Post on 07-Aug-2020
Prebiotics – support for your natural microbiota and
your health
Anke Sentko, Vice President Nutrition Communication & Regulatory Affairs
18090p-ASO-FoodTechSummit, Septemer 26, 2018
Setting the scene
2
© 2018 BENEO
Scientific milestones in the prebiotic research
BENEO as pioneer since the 1990s
*Roberfroid et al. (2010) Br J Nutr 104(S2):S1-S63. https://www.ncbi.nlm.nih.gov/pubmed/20920376 3
First observations that beneficial bifidobacteria
are specifically stimulated by fructo-
oligosaccharides
First prebiotic definition published:
Roberfroid & Gibson
20102008200419951980s 2017
"The prebiotic effect is now a
well established scientific fact"*
ISAPP: International Scientific Association
for Probiotics and Prebiotics review
The prebiotic concept becomes global
BENEO (Orafti) has supported microbiota research
of European scientists for more than 20 years
© 2018 BENEO
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Publications
Significant attention has been given to the beneficial effects of
prebiotics
• Since concept was first defined, it has been subject of intensive research
• Prebiotic research has continued at a rapid pace with >2000 research articles published
over the past 5 years>2000 articles
4
© 2018 BENEO
Prebiotics and probiotics are both beneficial for health
But what is the difference?
* https://isappscience.org/prebiotic-definition-updated-isapp/ ; https://isappscience.org/probiotics/
• What are prebiotics?
• Food/feed for beneficial microbes
that live in our colon.
• eaten by the ‘good’ gut microbes as
their “favorited dish”
• positive impact on the gut environment,
with an overall health benefit."
• What are probiotics?
• live microorganisms from other
sources than the human gut
• Swallowed and need to survive the
stomach and small intestine passage
• Need to provide strain-specific evidence
in humans about their health benefit
© 2018 BENEO
Drivers of digestive health
Consumers are informed about digestive health
Source: BENEO’s consumer research on prebiotics, 2017
consumers have read some pieces lately
on the topic of digestive health
Almost 1 in 3 (30%)
Almost 1 in 4 (23%)
Very/extremely interested in the gut
microbiome(how good and bad bacteria in your gut impacts your overall health)
52%
Gut health books
Social media
Scientific developments in the media
© 2018 BENEO
Drivers of digestive health
The gut is our second brain
Source: New Nutrition Business, 10 key trends in Food, Nutrition & Health 2017 & HFI, Global Trend Study, 2018 & BENEO’s qualitative research, 2018 (ongoing)
The gut is a second brain, capable of influencing a variety of processes in the body
79% thinks digestive
health plays an
extremely/very
important role in
physical health
67% thinks digestive
health plays an
extremely/very important
role in mood
65% thinks digestive health
plays an extremely/very
important role in daily
energy levels
68% thinks digestive health
plays an extremely/very
important role in immune
function
66% thinks digestive health
plays an extremely/very
important role in weight
management
61% thinks digestive health
plays an extremely/very
important role in physical
appearance
The colon –
the starting point
for the prebiotic
outreach
8
© 2018 BENEO
…. and more!
The microbiota is influencing many things…..
Hormoneproducing
organ
Microbiota(population &
composition)
Nervous
system(our second
brain)
Immune
system!
Barrierbetween in-
and outside:
Mucosa
Weight
management
Blood sugar
management
Improved
calcium
intake & bone
support
9
Regularity
The gut microbiota
What is a healthy gut microbiota????
What if the gut microbiota is out of balance?
What are the preferred microorganisms to support a healthy
microbiota and a balanced microbiota?
10
© 2018 BENEO
Characteristics of the microbiota with implications to the host
Peptolytic fermentation
- amines
- putrefactants
- phenols, indoles
- N-nitroso compounds
- ammonia
Proinflammatory agents
Lipopolysaccharides
Toxic load of luminal
contents/faeces
- genotoxicity
- cytotoxicitySaccharolytic fermentation
Short chain fatty acids- acetate
- butyrate
- propionate
- lactic acid
- pH reduction
Secondary metabolism- vitamin synthesis
- bacteriostatic/-cidal compounds
Pathogenicity
Exotoxins
Toxic volatiles
- hydrogen sulphide
- mercaptanes Secondary enzymes
- azoreductase
- nitroreductase
- beta-glycosidases
- alpha-glucuronidases
Inert gases
- carbon dioxide
- methane
- hydrogen
Immuno-modulating effects
11
© 2018 BENEO
Saccharolytic fermentation supports health
Inspired by O’Keefe, S. J. D. (2016) Diet, microorganisms and their metabolites, and colon cancer
Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2016.165 and Gibson et al. (2017) Nat Rev Gastroenterol Hepatol:.
http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf12
© 2018 BENEO
Imbalances in the gut microbiota have been linked to various
diseases….
