Ontogenesis Imperfecta

By: Charles Xu

Info on OI

• The scientific name of the disease is Lobstein Syndrome.

• OI codes for Collagen I

• As of now there is no treatment for the disease

• The disease is caused by a dominant factor and if neither of the parents have it it’s a spontaneous mutation

More info on OI

• There are 8 types of OI each more sever then the next.

• You can live a normal life depending on the severity and the age.

• It requires great medical care.

Symptoms

• Symptoms include• Bones fracture easily• Short Stature• Hearing loss at a young age• Discolored or brittle teeth• Blue sclera• Weak muscles• And many more

Chromosome that carries OI

The genes have switched parts by crossing over

Pedigree

Bibliography• Tulane University. Web. 16 Apr. 2011. <http://www.tulane.edu/>. • Osteogenesis Imperfecta Foundation: Fast Facts." Osteogenesis

Imperfecta Foundation:. Web. 16 Apr. 2011. <http://www.oif.org/site/PageServer?pagename=fastfacts>.

• "Discovery Health "Living with Osteogenesis Imperfecta"" Discovery Health "Health Guides"Web. 16 Apr. 2011. <http://health.howstuffworks.com/diseases-conditions/musculoskeletal/osteogenesis-imperfecta4.htm>.

• "Google Images." Google. Web. 16 Apr. 2011. <http://www.google.com/imgres?imgurl=http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Translocation_8-14.gif>

• Osteogenesis Imperfecta Symptoms." Bones Home Page. Web. 16 Apr. 2011. <http://bones.emedtv.com/osteogenesis-imperfecta/osteogenesis-imperfecta-symptoms.html>.