LEGIONELLA - Evoqua · ©2018 Evoqua Water Technologies Confidential | Page 1 TRANSFORMING WATER....

LEGIONELLAWater Management, Detection and Disinfection

Janet E. Stout PhD

• I am a microbiologist and president of Special Pathogens Laboratory, a laboratory and consulting firm specializing in Legionella detection and control

• Research Associate Professor in the Dept. of Civil & Environmental Engineering at the University of Pittsburgh

Experience

Learn From The Experience of Others

• Legionella is in our building water systems and presents a real and defined health risk to occupants

• Evaluating risk – environmental testing for Legionella

• Approaches to prevention• How we can end Legionnaires’

disease!

Celebrating More Than 40 Years of Making Headlines

Perspective: Things That Happened in 1976 in Philadelphia

42 years is a long time!

1976 Philadelphia

• 58th convention of the American Legion held July 21-24

• Mysterious illness effects 221 and kills 34

• Causative agent of pneumonia would not be identified until 1977

1980: Research Begins in Pittsburgh

• More than 30 years studying Legionnaires’ disease I’m a

Legionellologist

• Mission: What I’ve learned can help you address Legionella risk

Since 1980: Research Pioneers

• Over 100 nosocomial cases identified in 5 years in one hospital

• The source of the outbreak was the hospital water system – not a cooling tower!

Janet E. Stout and Victor L. Yu

• NOT a common source for sporadic and hospital-acquired cases

• More commonly associated with large community outbreaks

Paradigm Shift: Not Cooling Towers

What We Know Now

Potable water especially in hospitals (and other buildings)

with complex hot water systems,is the most important source of

Legionella transmission.

PREVENTING LEGIONNAIRES’ DISEASE

How Are We Doing?

Progress Has Been Slow…

Legionellosis in the U.S.

Outbreaks continue to occur (building warm water systems, cooling towers, fountains)

Outbreaks in Nursing Homes & Assisted Living Facilities

Hotel Outbreaks

Hospital Outbreak: 11 cases & 1 death

• New $135M 12-story patient tower

• 74% of distal outlets positive for Legionella

• Media coverage, legal action, $61k for outbreak management

South Bronx Outbreak 2015

• 138 cases,16 deaths

• 26 were culture-confirmed with Legionella pneumophila,serogroup 1 isolated.

Outbreak Linked to Hotel Cooling Tower

Legionnaires’ Disease Is International

Warstein, Germany • 165 cases, 12 ICU, 2 deaths caused by

Legionella pneumophila, serogroup 1

• Outbreak strain found in 2 cooling towers + other sources – including wastewater from a brewery!

• Public health communication

Public Safety Announcement

“Whether or not the Warsteiner brewery is found to be the breeding ground for the Legionella bacteria, officials have been making it clear that …

the beer is completely safe to drink.”

DRINKING WATER

What Ben Franklin Said

with water comes bacteria Legionella.”

“With wine comes wisdom, with beer comes freedom,

Consider This…

Legionellosis cases have increased substantially – over 300% in last 10 years

2016 CDC Report on Legionnaires’ Disease Outbreaks

Outbreak Sources: More Than Healthcare

• 27 Outbreaks - Sources 44% Hotels and resorts 19% Long-term care facilities 15% Hospitals 21% Senior living facilities,

• workplaces, and the community

Potable Water vs. Utility (Cooling Towers)

• Potable water was the most frequent source of exposure (56%), followed by cooling towers (22%)

• Potable water sources accounted for 67% of health care–associated outbreaks (in hospitals and long-term care facilities).

Hospitals at Significant Risk According to Recent

CDC Report

Legionella in hospitals –accounted for 57% of all cases and 85% of deaths

PREVENTING LEGIONNAIRES’ DISEASE

How Are We Doing?

Report Card

Today The D’s Are For…

• Denial

• Diagnosis

• Detection (Environmental)

• Disinfection

Denial

Most wait to address

the problem until after

a case of Legionnaires’

disease is diagnosed.

Denial

• We don’t have any cases of Legionnaires’ disease.

• Legionella is everywhere (ubiquitous)

• If I test for Legionella and find it, I’ll be in more trouble than if I don’t test at all.

CLINICAL CHALLENGES OF LEGIONNAIRES’ DISEASE

Diagnosis

• Majority diagnosed with the urinary antigen test (specific for L. pneumophila serogroup 1 only)

• No Cases…Maybe Cases Missed? Diagnostic tests for Legionella not routine –

often not done

• Many studies have demonstrated under reporting/missed diagnosis

Who’s at Risk?

