Quenching of Pyrophoric Materials · Quenching of Pyrophoric Materials Hazardous Operation SOP Rev....

QuenchingofPyrophoricMaterialsHazardousOperationSOP

Rev.Date:2017-03-28

QuenchingofPyrophoricMaterialsH250

Examples:tert-ButylLithium,sec-ButylLithium,n-ButylLithium,DiethylZinc,Organoaluminumcompounds(asEt3Al,

Et2AlCl,EtAlCl2,Me3Al),RaneyNickelcatalyst

WORKING ALONE1 is PROHIBITED while quenching PYR materials

ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.

Department: Chemistry

DateSOPwaswritten: Thursday,March23,2017

DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017

PrincipalInvestigator:Name:F.Fischer

Signature:______________________________

InternalLabSafetyCoordinatororLabManager:Name:StephenvonKugelgen

LabPhone:510.301.1058

OfficePhone:510.642.8252

EmergencyContact:Name:StephenvonKugelgen

PhoneNumber:510.301.1058

Location(s)coveredbythisSOP: TanHall674,675,676,679,680,683,684

1.Purpose

This SOP covers the precautions and safe handling procedures for the Quenching of PyrophoricMaterials.

Allmaterialsmentionedinyourlaboratory“PyrophoricMaterials”(PYR)ClassSOParecoveredbythishazardousoperationsSOP.

Also,thisSOPcoversanymaterialssynthesizedusingpyrophoricliquidsorsolids.

1Whenincludedinastandardoperatingprocedure,foranydurationoftime,apersonisworkingalonewhenperformingataskinalaboratoryandtheycannotbeseenorheardbyotherworkers,andwhenassistanceisnotreadilyavailable.Inthiscontext,ataskisanyportionorsectionofanoperationorjob,anddoesnotrefertoajobinitsentirety.

Rev.Date:2017-03-28

Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.

2.Physical&ChemicalProperties

Forphysicalandchemicalpropertiesonpyrophoricmaterials,pleaserefertoyourlaboratory“PYR”SOPandtospecificSafetyDataSheets(SDS)ofchemicalsinuse(SeeSection11–SDSLocation).

3.PotentialHazards

When exposed to moisture or air, these reagents may ignite spontaneously. When quenchingpyrophoricmaterials,theindividualhazardsofthepyrophoricsandthesolvent,aswellasthehazardofthemixture,mustallbeconsidered,andproceduresforsafequenchingmustreflectthisconsideration.

As defined by the Globally Harmonized System of Classification and Labeling of Chemicals (GHS),pyrophoricsaredesignatedbyfollowingHcode:

H250Catchesfirespontaneouslyifexposetoair

4.EngineeringControls

Thefollowingisthesetofengineeringcontrolsrequiredwhenquenchingpyrophoricmaterials:

• Work under an inert atmosphere (e.g., argon, nitrogen) using a Schlenk line, in a glove box,vacuummanifold,oranyenclosedinertenvironment.

• If procedure is done in the fume hood, use the sash as a safety shield. For hoods with ahorizontalslidingsash,positionthesashallthewaydown,standbehindtheslidingwindowsandreacharoundtoperformthemanipulationsrequired.Forhoodswithverticalslidingsash,keepthesashaslowaspossible.

• Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsashorwhenthehoodsashisopen.

• Remove any flammables (squirt bottles containing solvents, oil baths) and combustibles(Kimwipes,papertowels)fromtheworkarea.

• LaboratoriesandroomswherePyrophoricsareusedmusthavegeneralroomventilationthatisnegativepressurewithrespecttothecorridorsandexternalenvironment.Thelaboratory/roomdoormustbekeptclosedatalltimes.

5.PersonalProtectiveEquipment

Ataminimum,thefollowingPPEmustbewornatalltimes:

EyeProtection

A. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.

• OrdinaryprescriptionglasseswillNOTprovideadequateprotectionunlesstheyalsomeetANSIstandardandhavecompliantsideshields.

B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.

SkinProtection

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A. Wearnon-syntheticclothingunderlabcoat.

