biotransport.files.wordpress.com … · Web viewNotation, p xxi, for G. B, the phrase should read,...

Page Edits for Basic Transport Phenomena in Biomedical Engineering, 4th ed.,

K29261, Ronald L. Fournier

1. Inside the cover title page, use full professional title, i.e., Ronald L. Fournier, PhD, PE Department of Bioengineering

The University of Toledo2. Contents, p vii, 1.3.4, should read, Material balances3. Contents, p xi, 6.2.1, add a space between LP and the comma, i.e., LP , Pm , and 4. Notation, p xx, remove the line that reads, D dilution rate5. Notation, p xx, for 2nd F entry , phrase should be, Volumetric flowrate to the device6. Notation, p xxi, for GB, the phrase should read, Glucose concentration in the blood,

remove the word plasma7. Notation, p xxi, for HT, the phrase should read, Tube hematocrit8. Notation, p xxi, after first entry of i, add the following new line,

~i ,~j ,~k Unit vectors in x,y, and z directions9. Notation, p xxi, the phrase for the km entry should read ‘Length averaged mass transfer

coefficient’10. Notation, p xxi, k m should be replaced with km local, and the phrase should then read ‘Local

mass transfer coefficient’11. Notation, p xxii, remove the line that reads, KS Monod constant12. Notation, p xxii, remove the line that reads, P,P’ Product concentration13. Notation, p xxii, remove the line that reads, Pc Permeability of the capillary wall to

oxygen14. Notation, p xxiii, there is a bar above and a bar above P, there should just be one bar

like this ∆ P15. Notation, p xxiii, rC should be rc where the c is lower case16. Notation, p xxiv, ~v t should be ~v i

17. Notation, p xxv, remove the line that reads, YX/S, YP/S, YP’/S Yield coefficients18. Notation, p xxvii, remove the line that reads, µ Specific growth rate

Chapter 1

1. p 9, last sentence under 1.3, the ‘Are’ should be ‘are’2. p 13, very last sentence on the page, the ‘And’ should be ‘and’3. p 14, very first sentence, Section 2.6.3.13 should be Section 2.6.3.154. p 19, line 6, the ‘And’ should be ‘and’5. p 20, line 5, where it says, ‘,i.e., y ,’ the y should be ‘, i.e., √τ y’6. p 22, line 8, where it says, ‘,i.e., y ,’ the y should be ‘, i.e., √τ y’

AQ1 – AQ4: the answer is YES for each issue

1

Chapter 21. p 40, in paragraph following eqn 2.13 the two Cp’s should be CP , where the subscript

is an upper case P2. p 41, in paragraph following eqn 2.19 the Cp should be CP , where the subscript is an

upper case P3. p 58, the very last summation symbol in eqn 2.78 should have an i under the symbol

like the preceding term in this equation4. p75, in phrase before eqn 2.137, ‘Equations 2.136 and 2.137’ should be ‘Equations

2.135 and 2.136’5. p79, in line 5, the should be 6. p79, in 2nd line after eqn 2.145, (PA-PB) should be (PA – PB)7. p79, in 2nd line after eqn 2.145, the should be 8. p79, in eqns 2.146 and 2.147, the should be 9. p80, in eqn 2.148, the should be 10. p80, in Example 2.15 under Solution, the in the equation should be 11. p 82, in 1st and 2nd lines of Example 2.17, Ko/w should be KO/W

12. p 85, in the very last line x3II looks to be italicized which is not the style

13. p 86, in the line before eqn 2.166 ‘phase I’ should be ‘phase II’14. p 94, at the end of the sentence in the 1st paragraph of section 2.6.3.11 write at the end

of the last sentence in the paragraph as ‘…processes as capillary flow and wicking.’15. p 102, in the 1st sentence under Solution the 104 M-1 should be 104 M-1.16. p104, in the sentence following eqn 2.210 µNa = should be µNaCl = 17. p105, in the first line remove ‘Implicit in these equations is that…’ and replace with

‘When ZM > 0, Equations 2.214 and…’18. p105, in the 1st line following eqn 2.219, replace ‘where ZM > 0.’ with ‘where ZM < 0.’19. p106, in eqn 2.220, the should be 20. p106, in line 10, the should be 21. p106, in eqn 2.221, the should be 22. p107, inside the Solution, there are two ’s in the calculation that should be 23. p107, in that 1st calculation before the 0.0821 L atm mol-1K-1 term there are “…”, this

means that the line should be broken after the “…”, so the 0.0821 L atm mol-1K-1 term should be on the next line preceding the x 298 K etc term

