Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise...
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Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise Research Institute www.deri.i e Enabling Networked Knowledge An Ontology for Clinical Trial Data Integration Dr. Ratnesh Sahay SMC 2013, Manchester, UK 15-10-2013
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Transcript of Copyright 2011 Digital Enterprise Research Institute. All rights reserved. Digital Enterprise...
Copyright 2011 Digital Enterprise Research Institute. All rights reserved.
Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
An Ontology for Clinical Trial Data Integration
Dr. Ratnesh SahaySMC 2013, Manchester, UK
15-10-2013
Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge2
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The Problem
If you have heterogeneous clinical terminologies and you want to integrate them….
and if scale of integration grows…
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Heterogeneous Clinical Terminologies
Terminology Integration
Lot of complex terminologies
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Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
Integrating Clinical Terminologies
return number of subjects (i.e., patients) that have been administered the drug
Insulin and exhibit BMI > 25 and Dyslipidemia and Agoraphobia as adverse events
RxNorm LOINC SNOMED DSM-4
Legal and Ethical Regulations
HL7/openEHR
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Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
Semantic EHR Ontology
The Semantic EHR Ontology represents the clinical trail domain and described as a domain level ontology
Objectives Enable sharing and linking of healthcare and clinical
terminologies Sharing consistent and unambiguous knowledge for
decision making in medical and clinical research domains (Sub)Domains
Partially covers Breast Cancer, Diabetic, Adverse Event (AE), Concomitant Medication (CE), Neurology, Genetics, Psychiatric Disorder, and Respiratory
Local institute (domain)-specific variables
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Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
Layering: Semantic EHR Ontology
ACGT
BFO
imports
imports
Do
ma
in
SEHR
CHUVCardiovascularPsychiatricAdverse Events
CINGBreast CancerDiabeticNeurologyGeneticsAdverse Event (AE)
ZEINCROAdverse Event (AE) Concomitant Medication (CE)Respiratory
UP
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UMLS, OBO Foundry(Basic Formal Ontology)
Advancing Clinico-Genomic Trials on Cancer (ACGT)
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Class 1859
Object Property 225
Data Property 575
Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
Evaluating Semantic EHR Ontology
The questionnaires were answered by clinical experts from various sub-domain of Healthcare and Life Sciences
Clinical experts suggested conceptualisation fixes (i.e., hierarchy and/or names of classes and properties) that suit their local requirements
Clinical experts agree that SEHR ontology covers the needs of the clinical trial domain
We are doing a final (fourth) round of evaluation
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Digital Enterprise Research Institute www.deri.ie
Enabling Networked Knowledge
Thank you
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