B. Flame-resistant lab coat (Nomex IIIA, NFPA 2112) must be worn when working withpyrophorics.

C. Acombinationoffireresistant(FR)liners,coveredwithapairofchemical-resistantdisposablegloves (e.g.nitrileglovesor thosespecified in the specificSDS),mustbewornATALLTIMES.The following products are Approved FR Liners: Ansell Kevlar® Goldknit® Lightweight 70-200andHanzExtremityWearNomex®UtilityLiners.

D. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.

6.FirstAidProceduresandMedicalEmergencies

Intheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.

GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or

Call911(fromacellphone:510-642-3333)if:

• itisalifethreateningemergency;or

• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or

• thecontaminated/injuredpersonisnotbreathingorisunconscious.

Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.

Incaseofskincontact

Ifskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopious amounts of water for no less than 15 minutes to remove any remaining contaminants. Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.

Incaseofeyecontact

Rinse thoroughlywith plenty ofwater using an eyewash station for at least 15minutes, occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.

Ifswallowed

DoNOT induce vomiting unless directed otherwise by the SDS. Never give anything bymouth to anunconsciousperson.Rinsemouthwithwater.

Needlestick/punctureexposure

Washtheaffectedareawithantisepticsoapandwarmwaterfor15minutes.

Ifinhaled

Moveintofreshair.

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7.SpecialHandling,Storage,andDisposalRequirements

Pyrophoricreagentscanbehandledandstoredsafelyaslongasallexposuretoatmosphericoxygenandmoisture or other incompatible chemicals is avoided. Never leave a container with a residue of apyrophoricmaterialopentotheatmosphere.

Lab-specific informationonhandling and storagemaybe included in Section12 - Protocol/Proceduresection.

HandlingandStorageofPyrophoricMaterials

• Processistobeperformedunderaninertatmospheregas(useargongasinthecaseoflithiummetal).

• Liquids may be safely transferred without the use of a glove box by employing techniquesdiscussedinyourlaboratory“PYR”ClassSOP(syringeandcannulatechniques).

DisposalofPyrophoricReagents• Neverleaveacontainerwitharesidueofapyrophoricmaterialopentotheatmosphere.• Anyunusedorunwantedpyrophoricmaterialsmustbedestroyedbyfollowingthespecific

destructionprocedure(s)includedinyour“HazardousOperationSOP–QuenchingofPyrophoricMaterials”.Asanalternativetoquenching,rememberthatpyrophoricchemicalscanbedisposedofashazardouswaste(contactEH&Sforguidanceondisposal).

• RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolvent.Therinsesolventmustbetransferredinandoutofthecontainerunderaninertatmosphereusingthesyringeorcannulatechnique.

• Solventrinsesmustbedisposedofashazardouswaste.

8.ChemicalSpillandFireResponse

PyrophoricSpillResponse• Inthecaseofaspill,announcethesituationloudlyintheimmediateareaandhaveanynearby

personsmovetoasafelocation.• Immediatelyeliminate/removeallnearbyignitionsources.

• Ifspilloccursinafumehood,coverwithMet-L-X,drysand,orothernon-combustiblematerial,closethehoodsashandifpresent,presstheredpurgebutton.

• If a spilloccursoutsidea fumehood, coverwithMet-L-X,dry sand,orothernon-combustiblematerial,andstandawayfromthespill.

• Locateandhaveaproperfireextinguisher(drychemical-based)readyincaseofignition/fire.

• Useclean,non-sparkingtoolstocollectabsorbedmaterialandplaceintoloosely-coveredmetalorplasticcontainersreadyfordisposal.

• Do not use combustible materials (paper or cloth towels) to clean up a spill, as these mayincreasetheriskofignitingthereactivecompound.

• Ifyoucannotassessthesituationwellenoughtobesureofyourownsafety,donotapproachthespill.

• Keepothersfromenteringcontaminatedarea(e.g.,usecautiontape,barriers,etc.).

• Reportthespillto510-642-3073.