24. p115, in 2.1, the Cp should be CP

25. p115, in 2.2, the Cp should be CP

26. p115, in 2.6 the Cp should be CP

27. p117, in 2.16, all occurences of z should be replaced with Z28. p118, in 2.17, in the 1st line of this problem replace 625 with 325. In the table for this

problem replace 5850 with 482529. p120, there are 5 places where should be 30. p121, at the top of the page there are two places where the should be 31. p122, the words for problem 2.33 should be replaced with, ‘Protein concentration in a

membrane bag is 0.005 M with ZM = +15. NaCl outside the bag is 0.15 M. Find of the protein in the bag.’

2

32. p122, in 2.39, between the words ‘solution containing’ insert ‘at 37 oC’33. p124, in 2.50, the phrase ‘Osmotic Pressure of Albumin Solutions (Vilker et al.,

1981)’ should be moved down and placed as the caption to the table that is given

AQ1: PVT was defined at the beginning of section 2.3 and is a common abbreviation for pressure, volume, and temperature

AQ2: yes and in my corrections too

AQ3: this is ok

AQ4: yes

AQ5: PA -PB is better so make those changes accordingly

AQ6: ok

AQ7: that is ok

AQ8: that is ok

AQ9: the numbering as shown is correct

AQ10: I prefer NaAscorbate as shown

Chapter 3

1. p126, in table 3.1, please tab in the rows beginning with ‘Interstitial’ and ‘Plasma’ since they are subheadings to ‘Extracellular’

2. p130, in eqn 3.3, the should be 3. p138, in the LP eqn add the leading 0 to .5 m2

4. p139, in the 2nd line, in the equation, change Dc2 to dcapillary

2

5. p139, in the beginning of the 2nd paragraph under section 3.7 replace ‘Two types of edema can occur. The first type involves…’ with ‘Edema is …’

6. p143, in the 2nd to the last paragraph, there are 3 occurrences of Ca+. These should be replaced with Ca++

7. p145, in the 2nd and the last paragraphs replace Table 3.3 with Table 3.48. p148, in 3.12, after the equation for V add a comma and then mV, i.e., ‘, mV’9. p149, in 3.14, in line 7, 0.00015 should be 0.001510. p150, in 3.18, the last sentence, LpS should be LPS11. p150, in 3.19, line 3, the tm should be L

AQ1: mOsM is ok to use

3

AQ2: for osmotic pressure use and is reserved for pi which is 3.1415…, I have corrected these

AQ3: I prefer NaAscorbate

AQ4: I have made the correction for this

AQ5: yes that is correct

AQ6: - - 3 can be changed to – (-3)

AQ7: please add the leading zero before the decimal point where appropriate

AQ8: you are correct, should be mmHg

AQ9: electric potential is better

Chapter 4

1. p154, in Table 4.1, under “formed elements”, 109, 109, 107, 106, 108 should be changed to 109, 109, 107, 106, 108

2. p157, in 3rd paragraph, replace Equation 4.2a and b with Equation 4.13. p158, in 1st paragraph in section 4.4 line 5, add a minus sign in front of P4. p158, figure 4.4 is really figure 4.5 and then figure 4.5 is really figure 4.45. p159, in line 6 the ‘At’ should be ‘at’6. p159, in 1st line after eqn 4.3, insert ‘the’ between ‘and’ and ‘middle’7. p161, in 2nd line after eqn A remove the ‘of’ between ‘than’ and ‘liquids’8. p162, in example 4.2 under the solution change the final number of 7218 to 72249. p164, in eqn 4.22, and 2 lines above that, use the unbolded form of U10. p165, in table 4.3, the last row, in the equations change the D3 to d3

11. p166, figure 4.5 is really figure 4.412. p167, in eqn 4.27 use the unbolded form of U13. p168, in example 4.6, line 9, Equation 4.26 should be Equation 4.2714. p173, under section 4.8.3, in line 4, replace ‘hematocrit’ with core and plasma viscosities’15. p175, in example 4.8, line 1, remove the reference to Bayliss 1952 and Gaehtgens 198016. p178, in the line before eqn 4.51, remove ‘and b’17. p184, in the line before eqn 4.67, remove ‘and b’18. p186, in the 4th line after eqn 4.76 remove the ‘and’ so it says ‘…layer problem is quite

good not only…’19. p190, the phrase ‘within tube section’ should read ‘within tube section i’20. p194, in the 3rd to the last line the V2’s should be V2

