© BIOPAC Systems, Inc. 2016 1€¦ · and spatial working memory training: Continuous monitoring...

© BIOPAC Systems, Inc. 2016 www.biopac.com 1

BIOPAC—Inspiring people and enabling discovery about life

How to get High Quality Brain Imaging Data

Alex DimovBIOPAC Systems, Inc.



BIOPAC Systems, Inc.

Hasan Ayaz, PhDAssociate Research Professor, Drexel University

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Experiment Setup and Data Acquisition

Principles of Optical Brain Imaging



Signal Processing and Data Analysis

Principles of Optical Brain ImagingHasan Ayaz,



Hasan Ayaz,PhDAssociateResearchProfessor,DrexelUniversity

Functional Near-Infrared Monitor [fNIR]

>> Cortical activation-related to hemodynamic changes innatural environments and diverse field conditions

Brain Activity Monitor



Physiological Principles of fNIR:

• Neurons consume energy (glucose) when activated

• Oxygen is required to metabolize the glucose

• As clusters of neurons are activated, there is anincreased need for oxygen in that area

• Oxygen is transported to neural tissue via oxy-hemoglobin in the blood

Neural Activity & Hemodynamic Response



Oxy-Hb and deoxy-Hb are correlates of brain activitythrough oxygen consumption by neurons

• The oxygen exchange occurs in the capillary beds

• As oxy-hemoglobin gives up oxygen to the neuraltissue, it is transformed into deoxygenatedhemoglobin

David J. Heeger & David Ress. (2002) What does fMRI tell us about neuronal activity?Nature Reviews Neuroscience 3, 142-151

Physical Principles of fNIR: Photon Migration in Tissue



Modern Portable System (Desktop)

2015…

fNIR Instrumentation



Modern Portable System (Desktop)


McKendrickMcKendrick, R., Ayaz, H., Olmstead, R., &, R., Ayaz, H., Olmstead, R., & ParasuramanParasuraman,,R. (2014). Enhancing dualR. (2014). Enhancing dual--task performance with verbaltask performance with verbaland spatial working memory training: Continuousand spatial working memory training: Continuousmonitoring of cerebral hemodynamics with NIRS.monitoring of cerebral hemodynamics with NIRS.Neuroimage, 85, Part 3(0), 1014Neuroimage, 85, Part 3(0), 1014--1026.1026.

Ayaz, H., Onaral, B., Izzetoglu, K., Shewokis, P. A.,Ayaz, H., Onaral, B., Izzetoglu, K., Shewokis, P. A.,McKendrickMcKendrick, R., &, R., & ParasuramanParasuraman, R. (2013). Continuous, R. (2013). Continuousmonitoring of brain dynamics with functional nearmonitoring of brain dynamics with functional near

Select ReferencesSelect References

2015…



monitoring of brain dynamics with functional nearmonitoring of brain dynamics with functional nearinfrared spectroscopy as a tool forinfrared spectroscopy as a tool for neuroergonomicneuroergonomicresearch: Empirical examples and a technologicalresearch: Empirical examples and a technologicaldevelopment.development. Frontiers in Human Neuroscience, 7Frontiers in Human Neuroscience, 7, 1, 1--13.13.

Ayaz, H., Shewokis, P. A.,Ayaz, H., Shewokis, P. A., BunceBunce, S., Izzetoglu, K.,, S., Izzetoglu, K.,Willems, B., & Onaral, B. (2012). Optical brainWillems, B., & Onaral, B. (2012). Optical brainmonitoring for operator training and mental workloadmonitoring for operator training and mental workloadassessment. Neuroimage, 59(1), 36assessment. Neuroimage, 59(1), 36--47.47.

• Cell-phone sized,• Battery operated,• Fast-setup/no gel

required• Suitable for field

applications

Mini Wireless system (Pocket)




• Cell-phone sized,• Battery operated,• Fast-setup/no gel

required• Suitable for field

applications

Mini Wireless system (Pocket)

fNIR Instrumentation Select ReferencesSelect References

Mckendrick, R., Parasuraman, R., Murtza, R., Formwalt, A.,Baccus, W., Paczynski, M., & Ayaz, H. (2016). Into The Wild:Neuroergonomic Differentiation of Hand-Held andAugmented Reality Wearable Displays During OutdoorNavigation with Functional Near Infrared Spectroscopy.Frontiers in Human Neuroscience, 10.

McKendrick, R., Parasuraman, R., & Ayaz, H. (2015).Wearable functional Near Infrared Spectroscopy (fNIRS)and transcranial Direct Current Stimulation (tDCS):



and transcranial Direct Current Stimulation (tDCS):Expanding Vistas for Neurocognitive Augmentation.Frontiers in Systems Neuroscience, 9(27).

Ayaz, H., Onaral, B., Izzetoglu, K., Shewokis, P. A.,McKendrick, R., & Parasuraman, R. (2013). Continuousmonitoring of brain dynamics with functional near infraredspectroscopy as a tool for neuroergonomic research:Empirical examples and a technological development.Frontiers in Human Neuroscience, 7, 1-13.

• Raw fNIR signals are light intensity values atdetectors

• The physiologically irrelevant data (such asrespiration and heart pulsation effects) andequipment noise, etc. are first eliminatedfrom the raw fNIR measurements

fNIR Signal Processing



from the raw fNIR measurements

• Saturation, motion artifact and other noiseneeds to be eliminated (or excluded fromanalysis

Ayaz, H., Shewokis, P. A., Curtin, A., Izzetoglu, M., Izzetoglu, K., & Onaral, B. (2011).Using MazeSuite and Functional Near Infrared Spectroscopy to Study Learning inSpatial Navigation. J Vis Exp(56), e3443. doi: 10.3791/3443


Motion Artifact Detection& Removal

• Low-pass / Band-pass Filters

• Wavelet Analysis

• Independent Component Analysis(ICA)



(ICA)

• Principle Component Analysis (PCA)

• Coefficient of Variance related(SMAR, etc.)

• Optimal Filtering(Adaptive; Wiener; Kalman)

Experiment Setup and Data Acquisition:Alex Dimov



Experiment Setup and Data Acquisition:Alex DimovBIOPACSystems, Inc.

Signal Processing and Data Analysis: Hasan Ayaz,



Signal Processing and Data Analysis: Hasan Ayaz,PhDAssociateResearchProfessor,DrexelUniversity

For more information:[email protected]

-Information on fNIR systems

How to get High Quality Brain Imaging Data



-Information on fNIR systems-Other BIOPAC webinars

Thank you for your time and attention!

© BIOPAC Systems, Inc. 2016 1€¦ · and spatial working memory training: Continuous monitoring...

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Transcript of © BIOPAC Systems, Inc. 2016 1€¦ · and spatial working memory training: Continuous monitoring...