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PyrophoricFireResponse• Call911(fromacellphone:510-642-3333)foremergencyassistanceandforassistancewithall

fires,evenifextinguished.• Ifthespill ignites,andifyouaretrainedandyoufeelcomfortabletodoso,extinguishthefire

withanappropriatefireextinguisher.Useonlydrychemicalfireextinguishers(classesABCorD).DonotuseaCO2extinguisher.

• AcanofMet-L-Xordrysandintheworkarea,withinarm’sreach,mightbehelpfultoextinguishanysmallfireasitcansmothertheflames.

• Donotusewatertoextinguishapyrophoricchemicalfireasitmayenhancetheintensityofthefire.Anexceptiontothiswouldbeinthecaseofskincontactorignitedclothing/skin.Inthesecases,rinsinganyunreactedchemicaloffisofprimaryimportance.

BeAWARE:Smallflamesatthetipoftheneedlescanbeproduced–expectthistooccur,anddonotpanic.ThecanofMet-L-X/sandisinthehoodtoquicklyextinguishthosesmallflames.

CarbonDioxide,Foam,Halon,andFireblanketareUNSUITABLEforextinguishingmetalalkylfires.

9.CleaningandDecontamination

Lab-specificinformationondecontaminationmaybeincludedinSection12-Protocol/Procedure.

• WearingproperPPE,laboratoryworksurfacesmustbecleanedattheconclusionofeachprocedureandattheendofeachworkday.

• Decontaminateallequipmentbeforeremovingfromadesignatedarea.

10.HazardousWasteDisposal

LabelWaste

• Labelallwastecontainers.SeetheEH&SFactSheet,“HazardousWasteManagement”forgeneralinstructionsonproceduresfordisposingofhazardouswaste.

DisposeofWaste

• Disposeofregularlygeneratedchemicalwastewithin6months.

• CallEH&Swithquestions.

11.SafetyDataSheet(SDS)Location

SDScanbeaccessedonlineathttp://ucsds.com

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12.Protocol/Procedure-QuenchingofPyrophoricMaterials

Procedure/Use Scale EngineeringControls/Equipment

PPE (eye, face, gloves,clothing)

Procedure Steps and Special Precautions forthisProcedure

1.Quenchingoftert-butyllithium(t-BuLi)remaininginbottleorleftafterreactions.

Upto20mLofcommercialt-BuLisolution,dilutedincarriersolvent.Quenchingoft-BuLiinamountsgreaterthan20mlatatimeisnotpermitted.

Seenoteforappropriateglasswaresizeselection.

Minimalquantitieswillbeleftafterreactionscarriedoutatscaleslistedinyourlaboratory“PYR”ClassSOP.

Asanalternativeto

ConductinacleanfumehoodwiththesashaslowaspossibleusingSchlenktechniques,oraninertatmosphereglovebox.

EyeProtection:Wearfittedsafetygogglesorsafetyglasseswithsideshields.

FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.

HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.

Generalguidance:

Forindirectcontact(closed-systemproceduressuchastransfersviasyringeorcannula)ANDdirectcontact(opensystemproceduressuchasspillhandling,wipingofresidualpyrophorics)withpyrophoricmaterial-acombinationoffireresistant(FR)liners,coveredwithapairofchemical-resistantdisposablegloves(e.g.nitrileglovesorthosespecifiedinthespecificSDS)),mustbewornATALLTIMES.ThefollowingproductsareApprovedFRLiners:AnsellKevlar®Goldknit®Lightweight70-200andHanzNomex®FlameResistantUtility

NoteonGlasswareSize:Ifquenching20mLofpyrophoricsolution,thepyrophoricmaterialwillbedilutedin380mLofinertsolventtostartthequenchingprocedure(5%wtsolution).Inthiscase,therequiredsizeforthequenchingvesselis1L,noless.-QuenchinginaFUMEHOODusingaSchlenkline-Generalconsiderations:

Quenchingproceduresusuallyinvolvethereactionofthepyrophoricmaterial,underinertatmosphereandonanicebath,withareagentthathasareactivehydroxylgroup.

