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CELL INJURY:MECHANISM &

CONSEQUENCES

4th September, 2015

Prepared by : PBL 5

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ADAPTATION VS CELL INJURY

Cell injury is a reversible or irreversible conditions which occur after the limits of adaptive response to a stimulus are exceeded

Cells may recover if the injury is mild and transient (reversible) but if the stress is severe and progressive, cell death occurs (irreversible)

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CAUSES OF CELL INJURY

Oxygen Deprivation (Hypoxia)Chemical Agents Infectious AgentsImmunological ReactionsGenetic FactorsNutritional ImbalancesPhysical AgentsAgeing

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REVERSIBLE INJURY

Cellular swelling: Inability to maintain ion and fluid homeostasis

Fatty change : Lipid vacuoles in the cytoplasm

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MECHANISMS OF CELL INJURY

Mitochondrial damage Influx of Calcium Ions Membrane damage Protein misfolding/DNA damage

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