2

21. p199, in the 5th line, change ‘The IV is fed…’ to ‘The IV fluid is fed…’22. p200, in the 3rd line the 3 minus signs in front of the given numbers seem to be rather

long23. p200, in the equation just above section 4.11 the D should be d in the Re calculation24. p203, in eqn 4.98, in the last term of the equation the …R3 h(t) should be …R2 h(t)

4

25. p206, in 4.13, the phrase ‘You want a flow rate of …’ should be ‘You want a blood flow rate of …’

26. p208, 3 lines above problem 4.24, ‘Analysis’ should be ‘analysis’27. p208, the line that reads “Apparent viscosity of Conceptrol….” should be the caption to

the table28. p210, in the last line before problem 4.26, remove the ‘are’ after PL

29. p212, in the equation after the 7th line for z = change the D to d30. p214, in problem 4.44, remove the sentence “The difference in fluid levels…” with “The

surface of the liquid contained in the filtration feed tank is 20 feet above the surface of the liquid in the fermentor.”

31. p215, problem 4.51, Remove the problem and replace with

The rheological properties of a new personal lubricant were studied in a viscometer. A linear regression of these data was performed after first taking the natural log of the apparent viscosity (cP) and the natural log of the shear rate (1/sec). The equation for the regression line is: ln µapparent = 11.02 – 0.75 ln γ. What are the parameters in an appropriate viscosity model? Be sure to state what the viscosity model is and any units on your parameters. Is this lubricant’s behavior Newtonian or Non-Newtonian ?

32. p215, in problem 4.57, replace the last sentence with “Assume cos = 1.”33. p215, in problem 4.58, line 8, should read “…there are also 8 – 90o elbows…”34. p216, problem 4.69, change 1.5 mm to 4.0 mm35. p217, 2nd line from top, change 30 seconds to 10 seconds36. p219, in 4.86, remove the 2nd line beginning with “According to this…”37. p219, in 4.88, Problem 88 should be problem 4.8638. p219, in 4.89, change to “A fire suppression system (FSS) at a remote resort…”39. p219, in 4.92, in the 4th line, change “an oil with a…” to “a polymeric fluid with a…”

AQ1: this is ok with meAQ2: in figure 4.1 the (a) caption is “top view”, the (b) caption is “side view”, and the (c) caption is “rouleaux” which is already there. For figure 4.10, for (a) “plate and fluid at rest”, for (b) “plate begins to move”, and for (c) “plate moves at constant velocity V”AQ3: I changed the text for this so it is more clearAQ4: I recommend the less bold formAQ5: these references for Bayless and Gaehtgens can be removed and the main source is just Gaehtgens 1980AQ6: I don’t see why bold font in this table is neededAQ7: this sentence is ok as writtenAQ8: Owen is the source for the data in the tableAQ9: this Bush et al. reference can be added to the end of book references. Also the article title is “On the flow through the human female urethra”AQ10: viscometer data is better

5

AQ11: problem 88 should be problem 4.86

Chapter 5

1. p221, in section 5.2, line 10, I prefer the summation sign to be reduced in size since it seems rather large.

2. p222, in equation 5.1, the summation signs are not of the same style. They should all look like the one in the last term on the far right

3. p222, in equation 5.2, the summation signs are not of the same style. They should all look like the one in the last term on the far right

4. p222, eqn 5.6, the ~ji should be ~J i , i.e., change the lc j to an uc J5. p222, eqn 5.6, the ~ji

+¿ ¿ should be ~J i+¿ ¿ , i.e., change the lc j to an uc J

6. p223, in the line before eqn 5.11 the ‘For’ should be ‘for’7. p223, in the line before eqn 5.12 the ‘For’ should be ‘for’8. p225, in section 5.2.4, 2nd line, the “And” should be “and”9. p225, in section 5.2.4.1, 1st line, the “Is” should be “is”10. p226, in the line before eqn 5.22, the “At” should be “at”11. p226, in the 1st line after eqn 5.23, the “And” should be “and”12. p226, in the 5th line after eqn 5.23, the “Can” should be “can”13. p227, in 2nd line before eqn 5.30, “Controlling” should be “controlling”14. p228, in the line before eqn 5.32, “Is” should be “is”15. p230, in the definitions below eqn 5.40, NA should be NA