AnyreactionorsuspensioncontainingthesereagentsMUSTbequenchedcarefully!Alltransfersmustbedoneunderinertatmosphereusingthesyringeorcannulatechniques.

AdditionofmaterialmustbedoneSLOWLY,underadequatestirring/mixing.

Wheneverquenching,besurethatitisnotdoneinasealedvesselaspressurewillbuildup.Thebestsituationistohaveaninertgasflowinginwithasmallexitneedleconnectedtoabubbler.

Ifyou’requenchinginaRBflaskoranyfloatingvesselinabath,clampit.Ifthesolutionlevelislow,youcandiluteitwithsomeinertsolventsuchastolueneorhexanefirsttolessthan5%wt.Procedure:

Transferthet-BuLisolutiontothequenchingvessel,bringthetemperatureofthequenchsolutionto-78oCusingadryice/isopropanolbath,turnonthestirrer.

Beforeproceedingwiththequenchingofthe

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quenching,rememberthatanyquantitiesoft-BuLicanbedisposedofashazardouswaste.

ObtainPIapprovalifhigherscaleisnecessary.

LinerGloves.Clothing:WearNomexIIIA(NFPA2112)labcoat;wearnon-syntheticclothingunderlabcoat;fulllengthpantsorequivalent;andclose-toedandclose-heeledshoes.

pyrophoricsolution,immediatelyproceedwiththecleaningoftheemptybottle.

RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolventsuchastolueneorhexane.Therinsesolventmustbetransferredinandoutofthecontainerunderaninertatmosphereusingthesyringeorthecannulatechnique.

Aftertheemptycontaineristriple-rinsed,removethesure-sealcapandleaveitopeninthebackofthefumehoodovernight.

Disposeofthesolventrinseashazardouswaste.

Proceedwiththequenchingofthepyrophoricsolutionbyaddingisopropanolslowlytothequenchingvesselusingasyringeoranadditionfunnel,underadequatestirring,untilnomorebubblingisobserved.

Keepthesolutioncoolduringthequenchingprocessbycontrollingthefeedrateofthealcohol.

Onceyou'veaddedtheisopropanol,addthefollowingsolventsinsequence,usingthesamestep-wisecaution:ethanol,methanol,andwater.

BeVeryCarefulwiththeadditionofwater!Evenaftermethanolhasbeenadded,thelithiatecanstillreactviolentlywithwater,especiallyistherehasn'tbeensufficientmechanicalstirringofthesolution.Addwaterinsmallaliquots.Theadditionofwaterdoesnotneedtobeconductedunderaninertatmosphere.Syringes(plasticorglass)areidealtoolstomaketheseadditions.

Oncetheadditionofwateriscomplete,letthesolutiontemperaturecomebacktoroomtemperaturewhilestirring.

Stirforanadditional2hoursbeforedisposingoftheaqueousorganicwaste.

-QuenchinginaGLOVEBOX-

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Generalconsiderations:

AnyreactionorsuspensioncontainingthesereagentsMUSTbequenchedcarefully!AdditionofsolventsmustbedoneSLOWLYwithadequatestirring/mixing.

Ifthegloveboxisequippedwithafridge,DONOTopenthefridgeduringthequenchingprocess.

Procedure:

TurnOFFthegloveboxcirculation.

Removebottlesure-sealcaporreactionvesselcapandaddastirrerifnecessary.

Typically,asolutionoflessthan5%wtofpyrophoricinaninertsolvent(suchasdryanddegassedhexaneorheptane)iscreated,followedbytheslowadditionofdryanddegassedisopropanoloralessvolatilealcoholsuchasoctanol,underadequatestirringuntilnomorebubblingisobserved.

Placeacaponthequenchingvesselandputthebottle/vesselinazip-topbagbeforetakingitoutoftheglovebox.

Movethequenchingvesseltoacleanfumehood.Alwaysplacethequenchingvesselinasecondarycontainerfortransfertothefumehood.

