through four stages of NREM during the first 30-45 minutes of sleep
REM sleep occurs after the fourth NREM stage has been achieved
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Types and Stages of Sleep: NREM
NREM stages include:
Stage 1 – eyes are closed and relaxation begins; the EEG shows alpha waves; one can be easily aroused
Stage 2 – EEG pattern is irregular with sleep spindles (high-voltage wave bursts); arousal is more difficult
Stage 3 – sleep deepens; theta and delta waves appear; vital signs decline; dreaming is common
Stage 4 – EEG pattern is dominated by delta waves; skeletal muscles are relaxed; arousal is difficult
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Types and Stages of Sleep: REM
Characteristics of REM sleep
EEG pattern reverts through the NREM stages to the stage 1 pattern
Vital signs increase
Skeletal muscles (except ocular muscles) are inhibited
Most dreaming takes place
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Sleep Patterns
Alternating cycles of sleep and wakefulness reflect a natural circadian rhythm
Although RAS activity declines in sleep, sleep is more than turning off RAS
The brain is actively guided into sleep
The suprachiasmatic and preoptic nuclei of the hypothalamus regulate the sleep cycle
A typical sleep pattern alternates between REM and NREM sleep
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Importance of Sleep
Slow-wave sleep is presumed to be the restorative stage
Those deprived of REM sleep become moody and depressed
REM sleep may be a reverse learning process where superfluous information is purged from the brain
Daily sleep requirements decline with age
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Sleep Disorders
Narcolepsy – lapsing abruptly into sleep from the awake state
Insomnia – chronic inability to obtain the amount or quality of sleep needed
Sleep apnea – temporary cessation of breathing during sleep
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Memory
Memory is the storage and retrieval of information
The three principles of memory are:
Storage – occurs in stages and is continually changing
Processing – accomplished by the hippocampus and surrounding structures
Memory traces – chemical or structural changes that encode memory
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Memory Processing
Figure 12.21
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Stages of Memory
The two stages of memory are short-term memory and long-term memory
Short-term memory (STM, or working memory) – a fleeting memory of the events that continually happen
STM lasts seconds to hours and is limited to 7 or 8 pieces of information
Long-term memory (LTM) has limitless capacity
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Transfer from STM to LTM
Factors that effect transfer of memory from STM to LTM include:
Emotional state – we learn best when we are alert, motivated, and aroused
Rehearsal – repeating or rehearsing material enhances memory
Association – associating new information with old memories in LTM enhances memory
Automatic memory – subconscious information stored in LTM
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Categories of Memory
The two categories of memory are fact memory and skill memory
Fact (declarative) memory:
Entails learning explicit information
Is related to our conscious thoughts and our language ability
Is stored with the context in which it was learned
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Skill Memory
Skill memory is less conscious than fact memory and involves motor activity
It is acquired through practice
Skill memories do not retain the context in which they were learned
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Structures Involved in Fact Memory
Fact memory involves the following brain areas:
Hippocampus and the amygdala, both limbic system structures
Specific areas of the thalamus and hypothalamus of the diencephalon
Ventromedial prefrontal cortex and the basal forebrain
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Structures Involved in Skill Memory
Skill memory involves:
Corpus striatum – mediates the automatic connections between a stimulus and a motor response
Portion of the brain receiving the stimulus
Premotor and motor cortex
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Mechanisms of Memory
Neuronal RNA content is altered
Dendritic spines change shape
Extracellular proteins are deposited at synapses involved in LTM
Number and size of presynaptic terminals may increase
More neurotransmitter is released by presynaptic neurons
New hippocampal neurons appear
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Mechanisms of Memory
Long-term potentiation (LTP) is involved and is mediated by NMDA receptors
Synaptic events involve the binding of brain-derived neurotropic factor (BDNF)
BDNF is involved with Na+, Ca2+, and Mg2+ influence at synapses
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Proposed Memory Circuits
Figure 12.22
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Protection of the Brain
The brain is protected by bone, meninges, and cerebrospinal fluid
Harmful substances are shielded from the brain by the blood-brain barrier
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Meninges
Three connective tissue membranes lie external to the CNS – dura mater, arachnoid mater, and pia mater
Functions of the meninges
Cover and protect the CNS
Protect blood vessels and enclose venous sinuses
Contain cerebrospinal fluid (CSF)
Form partitions within the skull
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Meninges
Figure 12.23a
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Dura Mater
Leathery, strong meninx composed of two fibrous connective tissue layers
The two layers separate in certain areas and form dural sinuses
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Dura Mater
Three dural septa extend inward and limit excessive movement of the brain
Falx cerebri – fold that dips into the longitudinal fissure
Falx cerebelli – runs along the vermis of the cerebellum