*Literature search and interpretation by Beneo Insitute, based on 24 pertinent publications13
Imbalances in the gut microbiota are linked to:
• Asthma and allergy
• Infections
• Colic and functional gastrointestinal disorders in infants
• Inflammatory bowel disorders
• Autism spectrum disorders
• …. Low numbers of bifidobacteria are linked to
several disease risk associations*:
• Type 2 diabetes
• Inflammatory bowel disease (IBD)
• Ulcerative colitis
• Crohn’s disease
• Coeliac disease
• Obesity / metabolic disorders
© 2018 BENEO
ISAPP 2017 Prebiotic Definition
Gibson et al. (2017) Nat Rev Gastroenterol Hepatol:Advanced online publication. http://www.nature.com/nrgastro/journal/vaop/ncurrent/pdf/nrgastro.2017.75.pdf [Accessed 19 June 2017] 14
A substrate that is selectively utilized by host
microorganisms conferring a health benefit
Changed:
• Prebiotics not limited to gastrointestinal tract
• Possibly includes non-carbohydrate substances and
diverse categories other than food
• Definition applies also for the prebiotic use in animals
Confirmed:
• Selectivity is key! ( criterion that
distinguish prebiotics from many other
substances)
• Selective effect must evoke a net health
benefit!
© 2018 BENEO
HOME
other bacteria (neutral, harmful)
Beneficial bacteria
What does selective fermentation mean?
Dietary prebiotics
© 2018 BENEO
Chicory root fibres are proven prebiotics!
1 Gibson et al 2017. Nat Rev Gastroenterol Hepatol. 14(8):491-502. https://www.nature.com/articles/nrgastro.2017.75 16
Chicory root fibres are
proven prebiotics and
are the most-well
studied.
Pro
ve
np
ote
nti
al
can
did
ate
s
po
ten
tia
l c
an
did
ate
s
potential candidates:
a lack of human studies showing
the health benefit, a crucial part
of the definition for prebiotics.
© 2018 BENEO
Strong body of scientific evidence for prebiotic chicory root fibres
The prebiotic effect of chicory root fibers
(inulin and oligofructose) is a
scientifically proven fact
>30 studies in adults
With as low as 5g chicory root fiber
per day the increase in Bifidobacteria
is demonstrated
>15 studies in infants and children
© 2018 BENEO
Inulin-type fructans selectivity on microbiota evidenced with next-
generation technique!
Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271 18
The study was conducted at the University of Leuven,
Belgium by Professor Jeroen Raes from the
Department of Microbiology and Immunology and
Professor Kristin Verbeke from the Translational
Research in Gastrointestinal Disorders Unit
Chicory root fibre selectively effects the human gut microbiota
© 2018 BENEO
Next-generation sequencing for gut microbiota analysis
Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271
Micka et al. (2017) Int J Food Sci Nutr Feb 68 (1):82–89. doi: 10.1080/09637486.2016.1212819. 19
• Randomised, placebo controlled, double-blind, cross-over design
• 44 participants with mild constipation consuming 12 g/d (3x4 g) Orafti®Inulin (compared to
maltodextrin) over 4 weeks
• Feacal samples were obtained before and after intervention and wash-out period for:
• Microbiota analysis (phylogenetic profiling) Next-generation sequencing
© 2018 BENEO
Selective growth of bacteria –
Prebiotic effect proven with state-of-the-art methodology
Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-31327120
The umbrella view on the colon’s
ecosystem demonstrates:
• Selective effect of chicory root fiber on the
human gut microbiota with newest
methodology
• Amongst almost 300 genera detected the
abundance of only 3 genera changed
significantly with inulin intake
• Bifidobacterium increased
• Anaerostipes increased
• Bilophila decreased
P: placebo, I: inulin
© 2018 BENEO
Improved well-being! Wellbeing parameters assessed with PAC-QoL(Patient assessment of Constipation Quality of Life)
Marquis et al. (2005) Scand J Gastroenterol 40(5):540–551. doi: 10.1080/00365520510012208 21
• PAC-QoL• Subscores used for „discomfort“ and „satisfaction“ comprising in total 9 questions
• Ratings from 0 (not at all, none of the time) to 4 (extremely, all of the time)
• Measuring the impact constipation has had on daily life during the past 2
weeks
• Discomfort: • „To what extent or intensity have you felt bloated to the point of bursting?“
• „How much of the time have you felt the need to have a bowel movement but not
been able to?“
• …
• Satisfaction: • „How much of the time have you had fewer bowel movements than you would
like?“
• „To what extent or intensity have you been satisfied with the regularity of your
bowel movements?“
• …
RESULTS of PAC-QoL:
Physical discomfort
score: No difference
Satisfaction: significant
improvement with chicory
root fibre
© 2018 BENEO
Improved digestive well-being by chicory root fiber
Vandeputte D, et al. Gut 2017;0:1–7. doi:10.1136/gutjnl-2016-313271 22
• Correlation between Bilophila abundance variation and changes in stool consistency was
found
&
• Correlation between the reduced numbers of Bilophila in the gut and improved
constipation-related wellbeing parameters ( Quality of Life questionnair) was observed
Author’s conclusion:
“the observed association between Bilophila decreases on inulin consumption
and quality-of-life increase urges the need for further research on
the role of this taxon in host well-being.”
