Tumor Necrosis Factor Trivia

By: Nina Bullock

In what 2 ways can TNF be classified as?

Cytokine and Adipokine

What are the two receptors that TNF can bind with?

TNFR1 and TNFR2

How many amino acids are in TNF?

212 amino acids

What type of cells produce TNF?

White Blood Cells

What ability does TNF have?

Tumor cell apoptosis

Where can TNFR1 be found?

In most human tissues

Where can TNFR2 be found?

In the cells of the immune system

What disease is TNF involved in?

Crohn’s Disease

Which part of the body does Crohn’s Disease attack?

Intestines colon and ileum

Upon contact with ligands, what do TNF receptors form?

Trimers

Work Cited "Tumor Necrosis Factor Definition - Medical Dictionary Definitions of Popular Medical

Terms Easily Defined on MedTerms." Medterms. N.p., n.d. Web. 09 Dec. 2013 "Crohn's Disease: Topic Overview - WebMD." WebMD. WebMD, n.d. Web. 09 Dec.

2013 " National Center for Biotechnology Information. U.S. National Library of Medicine,

n.d. Web. 09 Dec. 2013 N.d. Photograph. n.p. Web. 9 Dec 2013. <http://www.healthcentral.com/ibd/irritable-

bowel-syndrome-000103_1-145.html>. N.d. Photograph. n.p. Web. 9 Dec 2013.

<http://wi.mit.edu/news/archive/2008/human-blood-stem-cells-are-multiplied-20-fold-culture>.

N.d. Photograph. n.p. Web. 9 Dec 2013. <http://www.pnas.org/content/95/7/3408/F7.expansion.html>.

N.d. Photograph. n.p. Web. 9 Dec 2013. <http://www.jneuroinflammation.com/content/8/1/87/figure/F1>.