Post on 22-Jan-2015
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Parkinsons Disease dysfunction of Basil Ganglia (show video) 4. 5. From McIntyre working group, 2006.3-D reconstruction + DBS electrode placement + simulation of electric fields 6. Temporal pattern of pulse delivery see P Tass, use of nonlinear dynamical systems 7. Computational Neuroscience What computations are done by a neural system? How are they done? WHAT? Feature detectors, eg visual system. Coincidence detection for sound localization. Memory storage. Code:firing rate, spike timing. Statistics of spike trains Information theory Decision theory Descriptive models HOW? Molecular & biophysical mechanisms atcell &synaptic levels firing properties, coupling. Subcircuits. System level. 8. Computational Neuroscience What computations are done by a neural system? How are they done? WHAT? Feature detectors, eg visual system.(Hubel & Wiesel & Sperry: Nobel, 1981) Coincidence detection for sound localization. Memory storage. Code:firing rate, spike timing. Statistics of spike trains Information theory Decision theory Descriptive models HOW? Molecular & biophysical mechanisms atcell &synaptic levels firing properties, coupling. Subcircuits. System level. 9. In vivo data from the barn owl shows auditory brain stem (NL) neurons encode ITD for sound localization A B C D E PLACE CODE OUTPUTS DELAY LINE INPUTS DELAY LINE INPUTS C 5 left ear leadsright ear leads INTERAURALTIMEDIFFERENCE(sec) 100 50 0 4409 Hz 0 -300 -150 150 300 -30 sec % MAXIMUM RESPONSE A neural computation by single cellbut how? And soooo fast, when spikes and synaptic potentials are 1 ms time scale 10. Dynamics of Excitability and Repetitive Activity Auditory brain stem neuronsfire phasically,not to slow inputs. w/ Svirskiset al, J Neurosci 2002 11. Neuroscience-- a field with foundational understanding based on mathematical & computational approaches Nobel Prize, 1959 shared with JC Eccles Wilfrid Rall (starting 1950s) developed cable theory for dendrites 12. Computational Neuroscience What computations are done by a neural system? How are they done? WHAT? Feature detectors, eg visual system. Coincidence detection for sound localization. Memory storage. Code:firing rate, spike timing. Statistics of spike trains Information theory Decision theory Descriptive models HOW? Molecular & biophysical mechanisms atcell &synaptic levels firing properties, coupling. Subcircuits. System level.