Tranexamic Acid (TXA) Trial Study

Key Points

Inclusion Criteria

O Trauma Patients over age 18 with sustained blunt or penetrating injury within 3 hours of patient contact time

O *Trauma base hospital contact is mandatory*

Inclusion CriteriaO Prehospital TXA should be

considered for any 18 years or older trauma patient with:O SBP < 90 at any point during patient

contact/transportO Blunt or penetrating mechanism

within 3 hours of patient contact with signs/symptoms of hemorrhagic shock

High Risk Patients O High risk patients:

O Signs and symptoms of hemorrhagic shock

O EBL of 500 mL with a heart rate greater than 120 or SBP < 90

O Uncontrollable bleedingO Amputation above wrist(s) or ankle(s)

Exclusion CriteriaO Under 18 years of ageO Any thromboembolic events within

the past 24 hours (Stroke, MI, PE)O 3 hours post injuryO Hypersensitivity or anaphylactic

reaction to TXA O Some specific injuries are excluded

as well

Exclusion CriteriaO Injury exclusion criteria:

O Penetrating cranial injuryO Isolated hanging/drowningO TBI with exposed brain matterO Cervical injury with motor deficitO Traumatic arrest with 5 minutes or

more of CPR with no ROSC

DocumentationO Description of injury/injuries to

patient(s), time of injury – key point!O Flex field added to Sansio when TXA

selected to be administeredO Trial Study tab activated in MEDS for

AMR crews

Data elementsO Date / timeO Incident numberO Patient age/gender/weight/race/ethnicity

and allergies and history / estimated blood loss

O Type of injury (blunt/penetrating)O Time and mechanism of injuryO Trauma triage criteria metO TXA dose/route/time of adminO Vital signs pre/post TXA admin – include

GCS, full BP, skin signs,

cQI O After TXA Administration, complete your

documentation and notify your cQI department

O 100% audit of all TXA PCR’sO Following patient in hospital for

continuum of careO Monitoring 24 hour mortality/morbidityO Monitoring 48 hour mortality/morbidityO Length of hospital stay and hospital

disposition