© Fraunhofer

www.mevis.fraunhofer.de

Bremen / Lübeck - Germany

Fraunhofer MEVIS

Institute for Medical Image Computing

© Fraunhofer

Contents

1. Overview

2. Evolution and structure

3. Fraunhofer MEVIS

4. Innovation chain

5. Perspectives

© Fraunhofer

Computer assistance for

image-based, personalized

diagnosis and therapy

Field of Work

© Fraunhofer

Til Mette

stern - April 2005

© Fraunhofer

Characteristics

Focus on image-based SW solutions for clinicians Whole chain: early detection, diagnosis, therapy, monitoring Epidemiologically important diseases

Patient-individual solutions

Transdisciplinary approach

Clinical network 150+ clinical and scientific partners worldwide

Complete innovation chain basic research research prototype product

Medicine

IndustryScience

© Fraunhofer

Modality

2-D

3-D

Dynamic [t]

Radiography (MX, AX)

Computed tomography(CT, CTA)

Magnetic resonance imaging (MRI, MRA)

Ultrasound (US)

Image Modalities

…

…

MR Spectroscopy, Microscopy/Histology, …

© Fraunhofer

Why computer support?

© Fraunhofer

Why computer support?

© Fraunhofer

Dimensions of Competence

Diagnosis

Clinical Workflow

Early Detection Diagnostic Planning Procedure MonitoringTherapy

Organs

Liver

Lung

Breast

Brain

Heart/Vessels

Bones/Joints

Diseases (Tumor, Inflammation, Degeneration, etc.)

MethodsMeVisLab

Validation

Navigation

Risk analysis

Visualization

Quantification

Segmentation

Registration

Modeling/SimulationImaging/Modality

© Fraunhofer

Fields of Activity Algorithms, Software Applications &

Computing Visualization & Human Computer

Interaction Workflow, Clinical Usability, …

Intra-operative/-interventional Support Liver, Lung, Breast, …

Mathematical Modelling & Numerical Simulation Foundation Professorship at Jacobs University

MR Imaging & Physics Foundation Professorship at University Bremen

Image Registration Project Group at University Lübeck

© Fraunhofer

2. Evolution and structure

© Fraunhofer emerged from daughter of

2001

2003

1995

1997

1999

2005

2007

2009

1993

University Non-profit Commercial

MeVis Family Tree

::

© Fraunhofer

Structure since 01/2009

Non-profit Commercial(75 employees) (230 employees)

Bremen USA Japan

51% 100%

50%

100%

41%

NL

BremenInstitute forMedical Image Computing

Bremen50%

EFRE

Bremen

S-HProject GroupImage Registration

Lübeck (since 04/2010)

50%

50%

EFRE

© Fraunhofer

3. Fraunhofer MEVIS

© Fraunhofer

■ 59 institutes in GER

■ 17 000 employees

■ about 1.6 billion EURresearch budget

■ 2/3 from industry andpublic agencies

Fraunhofer Groups■ Information & Communication

Technology■ Life Sciences

■ Microelectronics■ Surface Technology & Photonics■ Production■ Materials & Components■ Defense & Security

Fraunhofer Society

© Fraunhofer

59 Institutes in GER

Institutes

Branches, Working Groups, Application Centers

Karlsruhe

DarmstadtWürzburg

Jena

Stuttgart

Duisburg

Oberhausen

Nuthetal

Dortmund

München

Saarbrücken

St. Ingbert

Magdeburg

Halle

Dresden

Leipzig

Ilmenau

Cottbus

Braunschweig

BerlinPotsdam

Teltow

Aachen

Schmallenberg

Sankt Augustin

Erlangen

Nürnberg

Freising

Holzkirchen

Pfinztal

Freiburg

Efringen-Kirchen

RostockItzehoe

Hannover

Bremen

Euskirchen Chemnitz

WertheimKaiserslautern

Paderborn

Schkopau

LübeckBremerhaven

Fraunhofer Society

© Fraunhofer

Organization Chart

Institute DirectorProf. Peitgen

Extended BoardKG plus

Dr. Kuhnigk, Dr. Zidowitz,

Person of Trust

Management Board (KG)

Prof. Peitgen, Prof. Hahn,Prof. Preußer, Prof. Günther,

Prof. Fischer, Dr. Kraß, Dr. Lang, Dr. Prause, T.

Forstmann

AdministrationT. Forstmann

Advisory Board Persons of Trust

© Fraunhofer

Organization of Work

Team-oriented Open-minded Self-organized Flexible Adaptive

© Fraunhofer

Prof. Dr. H. Maier

Dr. R. Jansen Dr. U. Niebling

Dr. C.J.G. Evertsz Dr. B. Gewiese

Prof. Dr.-Ing. E.R. Reinhardt

W. Märzendörfer

Chair:

ResearchFunding:

Industry:

Advisory Board of Fraunhofer MEVIS

© Fraunhofer

Prof. Dr. J. Hennig Prof. Dr. W.A. Kalender

Prof. Dr. R. Kikinis

Prof. Dr. H.-P. Bruch Prof. Dr. K.J. Klose Prof. Dr. M. Reiser Prof. Dr. U. Sure

Science:

Medicine/Clinic:

Uni Bremen: Jacobs University:

Prof. Dr. G. SzékelyProf. Dr. H.-P. Schlemmer

Prof. Dr. J. Falta Dr. A. Ziegler-Jöns

Advisory Board of Fraunhofer MEVIS

© Fraunhofer

Management Board

Prof. Dr. Heinz-Otto Peitgen Prof. Dr. Horst K. Hahn Dipl.-Betrw. Thomas Forstmann

Institute Director Deputy Institute Director Head of Administration

Prof. @ Uni Bremen Adj. Prof. @ Jacobs UniProf. @ Uni Boca Raton Research

Prof. Dr. Matthias Günther Prof. Dr. Tobias Preußer Prof. Dr. Bernd Fischer

Head of MR Imaging Head of Modeling & Simulation Head of PG Image Registration

Found.Prof. @ Uni Bremen Found.Prof. @ Jacobs Uni Head of MIC Institute

Prof. @ Uni Lübeck

Dr. Stefan Kraß Dr. Markus Lang Dr. Guido PrauseClinical cooperations Scientific personell Publicly funded

projectsIndustry projects Industry projects PR / Advisory BoardPublicly funded projects IPR / contracts Deputy

Head of Administration

© Fraunhofer

Dr. Jan-Martin KuhnigkIT, Software Development

Dr. Stephan ZidowitzQuality Management

Extended Management Board

22

Persons of Trust

Melanie Bohn

Bianca Lassen

Lars Bornemann

Dr. Benjamin Geisler

© Fraunhofer

Finance(MEVIS Bremen)

TEUR

Inv.

BHH

EFRE

HBHB

HBHB

HBHB

© Fraunhofer

Personnel(MEVIS Bremen)

MMS: ≈ 230

CeVis: ≈ 10

© Fraunhofer

Certification

Certificate for quality assurance (since 2005)

Introduction and application of a quality management system in compliance with EN ISO 9001 / 12.2000 EN ISO 13485 / 07.2003 (medical devices)

Scope: Research and development for image-based

medical diagnosis and therapy Development of software

© Fraunhofer

AwardsScientific Exhibit Award with Certificate of Merit(Radiological Society of North America)

Bundesverdienstkreuz erster Klasse für Prof. Peitgen(Bundespräsident Roman Herzog)

Karl Heinz Beckurts-Preis für Forschung und Innovation(Karl Heinz Beckurts-Stiftung)

Magna Cum Laude Award for Most Innovative Contribution(European Congress of Radiology)

Werner Körte Medaille in Gold(Deutsche Gesellschaft für Chirurgie)

Bremer Unternehmerpreis für Wissenstransfer (ASU, BJU)

Induction of Prof. Peitgen into Hall of Fame at FAU

Deutscher Gründerpreis 2006(Sparkasse, McKinsey, stern, ZDF)

Eurographics 2007 Medical Prize

Bernd-Artin Wessels-Preis 2007

RSNA 95/97/00-

02:

Oct 1996:

Dec 1999:

Mar 2005:

Apr 2005:

Mai 2005:

Feb 2006:

Sep 2006:

Sep 2007:

Nov 2007:

© Fraunhofer

Sep 12, 2006: ZDF studio in Berlin

German Founders Prize 2006

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4. Innovation chain

© Fraunhofer

Innovation Chain

Clinical Network

>150

Siemens

Hologic

Invivo

Philips

Europe, Asia, USA

INPUT OUTPUT

Toshiba

© Fraunhofer

Technical

Testing

Algorithmic

Development

R&D Structure at MeVis

MeVisLab: SW Platform for R&D, Prototyping, Evaluation & Integration

Idea Algorithm

Customization

Clinical

Testing

Network

Integration

ClinicalEvaluation

Prototype

Product

::

© Fraunhofer

Publicly Funded ProjectsBMBF: FUSION (6,75 WiMi + 1 MTRA) kostenn. Verlängerung

DOT-MOBI mit DKFZ, ITWM, MMS und Siemens (6 WiMi)

Kompetenznetz ASTHMA-MRI mit 6 klin. Partnern (1 WiMi) LungSys mit 12 Partnern (1 WiMi) PMRIT: Physiological MRI during Throbolysis (1,5 WiMi) Virtuelle Leber: Mathematische Modellierung der Leber mit div. Partnern (3,7 WiMi) bis 03/2015 Spitzencluster: Medical Valley mit Siemens, IIS und div. Partnern (1,5 WiMi) bis 09/2013

MoBiTech3: MALDI-AMK mit Bruker, ZeTeM, CUCA u.a. (1 WiMi) bis 12/2013

DFG: RFITT mit UKBF (0,5 WiMi)

Klinische FG Essen: LLS/A2 - OP (1 WiMi) kostenn. Verlängerung

Klinische FG Essen: LLS/B2 - Histologie (1 WiMi)

Lunge/COPD mit DKFZ (1 HiWi)

Lungenchirurgieplanung (1 WiMi + 0,5 MTRA + 1 HiWi)

