Post on 06-Feb-2015
description
Lipid Transport and Storage
Dr. Bibi KulsoomAssistant Professor
Department of Biochemistry
Countrywide Transport
Structure of Small Intestine
Structure of Small Intestine
Triglyceride Packing & Transport
Chylomicron
A-II
A-II
Lymphatic system
Blood Circulation
A II
Chylomicron
HDLApo C II, E
B 48
E
C II
Triacylgycerol Storage
Triacylgycerol Storage
http://www.trudicanavan.comhttp://www.vivo.colostate.edu
Brown Adipose Tissue
Chylomicron Transport to Liver
Countrywide Transport
Hepatic uptake of Chylomicron Remnants
Fate of Chylomicron Remnants
Chol
TGFFA
PhoL
Secretion of VLDL
Lipoproteins
Lipoprotein Structure
Composition of Lipoproteins
Lipoprotein Sources Main Lipid Apolipoproteins
Chylomicron Intestine Triacylgycerol A-I, A-II, A-IV, B-48,
C-I, C-II, C-III, E
Chylomicron
remnants
Chylomicron Triacylgycerol, Phospholipids, Cholesterol
B-48, E
VLDL Liver Triacylgycerol, Cholesterol
B-100, C-I, C-II, C-III
IDL VLDL Triacylgycerol B-100, E
LDL IDL Cholesterol B-100
HDL Liver, Intestine Phospholipids, Cholesterol
A-I, A-II, A-IV, C-I,C-II, C-III, D, E
Free fatty acids with Albumin
Adipose tissue
Free Fatty acid
Apolipoproteins
Apoprotein Function
ApoA-I Activates LCAT.
ApoA-II Enhanced hepatic lipase activity.
ApoA-IV Contributes to structure.
ApoB-48 Contributes to structure.
ApoB-100 Binds LDL receptor.
ApoC-I Probably activates LCAT.
ApoC-II Activates LPL.
ApoC-III Inhibits LPL.
ApoD Closely associated with LCAT.
ApoE Binds to LDL receptors.
Triacylglycerol Transport
Bood circulation
Harper’s Illustrated Biochemistry
Triacylglycerol & Cholesterol Transport
Harper’s Illustrated Biochemistry
Reverse Cholesterol Transport
Harper’s Illustrated Biochemistry
Dislioproteinemias
• Hypoliproteinemias– abetalipoproteinemia
• Hyperliproteinemias– Deficiency of
• LPL
• Hepatic lipase
• LCAT
• LDL receptor
• Apo E
etc
Suggested Reading:• Harper’s Illustrated Biochemistry, 28 Ed. McGraw-Hill.• Lehninger Principles of Biochemistry, 5 Ed. WHFreeman & Co.
Lipid Transport and Storage