Impact from Excellence

Aligning our research with

the Medtech Industry’s

requirements for Bio-

Photonics and Photonics

Integration.

Ray Burke Program Manager ICT for Health

Tyndall National Institute

Cork, Ireland

III-V FAB

Ireland’s National Institute for ICT Research Development and Innovation

ICT for Health at Tyndall

Tyndall will deliver

new opportunities for Ireland’

economic growth creating

impact from excellent research,

systems development and graduate training, delivering

disruptive ICT solutions &

highly trained people to meet challenges

in the HEALTH, Medical Devices

and Life Sciences’ sector.

Impact from Excellence in ICT for Health

ESTHER

Emerging and Strategic Technologies for Healthcare

Deliver

Commercial

Output

Technology

Platforms &

Solutions

Industry

Collaboration

Demos

Licenses

Start-ups

Primary focus on Scientific Discovery

delivering science, publications & patents

Expertise, know-how, Background IP

Commercial

PIs (Progr.

Managers)

&

Researchers

Foreground

IP

Multidisciplinary Solutions for industry

Photonics Micro/Nano Systems

Health

Secure, Agriculture, Food & Environment

Energy

Communications

Centre and Industry Sector Matrix

ICT for Health at Tyndall

Smart Systems

Electronics & Photonics

Micro & Nano Technologies

Core Enabling Technologies

Core Enabling Technologies

ICT for Health at Tyndall

Smart Systems

Electronics & Photonics

Micro & Nano Technologies

Core Enabling Technologies

Molecular modelling

Advanced Sensors

Advanced Processing

Micro Power

Photonic devices

Photonic packages

Photonic systems

Wireless inertial sensing

Lab on chip systems

Electronic integration

Research & Technology platforms

Research &Technology platforms

ICT for Health at Tyndall

Smart Systems

Electronics & Photonics

Micro & NanoTechnology

Core Enabling Technologies

Molecular modelling

Advanced Sensors

Advanced Processing

Micro Power

Photonic devices

Photonic packages

Photonic systems

Wireless intertialsensing

Lab on chip systems

Electronic integration

Applications

Research &Technology platforms

Diagnostics

Connected Health

Therapeutic Systems

Cardio-Neuro

Interfacing

Surgical Innovation

& TEL

We Collaboratewith global

medtech companies, world

leading clinicians and

leading scientists.

Tyndall ICT4 Health

- leading an ABC Ecosystem

Clinicians & Patients

Tyndall & Academic partners

Clinical Partners

BusinessPartners

ABC Ecosystem

Academic,

Business,

Clinical)

Photonics – expertise/capabilities

Photonics

Theory

Electronic structure

and properties, III-V

materials & devices

Device

Fabrication

Optical design to device

dynamics, laser physics,

power scaling, ultrafast

pulses

Device Design &

Test

Novel photonics structures

Visible, near-IR & UV

lasers, (micro)LEDs,

modulators & detectors

MicroelectronicsDriver and receiver

integrated circuits

III-V & III-Nitride

materialsSemiconductor

optoelectronic device

structures, quantum well,

wires, dots &

nanostructured epitaxy

Photonic

Integration

High-speed integrated

optoelectronic

transceivers

Packaging

Packaging & hybrid

integration

Optoelectronic

Systems

Optical fibre

communications &

optical interconnects

Bio-photonic

SystemsPoint of care

diagnostics, smart

surgical instruments &

wearable devices

Silicon Photonics

Quantum

InformationSingle photon sources,

quantum key

distribution systems

Micro-transfer printing,

integrated electronic

and photonic circuits

Basic Phenomena

Materials Epitaxy

Devices Integration Systems

Bio-PhotonicsLight and tissue

interactions

World-Class Facilities ‘atoms to systems approach’

11

Photonics - Team

• Largest photonics research activity in Ireland

– 16 PIs + teams (150 people in total, 50 PhDs)

• Internationally competitive, connected and visible

• Significant PI industry

experience:

• Lead/host for SFI/industry-

funded Irish Photonics

Integration Centre (IPIC)

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ic

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en

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O’Reilly

Photonics TheoryElectronic structure and properties

of III-V materials & devices

Device DynamicsCAPPA group: Laser dynamics,

material studies & optical design

III-V Materials& Devices

Visible & near-IRlasers & LEDs

Huyet McInerneyCorbett

TownsendGunning

Photonic SystemsFibre communications

High speed microelectronics design

Laser PhysicsLasers & devices

Morrison

Optical DetectorsAPDs & IC integration

Peters

Pelucchi

Epitaxy & Physics of Nanostructures

III-V Epitaxy, quantum dots & quantum optics

Photonic IntegrationHigh speed integrated

optoelectronic devices

III-Nitride MaterialsUV & visible sources

Parbrook

O’Brien

Photonic PackagingPackaging

& hybrid integration

Ossieur Zhao

Hegarty

Bio photonics Medical devices and bio-imaging

Schultz

Andersson-Engels

Expanding Biophotonics and Medical Application Expertise

• International search identified Prof. Stefan Andersson-Engels, Director of Medical Laser Centre at Lund University, Sweden as leading candidate