Tentorium cerebelli – horizontal dural fold extends into the transverse fissure
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Dura Mater
Figure 12.24
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Arachnoid Mater
The middle meninx, which forms a loose brain covering
It is separated from the dura mater by the subdural space
Beneath the arachnoid is a wide subarachnoid space filled with CSF and large blood vessels
Arachnoid villi protrude superiorly and permit CSF to be absorbed into venous blood
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Arachnoid Mater
Figure 12.23a
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Pia Mater
Deep meninx composed of delicate connective tissue that clings tightly to the brain
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Cerebrospinal Fluid (CSF)
Watery solution similar in composition to blood plasma
Contains less protein and different ion concentrations than plasma
Forms a liquid cushion that gives buoyancy to the CNS organs
Prevents the brain from crushing under its own weight
Protects the CNS from blows and other trauma
Nourishes the brain and carries chemical signals throughout it
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Choroid Plexuses
Clusters of capillaries that form tissue fluid filters, which hang from the roof of each ventricle
Have ion pumps that allow them to alter ion concentrations of the CSF
Help cleanse CSF by removing wastes
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Choroid Plexuses
Figure 12.25a
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Blood-Brain Barrier
Protective mechanism that helps maintain a stable environment for the brain
Bloodborne substances are separated from neurons by:
Continuous endothelium of capillary walls
Relatively thick basal lamina
Bulbous feet of astrocytes
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Blood-Brain Barrier: Functions
Selective barrier that allows nutrients to pass freely
Is ineffective against substances that can diffuse through plasma membranes
Absent in some areas (vomiting center and the hypothalamus), allowing these areas to monitor the chemical composition of the blood
Stress increases the ability of chemicals to pass through the blood-brain barrier
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Cerebrovascular Accidents (Strokes)
Caused when blood circulation to the brain is blocked and brain tissue dies
Most commonly caused by blockage of a cerebral artery
Other causes include compression of the brain by hemorrhage or edema, and atherosclerosis
Transient ischemic attacks (TIAs) – temporary episodes of reversible cerebral ischemia
Tissue plasminogen activator (TPA) is the only approved treatment for stroke
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Degenerative Brain Disorders
Alzheimer’s disease – a progressive degenerative disease of the brain that results in dementia
Parkinson’s disease – degeneration of the dopamine-releasing neurons of the substantia nigra
Huntington’s disease – a fatal hereditary disorder caused by accumulation of the protein huntingtin that leads to degeneration of the basal nuclei
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Embryonic Development of the Spinal Cord
Develops from caudal portion of neural tube
By week 6, there are two clusters of neuroblasts:
Alar plate – will become interneurons
Basal plate – will become motor neurons
Neural crest cells form the dorsal root ganglia
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Embryonic Development of the Spinal Cord
Figure 12.27
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12The Central Nervous System
Part D
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Spinal Cord
CNS tissue is enclosed within the vertebral column from the foramen magnum to L1
Provides two-way communication to and from the brain
Protected by bone, meninges, and CSF
Epidural space – space between the vertebrae and the dural sheath (dura mater) filled with fat and a network of veins
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Spinal Cord
Figure 12.28a
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Spinal Cord
Conus medullaris – terminal portion of the spinal cord
Filum terminale – fibrous extension of the pia mater; anchors the spinal cord to the coccyx
Denticulate ligaments – delicate shelves of pia mater; attach the spinal cord to the vertebrae
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Spinal Cord
Spinal nerves – 31 pairs attach to the cord by paired roots
Cervical and lumbar enlargements – sites where nerves serving the upper and lower limbs emerge
Cauda equina – collection of nerve roots at the inferior end of the vertebral canal
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Cross-Sectional Anatomy of the Spinal Cord
Anterior median fissure – separates anterior funiculi
Posterior median sulcus – divides posterior funiculi
Figure 12.30a
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Gray Matter and Spinal Roots
Gray matter consists of soma, unmyelinated processes, and neuroglia
Gray commissure – connects masses of gray matter; encloses central canal
Posterior (dorsal) horns – interneurons
Anterior (ventral) horns – interneurons and somatic motor neurons
Lateral horns – contain sympathetic nerve fibers
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Gray Matter and Spinal Roots
Figure 12.30b
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Gray Matter: Organization
Dorsal half – sensory roots and ganglia
Ventral half – motor roots
Dorsal and ventral roots fuse laterally to form spinal nerves
Four zones are evident within the gray matter – somatic sensory (SS), visceral sensory (VS), visceral motor (VM), and somatic motor (SM)
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Gray Matter: Organization
Figure 12.31
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White Matter in the Spinal Cord
Fibers run in three directions – ascending, descending, and transversely
Divided into three funiculi (columns) – posterior, lateral, and anterior
Each funiculus contains several fiber tracks
Fiber tract names reveal their origin and destination