16. p231, in the DAB calculation at the bottom of the page, the “kg mm” should be “kg m m”17. p234, in the 2 lines before eqn 5.51, the “And” should be “and” and the “For” should be

“for”18. p234, in the 2nd line after eqn 5.53, remove the phrase “that is initially at rest”19. p251, in the 2nd to the last line, “we first we need” should be “we first need”20. p253, in the table at the bottom of the page, in the table headings, change MAtotal to mA

21. p254, in 2nd line of section 5.9.1.1, change << to 22. p257, in eqn 5.108, and the line following, there is a symbol font style difference for zeta,

i.e., , see if there is a way to be consistent with zeta23. p258, in the line following eqn 5.113, “Given” should be “given”24. p260, please remove the sentence following eqn 5.11925. p261, under Solution, line 5, Equation 1.18 should be Equation 1.826. p264, in eqn 5.124, BC3, “ y=∂C(x)” should be “y=δC(x )”27. p265, in the line following eqn 5.129, in the definition of Sc, the D should be DAB

28. p266, in eqn 5.131, the subscript “c” in in the first term on the left should be uc, i.e., “C”

29. p266, in eqn 5.131, there are two occurrences of D which should be DAB

30. p266, in eqns 5.133 and 5.134, add a space, i.e., kmlocal should be km local

31. p266, in eqn 5.135, the D should be DAB

32. p268, in the top equation the D should be DAB

33. p268, in the 2nd to the last line, the “For” should be “for”

6

34. p274, in the 3rd to the last line, the “In” should be “in”35. p278, in the last line, the “Are” should be “are”36. p279, in Table 5.1, in the 3rd and 6th equations, kmlocal should be km local

37. p280, in table 5.1, 2nd eqn, kmlocal should be km local

38. p281, 1st line under Solution, the “At” should be “at”39. p283, in 5.10, change 0.79 to 0.80 and change 0.68 to 1.19840. p283, in 5.10, change “…disk is zero.” to “…disk is zero and the temperature is 20 oC.”41. p285, in 5.24, remove “was measured” and replace with “is”42. p286, in 5.36, 2nd line, the “Is” should be “is”43. p286, in 5.37, last line, the “Is” should be “is”44. p287, in 5.39, “Example 5.10” should be “Example 5.12”. Second sentence should be

changed to read as “Assume there is no oxygen in the entering plasma and that the saturation oxygen level in plasma is 216 µM.”

AQ1: that is okAQ2: I prefer equilibrium solubilityAQ3: that is okAQ4: the symbol should be zeta and it seems as I mentioned above that there are two symbol font styles being usedAQ5: I have asked that we remove that sentence which includes the referenceAQ6: the correct equation is 1.8

Chapter 6

1. p289, replace the last 2 lines of 1st paragraph under section 6.1.1 with “The porosity, i.e., , of the membrane is then given by AP/S.

2. p290, in 2nd line, the L should be L 3. p291, replace the 1st sentence after the caption for section 6.1.1.2 with “Now we can

apply Fick’s first law to the situation of solute diffusion through a single straight cylindrical pore.”

4. p292, in the 4th line, the L should be L 5. p292, in the 1st line after eqn 6.4 remove the phrase “…of a thin planar membrane…”6. p293, in the 1st line after eqn 6.10, remove the phrase “…or a void volume fraction…”7. p300, in the line after eqn 6.28, inside the integral term after “where” remove the two

multiplication signs and replace them with “x”8. p300, in the 2nd line after eqn 6.30, in the 1st math expression in that line, the “E” should

be “CA”9. p302, in the 2nd line after eqn 6.38, replace A0-SLCA

0 with A0 = SLCA0

10. p312, the summations in equations 6.67, 6.68, and 6.69 should have added “i=1” and N,

i.e., like this ∑i=1

N

❑

11. p315, under Solution, in the 6th line, the equation reference should be 6.46 and not 6.4512. p315, under Solution, in the 9th line, the equation reference should be 6.60 and not 5.60

7

13. p316, under Solution, in the 6th line, the equation reference should be 6.46 and not 6.4514. p322, in the 2nd line after eqn 6.84, remove the sentence “This is illustrated in Example

6.8 below.”15. p328, in equations 6.95, 6.96, 6.98, rC should be rc, i.e., the c should be lower case16. p329, in equation 6.101, the C should be C A and the C0 should be C A

