Can genomics,

facilitated by NGS and cloud computing,

enhance phytomedicine in early stage R&D?

Will Spooner, CTO, Founder, Eagle Genomics LtdWilliam.spooner@eaglegenomics.com

Molecular Psychiatry advance online publication 30 August 2011; doi:10.1038/mp.2011.101

Scientific impact of genomics

Image: Sartr http://sartr.deviantart.com/gallery/?offset=96#/d1u0z75 CC BY-NC-ND 3.0

Phen

otyp

e As

soci

ation

PhenotypicAssociation[biomarker]

Stratified Medicine

Right drug

Right patient

Right time

Pharmacogenomics

Genotypic

Transcriptomic

Epigenetic

Genomics in pharmacology

©

Genomics in plant breedingGermplasm/Pedigree

Phenotype/Genotype association

Phenotype Genotype

GenotypingPhenotyping

Assays

Breeding

Plant models for lead optimisation

Image By: G. Nicolella http://luirig.altervista.org/cpm/albums/bot-002/normal_medicago-truncatula3637.jpg CC BY SA

Physcomitrella patens

Image By: Ralf Reski CC BY-ND

Aquilegia coerulea

Sequenced phytomedicinal plants

Cannabis sativa

Theobroma cacao Ricinus communis

Image By: Actv [CC] Image By: Eric Lyons

Image By: Kai Yan, Joseph Wong [CC] Image By: Howard F. Schwartzs [CC]

Genomics in research productivity

Apoptotic execution Phase

Synergy in phytopharmacology

2 + 2 = more

NGS - democratising genomics

The Cost of Big Data

Now Soon

Image: PictureGirl http://pixdaus.com/single.php?id=256700 CC-BY-SA

Cloud Computing = Greater ScalabilityCloud Computing = Lower Cost

+ Greater agility+ More flexibility+ Faster time to market+ Improved business process

Open Innovation

ExploreWork together to find a commonpurpose

NurtureBuild trust, shared language

ExploitTurn ideas intotangible benefits

CollaborateEnterpriseAcademiaGovernmentFoundations

Pre-Competitive Collaboration

©

Ensembl as a GCMS

Comparative Genomics

Functional Genomics

Variation

Assembly/GenesData Integration

Data Reporting

Data Analysis

Data Integration

Data Querying

Data QC

API

Leveraging Public Resources

Summary

• Genomics is revolutionising:– Basic research, – Plant breeding, – Pharma R&D

• Genomics can be applied to phytomedicine:– Lead discovery/optimisation,– Study of mode of action/synergy

• Genomics R&D is empowered by:– NGS, – Cloud computing, – Open innovation.

Questions and Comments

William.spooner@eaglegenomics.com @wspoonrON EMAIL

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