cdn-links.lww.com · Web view77 ± 73 0.005 CD 23 ± 14 95 ± 59
Transcript of cdn-links.lww.com · Web view77 ± 73 0.005 CD 23 ± 14 95 ± 59
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Supplementary table 1. The corresponding values of each marker with respect to endoscopic Mayo score in ulcerative colitis
Mayo 0(N=14)
Mayo 1(N=9)
Mayo 2(N=11)
Mayo 3(N=6)
P value (between groups)
P value (within groups)
FCT (ug/g) 74 ±18
114 ±31
626 ±132
755 ±116
<0.001 all <0.001 except 0.726 (0 vs 1) and 0.342 (2 vs 3)
FIT (ug/g) 16 ±1 35 ±20 57 ±20 112 ±31
0.007 0 vs 1: 0.4060 vs 2: 0.0640 vs 3: 0.0011 vs 2: 0.3671 vs 3: 0.0112 vs 3: 0.055
CRP (mg/dL)
0.38 ±0.04
0.42 ±0.08
0.74 ±0.17
1.38 ±0.46
0.003 0 vs 1: 0.8580 vs 2: 0.1090 vs 3: 0.0011 vs 2: 0.2011 vs 3: 0.0022 vs 3: 0.023
ESR (mm/hour)
12 ±1 30 ±5 46 ±8 41 ±13 0.001 0 vs 1: 0.0010 vs 2: <0.0010 vs 3: 0.0021 vs 2: 0.1371 vs 3: 0.4002 vs 3: 0.737
Albumin (g/L)
44 ±1 45 ±1 40 ±2 36 ±3 0.005 0 vs 1: 0.5260 vs 2: 0.0930 vs 3: 0.0031 vs 2: 0.0381 vs 3: 0.0012 vs 3: 0.094
Platelet count ( x109/L)
250 ±13
260 ±29
555 ±84 484 ±52
<0.001 0 vs 1: 0.7230 vs 2: <0.0010 vs 3: <0.0011 vs 2: 0.0071 vs 3: 0.0012 vs 3: 0.565
Hemoblogbin (g/L)
13.7 ±0.4
13.3 ±0.4
12.1 ±0.6
11.5 ±0.8
0.026 0 vs 1: 0.5420 vs 2: 0.0250 vs 3: 0.0091 vs 2: 0.1391 vs 3: 0.0492 vs 3: 0.440
CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test
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Supplementary table 2. The corresponding values of each marker with respect to SES-CD in Crohn’s disease
SES-CD 0-3 (remission)(N=17)
SES-CD 4-6(mild activity)(N=1)
SES-CD ≥7(moderate to severe activity)(N=8)
P value (between groups)
P value (within groups)
FCT (ug/g) 307 ±96 1000 ±N/A
930 ±69 0.001 remission vs mild: 0.108remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.747
FIT (ug/g) 23 ±3 69 ±N/A 98 ±21 <0.001 remission vs mild: 0.04remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.669
CRP (mg/dL) 0.50 ±0.09 0.35 ±N/A
2.73 ±0.76 0.001 remission vs mild: 0.712remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.330
ESR (mm/hour)
18 ±3 7 ±N/A 37 ±7 0.021 remission vs mild: 0.325remission vs moderate/ severe: 0.011mild vs moderate/ severe: 0.208
Albumin (g/L) 45 ±1 48 ±N/A 39 ±2 0.008 remission vs mild: 0.530remission vs moderate/ severe: 0.003mild vs moderate/ severe: 0.216
Platelet count ( x109/L)
255 ±13 139 ±N/A 394 ±30 <0.001 remission vs mild: 0.051remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.026
Haemoblogbin (g/dL)
13.9 ±0.2 13.7 ±N/A
12.8 ±0.6 0.183 remission vs mild: 0.847remission vs moderate/ severe: 0.069mild vs moderate/ severe: 0.658
CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, SES-CD: simple endoscopic score for Crohn’s disease
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Supplementary table 3. Clinical parameters of patients in endoscopic remission and non-
remission
Parameters PatientsEndoscopic
remission
Endoscopic non-
remissionP value
FCT (ug/g)
All patients* 182 ± 282 764 ± 352 <0.001
UC** 90 ± 81 672 ± 388 <0.001
CD*** 307 ± 96 938 ± 185 <0.001
FIT (ug/g)
All patients 23 ± 30 83 ± 68 <0.001
UC 24 ± 38 77 ± 73 0.005
CD 23 ± 14 95 ± 59 <0.001
CRP (mg/dL)
All patients 0.44 ± 0.28 1.48 ± 1.56 0.002
UC 0.40 ± 0.18 0.97 ± 0.84 0.003
CD 0.50 ± 0.38 2.47 ± 2.16 0.001
ESR (mm/hour)
All patients 19 ±13 41 ± 25 <0.001
UC 19 ± 14 44 ± 27 <0.001
CD 18 ± 11 34 ± 21 0.034
Albumin (g/L)
All patients 45 ± 3 39 ± 6 <0.001
UC 44 ± 2 39 ± 7 0.002
CD 46 ± 3 41 ± 6 0.010
Platelet count (x
109/L)
All patients 254 ± 59 473 ± 213 <0.001
UC 254 ± 65 529 ± 234 <0.001
CD 255 ± 54 366 ± 117 0.003
Haemoglobin
(g/dL)
All patients 13.7 ± 1.2 12.7 ± 1.9 0.002
UC 13.6 ± 1.3 11.9 ± 1.9 0.004
CD 13.9 ± 1.1 12.9 ± 1.7 0.079
CD: Crohn’s disease, CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, UC: ulcerative colitis
*All patients: Total number = 66. Endoscopic remission = 40; Endoscopic non-remission = 26**UC: Total number = 40. Endoscopic remission = 23; Endoscopic non-remission = 17***CD: Total number = 26. Endoscopic remission = 17; Endoscopic non-remission = 9
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Supplementary figure 1. AUROC values of each marker in UC vs. CD patients
Supplementary figure 2. Sensitivity and specificity of blood indices in all IBD patients
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Supplementary figure 3. Sensitivity and specificity of different biomarkers in UC
Supplementary figure 4. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active UC
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Supplementary figure 5. Specificity of combinations of fecal and blood biomarkers for
endoscopically active UC
Supplementary figure 6. Sensitivity and specificity of different biomarkers in CD
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Supplementary figure 7. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active CD
Supplementary figure 8. Specificity of combinations of fecal and blood biomarkers for endoscopically active CD