0

17. p337, in the last line, and in the equation that follows, the S0 should be SO

18. p343, in 6.10, 2nd line, rC should be rc, i.e., the c should be lower case

AQ1: that is ok

AQ2: yes

AQ3: Serra L., J. Doménech, N.A. Peppas. 2006. Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27:5440–51

AQ4: yes

AQ5: yes

AQ6: yes, this is ok as written

AQ7: there is no equation 6.102, so the current equations of 6.103 – 6.118 should all be decreased by 1, so Equation 6.103 becomes 6.102 etc., here are the in text reference corrections to these new equations

a. p331, 1st line after the definitions for the new equation 6.103, the sentence should be “Equation 6.103 can then be rearranged…”

b. p331, in 1st line after new eqn 6.105, the 6.105 and 6.106 equation references should be changed to 6.104 and 6.105

c. p331, in 2nd line above new equation 6.106, Equation 6.106 should now be “Equation 6.105 can then be rearranged…”

d. p331, under the new equation 6.106, should be “Sa is given by Equation 6.102”e. p332, 1st line “Equation 6.107” is now “Equation 6.106”f. p332, under Solution, in the 3rd line, “Equation 6.103” is now “Equation 6.102”g. p333, in the line above section 6.5.1, the “Equation 6.107” is now “Equation 6.106”h. p333, in 1st line after new Equation 6.108, change “In Equation 6.108…” to “In

Equation 6.107…”i. p334, in 1st line change “Equation 6.109” to “Equation 6.108”j. p334, in line above new Equation 6.110, “Equation 6.110” becomes “Equation 6.109”k. p334, in the line after new Equation 6.112, “From Equation 6.110…” becomes “From

Equation 6.109…”l. p334, in the 2nd line after new Equation 6.112, “Equation 6.113…” becomes

“Equation 6.112…”m. p334, in the line after new Equation 6.113, “Equation 6.114…” becomes “Equation

6.113…” and a bit later in that line the “Equation 6.110” becomes “Equation 6.109”

8

n. p334, in the last line before new Equation 6.114, “Equation 6.111” becomes “Equation 6.110” and “Equation 6.114” becomes “Equation 6.113”

o. p335. In the 1st line change “Equation 6.115” to “Equation 6.114” and in the 3rd line make that same change again

p. p335, in line after new Equation 6.115, change “Equation 6.116” to “Equation 6.115”q. p335, in line before new Equation 6.117, change “Equation 6.117” to “Equation

6.116”r. p335, in line after new Equation 6.117, change “Equation 6.118” to “Equation 6.117”s. p336, 6th line up from the bottom, change “Equation 6.107” to “Equation 6.106”t. p337, 6th line up from the bottom, change “Equation 6.103” to “Equation 6.102”u. p337, 2nd line up from the bottom, change “Equation 6.107” to “Equation 6.106”v. p338, in 1st line, change “Equation 6.117” to “Equation 6.116”w. p338, 7 lines up from the bottom, change “Equation 6.118” to “Equation 6.117”x. p342, 12 lines up from the bottom, change “Equation 6.110” to “Equation 6.109”

Chapter 7

1. p349, 1st line in 2nd paragraph, change “closed symbols” to “diamond symbols”2. p349, 5th line in 2nd paragraph, change “open symbols” to “square symbols”3. p352, 1st line in example 7.1, change “closed symbol” to “diamond symbol”4. p360, in section 7.7.1, 6th line, remove the “of” before “, respectively”5. p361, in the 2nd line of the 2nd paragraph after eqn 7.19, the 7 mL should be 7 nL, since

the flow rate is 7 nanoliters abbreviated as nL6. p361, 3rd line from the bottom, change “1-2” to “about 5”7. p362, under Solution, in the 6th line, “Are” should be “are”8. p364, in Equation 7.23, the last terms should read oxygen S x 9. p365, 1st line, change “combined cell layer and void space” to “tissue”10. p366, last line before Example 7.6, remove the word “two” before the word “examples”11. p368, in the line before Equation 7.31, remove the phrase “by simply replacing Pm with

km”12. p373, in Equation 7.33 replace the minus sign in front of the 2nd occurrence of SDT with a

plus sign13. p379, in the line before Example 7.12, change “xcritical” to “”14. p380, 1st line, Pe should be Peh

