015.effect of periodontal diseases on outcome of various systemic conditions
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Dr Jaffar Raza Syed Page 1 Effect of PDD on outcome of various SYSTEMIC Conditions There is definite association between oral infection and systemic diseases e.g. --atherosclerosis, --cardiovascular diseases, --cerebrovascular diseases, --premature low-birth infants Adverse pregnancy outcomes --pulmonary diseases
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Transcript of 015.effect of periodontal diseases on outcome of various systemic conditions
Dr Jaffar Raza Syed Page 1
Effect of PDD on outcome of various SYSTEMIC Conditions There is definite association between oral infection and systemic diseases e.g. --atherosclerosis, --cardiovascular diseases, --cerebrovascular diseases, --premature low-birth infants Adverse pregnancy outcomes --pulmonary diseases
Dr Jaffar Raza Syed Page 2
Periodontal Disease And Coronary Heart Disease/Atherosclerosis --correlation between the PD disease and degree of coronary atheromatosus --periodontal disease is a risk factor for CHD, independent of other classic risk factors --other risk factors are smoking, diabetes and low socioeconomic status
Dr Jaffar Raza Syed Page 3
Effect Of Periodontal Infection On Ischemic Heart Diseases --IHD is associated with the process of atherogenesis and thrombogenesis. --Increased viscosity of blood may promote major ischemic heart disease and stroke by increasing the thrombus formation --Increased plasma fibrinogen is a recognized risk factor --elevated white blood cell count and coagulation factor VIII has been associated with risk of ischemic heart disease
Dr Jaffar Raza Syed
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Dr Jaffar Raza Syed
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Dr Jaffar Raza Syed
Atherosclerosis
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Dr Jaffar Raza Syed Page 7
Periodontal Disease And Diabetes Mellitus --Systemic infection increases tissue resistance to insulin, --preventing glucose from entering target cells causing elevated blood glucose level and requiring increased pancreatic insulin production to maintain normoglycemia. --possible that chronic Gram-negative periodontal infection may also result in increased insulin resistance and poor glycemic control.
Dr Jaffar Raza Syed Page 8
Role Of Periodontitis In Pregnancy Outcome --role in preterm low birth weight and preeclampsia. --Periodontopathic organisms Host cytokines production --P.g associated with significant increase in fetal death and a decrease in fetal birth weight --significant increase in TNF- α and PGE2 levels --correlation between TNF- α and PGE2 levels, as well as fetal death and growth retardation --women with severe periodontitis are 7.5 times more likely than women without periodontal disease to have an infant with preterm low-birth weight.
Dr Jaffar Raza Syed
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