Quantitative Imaging Biomarkers in Medicine

www.quibim.com

@Quibimbiomarker

QUIBIM PRECISION

Powering AI and Imaging Biomarkers

1896. William Morton

First radiology report: Abdomen X-Ray

“… there is no stone of appreciable size in

the kidney…”

2018

Today radiology report: CT renal stones

“… no adenopathy is seen.”

DISEASE vs. THE EYE

THE NEED:MEASUREMENTS

“When you can measure what you are

speaking about, and express it in

numbers, you know something about it”

Lord Kelvin

Imaging BiomarkersIt is a measurement obtained objectively from medical images which represents and quantifies a tissue property

(structural, functional or biological) extracted after applying computational models to images and specific signal

processing, resolved in space and time.

to measure is to know

QUIBIM PRECISION®

platform

ONCOLOGYSolid tumours, hematology

Diffusion (IVIM, DKI),

Pharmacokinetics, Bone

Marrow Infiltration, Multi-

Parametric Analysis

BONEOsteoporosis

Trabecular morphology,

fractal irregularity,

anisotropy, mechanical

resistance & elasticity

LUNGCOPD

Lung & lobes volumes,

emphysema percentage,

bronchia wall, trachea wall

NEUROAlzheimer, ALS, MS, Stroke

Volumetry, cortical thickness,

lesions segmentation, iron

quantification, tractography

LIVERSteatohepatitis, fibrosis,

hemochromatosis

Fat fraction quantification,

iron concentration, Diffusion-

IVIM

IMAGING BIOMARKERS DEVELOPMENT

Value

Proof of concept Proof of mechanism Image acquisition Image processing Image analysis

Measurements Proof of principleProof of efficacy

and effectivenessStructured report

Idea

Martí-Bonmati ́ L, Alberich-Bayarri A, et al. Imaging biomarkers, quantitative imaging, and bioengineering. Radiologia. 2012;54:269-278.

ESR statement on the stepwise development of imaging biomarkers. Insights Imaging (2013) 4:147–152.

Our stepwise methodology was

adopted in 2013 by the European

Society of Radiology guidelines

IMAGING BIOMARKERS DEVELOPMENT

SCIENTIFIC EXCELLENCE

1ST IMAGING BIOMARKERS Book

Editors: QUIBIM Founders

Examines all aspects of the development of

imaging biomarkers and their integration into

clinical practice

TARGET MARKETS

Innovative Medical Doctors and

Researchers

Boost your imaging workflows!

We act in the full process of imaging biomarkers

integration, from the optimization of the images

acquisition in the equipments up to the biomarkers

report integration into the PACS.

Step-up your clinical trials!

We can safely detect and monitor early biological

changes in the organs and tissues as a

consequence of a given therapy.

CRO’s and Biotech Companies

QUIBIM Care QUIBIM Pharma

BUSINESS MODELS

Local

Basic license + modules 1st year

yearly manteinance

Cloud

Pay per analysis

Customized versions

From Images to Data

QUIBIM Precision® Platform

Our Advanced Cloud Platform for centralized image

management, storage and quantitative analysis.

QUIBIM Precision® platform

• Web

application/non-

installation required.

• Accesible from any

computer with

internet.

• Includes Quantitative

Analysis Plugins.

• Upload your image studies just with a ‘Drag&Drop’ action on

your DICOM files!

• Pre-visualization DICOM viewer

QUIBIM Precision® platform

• The Platform includes a Cloud DICOM Viewer with ROI &

Segmentation tools.

QUIBIM Precision® platform

• The platform includes automatic imaging biomarkers tools for

different pathologies in: Brain, Musculoskeletal, Oncology, Liver and

Lung.

• DataMiner Module

QUIBIM Precision® platform

All the raw data and variables are downloadable by the customer in a wide

range of formats: XLS, SPSS, CSV, MATLAB

STRUCTURED REPORTS

• Designed in collaboration with K.O.L.’s in each specialty

• Patient data compared to normative data

METRICS

2200

7516

0

1000

2000

3000

4000

5000

6000

7000

8000

2016 2017

Analysis

Analysis

Reached 1000

analysis/month

in NOV-2017

2016 2017

Revenue

Analysis

METRICS

52000€

Analysis distribution per Platform technol

ogy

LOCAL

23%

CLOUD

77%

Analysis distribution per Business Un

it

PHARMA

39%CARE

61%

LIVER

25%

ONCO

5%

BONE

10%

CUSTOM

2%

Analysis per disease area

NEURO

15%

LUNG

42%

An exciting track record

LANZADERA acceleration program by Juan Roig 180k€

Development of the new QUIBIM platforms (MINION &

MASTER)

Customers retention

Marketing & sales strategy

2014

2015 2016QUIBIM Precision® platform v1.0

released

Booth at ECR

New customers

Seed round 550k€

First international customer (US)

Development of new algorithms

Patent application (lung emphysema)

Development of the business model

Spin-off company of IIS La Fe

2012 - 2013QUIBIM is founded by Angel Alberich-

Bayarri and Luis Martí-Bonmatí, K.O.L.’s in

image processing and radiology

First customers

2017Growth and consolidation

1.25M€ SME Instrument

ECR & RSNA booth

Filed v2.3 CE mark certification

Filed v2.3 FDA 510k certification

OUR TIMELINE

2018Partnerships with big players

ECR & RSNA booth (Machine Learning SC)

Medical Device certified

Series A for product improvement and sales

QUIBIM Care

QUIBIM Pharma

CUSTOMERS

OUR TEAM

Mª Carmen

Rodríguez

Team Coordinator

Image Analysis

Scientist

Fabio García

Castro

Ana Jiménez

Pastor

Image Analysis

Scientist

Irene Mayorga

Ruiz

Clinical Trials

Coordinator

Raúl Yébana

Huertas

Image Analysis

Technician

CTO

Rafael Hernández

Navarro

Alfredo Torregrosa

Lloret

Image Analysis

Scientist

Founder & CEO

Ángel

Alberich-Bayarri

Marketing Manager

Katherine Wilisch

Ramírez

Alejandro Mañas

García

Full Stack

Senior Developer

Belén Fos

Guarinos

Image Analysis

Scientist

COO

Encarna Sánchez

Bernabé

Chief Financial Officer

Pedro

de Álava

Management Marketing

Development

Image Analysis

Pharma

Core Lab

services

SCIENTIFIC ADVISORY BOARD

QUIBIM SL

Polytechnics and University Hospital La Fe

Av. Fernando Abril Martorell 106, Torre A, Biopolo La Fe (Valencia, Spain)

Headquarters