Post on 14-Sep-2020
SUPPLEMENTARY FILES
Supplemental figure 1. Flow chart
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Supplemental Figure 2. Distribution of liver stiffness values according to the individual
components of Anali score without gadolinium: dysmorphy (Supplemental Fig. 2a), portal
hypertension (Supplemental Fig.2b), intrahepatic bile duct dilatation (Supplemental Fig. 2c).
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Supplemental table 1. Graphic description of Anali score without gadolinium
Component of Anali score
without gadolinium
Grade Example
Intrahepatic bile duct
dilatation
0: 3 mm
1: 3.1-4.9 mm
2: 5 mm
Dysmorphy 0: absent
1: present
Portal hypertension 0: absent
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1: present
Anali score without gadolinium =
1 x IHBD dilatation + 2 x Dysmorphy + 1 x Portal hypertension
Notes: The grade of IHBD dilation is defined by the greatest IHBD dilatation. Dysmorphy was
defined by the presence of an increase of the modified caudate/right lobe ratio evaluated
with use of the right portal vein to set the lateral boundary of caudate lobe. Portal
hypertension is defined by the presence of portosystemic shunts including left gastric,
paraumbilical, splenorenal and splenogastrorenal shunts with or without splenomegaly as
defined by splenic index higher to 480 cm3.
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Supplemental table 2. Correlations between liver stiffness or Anali score without
gadolinium and biochemical variables.
Liver Stiffness Anali score without gadolinium
Spearman’s P Spearman’s P
Total bilirubin 0.35 <0.001 0.24 <0.01
AST 0.52 <0.001 0.34 <0.001
ALP 0.48 <0.001 0.33 <0.001
GGT 0.50 <0.001 0.40 <0.001
Albumin -0.31 <0.001 -0.26 <0.01
Platelets -0.18 <0.001 -0.09 n.s.
Abbreviations: AST, aspartate aminotransferase; ALP, alkaline phosphatase; GT, gamma-glutamyl
transpeptidase.
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Supplemental table 3. Results of Cox regression analysis for each component of ANALI
score without gadolinium and LS.
Cox regression model including LS and dysmorphy
Variable HR 95%CI p
LS 1.02 1.01-1.04 0.007
Dysmorphy 5.27 2.01-13.85 0.001
Cox regression model including LS and IHBD dilatation
Variable HR 95%CI p
LS 1.03 1.01-1.05 0.001
IHBD dilatation 2.35 1.46-3.78 < 0.001
Cox regression model including LS and portal hypertension
Variable HR 95%CI p
LS 1.02 1.00-1.04 0.035
Portal hypertension 2.83 1.32-6.06 0.007
Cox regression model including LS, dysmorphy, IHBD dilatation and portal hypertension
Variable HR 95%CI p
LS 1.02 1.01-1.04 0.011
Dysmorphy 3.32 1.16-9.46 0.025
IHBD dilatation 1.77 1.05-2.97 0.033
Abbreviations: LS, liver stiffness; HR, hazard ratio; CI, confidence interval; IHBD, intrahepatic
bile duct
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