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Modern Wellness:Stress, Your Self, Your Skin

Howard Murad, M.D., FAADAssociate Clinical Professor of Medicine-Dermatology,

David Geffen School of Medicine, UCLA Board Certified Dermatologist, Pharmacist, Researcher,

Founder of Murad, LLC.

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The Science of Cellular Hydration

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The Pitcher of Wellness

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Dedicating 30 Years to Stress

& SkinWHY?

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48% of Americans feel their stress has increased

over the last 5 years.

SOURCE: Statistic Brain Research Institute, American Institute of Stress,

NY July 19, 2016

1 in 5 Americans say technology is a major

source of stress.

58% of Americans say work is a significant

source of stress.

One in 4 millennials claim they are ‘stressed out’

every day.

SOURCE: American Psychological Association - Stress in America survey.

2017

SOURCE: American Psychological Association - Stress in America survey.

2017

SOURCE: Mintel 2018

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Scale of Cultural Stress

Yerkes-Dodson Human Performance Curve

S T R E S S

FU

NC

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I!er To""ler

Traditional Stress

Cultural Stress

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A Pilot Study on Cultural Stress: The Gene Study

OBJECTIVEThe purpose of this pilot study is to explore the effectiveness of a Murad’s Inclusive Health method to treat Cultural Stress (CS).

OVERVIEW • Six subjects recruited into the Murad Inclusive Health Program (IHP)• Total Program length: 24 weeks• Blood and skin biopsy samples collected at baseline (time 0), 12 weeks,

and 24 weeks• General health parameters were collected throughout the study by Dr.

Murad’s personnel (Including self-assessments completed by the subjects throughout the course of the study)

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Gene Expression

FINDINGS

Global gene expression analysis was carried out using Affymetrix microarrays to identify

gene expression changes correlated with improved health outcomes as a result of the

program.

Affymetrix microarrays contain approximately 45,000 transcripts

representing the ~23,000 human genes and are an ideal method for screening the entire

genome.

Comparison of the Genes in the Blood and Skin Datasets

As expected, the blood and skin datasets have little in common. Based on thesmall overlap in specific genes, each tissue was further analyzedindependently.

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Insight StudyEffectiveness of positive insights in emotional wellbeing and stress reduction

Insight StudyWhat these insight cards encourage

ResultsI N S I G H T S T U D Y

Measured Vitals Baseline (SD) Week 4 (SD)

PSS Total Score 19.75 (4.75) 17.64 (3.15)*

Heart Rate 75.15 (13.04) 72 (13.44)*

Systolic Blood Pressure 122.15 (17.33) 120.63 (15.69)

Diastolic Blood Pressure 78.48 (11.76) 77.35 (9.93)

ICW 26.35 (3.96) 26.58 (4.03)

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What do you see?

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“Learn from yourself.” “A bear hug a day keeps the Doctor and

Psychiatrist away.”

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