Cross Talk
23
© 2018 BENEO
…. and more!
The microbiota is influencing everything…..
Hormoneproducing
organ
Microbiota(population &
composition)
Nervous
system(our second
brain)
Immune
system!
Barrierbetween in-
and outside:
Mucosa
Weight
management
Blood sugar
management
Improved
calcium
intake & bone
support
24
Regularity
© 2018 BENEO
From the colon to other organs of the body: The reach-out of the
microbiota …
25
BrainLung
Neurotransmitter
SerotoninCytokines
Bacterial metabolites
SCFA, others
GLP-1, PYY,..
microbiotaLarge intestine
Immune cellsNervous system Hormonal system
Kidney
Liver
Blood
Muscles
Metabolite reach out to…..
© 2018 BENEO
From gut-brain to gut-skin, gut-bone, gut-muscle axis etc.
https://www.nutraingredients.com/Article/2017/01/12/Heard-of-the-gut-brain-axis-Meet-the-gut-skin-axis 26
Digestive wellbeing by chicory root fiber
Improved regularity and digestive well-being in adults and
children
27
© 2018 BENEO
Support of digestive health and well being by chicory fiber…
Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89. 28
run-in
2 weeks
period 1
4 weeks
wash-out
2 weeks
run-in
2 weeks
period 2
4 weeks
• Inulin vs Maltodextrin (control)
• 3x4g per day
• Inulin (and MDX) was taken with 200 ml of drinks at breakfast,
lunch and dinner
• Primary outcome: frequency of bowel movements
• Design:
• Randomized
• placebo-
controlled
• double-blind
• cross-over
• mono-center
• n = 44 healthy adults
mildly constipated
• Duration of
intervention 4 weeks
© 2018 BENEO
Improved regularity
Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89. 29
Bowel movement frequency per week after a 4 week intervention with 3x4g/d
Orafti®Inulin (compared to maltodextrin) significantly improved!
p = 0.038
*
0
1
2
3
4
5
Maltodextrin Orafti® Inulin
Bo
we
l m
ove
me
nts
/we
ek
Maltodextrin
Orafti® Inulin
© 2018 BENEO
…. A complex orchestra that is positively influenced by chicory root
fibers …..
30
not digestible in small intestine
water bindingcapacity
softer stools
bacterial fermentationin large intestine
bacteria
bowel content
faecal bulk
intestinal transit time
bowel movementfrequency
gas production
SCFA production
chemical stimulationof peristaltic reflex
Physiological mechanism fully
accepted by EFSA
The prebiotic fermentation of
chicory inulin plays a key role!
water content ofdigesta/faeces
BENEO´s 13(5) EFSA dossier submitted in May 2014, received a positive Opinion in January 2015
© 2018 BENEO
Digestive comfort
Assessed with a “discomfort” diary (5-point scale) (3x4g/d intake)
Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89. 31
IIntervention
InulinP Placebo
© 2018 BENEO
Improved well-being!
Health related QoL questionnaire specific for constipated subjects
32
• PAC-QOL (Patient-Assessment of Constipation
Quality of Life)
• a validated instrument to assess QoL in patients suffering from
constipation.
• Selected validated test blocks: physical discomfort and
satisfaction dimension
Physical discomfort score:
No difference between Chicory root fiber and placebo
Satisfaction:
significant improvement with chicory root fibre
Micka et al. (2017) Int J Food Sci Nutr. 68(1):82-89.
