Post on 12-Apr-2018
22nd & 23rd September 2017
Göttingen Channels 2017"Of Benches and Beds"
Herzforschungszentrum, Robert-Koch-Str. 42a, 37075 Göttingen, Germany
WELCOME
Dear Colleagues and Friends,
I am delighted to welcome you to the second “Channels symposium” of the German Cardiac Society Working Group on Cellular Electrophysiology (WG18).
After the great success of the first “Channels symposium” organized by Dierk Thomas in Heidelberg two years ago, we decided to establish this meeting as an integral part of our working group’s activities.
“Of Benches and Beds”, this year’s title, highlights the mission of our working group: to operate at the interface between basic science and clinical application. The selection of speakers and session topics reflect this translational aspect. The symposium’s small size, with a maximum of 60 attendees, and its focused topics provide the ideal platform for productive interplay among scientists in a familiar atmosphere.
To support the contribution of young scientists, we have invited outstanding MD and PhD students, in collaboration with the Scientists of Tomorrow (SoT) of the European Society of Cardiology, to present at the meeting. Along with an enhanced interaction between senior scientists, we want to give young researchers the opportunity to take part in sti-mulating discussions and debates.
It is a special honour to welcome Prof. Dr. W. J. Lederer as the keynote speaker. He is the director of the Center for Biomedical Engineering and Technology and Professor of Physiology at the University of Maryland in Baltimore, USA. Prof. Lederer made funda-mental discoveries in the physiology of cytosolic Ca2+ handling that changed our view of biology and medicine. He will provide an overview about newly-investigated aspects of mitochondrial Ca2+ homeostasis in the heart and this will serve as an introduction for one of the major topics of the meeting. Mitochondria and their impact on cellular electrophy-siology and arrhythmogenesis will be an important theme in the majority of our sessions.
Göttingen Channels 2017 will be held in the new cardiac research building of the Univer-sity Medical Center Göttingen (Herzforschungszentrum), especially designed for cutting edge cellular and subcellular cardiac research. It accommodates the most novel electro-physiological and microscopy technologies including super-resolution microscopy (STED). The cardiac research building, a unique platform for the interaction of internal and exter-nal research groups, provides the ideal environment for Göttingen Channels 2017.
I wish all of you a very stimulating and exciting stay here in Göttingen.
Yours,
Niels VoigtInstitute of Pharmacology and Toxicology,University Medical Center Göttingen, Germany
FRIDAY, 22nd SEPTEMBER 2017
2.00 pm Arrival
2.55 pm Welcome address and introduction Niels Voigt (Göttingen, Germany)
3.00 – Inherited Channelopathies and Mitochondriopathies4.35 pm Chairs: Dörthe Katschinski (Göttingen, Germany)
Wolfram-H. Zimmermann (Göttingen, Germany)
3.00 pm Mitochondrial redox mismatch in cardiac hypertrophic cardiomyopathy triggers arrhythmias Christoph Maack (Würzburg, Germany)
3.20 pm Barth syndrome Peter Rehling (Göttingen, Germany)
3.40 pm Transgenic rabbit models for long QT syndrome - electro-mechanical function and arrhythmia mechanisms Katja Odening (Freiburg, Germany)
4.00 pm Cellular electrophysiology of hiPSC-derived cardiomyocytes Torsten Christ (Hamburg, Germany)
4.20 pm Ca2+-handling abnormalities in hiPS-derived cardiomyocytes from patients with tetralogy of fallot Rebekka Dülk (Göttingen, Germany)
4.35 pm Coffeebreak
5.00 – Heart Failure Induced Atrial and Ventricular Remodeling6.35 pm Chairs: Larissa Fabritz (Birmingham, UK)
Cristina E. Molina (Göttingen, Germany)
5.00 pm Time-course of atrial remodeling in dogs with heart failure Jordi Heijman (Maastricht, The Netherlands)
5.20 pm Subcellular Ca2+ signaling in heart failure induced atrial remodeling Felix Hohendanner (Berlin, Germany)
5.40 pm Atrial remodeling of two-pore channels in patients with heart failure Constanze Schmidt (Heidelberg, Germany)
6.00 pm Remodeling of ventricular Na+-channels in heart failure Samuel T. Sossalla (Göttingen and Regensburg, Germany)
6.20 pm Targeting ventricular remodeling in aging-induced heart failure Mahmoud Abdellatif (Graz, Austria)
8.00 pm Faculty dinner
8.30 – AtrialFibrillation10.05 am Chairs: Frank Heinzel (Berlin, Germany)
Ursula Ravens (Freiburg, Germany)
8.30 am Novel strategies to treat atrial fibrillation: Much ado about nothing?
