OCULAR PATHOLOGY CASE CONFERENCE. Chirag Patel, M.D. (PGY-2) Hilary Nikols, M.D. (PGY-3) Mark Becher, M.D. Louise Mawn, M.D. October 20, 2008. Case #3. Case #3 (cont’d). Case 3 : Basal Cell Carcinoma. Case 3 : Basal Cell Carcinoma. Case #5. Case #5 (cont’d). Case #5 (cont’d). - PowerPoint PPT Presentation
Transcript of OCULAR PATHOLOGY CASE CONFERENCE
OCULAR PATHOLOGY OCULAR PATHOLOGY CASE CONFERENCECASE CONFERENCE
Deletion of both RB1 tumor suppressor genesDeletion of both RB1 tumor suppressor genesHereditary form 40%Hereditary form 40% Germ cell line mutation; loss of one gene at Germ cell line mutation; loss of one gene at
embryogenesisembryogenesis Usually presents bilaterally and earlyUsually presents bilaterally and early Risk of second malignancyRisk of second malignancy
Non-hereditary form 60%Non-hereditary form 60% Somatic mutation at level of retinal cellSomatic mutation at level of retinal cell Usually unilateral and presents later in childhoodUsually unilateral and presents later in childhood
Case #9Case #9
Case #9 (cont’d)Case #9 (cont’d)
Case #9 (cont’d)Case #9 (cont’d)
Case #9 (cont’d)Case #9 (cont’d)
Case 9Case 9: Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma
Case 9Case 9: Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma
Case 9Case 9: embryonal rhabdomyosarcoma: embryonal rhabdomyosarcoma
desmin myoD1 myogenin
Case #10Case #10
Case #10 (cont’d)Case #10 (cont’d)
Case #10 (cont’d)Case #10 (cont’d)
Case 10Case 10: cavernous hemangioma: cavernous hemangioma
Case 10Case 10: cavernous hemangioma: cavernous hemangioma