<br />CALGB/SWOG 80405: Phase III trial of FOLFIRI or FOLFOX with Bevacizumab or Cetuximab for patients w/ KRAS wild type untreated metastatic adenocarcinoma of the colon or rectum <br />

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 2

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: <br /> FINAL DESIGN

Presented By Alan Venook at 2014 ASCO Annual Meeting

COLORECTAL CANCER IN 2004 <br /> IS THERE AN OPTIMAL 1ST LINE TREATMENT ?

Presented By Alan Venook at 2014 ASCO Annual Meeting

2004: A lot can happen in 10 years

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB / SWOG 80405: <br /> WHY DID IT TAKE TEN YEARS?

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Eligibility Criteria

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Endpoints

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Statistics

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Statistics

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 11

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 12

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Overall Survival <br />

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Progression-Free Survival<br />(Investigator Determined)

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 15

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Overall Survival<br />FOLFOX Treated

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Overall Survival<br />FOLFIRI Treated

Presented By Alan Venook at 2014 ASCO Annual Meeting

Patients Rendered Disease-Free<br />Overall Survival

Presented By Alan Venook at 2014 ASCO Annual Meeting

Grade 3-4 Toxicities<br />

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 20

Presented By Alan Venook at 2014 ASCO Annual Meeting

80405: Data Pending

Presented By Alan Venook at 2014 ASCO Annual Meeting

Quality of Life and Symptoms

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 23

Presented By Alan Venook at 2014 ASCO Annual Meeting

“Expanded RAS”

Presented By Alan Venook at 2014 ASCO Annual Meeting

<br /> Correlative Studies<br /> Tumor / Plasma / Serum > 44000 samples<br />

Presented By Alan Venook at 2014 ASCO Annual Meeting

80405: Upcoming Presentations

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Conclusions

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Conclusions

Presented By Alan Venook at 2014 ASCO Annual Meeting

CALGB/SWOG 80405: Conclusions

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 30

Presented By Alan Venook at 2014 ASCO Annual Meeting

TAKE HOME MESSAGE

Presented By Alan Venook at 2014 ASCO Annual Meeting

Value of publicly funded clinical research

Presented By Alan Venook at 2014 ASCO Annual Meeting

ACKNOWLEDGEMENTS / THANKS Collaborators

Presented By Alan Venook at 2014 ASCO Annual Meeting

ACKNOWLEDGEMENT / THANK YOU

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 35

Presented By Alan Venook at 2014 ASCO Annual Meeting

Slide 36

Presented By Alan Venook at 2014 ASCO Annual Meeting