Nina Mian, Head of Biomedical Informatics Advanced Analytics Center, AstraZeneca April 2015

Patient-Centered Analytics Tools and technologies to enable patient centered insight

The Advanced Analytics Centre Transforming drug development decision making through applied data science

Patient centered…

analytics?

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Deliver actionable insights to

AstraZeneca and patients

Solicit and acquire

patient views & data

Derive insight from

data: analytics

Challenges you might have come across...

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..and why we need to resolve them

Motivation to do great things for patients Motivation to do great things for patients

Impact of disease Status of current treatment

Unmet need Endpoints that matter

Recruitment & retention Reducing missing data Adherence + efficacy

Benefit-Risk (tolerability) Transparency

True patient journey Patient group education

and advocacy Brand awareness Medicines Access

Improved health outcomes & experiences

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http://commons.wikimedia.org/wiki/Category:Hype_cycle

Tools & Technologies Peak of Inflated Expectation

Data & Insights Active and passive

PRO/ PRE

Blogs

Forums

YouTube Searches

Biomarkers

Podcasts

Location and

movement

Mobile

Social

Wearable Consumer reports Patient

health record

PatientsLikeMe

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Ovarian Cancer – “In your own words”

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Total # 30 (56.3 ± 9.2 y.o) Caucasian females BRCA+ n = 4 BRCA - n = 11 BRCA Unknown n = 15

Treatment pathway

• Structured

• Longitudinal

• Targeted additional data

• Fast

•Account for bias

(population, recall)

•Where the patients

already are

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The approach

Patient centric learning Listening, and understanding what patients are willing to share

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“I spent Sunday in bed shaking off a headache and feeling unwell.”

“Still there has been no return of the swelling to my ankle or foot and No discomfort while eating. So I'm in pretty good shape really ”

“I'm not doing an awful lot because of the fatigue that is really quite, quite overwhelming.”

“the taste of the pills is unpleasant even though they are in the mouth for only a couple of seconds, ...”

“the rash is gone from my face and is greatly reduced on my chest” ... “My skin continues to be dry but is responding to XXX and is not a problem.”

Insight to Interpretation

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Safety

Skin Gastrointestinal

Dry skin Pimply rash Diarrhoea Constipation

• Characterisation of issues

• Impact

• Management

Informed medical teams

Informed patients

Gives our patients a voice, and us a way to listen, so that we can strengthening the link between our science and patient-driven needs

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How does it help the patients? How does it help us?

Finalist: Customer Innovator Award

Me&My: Global Patient and Physician Support

Key Modules •Patient Profiling based on behaviour and disease state

• guides messaging strategy and other interventions

•Data Collection from Patients •Integration of devices for adherence support and detecting change in disease state •Devices to collect physiological data •Patient reported outcomes

•Supported self management •Individualised messages based on data collected •Content from medically valid sources •Goal setting and tracking •Decision support •Links to HCP and HCP services

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Navigating the trough of disillusionment

> Patients making medical decisions… > New methods of data capture… > Holistic view of patient experience

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Patient +

Provider +

Payer +

Pharma

http://www.thecyranosmccann.com/

Improved health outcomes & experience

Acknowledgements

Jenny Royle, Patient Safety Åsa Strom, Clinical informatics, R&D Information Stephanie Roberts, Advanced Analytics Center Christelle Gendrin, Advanced Analytics Center Amrik Mahal, R&D Information Lili Peng, R&D Information Donal Landers, Early Clinical Development Andrew Hughes, Early Clinical Development Shirley Spratt, Patient Safety Katarina Halling, PRO Group Daniel Eek, PRO Group Lisa Banks, Intelligent Pharmaceuticals Matt Bonam , Intelligent Pharmaceuticals Jan Frövenholt, R&D Information Sarah Keegans, Intelligent Pharmaceuticals Our partners at PLM and many other collaborators.

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Confidentiality Notice

This file is private and may contain confidential and proprietary information. If you have received this file in error, please notify us and remove

it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the

contents of this file is not permitted and may be unlawful. AstraZeneca PLC, 2 Kingdom Street, London, W2 6BD, UK, T: +44(0)20 7604 8000,

F: +44 (0)20 7604 8151, www.astrazeneca.com

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