Lectures on Computational Biology

HC LeeComputational Biology Lab

Center for Complex Systems & BiophysicsNational Central University

EFSS IINational DongHua University

Hualien, 2002 July 1-5

What is Computational Biology?The use of computational techniques to model biological

systems at various levels of complexity - atomic, metabolic, cellular and pathologic.

Central dogma for molecular biology

DNA

RNA

Protein

Yeast alanyl transfer RNA

DNA

StandardGenetic

Code

Amino acid codes Name, 3-letter and single-letter codes

Aspartic Acid Asp D Glutamic Acid Glu E Phenylanine Phe F Glycine Gly G Alanine Ala A Cystine Cys C Histidine His H Isoleucine Ile I Lysine Lys K Leucine Leu L Methionine Met M Asparagine Asn N Proline Pro P Glutamine Gln Q Arginine Arg R Serine Ser S Threonine Thr T Valine Val VTryptophan Trp W Tyrosine Tyr Y

A protein cartoon Sperm whale myoglobin (1MBN)

The Protein Folding Problem

Central Paradigm

Central paradigm for Bioinformatics

Lecture 1

Sequence Alignment

Lecture 2

Hidden Markov Model

Lecture 3

Molecular Evolution and Phylogeny

Lecture 4

Microarray & Analysis