15. p381, in the footer, “Chapter 5” should “Chapter 6”16. p383, in Equation 7.59, in the 1st line of that equation and on the right side of the equation

sign, there should be a + sign in front of (-2rr) and not a – sign17. p385, in equation 7.68, on the left side of the equal sign pO2 should be <pO2> 18. p387, in the last line, change “and 5% dextrose” to “and a 5% dextrose solution”19. p392, in 7.13, line 9, change “Foster (1993) state…” to “Foster (1993) states…”20. p393, in 7.15, 2nd line, replace “chondrocytes” with “cells” and “cartilage” with “tissue”21. p393, in 7.15, 4th line, replace “chondrocytes” with “cells”

9

22. p393, in 7.18, 4th line, at the very end of that line add “…and = 0.15.”23. p395, in 7.37, 4th line, remove “in” at the end of that line24. p397, in 7.48, 3rd line, remove “void”25. p397, in 7.50, 3rd line, replace “being” with “is”

AQ1: Brockmann is the correct spelling

AQ2: goramy is correct

AQ3: within the islet bodies is ok to use

AQ4: that is correct

AQ5: Archibald is correct

AQ6: I would remove the – and just go with for example x intercept

AQ7: DPG is ok

AQ8: this is ok to do

AQ9: remove the “of” after “mmHg”

AQ10: summarized is better

AQ11: Ehsan and George is the correct citation



AQ14: I like successful better

AQ15: this is correct

AQ16: this sentence is correct

AQ17: the renumbering is correct



AQ20: RPM is the correct way to express this





AQ25: Andromedian qwak is correct

10

Chapter 8

1. p410, 2nd line, should read as “…is controlled by antidiuretic hormone providing…” 2. p410, 5th line, should read as “…under the control of antidiuretic hormone and…”3. p416, in example 8.3, move the sentence “Inulin elimination from a Laboratory Rat…” so

it is over the top of the table since this is a caption for the table4. p419, in equation 8.40, change the ’s to 5. p419, 2 lines above equation 8.41, change the ’s to 6. p419, in equation 8.41, change the ’s to 7. p420, 4 lines under equation 8.44, change the to 8. p420, in equation 8.45 and equation 8.46, change the ’s to 9. p422, Table 4.5 should be Table 4.410. p432, under Solution in the 7th line, the 2.5 mg L-1 should be 25 mg L-1

11. p435, in equation 8.81, there should be a kpt after Ddrug, i.e., it should be Ddrug kpt

12. p435, in equation 8.81, the Vplasma should be Vtissue

13. p450, remove problem 8.29

AQ1: PK is for pharmacokinetics

AQ2: it is correct





AQ7: kg is acceptable when associated with a number

AQ8: yes this is ok

AQ9: yes this is ok

AQ10: should be Table 4.4

AQ11: yes this is correct

Chapter 9

1. p452, in Figure 9.1 for the Coil dialyzer drawing there are two dashed lines that should be removed if that is possible

2. p453, 3rd line in section 9.3.1, Table 5.2 should be Table 5.13. p454, 2nd line before section 9.3.2, Table 5.2 should be Table 5.14. p458, in eqn 9.6, the should be

11

5. p458, in 2nd line after eqn 9.6, the should be 6. p461, in eqn 9.17, there should be an = sign after the term that involves the C’s7. p463, 1st line, the DH should be dH

8. p463, 5th line, the DH should be dH

9. p464, in the 6th line change Wang et al. to Ding et al.10. p464, in the 4th line above the Table, change Wang et al. to Ding et al.11. p467, in eqn 9.24, summation should be from i = 1 to N12. p468, in eqn 9.25, there should be an “S” after the Pmi 13. p470, 1st sentence in section 9.5.1 should be rewritten to read as “Heart surgery

oftentimes requires that the heart be stopped or arrested (cardioplegia).” 14. p475, in eqn 9.33, 1st line, the W should be Wb

15. p475, in eqn 9.33, 2nd line, the W should be Wg

16. p476, in eqn 9.34, 1st line, the W should be Wb


18. p476, in eqn 9.35, the W should be Wb

19. p477, in eqn 9.39, 2nd line, the W should be Wb

20. p477, eqn 9.41 should be equation 9.4021. p477, eqn 9.40, should be equation 9.4122. p478, in line before eqn 9.47, add after x, “in the blood flow direction.”23. p479, in the 2nd paragraph of section 9.5.4.3, there are two DH’s which should be dH

