○ Vision And Objectives

Through the Global 5-5-10Through the Global 5-5-10 Project for Division ofProject for Division of Dental Sciences, Yonsei University School of Dental Sciences, Yonsei University School of Dentistry will become one of the world’s leading Dentistry will become one of the world’s leading educational and research institutes.educational and research institutes.

○ Organization and Participants

○ Organization and Participants

Cell signalingCell signaling Shin Dong Min Lee Syng Ill Seo Jeong Taeg Ahn Hyung Joon

Tissue regenerationTissue regenerationJung Han Sung Park Young Chel Lee Sang Hwy Lee Seung Jong

Lee Jae Ho Cho Sung Won Choi Byung Ho 　

Digital imagingDigital imagingKim Hee Jin Kim Kee Deog Park Chang Seo Hu Kyung Seok

Hwang Chung Ju 　 　 　

Development of dental Development of dental materials and medical materials and medical

devicesdevices

Kim Kwang Mahn Kim Kyoung Nam Park Sung Ho Lee Keun Woo

Han Jong Hyun 　 　 　

Periodontal disease and Periodontal disease and immune systemimmune system

Cha Jung Heon Kwon Ho Kwen Kim Baek Il Kim Chong Kwan

Yu Yoon Jung Cho Kyoo Sung Choi Seong Ho 　

Carcinogenesis and Carcinogenesis and cancer preventioncancer prevention

Kim Jin Yook Jong In Chung Won Yoon Park Kwang Kyun

○ Research Fields

● ● Cell signalingCell signaling

- Cell signaling associated with bone - Cell signaling associated with bone formation formation - Development of drugs that induce bone Development of drugs that induce bone formation and formation and prevent bone absorptionprevent bone absorption Cell Signaling in Bone cells

▶ Cell signaling associated with bone remodeling▶ Development of drugs to induce bone formation and prevent bone resorption

○ Research Fields

● ● Tissue regenerationTissue regeneration

- Artificial tooth and bone Artificial tooth and bone formation formation using organ culture system using organ culture system - Orofacial hard tissue Orofacial hard tissue regeneration regeneration with an aid of artificial with an aid of artificial teeth and teeth and bonesbones

▶ ▶ Construction of artificial Construction of artificial tooth tooth and periodontium and periodontium

○ Research Fields

● ● Digital imagingDigital imaging

▶ Development of diagnosis technique using digital image▶ Data analysis using 3-D image

● ● Development of dental mateDevelopment of dental materials and medical devicesrials and medical devices

▶ ▶ Development and Development and application of application of bioceramics for bioceramics for bone replacement bone replacement

▶ ▶ Development of Development of new dental new dental casting metalscasting metals

○ Research Fields

● ● Periodontal disease and immune systemPeriodontal disease and immune system

▶ ▶ Treatment and prevention of periodontal disease Treatment and prevention of periodontal disease ▶ ▶ Drug development inducing periodontal tissue Drug development inducing periodontal tissue

regeneration regeneration

▶ ▶ Research on the Research on the carcinogenesiscarcinogenesis

▶ ▶ Mechanism of Mechanism of CarcinogenesisCarcinogenesis

▶ ▶ Drug development for Drug development for cancer cancer treatment and prevention treatment and prevention

● ● Carcinogenesis and cancCarcinogenesis and cancer preventioner prevention

○ Activities and Outputs

● ● ActivitiesActivities

Student exchangeStudent exchange programprogram

▶ ▶ Tokyo Dental collegeTokyo Dental college

▶ ▶ UCLAUCLA

▶ ▶ University of University of PennsylvaniaPennsylvania

▶ ▶ Tuft UniversityTuft University

● ● OutputsOutputs▶ Molecular interactions between Tbx3

and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci USA, 103(45):16788-16793, 2006

▶ A Wnt-Axin2-GSK3 cascade regulates Snail activity in breast cancer cells. Nature Cell Biology. 8(12):1398-1406, 2006

▶ Xanthorrhizol inhibits 12-0-tetradecanoylphobol-13-acetate-induced acute inflammation and two-stage mouse skin carcinigenesis by blocking the expression of ornithine decarboxylase, caclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nucleas factor-kappa B. Carcinogenesis. 28(6):1224-1231, 2007

▶ Skeletal muscle dressed in SOCs. Nature Cell Biology. 10(6):639-641, 2008

○ Contact Point

● ● DirectorDirector : Syng-Ill Lee, D.D.S., Ph.D. : Syng-Ill Lee, D.D.S., Ph.D.

● ● AddressAddress : Department of Oral Biology, Yonsei : Department of Oral Biology, Yonsei University College of Dentistry 134 Shinchon-dong, University College of Dentistry 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea Seodaemun-gu, Seoul 120-752, Korea

● ● TelTel : +82-2-2228-3052: +82-2-2228-3052 FaxFax : +82-2-364-1085: +82-2-364-1085

● ● E - mailE - mail :: lsi@yuhs.ac lsi@yuhs.ac WebsiteWebsite :: http://bk21-dentsci.yonsei.ac.krhttp://bk21-dentsci.yonsei.ac.kr