Post on 13-Jan-2017
Quinton OswaldChief Executive Officer
OIS@AAOOctober 13 2016
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A NEW PARADIGM FOR THE
Detectionof Ocular Diseases
FIRST APPLICATIONAge-Related Macular Degeneration (AMD)
The #1 Cause of Vision Loss in People 60+*
… in diseases where early detectioncan dramatically affect outome
* In developed countries
P H Y S I C I A N - D R I V E NDiagnosis and Treatment
PAT I E N T- A C T I VAT E DDetection
T E C H N O LO G Y- E N A B L E D
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AMD Innovation Focused on Physician-Driven Diagnosis and Treatment
1MarketsandMarkets Report 2 GlobalData estimate of 2023 AMD Global Treatment Market
ACCURATEDIAGNOSIS
EFFECTIVETREATMEN
T
Optical Coherence
Tomography(OCT)
Anti-VEGFsand
Future Novel Therapies
DrivingSignificant
Markets HOWEVER:
$1B1
~$10B2
Detection IsNot Timely
TreatmentDemonstrates Efficacy but
Functional Vision May Never Be
Restored
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Broad Macro Trends Support Focus onPatient Empowerment
2
Technology-EnabledRemote
Detection and Diagnosis
1
Earlier DiseaseDetection Drives
Better Outcomes
3
ReimbursementBecomes
Outcomes-Driven
$ $
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VisualAcuity
SevereVisionLoss
Dry AMD Wet AMD
Downward Cascade in Vision Loss
May Go Unnoticed by
Patients
The Challenge: Timely Detection of Wet AMD
SlowProgression
RapidProgression
Therapeutics (e.g. Anti VEGFs)
Treat Wet Form Only
Within Weeks:Narrow Window to Detect Transition from Wet Dry
Finding Patients at the Turning Point of Disease …
… So Early Treatment Can Preserve Functional Vision
… 36 Million Globally with AMD
THE DETECTION ‘LOTTERY’
THE CHALLENGE:
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Today: Vast Majority of Wet AMD Patients Are Diagnosed Too Late
Driving Thresholdi.e., ‘Functional
Vision’
Normal
LegalBlindness
20/200
20/40
20/20
TODAY’S REALITY
Lost with Late Dx
Gained with Tx
-18 Letters+8 Letters
~70%*
Below20/40 20/40+
No Longer Have Functional Vision at Diagnosis
BASELINE
May Not Regain Functional Vision with
Treatment
… and
* Analysis of Multiple AMD Studies
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Current Disease Detection Options Are Too Infrequent or Insensitive
Low
High
CLINICALROBUSTNESS
HighLow CONVENIENCE / FREQUENCY
Household Items
Amsler Grid
Smartphone Apps
At HomePatient-Activated
Detection
The Holy Grail
In-Office OCT
Physician-Driven Diagnosis
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CLINICALROBUSTNESS• 94% Maintained
Functional Vision (20/40+) in NIH Study
• Objective measure• Sensitive
Our Pioneering Innovation: Patient-Activated, Clinically Robust Early Disease Detection
CONVENIENCE• 3 minute test per eye• Unique design tailored to
older patient population– Device and Technology
ecosystem
• “Plug and play”• Results sent
directlyto physician
PROVEN
Preferential Hyperacuity Perimetry (PHP)
Detects Onset of Neovascular Leakage within DAYS vs. Week / Months Before
Patients Would Notice Change
3,000+Patients
2 MillionTests
4-5x/Week(for avg. 3.3
yrs)
FDA
Cleared
CE
Marked
MedicareCoverage
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Alert – in event of statistically significant change
5Reminder calls
3
CLOUD HOSTING
Notal Vision Data Monitoring
Center
A Complete, Personalized Monitoring System
Early Detection in Action
OUR ENGINE ROOM IN THE CLOUD• High touch• Technology-enabled• Scalable• Compliant and secure• Fully integrated
billing/reimbursement
1 Patient takes test daily
PHYSICIAN
Physician office calls patient for office visit and treatment
6
Data automatically sent via embedded cellular modem
2 Ongoing monitoring• Monthly reports
pushed• Online access
4
PATIENT
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COMPLEMENTARY
Finally Completing the Missing Linkfor AMD Treatment and Diagnosis
PHYSICIAN-DRIVENFormal Diagnosis
and Treatment with Effective Current and
Future Therapies
2006
PATIENT-ACTIVATED
Convenient, Objective, Accurate Early
Detection
2016
THE NEW REALITY
Taking AMD Treatment to the Next Level
...Shift from
Regaining Vision ... ...to Not Losing It in
the First Place
Enabling Timely Treatment
THANK YOUQUINTON OSWALD, CEOQOswald@notalvision.com(650) 255-4557
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