Barbara Casadei (Oxford, UK)
8.50 am Epicardial fat: A player in the pathophysiology of atrial fibrillation? Stéphane Hatem (Paris, France)
9.10 am Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation Ulrich Schotten (Maastricht, The Netherlands)
9.30 am miRNA in AF: Marker or therapeutic target? Reza Wakili (Essen, Germany)
9.50 am Postnatal development of atrial t-tubules Charlotte Smith (Manchester, UK)
10.05 am Coffeebreakandgrouppicture
10.30 – Keynote Lecture (DZHK Lecture)
11.30 am Chair: Gerd Hasenfuß (Göttingen, Germany)
New insights into cardiac mitochondrial Ca2+ homeostasis W. Jonathan Lederer (Baltimore, USA)
11.30 am Lunch
SATURDAY, 23rd SEPTEMBER 2017
12.30 – MitochondriaandCellularEnergyMetabolism2.05 pm Joint Session with the WG13 “Myocardial Function and Energetics” Chairs: Heiko Bugger (Freiburg, Germany)
Jens Kockskämper (Marburg, Germany)
12.30 pm Late Na+ current and Na+-sensitive Ca2+ sources during acute myocardial ischemia Antonio Zaza (Maastricht, The Netherlands)
12.50 pm Mitochondrial and sarcolemmal IK,ATP-channels in health and disease Blanche Schwappach-Pignataro (Göttingen, Germany)
1.10 pm Dynamic Mitochondria Ca2+ movement in the control of excitability Jérémy Fauconnier (Montpellier, France)
1.30 pm Mitochondrial metabolism in the atria Sander Verheule (Maastricht, The Netherlands)
1.50 pm Excitation-oxidative metabolism coupling adaptations to short term high-fat-sucrose diet Mathilde Lacôte (Montpellier, France)
2.05 pm Coffeebreak
2.30 – CardiacFibroblastsinHealthandDisease4.05 pm Chairs: Stephan E. Lehnart (Göttingen, Germany)
Dierk Thomas (Heidelberg, Germany)
2.30 pm Influence of culture format and co-culture on the electrophysiology of iPSC-cardiomyocytes
Godfrey Smith (Glasgow, UK)
2.50 pm Fibroblasts-cardiomyocytes electrotonic crosstalk: Consequences on cardiac electrophysiology
Ange Maguy (Bern, Switzerland)
3.10 pm Ca2+-handling in fibroblasts Susanne Lutz (Göttingen, Germany)
3.30 pm Disease-related remodeling of human fibroblasts in cardiovascular tissues
Remi Peyronnet (Freiburg, Germany)
3.50 pm Are stretch-activated channels in human atrial fibroblasts remodelled in atrial fibrillation? Alexander Klesen (Freiburg, Germany)
4.05 pm Concludingremarksandendofthemeeting Niels Voigt (Göttingen, Germany)
SATURDAY, 23rd SEPTEMBER 2017
FACULTY
Meeting Organization
Niels Voigt – Göttingen, Germany, niels.voigt@med.uni-goettingen.de
Maren Wehner – Göttingen, Germany, maren.wehner@med.uni-goettingen.de
Session Chairs
Heiko Bugger – Freiburg, Germany, heiko.bugger@universitaets-herzzentrum.de
Larissa Fabritz – Birmingham, UK, l.fabritz@bham.ac.uk
Gerd Hasenfuß – Göttingen, Germany, hasenfus@med.uni-goettingen.de
Frank Heinzel – Berlin, Germany frank.heinzel@charite.de
Dörthe Katschinksi – Göttingen, Germany, doerthe.katschinski@med.uni-goettingen.de
Jens Kockskämper – Marburg, Germany, jens.kockskaemper@staff.uni-marburg.de
Stephan E. Lehnart – Göttingen, Germany, slehnart@med.uni-goettingen.de
