Transcript of Prach Siriviriyakul. Chromosome must be protected.
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- Prach Siriviriyakul
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- Chromosome must be protected
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- Telomere
http://publications.nigms.nih.gov/thenewgenetics/chapter2.html
TetrahymenaTTGGGG VertebratesTTAGGG S.cerevisiae(TG) 1-6 TG 2-3
Non-coding repeated sequence
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- However, telomeres also play other important roles in cell
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- Lets review DNA replication
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- End of replication problem
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- Telomerase
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- How telomerase work
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- Telomerase in humans Telomerase presents with high level in
various proliferative cells Stem cells Activated lymphocytes Hair
follicles Cancer cells Etc.
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- Telomerase in humans Telomerase presents with detectable level
in some adult cells Epithelial Fibroblast Endothelial Etc.
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- Protective function Chan and Blackburn, 2003
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- Telomerase in cancer cell cancer cell
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- Telomerase in cancer cell
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- This event certainly require telomerase
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- Telomerase in cancer cell Li et al. 2004; Bagheri et al
2006
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- the high levels of telomerase promote an undifferentiated,
stem-cell-like phonotype Other experiments support that
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- Knock-down of telomerase inhibits metastasis in vivo mouse
melanoma model Kashani-Sabet et al, 2004
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- Telomerase and Aging Cawthon et al, 2003
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- Telomerase and Aging Cawthon et al, 2003 Shorter telomeres 3.2
fold higher mortality rate from heart disease 8.5 fold higher
mortality rate from infectious disease
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- Chronic stress and telomere Blackburn et al, 2004
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- As lots of researches suggested that telomere plays important
role in cancer and aging, telomere is expected to be the effective
target for drug involving aging and cancer.
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- Reference Gerald carp, Cell Biology,6th edition, Wiley.
Elizabeth Blackburn, Lecture on telomerase part1-3. www.youtube.com
http://www.pharmacy.ubc.ca/faculty_staff/facultysites/jwonglab
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544082/ Li et al.
Genes and pathways downstream of telomerase in melanoma metastasis,
2004. Chan, S. W.-L and Blackburn, E.H. Telomerase and ATM/Tel1p
protect telomeres from nonhomologous end joining., 2003