Pulmonary arterial denervation Pulmonary arterial denervation in in patients with PAHpatients with PAH

Shao-Liang Chen, MD, FACC, FSCAIShao-Liang Chen, MD, FACC, FSCAI

Nanjing First Hospital, Nanjing Medical Nanjing First Hospital, Nanjing Medical University, ChinaUniversity, China

Anatomy of pulmonary arteryAnatomy of pulmonary artery

Segmentation of PA

PAP during occlusion of basal trunk

PAP during occlusion of interlobar

Design of ablation levels

Devices of ablation

Change of PAP during occlusion of interlobar after PADN

Sympathetical labeling

Study flowchart

March 2012~ January 2013

PADN-1 PADN-2

Consecutive Randomized23 PAH 25 CHF pts

21 PAH with 3-m F/U

Table 1. Baseline characteristics in all patients

Table 2. Echocardiographic measurements in two groups

Table 3. Hemodynamic measurements by right heart catheterization

Table 4. Assessment of functional capacity

Tips and pitfalls of PADN

In conclusion

• PADN around the bifurcation level of main pulmonary artery is safe and effective for PAH

• Significant improvement of hemodynamics and functional capacity was monitored after PADN procedure

Thanks for your attention!