Cristina E. Molina – Göttingen, Germany, cristina.molina@med.uni-goettingen.de
Ursula Ravens – Freiburg, Germany, ursula.ravens@uniklinik-freiburg.de
Dierk Thomas – Heidelberg, Germany, dierk.thomas@med.uni-heidelberg.de
Wolfram-H. Zimmermann – Göttingen, Germany, wolfram.zimmermann@med.uni-goettingen.de
InvitedSpeakers
Barbara Casadei – Oxford, UK, barbara.casadei@cardiov.ox.ac.uk
Torsten Christ – Hamburg, Germany, t.christ@uke.de
Jérémy Fauconnier – Montpellier, France, jeremy.fauconnier@inserm.fr
Stéphane Hatem – Paris, France, stephane.hatem@upmc.fr
Jordi Heijman – Maastricht, Germany, jordi.heijman@maastrichtuniversity.nl
Felix Hohendanner – Berlin, Germany, felix.hohendanner@charite.de
Susanne Lutz – Göttingen, Germany, susanne.lutz@med.uni-goettingen.de
Christoph Maack – Würzburg, Germany, christoph.maack@uks.eu
Ange Maguy – Bern, Switzerland, maguy@pyl.unibe.ch
Katja Odening – Freiburg, Germany, katja.odening@uniklinik-freiburg.de
Remi Peyronnet – Freiburg, Germany, remi.peyronnet@universitaets-herzzentrum.de
Peter Rehling – Göttingen, Germany, peter.rehling@medizin.uni-goettingen.de
Constanze Schmidt – Heidelberg, Germany, constanze.schmidt@med.uni-heidelberg.de
Ulrich Schotten – Maastricht, The Netherlands, schotten@maastrichtuniversity.nl
Blanche Schwappach-Pignataro – Göttingen, Germany, blanche.schwappach@med.uni-goettingen.de
Godfrey Smith – Glasgow, UK, godfrey.Smith@glasgow.ac.uk
FACULTY
Samuel T. Sossalla – Göttingen/Regensburg, Germany, ssossalla@med.uni-goettingen.de
Sander Verheule – Maastricht, The Netherlands, s.verheule@maastrichtuniversity.nl
Reza Wakili – Essen, Germany, reza.wakili@uk-essen.de
Antonio Zaza – Maastricht, The Netherlands, antonio.zaza@maastrichtuniversity.nl
KeyNoteSpeaker
W. Jonathan Lederer – Baltimore, USA, jlederer@umaryland.edu
Scientists-of-TomorrowSpeakers
Mahmoud Abdellatif – Graz, Austria, mahmoud.abdellatif@medunigraz.at
Rebekka Dülk – Göttingen, Germany, rebekka.duelk@med.uni-goettingen.de
Alexander Klesen – Freiburg, Germany, klesenalexander@gmail.com
Mathilde Lacôte – Montpellier, France, mathilde.lacote@inserm.fr
Charlotte Smith – Manchester, UK, charlotte.smith-17@postgrad.manchester.ac.uk
NucleusWG18CellularElectrophysiologyoftheGermanCardiacSociety
Dierk Thomas (Chair) – Heidelberg, Germany, dierk.thomas@med.uni-heidelberg.de
Niels Voigt (Vice-Chair) – Göttingen, Germany, niels.voigt@med.uni-goettingen.de
Andreas Götte (Past-Chair) – Heidelberg, Germany, andreas.goette@vincenz.de
Torsten Christ – Hamburg, Germany, t.christ@uke.de
Larissa Fabritz – Birmingham, UK, l.fabritz@bham.ac.uk
Matthias Hammwöhner – Paderborn, Germany, m.hammwoehner@vincenz.de
Jordi Heijman – Maastricht, Germany, jordi.heijman@maastrichtuniversity.nl
Jens Kockskämper – Marburg, Germany, jens.kockskaemper@staff.uni-marburg.de
Dominik Linz – Homburg, Germany, dominik.linz@uks.eu
Katja Odening – Freiburg, Germany, katja.odening@uniklinik-freiburg.de
Patrick Schweizer – Heidelberg, Germany, patrick.schweizer@med.uni-heidelberg.de
Reza Wakili – Essen, Germany, reza.wakili@uk-essen.de
FACULTY