Purgethegloveboxfor20-30minutes.

Underadequatestirring,addwaterSLOWLYtothequenchingsolutionuntilnomorebubblingisobserved.Thisstepdoesnotneedtobeconductedunderaninertatmosphere.Syringes(plasticorglass)areidealtoolstomaketheseadditions.

BeVeryCarefulwiththeadditionofWATER!Evenafterisopropanolhasbeenadded,thelithiatecanstillreactviolentlywithwater,especiallyistherehasn'tbeensufficientmechanicalstirringofthesolution.Thereforethewatermustbeaddedinsmallaliquots.

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RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolventsuchastolueneorhexane.

Aftertheemptycontaineristriple-rinsed,leaveitopeninthebackofthehoodovernight.

Solventrinsesmustbedisposedofashazardouswaste.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.

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Procedure/Use Scale EngineeringControls/Equipment

PPE (eye, face, gloves,clothing)

2.Quenchingofpyrophoricliquids,suchas,butnotlimitedto,sec-BuLi,n-BuLi,Grignardreagents,remaininginbottleorleftafterreactions.

Upto100gofpyrophoricmaterialasaneatliquidorinsolutioninacarriersolvent,either

a)assuppliedinthereagentbottle,uptoamaximumof200mLtotalvolume,or

b)dilutedafteruseinareactionaccordingtothePyrophoricsSOP.

Quenchingofpyrophoricmaterialsinamountsgreaterthan100gor200mLofcommercialsolutionatatimeisnotpermitted.

ConductinacleanfumehoodwiththesashaslowaspossibleusingtheSchlencktechniques,oraninertatmosphereglovebox.

Generalguidance:

Forindirectcontact(closed-systemproceduressuchastransfersviasyringeorcannula)ANDdirectcontact(opensystemproceduressuchasspillhandling,wipingofresidualpyrophorics)withpyrophoricmaterial-acombinationoffireresistant(FR)liners,coveredwithapairofchemical-resistantdisposablegloves(e.g.nitrileglovesorthosespecifiedinthespecificSDS)),mustbewornATALLTIMES.ThefollowingproductsareApprovedFRLiners:Ansell

NoteonGlasswareSize:Ifquenching100gofpyrophoricmaterial,thepyrophoricmaterialwillbedilutedin500mLofinertsolventtostartthequenchingprocedure(20%wtsolution).Inthiscase,therequiredsizeforthequenchingvesselis1L,noless.-QuenchinginaFUMEHOODusingaSchlenkline-Generalconsiderations:

AdditionofmaterialmustbedoneSLOWLY,underadequatestirring/mixing.

Ifyou’requenchinginaRBflaskoranyfloatingvesselinabath,clampit.Ifthesolutionlevelislow,youcandiluteitwithsomeinertsolventsuchastolueneorhexanefirsttolessthan20%wt.Procedure:

Transferthedilutedsolutiontothequenchingvessel,placeaniceundertheflask,andturnonthestirrer.

Beforeproceedingwiththequenchingofthe

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Seenoteforappropriateglasswaresizeselection.Minimalquantitieswillbeleftafterreactionscarriedoutatscaleslistedinyourlaboratory“PYR”ClassSOP.

ObtainPIapprovalifhigherscaleisnecessary.

Kevlar®Goldknit®Lightweight70-200andHanzNomex®FlameResistantUtilityLinerGloves.Clothing:WearNomexIIIA(NFPA2112)labcoat;wearnon-syntheticclothingunderlabcoat;fulllengthpantsorequivalent;andclose-toedandclose-heeledshoes.

pyrophoricsolution,proceedwiththecleaningoftheemptybottle.

RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolventsuchastolueneorhexane.Therinsesolventmustbetransferredinandoutofthecontainerunderaninertatmosphere.

Aftertheemptycontaineristriple-rinsed,removethesure-sealcapandleaveitopeninthebackofahoodovernight.

Disposeofthesolventrinseashazardouswaste.