24. p479, in the 3rd line of the 3rd paragraph of section 9.5.4.3, Table 5.2 should be Table 5.125. p479, in 8th line of 3rd paragraph of section 9.5.4.3, insert “of blood” between “cross

flow” and “over mats of”26. p480, in 2nd line, there are 3 occurrences of DH which should all be dH

27. p480, in 2nd line, 3rd line, and 7th line two times, the “v” should be “V”28. p480, in eqn 9.51, the DH should be dH

29. p481, in the 2nd line after eqn 9.57, insert after “blood” the phrase “in the oxygenator”30. p482, in eqn 9.59, 1st line, the H should be HCO2 and the W should be Wb


32. p483, eqn 9.63 should be eqn 9.6233. p483, eqn 9.62 should be eqn 9.6334. p486, in the line before eqn A, “to find change” should be “to find the change”35. p487, 1st line, v should be V36. p487, in the equation for Re the v should also be V37. p487, in the line before the calculation of kb, “Since h = …” should be “Since Sh = …”38. p491, in the paragraph after eqn 9.68, the two occurrences of “Moles” should be “moles”39. p491, in the paragraph after eqn 9.68, the two occurrences of “Reaction” should be

“reaction”40. p492, in Example 9.8, the phrase “Heparin Degradation Kinetics” should be moved so it

becomes the caption to the Table41. p493, in Figure 9.10, Burke should be changed to Burk42. p493, 4th line, Burke should be changed to Burk43. p494, in eqn 9.69, the K should be r

12

44. p499, in 2nd line before eqn 9.87, Table 5.2 should be Table 5.145. p500, in eqn 9.90, the kSb term should be kKSb

46. p501, in eqn 9.93, remove the x that is in front of Axs

47. p501, in eqn 9.93, add a minus sign in front of (1 - R)

AQ1: that is okAQ2: cross flow is acceptableAQ3: that is okAQ4: this should be Table 5.1AQ5: this is okAQ6: yesAQ7: yesAQ8: low would be betterAQ9: the suggested change is okAQ10:this is okAQ11: please use dH as identified in my previous editsAQ12: Wang et al. should be Ding et al.AQ13: I have rewritten this sentence as given in my edits aboveAQ14: this is correctAQ15: that is correctAQ16: passage through the oxygenator is betterAQ17: yes that is correctAQ18: I have corrected this in my editsAQ19: gave is betterAQ20: phenomenon is correctAQ21: yes that is correctAQ22: Burk is correct spellingAQ23: first-order is betterAQ24: throughout is betterAQ25: ligands is correctAQ26: yes that is correctAQ27: yes that is correct

Chapter 10

1. p524, in 3rd paragraph of section 10.4.4, 3rd line, remove the ) after 95,000 2. p529, in the 3rd line from the bottom, change “depending” to “depends”3. p531, in 2nd paragraph of section 10.5.2.1, 1st line, change “the scaffold made” to “the

scaffold is made”4. p531, 2nd line from the bottom, change “approach to 3D” to “aaproach for the 3D”5. p532, 1st line, change “in” to “on”6. p532, in the 26th line, remove the comma after (PCL)

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7. p537, in the 1st paragraph of section 10.8, in the 9th line, change “provide a much better” to “provide much better”

8. p539, 2nd footnote, change to “See Sections 7.9.1 and 7.9.2 for a discussion of oxygen transport in perfusion bioreactors

AQ1: this is correct as written

AQ2: this is ok as written



AQ5: I recommend subunit

AQ6: MSC is mesenchymal stem cell

AQ7: please remove the PS on the polysulfone entry of Table 10.5

AQ8: they are the same compound so this is ok


AQ10: they are the same compound so this is ok




AQ14: yes this correct

Chapter 11

1. p553, 5th paragraph, last line, should be Iwata et al. (1996)2. p555, 2nd paragraph of section 11.4, 5th line, r should be r

3. p557, there are 4 occurrences where “Analysis” should be “analysis”4. p563, in 6th line from the bottom, change “microencapsule” to “microcapsule”5. p563, 2nd footnote, change 40 to 34.76. p564, 17th line, “guluronic content” should be “guluronic acid content”7. p564, 18th line, add “acid” after “guluronic8. p564, last paragraph, 4th line, should be “cynomolgus”9. p564, last paragraph, 5th line, remove “islets” after “EIN”10. p565, 3rd paragraph, 2nd line, change “within he” to “within the”11. p566, 7th line from the bottom, change “for an excellent transport” to “for excellent

transport”12. p567, in Example 11.2, 3rd line, “O2

B” should be “pO2B”