Neurochirurgie-Risikoanalyse mit Marburg (1 WiMi + 1 HiWi)

EU: HAMAM mit EIBIR-Partnern und Industrie (2 WiMi) ESFRI: Euro-BioImaging mit EIBIR-Partnern (0,1 WiMi) bis 07/2013 ICT-VPH: FUSIMO mit Uni Dundee, TU Delft, SINTEF u.a. (3 WiMi) bis 12/2013

Andere: R.-Bosch-Stiftung: OP-Projektion mit Prof. Lamade, RBKH Stuttgart (0,4 WiMi) WFB: 3D-MALDI mit ZeTeM und Bruker (0,2 WiMi)

DHZB: Cardio-MRI in Congenital Heart Disease (0,8 WiMi)

J F M A M J J A S O N D J F M A M J J A S O N D J F M A M J J A S O N D J F M A M J J A S O N D2009 2010 2011 2012

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Cooperations with Industry

Fraunhofer MEVIS MMS AG Siemens AG Stryker several others in publicly funded projects

OEM partners of MMS AG Siemens AG Hologic Philips/ Invivo Toshiba

© Fraunhofer

Breast Cancer Screening

- Digital Mammography

Breast-MRI- Neoangiogenesis and Biopsy

Surgery Planning

- Internet-based Service

Three Success Stories

Market share

>50%

>50%

>90%

© Fraunhofer

1. Breast-MRI: Tumor Dynamic & Biopsy

© Fraunhofer

2. Mammography WorkstationSoftcopy reading in digital mammography

Mammography Screening Bremen

EU Projects:- SCREEN- SCREEN-TRIAL

Today: World market leader with over 6.000 systems

Siemens: MammoReportPlus Reporting Station

Hologic: LORAD Selenia Reporting Station

First prototype: master thesis

© Fraunhofer

3. Liver Surgery Planning

© Fraunhofer

certified

Japan

USA

Australia

China

Korea

Singapore

Taiwan

Egypt

Europe

Distant Service via Internet

© Fraunhofer

› Kyoto University Hospital, Japan

› Yokohama City University Medical School, Japan

› Nagoya University Hospital, Japan

› University Hospital Kanazawa, Japan

› Kaohsiung University Hospital, Kaohsiung, Taiwan

› Lahey Clinic, Burlington, MA, USA

› Massachusetts General Hospital, Boston, MA, USA

› University of California at San Francisco, USA

› Columbia University, USA

› University of Michigan, USA

› Universtity of California at Los Angeles, USA

› Washington University St. Louis, USA

› Strong Memorial Hospital, Rochester, NY, USA

› NIH Clinic, Bethesda, MD, USA

› State University Hospital, Groningen, Netherlands

› Lund University Hospital, Sweden

› Verona University Hospital, Verona, Italy

› Naples University Hospital, Naples, Italy

› Univerity Hospital Sapienza Rome, Italy

› Gleneagles Hospital, Singapore

› Charité Berlin, Campus Benjamin Franklin

› Charité Berlin, Campus Buch

› Charité Berlin, Campus Virchow

› Allgemeines Krankenhaus Celle

› Universitätsklinikum Essen

› Johann Wolfgang Goethe Universität Frankfurt

› Universitätsklinik Freiburg

› Medizinische Hochschule Hannover

› Klinikum Hof

› Universitätsklinik Köln

› Klinikum Krefeld

› Klinikum Schleswig-Holstein, Campus Lübeck

› Universitätsklinikum Mainz

› Klinikum der Philipps-Universität Marburg

› Klinikum rechts der Isar München

› Universitätsklinik Tübingen

Status since 2003: > 5.000 plannings at MeVis ≈ 2.400 LDLTs ≈ 1.900 Tumor resections ≈ 700 Pancreas, kidney, spleen, …

GermanyAsia, USA, Europe

150+ Users Worldwide

© Fraunhofer

5. Perspectives

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Perspectives

New fields Modeling and simulation MR imaging Image registration

Personnel 82+ employees until 2013 at Fraunhofer MEVIS

MR Scanner

MeVis Campus

© Fraunhofer

Modeling and Simulation

Jacobs University Bremen

Foundation professorship by Conrad and Lotti Naber

Modeling of bio-physical processes

Numerical simulation

Examples RF-Ablation of liver tumors Numerical flow simulation High focused ultrasound

Prof. Dr. Tobias Preußer

© Fraunhofer

MR Imaging & Physics

University Bremen – FB Physics

Foundation professorship byStiftung Bremer Wertpapierbörse

Optimization of imaging

Development of new sequences and imaging protocols

Examples Arterial Spin-Label Imaging Diffusion Tensor Imaging

Prof. Dr. Matthias Günther

© Fraunhofer

Image Registration

Fraunhofer MEVIS – Project Group Lübeck University Lübeck – Institute of Mathematics

Basic funding by State Schleswig-Holstein

Anatomically correct mapping and fusion of medical image data

Examples Registration of pre-, intra- und postoperative

images Multimodal image registration

Prof. Dr. Bernd Fischer

© Fraunhofer

www.mevis.fraunhofer.de

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