Fiber tracts are composed of axons with similar functions
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White Matter: Pathway Generalizations
Pathways decussate
Most consist of two or three neurons
Most exhibit somatotopy (precise spatial relationships)
Pathways are paired (one on each side of the spinal cord or brain)
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White Matter: Pathway Generalizations
Figure 12.32
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Main Ascending Pathways
The central processes of fist-order neurons branch diffusely as they enter the spinal cord and medulla
Some branches take part in spinal cord reflexes
Others synapse with second-order neurons in the cord and medullary nuclei
Fibers from touch and pressure receptors form collateral synapses with interneurons in the dorsal horns
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Three Ascending Pathways
The nonspecific and specific ascending pathways send impulses to the sensory cortex
These pathways are responsible for discriminative touch and conscious proprioception
The spinocerebellar tracts send impulses to the cerebellum and do not contribute to sensory perception
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Nonspecific Ascending Pathway
Nonspecific pathway for pain, temperature, and crude touch within the lateral spinothalamic tract
Figure 12.33b
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Specific and Posterior Spinocerebellar Tracts
Specific ascending pathways within the fasciculus gracilis and fasciculus cuneatus tracts, and their continuation in the medial lemniscal tracts
The posterior spinocerebellar tract
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Specific and Posterior Spinocerebellar Tracts
Figure 12.33a
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Descending (Motor) Pathways
Descending tracts deliver efferent impulses from the brain to the spinal cord, and are divided into two groups
Direct pathways equivalent to the pyramidal tracts
Indirect pathways, essentially all others
Motor pathways involve two neurons (upper and lower)
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The Direct (Pyramidal) System
Direct pathways originate with the pyramidal neurons in the precentral gyri
Impulses are sent through the corticospinal tracts and synapse in the anterior horn
Stimulation of anterior horn neurons activates skeletal muscles
Parts of the direct pathway, called corticobulbar tracts, innervate cranial nerve nuclei
The direct pathway regulates fast and fine (skilled) movements
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The Direct (Pyramidal) System
Figure 12.34a
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Indirect (Extrapyramidal) System
Includes the brain stem, motor nuclei, and all motor pathways not part of the pyramidal system
This system includes the rubrospinal, vestibulospinal, reticulospinal, and tectospinal tracts
These motor pathways are complex and multisynaptic, and regulate:
Axial muscles that maintain balance and posture
Muscles controlling coarse movements of the proximal portions of limbs
Head, neck, and eye movement
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Indirect (Extrapyramidal) System
Figure 12.34b
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Extrapyramidal (Multineuronal) Pathways
Reticulospinal tracts – maintain balance
Rubrospinal tracts – control flexor muscles
Superior colliculi and tectospinal tracts mediate head movements
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Spinal Cord Trauma: Paralysis
Paralysis – loss of motor function
Flaccid paralysis – severe damage to the ventral root or anterior horn cells
Lower motor neurons are damaged and impulses do not reach muscles
There is no voluntary or involuntary control of muscles
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Spinal Cord Trauma: Paralysis
Spastic paralysis – only upper motor neurons of the primary motor cortex are damaged
Spinal neurons remain intact and muscles are stimulated irregularly
There is no voluntary control of muscles
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Spinal Cord Trauma: Transection
Cross sectioning of the spinal cord at any level results in total motor and sensory loss in regions inferior to the cut
Paraplegia – transection between T1 and L1
Quadriplegia – transection in the cervical region
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Poliomyelitis
Destruction of the anterior horn motor neurons by the poliovirus
Early symptoms – fever, headache, muscle pain and weakness, and loss of somatic reflexes
Vaccines are available and can prevent infection
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Amyotrophic Lateral Sclerosis (ALS)
Lou Gehrig’s disease – neuromuscular condition involving destruction of anterior horn motor neurons and fibers of the pyramidal tract
Symptoms – loss of the ability to speak, swallow, and breathe
Death occurs within five years
Linked to malfunctioning genes for glutamate transporter and/or superoxide dismutase
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Developmental Aspects of the CNS
CNS is established during the first month of development
Gender-specific areas appear in response to testosterone (or lack thereof)
Maternal exposure to radiation, drugs (e.g., alcohol and opiates), or infection can harm the fetus’ developing CNS
Smoking decreases oxygen in the blood, which can lead to neuron death and fetal brain damage
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Developmental Aspects of the CNS
The hypothalamus is one of the last areas of the CNS to develop
Visual cortex develops slowly over the first 11 weeks
Growth and maturation of the nervous system occurs throughout childhood and reflects progressive myelination
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Developmental Aspects of the CNS
Age brings some cognitive declines, but these are not significant in healthy individuals until they reach their 80s
Excessive use of alcohol causes signs of senility unrelated to the aging process