© 2018 BENEO
Does oligofructose improve bowel regularity in chronically
constipated with low fibre intake?
• Does oligofructose improve bowel functions in subjects with self-reported chronic
constipation and a diet habitually low in dietary fibre?
• Can a dose-response relationship be established between oligofructose intake and stool
frequency?
• How well is oligofructose tolerated?
Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access) 33
© 2018 BENEO
Study design
• Placebo-controlled, randomised, parallel, double-blind trial
• Stepwise increase from 5 g, 10 g to 15 g Orafti®P95 per day versus maltodextrin
as placebo over 15 weeks.
• Each dosage was given in 3 sachets per day over 4 weeks
• 97 North American adults with mild constipation (3 or less bowel movements per week)
associated with a low fibre intake
• Assessment of stool frequency and gastrointestinal sensations
Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access) 34
© 2018 BENEO
Oligofructose improves bowel regularity
• Intake of 15 g/d Orafti®P95 showed a significantly higher stool frequency per week
• Effects were even more pronounced when subjects consumed a certain, but still
insufficient amount of fibre in their usual diet (>13 g fibre).
• Significantly higher stool frequency with 10 g/d versus study start and with 15 g/d versus placebo.
vs. baseline
vs. placebo
vs. baseline
Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access) 35
© 2018 BENEO
Oligofructose is well-tolerated
• Very low gastrointestinal sensations rated on a 0 to 10 scale in all groups.
• Compared to study start “noise”, “pressure” and “pain” significantly decreased in the
oligofructose group with higher dosages.
0
1
2
3
4
5
6
7
8
9
10
0 g 5 g 10 g 15 g 0 g 5 g 10 g 15 g
Placebo Oligofructose
Bloating Gas
Different letters indicate a significant difference within a group (oligofructose or placebo)
Buddington et al. (2017) Nutrients 9(12):1372. http://www.mdpi.com/2072-6643/9/12/1372/pdf (Open Access)
(significant difference: 5 g placebo vs. 10 g and 15 g placebo)36
© 2018 BENEO
Digestive health in children
Closa-Monasterolo et al (2017): International journal of food sciences and nutrition 68 (5), S. 587–594. DOI: 10.1080/09637486.2016.1263605. 37
Inulin-type fructan intervention
V1 Screening
V3 After 3 wk
intervention
V2 RandomisationFinal inclusion
Follow-upRun-In/Baseline Maltodextrin Follow-up
2 wk 6 wk 3 wk
V4 End of
intervention
Children
V5End of
follow-up
• Double-blind, randomised, placebo-controlled
parallel group trial
• N = 17
• 2-5 year old constipated children, recruited at the
University Hospital Sant Joan de Reus (Spain)
• 2x 2g/day oligofructose/Inulin mixture vs.
maltodextrin in yoghurt/fresh cheese, during 6
weeks
© 2018 BENEO
Key Findings
Closa-Monasterolo et al (2017): International journal of food sciences and nutrition 68 (5), S. 587–594. DOI: 10.1080/09637486.2016.1263605. 38
Gastrointestinal
comfort:
No increase in
flatulence or distension
in the
inulin/oligofructose
group
• Inulin-type fructans lead to a change in stool consistency
(softer stools) after 4 or 6 wks
• Prebiotic inulin-type fructans improve the stool
consistency in functionally constipated 2-5 y old children
• Effect significant even when other confounders (e.g.
baseline or dietary variables) considered
© 2018 BENEO
Kindergarten children study: softer stools with chicory root fibres
Lohner et al. (2018) J Nutr 102(Suppl 2):261. https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772 39
Significantly softer stools
in the normal range
compared to placebo
**
** **
**p<0.01
Parents categorised the
stool consistency with the
Bristol Stool Chart
ranging from 1 (very hard)
to 7 (entirely liquid).
