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Functional considerations of the Vagus nerve:

An Endobiogenic perspective

Kamyar M. Hedayat, MDPresident, American Society of Endobiogenic Medicine and Integrative Physiology

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Overview

• Endobiogeny: A theory of terrain• Types of Adaptation• Function of the Vagus nerve• Vagotonia and foundation of disease• ANS and Adaptation• Assessment of vagal excess• Conclusions

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Endobiogeny: A theory of terrain

• Presented by French physician Christian Duraffourd, MD in the early 1980’s

• Terrain: functional expression of structural constitution in its internal equilibrium– Dynamic and Ceaseless– Consists of Inductive and Reactive elements

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Endobiogeny: A theory of terrain

• Terrain– Constitution: Genetic heritage, potential capacity

of the structure– Structure: materialized constitutive elements that

assure life. The achievement of constitution– Function: all the biologic and metabolic mechanics

that assure functioning of structure and dynamics of the organism

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Endobiogeny: A theory of terrain

• Morphology: Exterior configuration of structure in its function

Vagotonic 18 yo female with Migrainesseizuresceliac

Vagotonic 6 yo male with moderately severe asthma, eczema

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States of adaptation

• Adaptation: Momentary adjustment of equilibrium

• General adaptation syndrome (GAS): response to a non-recognized attack; progressive, ordered, and chronologic

• Adaptability: Adaptation to a new level of functioning without invoking GAS

• Adaptative states: Adaptation that does not return to the prior state of equilibrium

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ANS and Adaptation

• Parasympathetic– Origin: Cranial nerve: Pons– Nerve: Vagus nerve– Neurotransmitter: Acetyl Choline– Functions: Rest and digest:• Basal physiologic state• Increases the rate of production and volume of all

secretions, facilitates sleep and stillness• Solicits alpha-sympathetic activity

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Vagotonia and disease

• Vagotonic individuals susceptible to disorders due to parasympathetic hyper-functioning– DERM: Eczema, Psoriasis– PULM: Asthma, Bronchitis– CNS: Migraines– GI: Crohn’s disease, Ulcerative colitis, Gastritis

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ANS and Adaptation

• Alpha-sympathetic– Origin: Locus ceruleus, Pons– Nerve: Sympathetic Ganglion– Functions: Initiates, calibrates and/or maintains each type

of adaptation state, installs tension• Beta-sympathetic– Origin: Adrenal medula, Adrenal gland– Nerve: N/A, neurohoromone– Functions: facilitates movement, relieves tension through

the excretion of secretions, regulates serum glucose levels

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Global ANS Function

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ANS Dynamism and Entrainment

Alpha Sympathetic

Beta Sympathetic

Para Sympathetic

SEROTONIN CORTISOL

HISTAMINE

AUTONOMIC NERVOUS SYSTEM

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Altered ANS equilibrium: POTS

Alpha Sympathetic

Para Sympathetic

SEROTONIN

HISTAMINE

ANXIETY

Beta Sympathetic

CORTISOL

TACHYCARDIAVOMITING

Venodilation

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Assessment of Para: History

• Infancy: Quiet, easy baby, good eater• Toddler: Shy, timid; ENT pathologies,

Pulmonary pathologies• Adolescence: Sweats easily and throughout

body, falls asleep easily• General: Hungry first thing in morning,

abundant saliva

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Assessment of Para: Exam

• General: Round face• General signs of

digestive insufficiency– Enlarged parotids, dilated

canal of Stenon, tenderness of pancreas

• Signs of post-pubertal growth hormone related to the above– Bulbous nose, fleshy ear

lobes, large chin

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Conclusions

• 10th cranial nerve has an impact on nearly every aspect of basal and adaptive physiologic activity

• Contextualize Vagus nerve activity within the scheme of global functioning of the patient

• Endobiogeny offers a sophisticated method of evaluating functional implications of vagus dysfunction in psychological, mental and physical spheres

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Opportunities for learning

• ASEMIP offers fellowship in Endobiogeny:– History taking and physical exam skills– Systems-based evaluation of biomarkers– Phytotherapy, Aromatherapy, Diet, lifestyle guidance

• Applications being considered for 2014-2016 teaching cycle: www.endobiogeny.com

• To learn more and receive a free copy of this lecture:– Text: “Endo” to 619-456-0155– Email: president@endobiogeny.com– Call: 858-455-9726

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Questions and Answers