• Main fields of interest– Laser spectroscopy and imaging for medical

diagnostics, Photodynamic therapy, Tissue Optics

• Academic leader and active entrepreneur– >400 publications, H-Index of 52, 3 biomedical start-

up companies

– Extensive experience of working with clinicians

• Current status– SFI Professorship application (value €5M) funded

– Started full-time at Tyndall 1st September

13

Tissue Imaging

• Various techniques are today used

in medical imaging and

interactions.

• Optics provides unique molecular

contrast opportunities in tissues.

• There is a great need for improved

tools for interacting with deep

tissue regions.

• Photo-acoustics is a technique

starting to enter the preclinical

and clinical use.

Ultrasound Optical Tomography

1

5

Grand challenge: can we see through the body using light?

• Academic institutions

• Together with 20 industry partners

• €30 Million funding (30% industry, 70% SFI) for initial 6 years

• Focus areas: integrated systems for ICT and Medtech

Hybrid Integration

Monolithic Integration

Irish Photonic Integration Centre

Principal Investigators

• Full photonics and electronics ‘value chain’• 60 people directly funded, 150 people in wider teams

17

Prof. Stefan Andersson-Engels

(formerly Lund University)

€5M programme in

biophotonics

International Recognition

• Brian Corbett receiving 2013 Intel

Outstanding Researcher Award for

his work on light sources for

computer interconnects

• Eoin O’Reilly receiving the 2014 Rank Prize award for his pioneering work on strained-layer semiconductor laser structures

Industry Partner Expansion

• Pipeline of further target

companies being

developed with support

from IDA and Tyndall

Business Development

Team

2012 2013 2015 20162014

IPIC Start

Research Snapshots

Devices including Transfer Printed Lasers

III-V Materials & Theory

III-V PICs

New Lasers for OCTSuper Channel Systems and PONs

O2 Sensing in tissue

82.10 nm

0.00 nm

200nm

Nanostructure enhanced fluorescence

for biosensors

Optical Interconnects and Microelectronics

Photonics Packaging

Chip on tip Challange

URSUser Requirements Specification

SRSSystem Requirement Specification

DOSDesign Output Specification

DFEMADesign Failure Mode and Effects

Analysis

DVTDesign Verification Testing

FTFunctional Testing

TRSTest Requirement Specification

Implementation

Documentation DHF & Compliance

Implementation Example Flow Diagram

• Define User Case & URS• Market Analysis data• Commercial Strategy• Detailed Business Plan• Technology Licences• Clinical Requirements

Clinician Lead , Industry Lead, commercial input from team and EMR suppliers on technology, market etc.

• Design the product• Sensor Integration• Hardware• Software• Communications• Alpha Prototypes • Design for manufacture

Tyndall, Technion, Marturion Industry , EMR suppliers & Advisory Board

• Mechanical Design• Functional Prototype Build• Design verification testing• Verify Usability• Device testing• System level interface

Industry CMO, Technical TeamPartner HospitalsPartner CliniciansEMR suppliers & Advisory Board

Tyndall, Technion, Marturion Industry , EMR suppliers & Advisory Board

Industry , Partner Hospitals , distribution and manufacturing Network EMR suppliers & Advisory Board

AC

TIO

NS

STA

RT

Team

Market Analysis & Technology Phase Month 1-14

Regulatory and Commercialisation Phase Month 14-30

• Ethical Approval• Clinical Testing• Regulatory

Submissions• Approvals testing• Design Validation

Industry , Technical team, Partner Hospitals ,Distribution and manufacturing Network EMR suppliers & Advisory Board

• Commercialisation• Marketing• Distributor Development• Market Development• Product Roadmap

• Production Process• Process validation• Supply Chain Process• Sample volumes• Marketing

AC

TIO

NS

Team

Commercialisation Month 30-36

Some Suggestions

• Working with medtech companies or interested in translating

research to medtech sector, then we need to be strategic.

• They will want a system level approach or understanding.

• Device classification.

• Propose and build technology platforms. Third parties &

Supply Chain.

• Starting point remember the ABC Model.

• Understand the clinical procedures ask for a target or typical

procedure. Try and understand commercial application early.

• Regulatory Path , in-vivo testing , first in man & Clinical .

• Contract Research Agreement , NDA , get pro-forma versions

to the Industry partner early these can take a year to

conclude, insurance and liabilities.

• Researcher in Residence program.

Thank you

for your

attentionray.burke@tyndall.ie

www.tyndall.ie