Pathology 430/826

The Molecular Basis of Disease

Path 430/826 - 0.5 creditsCourse Coordinator

David Lillicrap

dpl@queensu.ca

Room 201G Richardson Laboratory

http://clinlabs.path.queensu.ca/path430/

PATH 430/826

Course Teaching Assistant

Alison Michels

8am64@queensu.ca

Monday 8.30 – 10.30 am

Room 101 Richardson Laboratory

Will need to start at 8.35 am

Course Format

5 Human Disease Themes

Blood malignancyBleeding diseases

Thrombotic diseasesNeurological disorders

Urological cancer

Course Instructors

Dr. David Lillicrap Coordinator/Anemia/Thrombosis/Bleeding diseases

Dr. Laura Swystun Bleeding diseases/Thrombosis

Dr. Michael Rauh Blood malignancies

Dr. David Good Blood malignancies

Dr. Harriet Feilotter Neurologic disease

Dr. John Rossiter Neurologic disease

Dr. David Berman Urological Cancer

Human Disease Themes

1. Common and rare

2. Inherited and acquired

3. Malignant and benign

4. Different organ systems

Course Objectives

1. To understand the molecular basis of a group of“model” human diseases (molecular pathogenesis).

2. To gain insights into diagnostic and therapeutic strategies for human disease.

Human Disease Pathology/Pathogenesis

Diagnosis of Disease

Treatment of Disease

Central Place of Disease Mechanisms

Human Pathology - Disease

Genetics

ImmunologyBiochemistry

Molecular biologyHistology

Microbiology

Diagnosis and Therapy

Week 1

1. Introduction to Path 430-826/Evaluations/Expectations

2. Introduction to Molecular Medicine/Personalized Medicine

3. A highly prevalent inherited disease – Thalassemia

Week 2

Introductory background to blood malignanciesLymphoma/leukemia

~40 mins - Then 10 min break

Student Presentation #1

20 mins + 15 mins discussion/questions

Week 3

2 X 20 minute students presentations

~15 mins discussion/questions per presentation

Leukemia/Lymphoma - introductory presentation (~30 mins)

Evaluative Components

Path 430 and Path 826

1 oral presentation 30%

1 Term paper 50%

Course Participation 20%

No mid-term or final exam

Term Paper Choice and Format

• 5 paper titles will be distributed just before Reading Week

• 10 pages – double spaced, not including figures/references

• Include at least 1 figure and 15 references

• Return by Monday April 4th 2016 at 4pm.

Path 430

Term Paper Choice and Format

• 1 paper title will be available by Reading Week

• 12 pages – double spaced, not including figures/references

• Include at least 2 figures and 25 references

• Return by Tuesday April 4th 2016 at 4pm.

Path 826

Student Presentations• No longer than 20 mins

• No more than 30 slides

• Focus on• Brief background• Study objectives• Overall study results• Study conclusions• Any study limitations/weaknesses

Do not get distracted/confused by the minutia of results

Better to present a clear representative example from the data - ie. several illustrative graphs or figures

Course Participation

• Expectation that everyone in class has read some of theassigned papers, and can ask relevant questions about the work.

• Each week, every student will be expected to hand to the Course TA, 2 questions pertinent to the papers being presented. Two or three of these questions will be asked during the class.

• In addition, for each paper presentation, two students will be asked at random (everyone will be asked equally over the term)to either comment on a weakness of the work, or to ask the presenter a question.

Course Expectations1. Possession of a good background knowledge of the biological

sciences

2. Show an interest in furthering this knowledge

3. Class involvement –

interest in discussion

responses to questions

4. Demonstrate the ability to communicate scientific knowledge, both orally and in writing, in a clear, precise and succinct manner.