Proceedwiththequenchingofthepyrophoricsolutionbyaddingisopropanolslowlytothequenchingvesselusingasyringeoranadditionfunnel,underadequatestirring,untilnomorebubblingisobserved.

Keepthesolutioncool(50oCorbelow)duringthequenchingprocessbycontrollingthefeedrateofthealcohol.

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-IfquenchinginaFUMEHOODusingdryice-Inthefumehood,placea5-gallonbuckettallenoughtoholdthecontainerofpyrophoricmaterialwithsixinchesofheighttospare.Fillthebucketwitha1-3inchesofdryiceandaddaninertsolventsuchastoluenetocover.Allow5minutesforthesolventtocoolandthecontainertofillwithanatmosphereofCO2.LowerthecontainertothebottomofthebuckettoimmerseitintheCO2atmosphere,carefullyuncapit,andslowlypourthecontentsontodryice.Rinsethewallsoftheemptycontainerintothebuckettwicewithasmallamountoftoluene,thenisopropanol.Gentlystirthedryicewithaspatulaorrodtomixtheisopropanolintothequenchingsolutionandallowtowarmtoroomtemperatureandsitatroomtemperaturefortwohourspriortodisposal.

-IfquenchinginaGLOVEBOX-Generalconsiderations:

AnyreactionorsuspensioncontainingthesereagentsMUSTbequenchedcarefully!AdditionofsolventsmustbedoneSLOWLYwithadequatestirring/mixing.

Procedure:

Removebottleorreactionvesselcapandaddastirrerifnecessary.

Typically,asolutionoflessthan20%wtofpyrophoricinaninertsolvent(suchasdryanddegassedhexaneorheptane)iscreated,followedbytheslowadditionofdryanddegassedisopropanoloralessvolatilealcoholsuchasoctanol,underadequatestirringuntilnomorebubblingisobserved.

Placeacaponthequenchingvesselandputthe

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bottle/vesselinazip-topbagbeforetakingitoutoftheglovebox.

Continuethequenchingprocedureinacleanfumehoodwithsashclosed.

Oncetheadditionofwateriscomplete,stirforanadditional2hoursbeforedisposingoftheaqueousorganicwaste.

RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolventsuchastolueneorhexane.

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Procedure/Use Scale Engineering

Controls/EquipmentPPE (eye, face, gloves,clothing)

3.Quenchingofpyrophoricsolids.

Upto10gofmaterial.

Seenoteforappropriateglasswaresize

Minimalquantitieswillbeleftafterreactionscarriedoutatscaleslistedinyourlaboratory“PYRClassSOP.

Asanalternativetoquenching,rememberthatanyquantitiesoft-BuLicanbedisposedofas

ConductinacleanfumehoodwiththesashaslowaspossibleusingtheSchlenktechniques,oraninertatmosphereglovebox.

Generalguidance:

Forindirectcontact(closed-systemproceduressuchastransfersviasyringeorcannula)ANDdirectcontact(opensystemproceduressuchasspillhandling,wipingofresidualpyrophorics)withpyrophoricmaterial-acombinationoffireresistant(FR)liners,coveredwithapairofchemical-resistantdisposablegloves(e.g.nitrileglovesorthosespecifiedinthe

NoteonGlasswareSize:Ifquenching100mLofpyrophoricsolution,thepyrophoricmaterialwillbedilutedin500mLofinertsolventtostartthequenchingprocedure(20%wtsolution).Inthiscase,therequiredsizeforthequenchingvesselis1L,noless.-IfquenchinginaFUMEHOODusingaSchlenkline-Generalconsiderations:

AdditionofmaterialmustbedoneSLOWLYandensureadequatestirring/mixing.

Ifyou’requenchinginaRBflaskoranyfloatingavesselinabath,clampit.Procedure:

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hazardouswaste.

specificSDS)),mustbewornATALLTIMES.ThefollowingproductsareApprovedFRLiners:AnsellKevlar®Goldknit®Lightweight70-200andHanzNomex®FlameResistantUtilityLinerGloves.Clothing:WearNomexIIIA(NFPA2112)labcoat;wearnon-syntheticclothingunderlabcoat;fulllengthpantsorequivalent;andclose-toedandclose-heeledshoes.