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13. p568, in 2nd line above section 11.6.2, change “an oxygen source” to “an in situ oxygen source”

14. p570, in the line above eqn 11.3, change “the glucose concentration and…” to “the glucose concentration, i.e., CG(t), and its rate of change:”

15. p570, in 2nd line below eqn 11.3, “Analysis” should be “analysis”16. p571, in 1st line under Solution, “Analysis” should be “analysis”17. p572, in 2nd line, change “…tration is in…” to “tration (GB) is in…”18. p579, in Table 11.2, hemodialysis and cross circulation should be unbolded and made the

same as the other entries below them19. p581, 9th line, should be Cima et al., 1991a20. p582, 4th line, add a footnote to the word hepatocytes where the footnote then reads “See

Section 7.9 on perfusion bioreactors”21. p588, 10th line, replace UF with “ultrafiltration (UF) flow”22. p588, 27th line, change “pluripotential” to “pluripotent”23. p590, 5th line, change H to HO2

24. p591, problem 11.7, please make the following change to this problem:

“The following perifusion data was obtained by Lakey et al. (1996) for canine islets of Langerhans. The islets were challenged with glucose that was initially at 50 mg dL-1 followed by a prompt increase to 500 mg dL-1. Use the Nomura et al. (1984) islet insulin release model to describe these data.”

Time, min Islet Insulin Release Rate, µU islet-1 min-1

0 0.10

5 0.83

8 0.75

28 0.61

50 0.68

60 0.50

25. p608, remove Warnock et al. 1992 reference

AQ1: islets is better

AQ2: virally infected is ok

AQ3: same as AQ2

AQ4: should be Iwata et al. (1996)

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AQ6: suggested change is correct

AQ7: I like cells


AQ9: disease is better

AQ10: yes this just completes the idea of the previous sentence


AQ12: should be microcapsule in this context

AQ13: should be guluronic acid content

AQ14: yep the change is the correct spelling

AQ15: yep remove “islets”


AQ17: maybe change this to “The results obtained from using the…”

AQ18: in the line following the AQ18 remove the word “now” and then the sentence reads ok




AQ22: has been focused is ok too

AQ23: should be Cima et al., 1991a

AQ24: ECM is extracellular matrix

AQ25: replace UF with “ultrafiltration (UF) flow”

AQ26: pluripotent is correct

AQ27: yes this correct

References

1. p604, 7th line from the bottom, change “twodimensional” to “two dimensional”

AQ1: Boca Raton, FL

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AQ2: 2015. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis.

AQ3: Federspieland Henchir (2004) New York, NY; Hubbell (1997) Austin, TX; Jauregui et al. (1997) Austin, TX; Lysaght and Moran (1995) Boca Raton, FL; Margiotta et al. (1994) Boca raton, FL; Pachence and Kohn (1997) Austin, TX; Parsons-Wingerter and Sage (1997) Austin, TX; Spotnitz (1987) New York, NY; Sturis et al. (1995) New York, NY; Thomson et al. (1997) Austin, TX; Zielinski et al. (1997) Austin, TX; Zydney (1995) Boca Raton, FL

AQ4: Foster et al. should be Foster, T.H., D.F. Hartley, M.G. Nichols, and R. Hilf.1993. Fluence rate effects in photodynamic therapy of multicell spheroids. Cancer Res., 53:1249-1254. And

AQ5: volume 40

AQ6: Hashimoto, S., M. Honda, M. Yamaguchi, M. Sekimoto, and Y. Tanaka. 1997. Pharmacokinetics of imipenem and cilastatin during continuous venovenous hemodialysis in patients who are critically ill. ASAIO J. 43:84-88.

AQ7: the site for this paper says that this is the proper citation: T.-W. Lee, K.-S. Bae, Heung S. Choi, and Ming-Jyh Chern, “Computational Simulations of Flow and Oxygen/Drug Delivery in a Three-Dimensional Capillary Network,” ISRN Biomathematics, vol. 2014, Article ID 359327, 11 pages, 2014. doi:10.1155/2014/359327

AQ8: for Pittenger the title is “Multilineage potential of adult human mesenchymal stem cells” and for Soon-Shiong 1992a “Long-term reversal of diabetes in the large animal model by encapsulated islet transplantation.”

AQ9: remove this reference as I have cited the wrong reference and the wrong data in problem 11.7, as in the chapter 11 edits above this has been corrected

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