Mr Basim Matti FRCS London Dr Peter Everts PhD Eindhoven, Holland

Mr Matti 31 Patients

Data Set as of 1st November 2011

PRP

PRP is an autologous blood product with a high concentration of platelets.

The platelets produce a cocktail of Cytokines and Growth Factors, which trigger and accelerate the regeneration of tissues.

PRP

It is concentration of human platelets in a small volume of plasma measured > than1,000,000 platelets /mm³ = 4-6x the normal

Normal value of platelet concentration in whole blood150,000-400,000mm³

Aim Of PRP Therapy

Regeneration of collagen and Elastine fibres

Prevention of collagen degradations

Rejuvenation of the skin

Wound healing principles

Platelet physiology

Platelet activation

Growth Factors

Platelet Rich Plasma Concentration of Growth Factors

PDGR – 130 times Platelet derived Growth Factor

TGF beta – 80 timesTransforming Growth Factor-beta.

VEGF – 11 timesVascular Endothelial Growth Factor

IGF 1 Insulin like Growth Factor, HGF Hepatocyte GF, Basic Fibroplasten GF

How Growth Factor Works

Areas for injection

Injection sites into dermal layer

and dermal junction

Source: Seishin Institute Japan

• >12,000 patients undergone PRP Therapy

• “NEW PRP Skin Regeneration Therapy,• three to five times richer in

platelets than conventional PRP therapy

• inject platelet-rich plasma containing white blood cells. “

http://www.saiseiiryou.com

Seishin Institute Japan.

Hyaluronic Acid

PRP

Cytomedix Angel System

Enclosed Point of Care System

Automatic collection of PRP

Peripheral blood Platelet level 276.000mm³ Dense Platelet

concentration 2.750.000mm ³ using Angel™ System

Other Test Tube systems

Our PRP Technique

52ml blood draw8mls citrate ACD-AAngel processing 18 minutesPRP yield 2mls highly concentratedaverage 12.2 x baseline platelets

Add 4mls platelet poor plasma= 6mls PRP injected with platelet concentration >850.000mm³ >3-4 x baseline platelet concentration

Video: Procedure 56secs www.youtube/avancemedical/final_edit_5th_November

Our Experience: Cohort n31

8 wksPostPre

Source: Sclafani A.P. (2010) Platelet Rich Fibrin Matrix for improvement of deep naso-labial folds . Journal of Cosmetic Dermatology , Vol.9: 66-71

Sclafani A.P. (2011) Safety, Efficacy and Utility of Platelet Rich Fibrin Matrix ARCH Facial Plastic Surgery Published on line Feb 2011 doi:10.1001/archfacial.2011.3Sclafani A.P. (2009) Applications of Platelet Rich Safety, Fibrin Matrix in Facial Plastic Surgery Facial Plastic Surgery Vol 25 No. 4

Patient Questionnaire

Key questions:Improvement in tone of skinImprovement in texture of skinReduction in linesImproved ‘glow’ or radiance of the skinVolumetric improvement ????

PATIENT SURVEY

Respondents 21 patients19% (4 patients) see no difference81% (17 patients) see and feel a difference in skin tone and texture.42.86% (9 patients) state they see a marked improvement in skin tone, texture and reduction of lines.38.1% (8 patients) extremely satisfied with the results.

Age Distribution

< 40yrs 40-50yrs

51-60yrs

>61 yrs

0

2

4

6

8

10

12

14

Number of patients 31n

Number of patients

Further Research

Number & intervals of treatmentsLongevity of treatmentCombination therapiesMicro needlingMesotherapyUltrasound

Cost of treatmentIs it worth it?

barbados meatingTHANK YOU

Thank you