Typically,asuspensionoflessthan20%wtofpyrophoricinaninertsolvent(suchashexaneortoluene)iscreated,followedbytheslowadditionofisopropanolusingasyringeoranadditionfunnel,underadequatestirringuntilnomorebubblingisobserved.

Duringthequenchingprocess,keepthesolutioncool,50oCorbelow,byapplicationofanexternalcoolingbath(icebath)andbycontrollingthefeedrateofthealcohol.

RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolvent.

-IfquenchinginaGLOVEBOX-Generalconsiderations:

AnyreactionorsuspensioncontainingthesereagentsMUSTbequenchedcarefully!Additionofsolvents

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mustbedoneSLOWLYwithadequatestirring/mixing.

Procedure:

Removebottleorreactionvesselcapandaddastirrerifnecessary.

Typically,asuspensionoflessthan20%wtofpyrophoricinaninertsolvent(suchasdryanddegassedhexaneorheptane)iscreated,followedbytheslowadditionofdryanddegassedisopropanoloralessvolatilealcoholsuchasoctanol,underadequatestirringuntilnomorebubblingisobserved.

Placeacaponthequenchingvesselandputthebottle/vesselinaZiplocbagbeforetakingitoutoftheglovebox.

Oncetheadditionofwateriscomplete,stirforanadditional2hoursbeforedisposingoftheaqueousorganicwaste.

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RinsetheemptycontainerthreetimeswithaninertdryCOMPATIBLEsolvent.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.Procedure/Use Scale Engineering

Controls /Equipment

PPE(eye,face,gloves,clothing) Procedure Steps and Special Precautions forthisProcedure

4.QuenchingofgloveboxtrashcontaminatedwithPyrophoricMaterials.

Asmall(<1quart)ziplockbagofdrygloveboxtrash(kimwipes,pipettes,weighpaper,etc.)contaminatedwithtracesofpyrophoricmaterial

Minimalquantitieswillbeleftafterreactionscarriedoutatscaleslistedinyourlaboratoryspecific“PYR”ClassSOP.

LargerquantitiesofPYRchemicalscanbedisposedofashazardouswaste.

ObtainPIapprovalifhigherscaleis

Thisoperationshouldbeperformedinthesinkin674Tanimmediatelyfollowingremovalfromtheglovebox.

EyeProtection:Weartight-fittingsafetygogglesorsafetyglasseswithsideshields.

FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsashorwhenthehoodsashisinopenposition.

Generalguidance:

Forindirectcontact(closed-systemproceduressuchastransfersviasyringeorcannula)ANDdirectcontact(opensystemproceduressuchasspillhandling,wipingofresidualpyrophorics)withpyrophoricmaterial-acombinationoffireresistant(FR)liners,coveredwithapairofchemical-resistantdisposable

AfterworkingwithPyrophoricMaterialsintheglovebox,quenchingofcontaminatedtrashshouldbeperformedinthesinkin674Tanimmediatelyfollowingremovalfromtheglovebox.

Allflammablematerialsmustberemovedfromtheareaaroundthegloveboxantechamberandtheadjacentfumehoodpriortobeginningtheprocedure.

GeneralProcedure:

Removethecontaminatedtrashfromthegloveboxinasealedziplockbag.Inasecondarycontainerinthefumehood,quicklyopenthebaganddrownthetrashwithwater.Theremaybeanexothermicreactionorevenbriefflareups,butthesmallquantityofpyrophoriccompoundshouldberapidlyquenchedandtheminimalquantityofflammablematerialinthetrashshouldbeeasilyextinguished.

Letthesoakedtrashquenchinthebagfortwohours.Visiblyinspectthetrashforanyunquenchedresidues(e.g.floatingair-filledvials,pipettesstickingoutofthewater,etc.)beforeappropriatelydisposingofthesolidwasteandwaterquench.

