Disease Biophysics Group Will Adams 1

Sarcolemmal Displacement

Will Adams

Disease Biophysics Group Will Adams 2

Cardiac Myopathies

Physiological

Dilated Cardiomyopathy

Hypertrophy (concentric)

medlib.med.utah.edu

medic.med.uth.tmc.edu

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Individual Myocyte Geometry

L = 80µm

R = 10µm

H = 50nm

L = 80µm

R = 16µm

H = 50nm

L = 110µm

R = 10µm

H = 50nm

PhysiologicalConcentric Hypertrophy

Dilated Cardiac Myopathy (eccentric hypertrophy)

Disease Biophysics Group Will Adams 4

Displacement

• Why displacement?– Mechanical energy

dissipated from internal viscosity will depend on displacement and velocity

– Perhaps the pathological morphology of the heart is maladaptive not only on a macroscale (ejection fraction) but on a microscale (intracellular drag)

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Longitudinal Displacement

Stress Displacement

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Longitudinal Displacement

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Transverse Displacement

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Results

SystoleDiastole Hypertension

Critical Ejection Fraction

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Directions• Maintain cytosolic volume conservation • Intregrate a t-tubule network into ABAQUS

http://mednote.co.kr/

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Acknowledgements

• Adrian Podpirka