IntroductionResults and Methodologies

Locating the Lesions Psychological Tests

Summary and Conclusions

Nicole Neil

Introduction

Subject Age of Injury Age at Test Source of InjuryBeth Birth 12 Hypoxia (birth trauma)

Jon 4 16 Hypoxia (convulsive seizures)

Kate 9 19 Hypoxia (seizures)

Mudra Bhatt

Hippocampal System

Episodic Memory

Hippocampal System

EpisodicMemory

SemanticMemory

SemanticMemory

Underlying Cortices

Nicole Neil

Methods Results

Volumetric Measurements

Hippocampus abnormally

small

T2 Relaxometry Remaining hippocampal

tissue severely compromised

Proton Magnetic Spectroscopy

Temporal Lobe normal

Molly O’Brien & James Guse

Parental Questionnaire Used Riverhead Mead Test to confirm

degree of impairment:

spatial temporal episodic

Molly O’Brien & James Guse

Copy of the Rey-Osterreith Complex Figure and 40-min delayed reproduction of it.

Normal control, copy and delayed reproduction by a typical 13-year-old.

Psychological TestsMolly O’Brien & James Guse

Molly O’Brien & James Guse

VIQ PIQ MQ

0

20

40

60

80

100

120Multiple IQ Comparisons

Beth

Jon

Kate

Normal

Standardized tests for IQ were done on all three children and compared to norms (green),

VIQ: Verbal Intellgence QuotientPIQ: PerformaceMQ:Memory Quotient

Molly O’Brien & James Guse

Working Memory

Combined foreward and reverse w.m. span

Normal

Kate

Jon

Beth

Working memory is at par with normal controls (green)!

Semantic (Intact)

Episodic (Damaged)

Verbal IQ Parent Report

Reading Comprehension Rey-Osterreith Complex Figure

Spelling* (exception Jon) Verbal Recall Tests

Richa SharmaMolly O’Brien & James Guse

Hippocampal System

Episodic Memory

Hippocampal System

EpisodicMemory

SemanticMemory

SemanticMemory

Underlying Cortices

Richa Sharma

Richa Sharma