Throat cancer Presented By Karjan Basumatary M.tech (IS&M)@ISiMUniversity Of Mysore-570006

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AimThe main aim is a treatment to remove

completely the cancer & preventing the spread of the cancer to other parts of the body.

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What is throat Cancer??Throat cancer is a condition where cancer affects the

vocal cords, voice box (larynx), or other areas of the throat.

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Types of throat cancer

Oropharyngeal cancer : The part of throat that is right behind your mouth.

larynx or Laryngeal CancerGlottic cancer begins in the vocal cords or Voice

boxNasopharyngeal Cancer: The part of throat just

behind your nose.Hypopharyngeal Cancer: The lower part of throat,

just above your esophagus and windpipe.

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Top: Diagram of a LarynxRight: Larynx with cancer

•The larynx is also referred to as the voice box. It contains vocal cords to help assist with speech

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Sign & symptomsAbnormal (high-pitched) breathing soundsHoarseness that does not resolve in 1 to 2 weeksSore throat that does not resolve in 1 to 2 weeks,

even with antibioticsCoughCoughing up bloodDifficulty swallowingNeck painSwelling in the neckUnintentional weight loss

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Throat cancer causes Major causes of Throat Cancer..when cells in our throat develop genetic mutations.SmokingAlcoholOccupational Exposures Genes from Ancestors

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Stages of Throat CancerStage 1Stage 2Stage 3Stage 4

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Types of treatmentsurgery.radiation treatmentchemotherapy

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Side effects for treatment of throat cancerTender mouth soresHair lossDry mouth (xerostomia)Sensitive tongueBitter taste in mouthNumbness in parts of the neck and throatLoss of appetiteNauseaFatigueDifficulty swallowing (dysphagia)Speech problemsWeak or stiff shoulder and neck

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Risk Factors of throat cancerDamage of DNA cells in mouth & throatHPV(Human Papillomavirus)Throat cancers can be cured in 90% of patients if

detected early

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Newly Discovered Cancer geneAdenoid Cystic Carcinoma (neck & head)

what is known as a fusion gene, created when two healthy genes join together as a result of a chromosome change.

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Histopathological image of adenoid cystic carcinoma of the salivary gland. Haematoxylin & eosin stain.

Problem Statement

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Detection of fusion gene through DNA sequence analysis.

Methodology

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Multiple sequence analysisIdentifying the throat fusion genes in the genome

Gene therapy

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Gene therapy is an experimental treatment that involves introducing genetic material (DNA or RNA) into a person's cells to fight disease. 

Approaches

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Replace missing or altered genes with healthy genes.  Researchers introduce “suicide genes” into a

patient's cancer cells. Will focused on the use of gene therapy to prevent

cancer cells from developing new blood vessels.P53 ‘Genome Guardian’: Gene therapy for cancer to

repair the malfunctioning of this natural genetic guardian.

Genes are not directly inserted into the patient's body, but uses viruses for that purpose. Such as retroviruses, adenoviruses, herpes viruses, lentiviruses and poxviruses.

Informatics

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A 24 hours On line systems.Inserts, store, manage & monitor the health

condition of patients for present & previous.Automatic alarm systems for emergency.System having Own X-Ray Machines.On line treatment systems with the other

countries doctor.

Thank you

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