Treatments Options by Type

SCID: Early Treatment Saves Lives

X-linkedADA-SCIDArtemis SCID (aka SCIDA or DCLRE1C)RAG-1 and RAG2IL7R deficiencyCD3 complexComponent DeficiencyCD45 deficiencyCernunnos-XLFDeficiencyCoronin-1A deficiencyDNA ligase 4 deficiencyDNA-PKcs deficiencyJAK3 deficiencyLAT deficiencyReticular dysgenesisLeaky SCIDOmenn Syndrome

Early diagnosis and treatment for SCID is necessary forimproving a child’s chances of survival. If a child isdiagnosed and treated within the first few months of lifebefore a serious infection develops, then the long-termsurvival rate is more than 90%. With early treatment,most children with SCID should be able to develop theirown working immune system. The best course oftreatment for a child with SCID depends on severalfactors including the type of SCID and the child’s health.

Hematopoietic Stem Cell Transplant (HSCT) is the standardtreatment for all types of SCID. In HSCT, donor stem cells areintroduced into the child and develop an immune system. Enzyme Replacement Therapy is a temporary treatment that isused to treat ADA-SCID. Gene therapy is an alternative treatment in clinical trialsavailable only for X-linked SCID, ADA-SCID, and Artemis SCID.Gene therapy uses a child's own corrected stem cells to buildan immune system.

SCID TypesSCID Diagnosis

This project is supported by the HealthResources and Services Administration(HRSA) of the U.S. Department of Healthand Human Services (HHS) as part of anaward totaling $4 million with 0% financeswith nongovernmental sources. Thecontents are those of the author(s) and donot necessarily represent the official viewsof, nor an endorsement, by HRSA, HHS orthe U.S. Government.