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necessary. gloves(e.g.nitrileglovesorthosespecifiedinthespecificSDS),mustbewornATALLTIMES.ThefollowingproductsareApprovedFRLiners:AnsellKevlar®Goldknit®Lightweight70-200andHanzExtremityWearNomex®UtilityLiners.Clothing:WearNomexIIIA(NFPA2112)labcoat;fulllengthpantsorequivalent;andclose-toedandclose-heeledshoes.

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13.DocumentationofTraining(signatureofallusersisrequired)• Prior to conducting any quenching of pyrophoric materials, designated personnel must provide

training to his/her laboratory personnel specific to the hazards involved in working with thissubstance,workareadecontamination,andemergencyprocedures.

• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPandacopyofthepyrophoricmaterialSDSprovidedbythemanufacturer.

IhavereadandunderstandthecontentofthisSOP:

Name Signature Identifier Date

Quenching of Pyrophoric Materials · Quenching of Pyrophoric Materials Hazardous Operation SOP Rev....

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Transcript of Quenching of Pyrophoric Materials · Quenching of Pyrophoric Materials Hazardous Operation SOP Rev....

CCP Transuranic Waste Certification Plan · Isolation Pilot Plant ... 3.5.1 Pyrophoric Materials ... CCP Transuranic Waste Certification Plan Page 8 of 168 LIST OF TABLES

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Hardening, Tempering, Quenching - Entech Energiteknik · PDF fileHardening Tempering Annealing Quenching Solution Annealing Forging Preheating Drying Ageing Hardening, Tempering, Quenching...

Quenching of Water-Reactive (WR) Materials · Hazardous Operation SOP Rev. Date: March 23, 2015 Page 2 of 13 Quenching of Water-Reactive Materials

Presented by Mr. Rajesh Kandhai · Process Mapping Hazard ... examination of a processing plant in order to identify hazards, failures and operability ... Pyrophoric materials

Use of a New Non-Pyrophoric Liquid Aluminum Precursor for … · 2019. 5. 9. · materials Article Use of a New Non-Pyrophoric Liquid Aluminum Precursor for Atomic Layer Deposition

Houghton on Quenching

Pyrophoric Chemicals SOP

Quenching of Pyrophoric Materials · Quenching of Pyrophoric Materials Hazardous Operation SOP Rev. Date: 31Aug2016 2 Also, this SOP covers any materials synthesized using pyrophoric

Quenching of Pyrophoric Materials. Date: March 23, 2015 Page 4 of 20 Quenching of Pyrophoric Materials The UC Berkeley Office of Environmental Health and Safety specifies not to work

Fire protection concept for the storage of pyrophoric materialsFire protection concept for the storage of pyrophoric materials Dr. Armin Heyn, Bayer Technology Services GmbH, Leverkusen,

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Pyrophoric Materials (PYR) - University of California ... · Pyrophoric Materials Chemical Class Standard Operating Procedure Rev. Date: 2017-03-28 Pyrophoric Materials (PYR) H250

Recommended Practice 101 - markfive.com · Table 8 Some Pyrophoric Materials ... Table 9 Some Chemical Structures Susceptible to Peroxide Formation ... and then either returns the

Hillstrom - Formation of Pyrophoric Fragments 1973

solar applications - Entegris · Entegris in Solar Applications ... broad offering of high-purity materials, process ... They can be inert, corrosive, toxic or pyrophoric in nature,

Pyrophoric Chemicals

Pyrophoric Materials (PYR) · PDF filePyrophoric Materials (PYR) H250 Examples: tert-ButylLithium, ... Chemical Spill and Managing Any Subsequent Fire Pyrophoric Spill Response

Oneira Corporation, an EPCM company, has provided process ... · and pyrophoric materials. ... Chromate handling process design and plant layout. ... New tank farm for the storage

RCED-95-49 Nuclear Materials: Plutonium Storage at … · operations TV process and fabricate plutonium at Rocky Flats were ... Plant raises a number of important, ... pyrophoric,