Synthesis and preliminary in vitro activity of mono- and bis-1H-1,2,3-triazole-tethered -lactam-isatin conjugates against the

human protozoal pathogen Trichomonas vaginalis

Raghu Raj . Vaishali Sharma . Melissa J. Hopper . Neal Patel . Dominique Hall . Lisa A. Wrischnik . Kirkwood M. Land . Vipan Kumar*

Supplementary information:

1H and 13C NMR spectra of representative compounds:

1H NMR spectrum of 6c:

Raghu Raj . Vaishali Sharma . Vipan Kumar*Department of Chemistry, Guru Nanak Dev University, Amritsar-143005, Punjab, India* E-mail address: vipan_org@yahoo.com; Tel: +91 183 2258802-09*3320; Fax: +91 183 2258819-20.

Melissa J. Hopper . Neal Patel . Dominique Hall . Lisa A. Wrischnik . Kirkwood M. Land Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA.

1H spectrum of 7a:

13C spectrum of 7a:

1H spectrum of 7d:

13C spectrum of 7d: