“ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011
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Transcript of “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011
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“Working with the web-database andBiobanking”
MEDICEL meeting 2011Bologna. April 5 2011
Jose Ramon Bilbao
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
it needs to grow
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
request for access…
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your country
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
![Page 8: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/8.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
you can only do two things now…
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
![Page 10: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/10.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
![Page 11: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/11.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
You should have your code safe with youcountry_XX = patient ID
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
This will be important for follow-up…
You should have your code safe with youcountry_XX = patient ID
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will check
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
![Page 18: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/18.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will check
“Lab” results
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkShould addrapid test (+/-)?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will check
Biological material
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will check
Is this realistic?
• Fixed?• Frozen?• Slide?• Paraffin block?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
we are implementing an image repository to upload images for training and for consultation
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
we are implementing an image repository to upload images for training and for consultation
we need them!!
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
![Page 26: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/26.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
RESEARCH!
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
RESEARCH! and…
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
…but are they necessary?Confirm rapid testsunclear results
Reference Laboratory
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkGenetic studies?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
Provide affordableHLA testing
SNP-basedDQ2.5DQ2.2DQ8
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?Provide affordable
HLA testing
DNAbank
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
Provide affordableHLA testing
Or should we share “image files” with
consultant pathologistsCould these two ideas be the basis for a
collaborative project?
![Page 34: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/34.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?symptoms/signs
![Page 35: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/35.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?symptoms/signs
are we happy?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
…let us know
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
![Page 40: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/40.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
![Page 41: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/41.jpg)
The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
270 w/out HLA typing!
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The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
270 w/out HLA typing! …should we?
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The MediCel database… what next?http//medicel.sedyne.org
type your name
…we want to do more than just two things
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The MediCel database… what next?http//medicel.sedyne.org
type your name
…we want to do more than just two things
![Page 46: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/46.jpg)
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD
- confirmed? - doubtful?
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD
- confirmed? - doubtful?
seek help from the “experts”…through the database
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information
- associated diseases- re-testing of TGA- re-byopsying
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images
linked to patient data
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD - confirmed? y/n2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images
linked to patient data
![Page 52: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/52.jpg)
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images5.- “Memo” field to share comments
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The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images5.- “Memo” field to share comments
and even more!... just ask [email protected]
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Potential R+D Projects in MediCel
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Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
![Page 56: “ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011](https://reader035.fdocuments.in/reader035/viewer/2022081604/5681600d550346895dcf0c91/html5/thumbnails/56.jpg)
Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
2. Validation of affordable technologies for lab testing in CDa) Retyping of HLA using proxy SNPs to validate in our populations
Set up a reference lab/protocol for typing of new cases w/ SNPsSharing of DNA samples (saliva, blood spots…)
b) Evaluate the performance of point-of-care methods in our settingSet up a reference lab/protocol for validation assaysSharing of serum samples
c) Creation of a BIOBANK through these projects
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Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
2. Validation of affordable technologies for lab testing in CDa) Retyping of HLA using proxy SNPs to validate in our populations
Set up a reference lab/protocol for typing of new cases w/ SNPsSharing of DNA samples (saliva, blood spots…)
b) Evaluate the performance of point-of-care methods in our settingSet up a reference lab/protocol for validation assaysSharing of serum samples
c) Creation of a BIOBANK through these projects