© 2018 BENEO
Art. 13(5) - Orafti®inulin & normal bowel function
Ref. Commission Regulation (EU) 2015/2314 of 7 December 2015 authorising a health claim made on foods, other than those referring to the reduction of disease risk and to children's development and health and
amending Regulation (EU) No 432/2012; available at:
http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32015R2314&rid=140
© 2018 BENEO
Overview on other fibre related “bowel function” health claims
Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is supplied upon the
condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. 41
Ingredient Claims wording Type of
health claim
EFSA
Opinion/status
Regulation
Native
chicory inulin
“contributes to normal bowel function by
increasing stool frequency”
13(5) Finished (ON-3951),
11.12.2014
positive
Reg. (EU) 2015/2314
(Authorised health
claim)
Fibersol-2
(resistant
Maltodextrin)
“contributes to a normal bowel function by
increasing faecal bulk, stool frequency and by
reducing colonic transit time”
13(5) Withdrawn,
23.07.2018
n/a
Polydextrose “contributes to an improved bowel function by
increasing stool bulk”13(5) Finished (ON-4480),
20.04.2016
negative
Reg. (EU) 2017/1200
(Non-authorised health
claim)
scFOS from
sucrose
“maintain normal intestinal regularity” 13(5) Finished (ON-4366),
11.12.2015
negative
Reg. (EU) 2017/1201
(Non-authorised health
claim)
scFOS from
sucrose
“reduce intestinal discomfort” 13(5) Withdrawn,
11.10.2012
n/a
© 2018 BENEO
Art. 10(3) reference “prebiotic” + Art. 13(5) health claim for
Orafti®inulin and bowel function
Legal Disclaimer: This information is presented in good faith and believed to be correct; nevertheless no responsibility/warranties as to the completeness or accuracy of this information are taken. This information is supplied upon the
condition that the persons receiving the same will make their own determination as to its suitability for their purposes prior to use. Confidential business information.42
Art. 10(3)
Art. 13(5)* Chicory inulin contributes to normal
bowel function by increasing stool
frequency
Front of pack Back of pack
Ingredients: …Nutrition Declaration:
* Chicory inulin contributes to normal
bowel function by increasing stool
frequency
This food, containing 4 g chicory inulin per
portion, is ideal as part of a varied and
balanced diet and a healthy lifestyle. The
beneficial effect is obtained with a daily
intake of 12 g chicory inulin, this means 3
portions of this food or from other foods,
containing chicory inulin.”
CoU
Art. 13(5)
Art. 10(3)
Support of the “inner resistance”
43
© 2018 BENEO
Healthier children with prebiotic chicory root fibres
Improved digestive health and immunity
Lohner et al. (2018) J Nutr 102(Suppl 2):261. https://academic.oup.com/jn/advance-article/doi/10.1093/jn/nxy120/5048772
*degree of polymerization (DP) ≥11 approx. 25-30% (on g/100 g DM), average DP of about 7 to 8 44
• 219 healthy kindergarten children aged 3 to 6 years
consumed daily 6 g Orafti® inulin-type fructans with
shorter and longer chains* versus maltodextrin as
placebo for 6 months given as supplement during winter
• Prebiotic chicory root fibres are well tolerated and show positive effects on:
Gut microbiota
Significantly higher levels of bifidobacteria
and lactobacilli
Immune system
Significantly less infections with fever
and sinusitis
Stool consistency
Significantlysofter stools in the
normal range
Strengthening the gut barrier function
45
© 2018 BENEO
Orafti®Synergy1 prevents a leaky gut!
Schroeder et al. Cell Host & Microbe 23, 27–40, January 10, 2018
46
Background:
The inner colonic mucus layer separates
gut bacteria from the host and thus is an
important protective physical barrier
between the outside world including trillions
of gut bacteria and the inside of a human
being.
Diet affects microbiota composition and the
microbiota influences the mucosa.
Key results (mice study):
• A Western-Style diet (WSD) leads to
• increased mucus penetrability and
• decreased mucus thickness, and
• a reduced growth rate of the inner mucus
layer, and
• is accompanied by distinct alternations in the
microbiota composition
• Orafti®Synergy1 supplementation
prevents the Western-Style-diet-induced
increase in mucus penetrability!
Blood Glucose Management
47
© 2018 BENEO
Health benefits of lowering blood glucose levels
International Scientific Consensus:
• Reducing the blood glucose response of
a meal is a beneficial physiological effect
• Carbohydrate-based diets with low effect
on blood glucose levels
• Improves blood glucose control in people with
type 2 and type 1 diabetes
• Reduces the risk of type 2 diabetes
• Reduces the risk of coronary heart disease
• Likely reduces total body fat mass and supports
body weight management
Sources: Augustin LS, et al (2015) Glycemic index, glycemic load and glycemic response: An International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis 25 (9)
795-815.48
© 2018 BENEO
BENEO
Helping to support a healthy blood sugar profile
• There is a need for more products on the market that help consumers achieve and
maintain a healthy blood sugar profile
• BENEO’s ingredients can help support blood sugar management by
Scientific
substantiation &
approved health
claims
Improving
physiological
properties
Reducing blood
sugar & insulin
responses
Improving
carbohydrate &
nutritional quality
Lower blood sugar response of BENEO’s ingredients confirmed in >50 human intervention studies!
