The University of Sydney Page 1

Translational Research

Closing the Gap Between Practice and

Research

Professor Tim ShawDirector Research in Implementation Science and eHealth (RISe)Faculty, Health Sciences

What is Translational Research?

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Applied research

Basic research

Why Translational Research?

• Consistent evidence of failure to translate research findings into clinical practice

• 30-40% patients do not get treatments of proven effectiveness

• 20–25% patients get care that is not needed or potentially harmful

(Runciman 2012; Grimshaw 2012; Schuster, McGlynn, Brook, 1998; Grol 2001)

Clinical & Translational Research: Valleys of Death

Basic Biomedical and HSR Research

Clinical Science& Knowledge

Clinical Practice& Health Decision

Making

Translational Continuum – 17 years

Valley 1 Valley 2

Copyright University of Pittsburgh 2006Reis et al. Clin Transl Sci 2008

14% enter into standard clinical practice; 1% lead to important health impacts

Thanks to Eva Grunfeld

Translation

Discovery Trials

Implementation

Improved Patient Outcomes

T1 T2

T3

Purposeful intent around an identified issue/priority

What’s so special?

Isn’t that what we have all being doing anyway?

Barriers

SilosAcadem

ia

Hosp

itals

Discip

lines

Geog

rap

hy

QI

Capacity and understanding

Eg TimelinesLanguageEnd points

MethodologiesRewards

Different planets?Academia/IS QI/Practice

Lack of access to data

Enablers

Building capacity

New Partnerships and FundingAdvanced Health Research and Translation Centres

Translational Cancer Research Centres

Academic Health Units

A systematic approach to identifying and closing evidence-practice gaps

Longitudinal Programs

Tim Shaw, Nicole Rankin, Sarah York, Phyllis Butow, Jane Phillips, Kate White, Jane Young, Puma Sundaresan, Sally Pearson, John Symes

Engaging MDTs in Translational Research

High Performing Tumour Program

Paul Harnett, Lynleigh Evans, Henry Pleass, Guy Eslick, Arthur Richardson, Kim Hill, Kylie Museth, Anna Janssen, Tracy Robinson, Tim Shaw

High Performing Tumour Program

Impact on clinical practice

+Impact on

professional development

+Impact on quality

improvement+

Generation of research questions

WS-LHD staff, Tim Shaw, Paul Harnett, Anna Janssen, Kylie Museth

Data Innovation Lab

High Performing Tumour Program

Disruptive technology

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