• Elderly (>50)• Smokers• Immunocompromised Transplant patients High-dose steroids for lung disease Diabetes Cancer

• Approx. 25% cases no known risk factors

Centers for Disease Controland Prevention Statistics

• 62% male• Hospitalizations occurred in 98% ICU admission in 39%Death in 10%–30%

Modes of Transmission for Legionnaires’ disease

• Aerosolization

• Aspiration

• Direct instillation into the patient (tap water rinsing of nasogastric tubes, respiratory tubing, etc)

• CPAP devices

1 Drop of Water CanContain

Thousands of Legionella

Origins of Legionella

• Incoming potable water (undetectable or very low conc.)

• Systems with warm water, such as water distributions systems and air cooling systems (provide growth factors)

• Biofilms within these systems (amplification)

The opinions, contents and pictures found on this slide are of Special Pathogens Laboratory

BUILDING WATER SYSTEMS

Legionella And Other Waterborne Pathogens

Millions of Bacteria In Our Pipes

Legionella Is Not Alone

• Legionella bacteria are part of a community of microorganisms—a consortium.

• They live synergistically—one benefiting the other for mutual survival.

Acinetobacter

Pseudomonas aeruginosa

S. maltophilia

Amoeba Resistant Microorganisms ( Mycobacteria )

Not Just Legionella in Our Faucets

BUILDING WATER SYSTEMSDetecting Legionella

Where You Can Find Legionella

• Building (warm) water systems Faucets, showers Hot water tanks Decorative fountains Pools, spas Cooling towers Ice Machines

Warm water (optimalnear 98.6)

+Nutrients in the water(soil, organics)

+Other microbes(bacteria andProtozoa/amoebae)

3 Factors Needed For Legionella Growth in Building Water Systems

Legionella are in 30–50% of water systems

©Special Pathogens LaboratoryThe opinions, contents and pictures found on this slide are of Special Pathogens Laboratory

Test to Find Out Where You Stand

• Myth – Legionella is not everywhere (ubiquitous)

• Is your facility in the 50% of buildings with or without Legionella? Healthcare facilities – greater risk

• Only 30-50% of cooling towers positive for Legionella

• Assess the risk

• Control the risk (through engineering controls or water treatment)

• Before cases occur

Why Test for Legionella?

Why Is Detecting LegionellaImportant?

If you don’t look for it, you won’t find it.

If you don’t find it, you don’t think you have a problem.

If you don’t think you have a problem, you don’t do anything about it.

−Bruce Dixon, M.D. Director, Pittsburgh ACHD

Is the Sky Falling?

If I Find Some Legionella?

Zero Legionella is virtually impossible to achieve in complex

water systems

Don’t Chase Zero

Preventing Legionnaires’ Disease Through Legionella Control

Zero Cases Is The Goal, Not

Zero Legionella

Preventing Legionnaires’ Disease

Many published studies show disease control by significantly reducing Legionella in water

systems.

Proactive Approach Reduced Legionnaires’Disease

Am. J. Infection Control 2005; 33(6):360-367

Proactive ApproachCulture hot water systems.

Was Legionella found?

Prior cases of legionellosis observed?

Colonization of distal sites >30%?

Prospective clinical surveillance detected

legionellosis?

Consider Secondary Disinfection

Continue Environmental Surveillance

YES NO

Reference: Approaches to Prevention and Control of Legionella Infection in Allegheny County Health Care Facilities. 1997.

Estimating Risk and Evaluating Efficacy (Validating) of Water Management

• Proportion of outlets positive for Legionellaof at least 10 distal sites (faucets or showers) that were tested.

• If >30% risk increases, especially if L. pneumophila, serogroup 1 is present (now part of NYS regulation)

• Estimates the probability of a patient “bumping into” Legionella (percent positive)

Proportion, Not Concentration

Risk of Legionnaires’ disease was better predicted by the

proportionof water system sites

testing positive for Legionellathan by the

concentration of Legionella bacteria.

Kool J L, et al. Infect. Control Hosp. Epid. 1999 20:797-805

HOW YOU SAMPLE MATTERS

FLUSH TO WASTE

PRE FLUSH(Positive)

POST FLUSH(Negative)

Concentration Is Variable

Courtesy M. Weinbren

First Draw Hot Water

• Do not Flush Collect hot water

immediately after opening faucet or shower valve Flushing reduces

recovery Immediate draw

97.7% positive reduced to 69.1% after 2 min. flush

• Method of sample collection and processing can dramatically affect the resultsCooling towersPotable water – building water

distribution systems• Hot water primary reservoir

How You Sample Matters

SAMPLE COLLECTION: FROM THE BASIN

You Can’t Tell by Looking

>3000 CFU/mL Legionella pneumophila serogroup 1

Automated dosing ofchemical biocides and clean

• Program uses biocides effective against Legionella (adjust with changing conditions)

• Keep clean (filtration)• Scale and corrosion control• Quarterly Legionella testing by

qualified laboratory (no surrogate)

How to Avoid Problems In Cooling Towers?

©Special Pathogens LaboratoryThe opinions, contents and pictures found on this slide are of Special Pathogens Laboratory

• Find out more about cooling tower control strategies and other information on the resources page at www.specialpathogenslab.com

Cooling Towers

Laboratory Detection (Test) Methods

Legionella Testing According to CDC

• CDC recommends using a testing method capable of detecting all members of the Legionella genus but also one that provides material for typing.

• At the moment, this means culture.• Particularly true during an investigation

and in the immediate aftermath

Culture Method

• Industry standard/best practice Standards based

• ISO 11731 (1&2)• ASTM D 5952• CDC• International – HSE L8 ACP 2013

Laboratory Proficiency Programs• NY ELAP• ELITE is not a traditional proficiency program

All Members:Over 60 Members (species)

Are All Legionella Alike?

All Legionella Are Not Dangerous

The Legionella Family Has Over 60 members (species)

Not All Legionella Are Pathogenic

• If you find Legionella – what type did you find?

• There are over 60 species and serogroups L. pneumophila serogroup 1 has highest

risk for diseaseMany species common in water, but

rarely cause infection (much less risk)• L. anisa, bozemanii, dumoffii, etc

Legionella Testing

• Culture is more reliable (sensitive & specific) than other “rapid tests”

• Preliminary results available in 4 days, final in 7 days.

• Alternative methods/approaches Molecular (qPCR and microarray) Most Probable Number (L. pneumophila only) Immunochromatographic (ICT) test

ICT-Type Test: Quick But Inaccurate?

Greater Focus On Legionella Prevention

CDC Focuses on Effective Water

Management For Legionnaires’ Disease

Prevention(AKA ASHRAE 188)

• ANSI/ASHRAE Standard 188

• First Legionella standard in the United States.

• ApprovedJune 26, 2015.

Purpose of ASHRAE Standard 188

• Establish minimum Legionellosis risk management requirements for building water systems.

• Survey the building for risk and if risk characteristics found (devices and building types), implement a water management program

Elements of Water Management Program

Program Team – Persons responsible for Program development and implementation.

Water Systems/Flow Diagrams – Describe potable and non-potable water systems and develop water system-schematics.

Water System Analysis/Control Measures – Evaluate where hazardous conditions may occur and decide where control measures should be applied.

Monitoring/Corrective Actions – Establish procedure for monitoring whether control measures are within operating limits and, if not, take corrective actions.

Confirmation – Establish procedure to confirm Program is being implemented as designed (verification) and the Program effectively controls the hazardous conditions (validation).

Documentation – Establish documentation and communication procedures for all activities of the Program.

Elements of aWater Management Program

• Validation Evidence that confirms the effectiveness of

the plan How to you know Legionella is being

controlled?• Establish validation measures

Confirmation – Establish procedure to confirm Program is being implemented as designed (verification) and the Program effectively controls the hazardous conditions (validation).

Legionella Testing

• Legionella testing can verify the performance of water treatment & water safety plans

CDC Toolkit and Legionella Testing

CDC Toolkit 2017

Environmental testing for Legionella is useful to validate the effectiveness of

control measures.

Revised Standard 188-2018

2018 Code-intended Language

Code Change and Regulations

• ASHRAE Standard 188 is a voluntarystandard

• Legionella prevention, detection and control requirements should be incorporated into building and plumbing code

Water Safety and Management Plan

• Section 8. Requirements For Designing Building Water Systems

Requirements for Designing Building Water Systems

• General• Final Installation Documents• Balancing• Commissioning

Standard 188-2018Normative Annex AHealthcare Facilities

Centers for Medicare and Medicaid Services (CMS)

Requirements for Surveyors and Healthcare Facilities

• This policy memorandum applies to: Hospitals, Critical Access Hospitals

(CAHs) and Long-Term Care (LTC). This policy memorandum is also

intended to provide general awareness for all healthcare organizations.

Effective Immediately

• Conduct a risk assessment to identify where Legionella and other opportunistic waterborne pathogens could grow and spread in the water system

CMS Expects Water Management

• Implement a water management program that considers the ASHRAE industry standard and the CDC toolkit

• Includes control measures such as physical controls, temperature management, disinfectant level control, visual inspections and

• Environmental testing for pathogens.

CMS July 6 Revision

CMS Eliminates Requirement For Legionella Testing

• Note: CMS does not require water cultures for Legionella or other opportunistic waterborne pathogens. Testing protocols are at the discretion of the provider.

• What happened between June 2017 and July 2018? CMS was lobbied to remove this provision.

DISINFECTION APPROACHES

I Have Legionella in My Building…Now What?

DISINFECTION OPTIONS

Secondary Disinfection Methods

• Thermal shock treatment(heat & flush)

• Shock chlorination (>10 mg/L residual), may require water tanks to be 20-50 mg/L

• Continuous chlorination (2-4 mg/L)

• Copper-silver ionization (continuous and short-course)

• Chlorine Dioxide (ClO2)• Monochloramine• Point-of-use filtration

How to Choose?

Evidence-based Approach to Evaluating Efficacy

• Do some research – don’t assume the salesperson will tell you everything you need to know Consult with experts Get information from other users of the

technology Don’t “google” it!

Efficacy of Disinfection Methods

• Testing should be performed to demonstrate efficacy: Baseline testing prior to installation and

start-up Test within 2-4 weeks of start-up Test quarterly for one year Adjust monitoring schedule based upon

performance and patient risk

Field Evaluation: Monochloramine

Field Evaluation: Point-of-Use Filtration

AJIC 2014; 42: 1193-1196

Journal Am Water Works Assoc 2014; 106(10): 24-32

Disinfection Review

Resourcewww.legionella.org

Summary

• Potable Water systems, especially in hospitals (and other buildings) with complex hot water systems, are the most important source of Legionellatransmission.

Summary

• Each building owner must assess the risk and validate their water management plans to demonstrate control of the hazard (Legionella).

• Determining the risk or validating a water management plan cannot be done without testing for Legionella.

Any organization that disputes this and tells people

not to testtheir water systems

as part of an effective preventionstrategy

is at best foolish and at worst endangering lives

Janet E. Stout, PhD, September 13, 2018Plumbing Engineer: Vol 46 (9)

https://www.phcppros.com/publications/1-plumbing-engineer

Join Me In The Fight To Protect!

TESTING PLAYS AN IMPORTANT ROLE IN

DISEASE PREVENTION

Your Future Legionella Prevention Report Card

We Can End Legionnaires’ Disease!

FILTRATION & DISINFECTION SOLUTIONS

Michael Ditton – Evoqua Product Manager

TYPICAL COOLING WATER SYSTEMOpen and Closed Cooling Systems

Make up Water

Side stream or full flow Filtration

Basin Agitation

Blowdown Filtration

Chilled Loop Filtration

WHAT’S IN YOUR WATER?

Turbidity TSS pH Hardness Anions/Cations Particle Size

WHERE DOES FILTRATION FIT INTO COOLING SYSTEMS

Selecting The Right Technology• Makeup water quality• Water quality objective• Application• Current chemical treatment

program• Cycles of concentration• Footprint requirements• Maintenance & operating

requirements

COOLING SYSTEM FILTRATION OPTIONSHigh Efficiency Microsand Filtration Self-Cleaning Screen Filtration

Microsand and Cross Flow hydraulic pattern create high performance filtration results

Utilize a weave-wire screen filtering element

Submicron Performance Continuous filtration down to 10 micron

Up to 80% less water used (compared to mmf) per backwash due to shallow media bed

Low water use (for rinse – no traditional backwash)

Small system footprint due to high flux rate

Small footprint (No skid required)

LEGIONELLA CONTROL – DISINFECTION OPTIONS1. Ultraviolet (UV) Light

• Prefer full flow treatment• Hot or cold water systems• No residual provided• No environmental or health impact

2. Chlorine Dioxide• Full or side stream treatment• Hot or cold water systems• No environmental or health impact

3. Applications – cooling towers, hospitals, nursing and retirement homes, pools and spas and many more

THANK YOU

Dr. Janet E. StoutPresident, Microbiologistinfo@specialpathogenslab.com

Michael DittonEvoqua Product Managermichael.ditton@evoqua.com

LEGIONELLA - Evoqua · ©2018 Evoqua Water Technologies Confidential | Page 1 TRANSFORMING WATER....

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