49
© 2018 BENEO
Blood sugar management matters to all age groups!
Lowering the blood glucose curve with chicory root fibres
50
© 2018 BENEO
2017 review continues to confirm
The low blood sugar response of chicory root fibres
Lightowler et al. (2017) Eur J Nutr. https://www.ncbi.nlm.nih.gov/m/pubmed/28255654 51
The effect of sugar reduction with chicory root
fibres on blood sugar and insulin response
has been investigated in:
• 9 human trials (including normal & overweight
individuals) showing that the more sugar you
replace with chicory fibres the lower the
blood sugar response
• Already 20% sugar replacement shows a
significant effect
• Demonstrated in different product applications
All studies show a reduced blood glucose response with chicory fibres
Sugar Reduction
52
© 2018 BENEO
My Sunday afternoon favorite…..
• 4 eggs
• 1 spoonful Vanilla sugar or/and
citron powder
• Some salt
• 1 spoonful of baking powder
250g Butter
250g Wheat
flour powder
250g Sugar
skip the
sugar, 1/3 of
the dough
would be
missing!
53
© 2018 BENEO
Simply replacing sugar is not enough
BENEO has the solutions
We see the need… …We know what we
want to achieve
Yes, and…
…how can we do it?
Which ingredients
qualify?
Lower blood glucose rise
Reduced energy or increased fat burning
Fibre enriched
Sugar reduction +
54
© 2018 BENEO
Simply replacing sugar is not enough
The type and quality matters
REPLACEMENT TYPE EFFECT
High glycaemic
Low glycaemic
Same calories
More calories
Reduced calories
Increased fat burning
Fibre enrichment
Fibre enrichment + prebiotic
+ digestive health
25-30% replacement & no increase in calories
compared to similar products
Type of
replacement
matters!
Sugar
reduction
++ +
++ +
++ +
+
++ +
++ +
++ +
-
-
-
-
-
-
-
++ +-
++
55
YES!
and
© 2018 BENEO
Chicory root fibres: The “two in one” approach
Lower rise in blood sugar with fibre enrichment
Fibre as a non-digestible carbohydrate = No glucose release
Lowers blood sugar response and insulin release by replacing
high glycaemic carbohydrates
Prebiotic fibre enrichment with chicory fibres
Positive EFSA opinion
EU-approved claim related to the
lower rise in blood sugar
Low blood sugar response plus prebiotic fibre
56
Summary and outlook
57
© 2018 BENEO
A healthy nutrition and lifestyle is needed NOW!
International Diabetes Federation. IDF Diabetes Atlas 8th Edition 2017. http://www.diabetesatlas.org/ 58
OECD (2017), OECD Health Statistics 2017. www.oecd.org/health/health-data.htm
Projected rates of obesityTop 10 countries/territories for number of
adults with diabetes (20-79 years),
2017 and 2045
Mexico:
No 5 in 2017
No 4 in 2045
© 2018 BENEO
The dietary fibre gap:
North and South America (females/males)
USA
Canada
Mexico Brazil Colombia
-25
-20
-15
-10
-5
0
Delta between dietary fibre intake and recommendation in g/d
females males
Literature search by BENEO Institute (2018) 59
© 2018 BENEO
The chicory root fiber map – the prebiotic outreach
PREBIOTIC
Chicory root fiber fermentation leading
to selective microbiota growth
Feeling of digestion
IBS Gut-Brain-Axis
Regular regularity
Quality of Life improvement
Metabolomicapproach
Bilophila reduction & QoL
Prevention & well-being
by prebiotic fermentation
Blood Sugar Management
Cholesterol lowering
Inner protection
Maternal nutrition & outreach
Ca absorption & Bone density
Weight management
Avoiding the negative
proteolytic fermentation
effects
Sugar reduction
“plus”
Healthy ageing
Type1 diabetes
improving inflammation
Fiber enrichment
60
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Questions?
61
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Anke Sentko
VP Regulatory Affairs &
Nutrition Communication
BENEO GmbH
Maximilianstraße 10
68165 Mannheim
Germany
Anke.Sentko@BENEO.com
Your local contact:
Thomas WEBER
Area Sales Manager BENEO
Mexico
Phone: +52 442 341103
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Thomas.Weber@BENEO.com