Post on 03-Mar-2016
description
LAMPIRAN G
PERHITUNGAN DOSIS UJI KELOMPOK PERLAKUAN DOSIS
1, perlakuan awal
- Dosis 400 mg/ kg BB
C = 400 = 61 mg = 0,061 g
C =
= 0,0203 g/ml x 5 ml = 0,1015 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 106,2 mg = 0,1062 g
C =
= 0,0354 g/ml x 5 ml = 0,177 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 132,3 mg = 0,1323 g
C =
= 0,0354 g/ml x 5 ml = 0,177 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-0
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
290,73240,60250,63
260,65260,65220,55
280,70300,75250,63
250,63320,80250,63
240,60310,78300,75
2, Perlakuan minggu ke-1
- Dosis 400 mg/ kg BB
C = 400 = 61,2 mg = 0,0612 g
C =
= 0,0204 g/ml x 5 ml = 0,102 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 81 mg = 0,081 g
C =
= 0,027 g/ml x 5 ml = 0,135 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 127,8 mg = 0,1278 g
C =
= 0,0426 g/ml x 5 ml = 0,213 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke 1
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
300,75200,50200,50
280,70200,50240,60
270,68220,55240,60
260,65250,63250,63
190,48240,60270,68
3, Perlakuan minggu ke-2
- Dosis 400 mg/ kg BB
C = 400 = 58,4 mg = 0,0584 g
C =
= 0,0292 g/ml x 5 ml = 0,146 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 90 mg = 0,09 g
C =
= 0,036 g/ml x 5 ml = 0,18 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 144 mg = 0,144 g
C =
= 0,0576 g/ml x 5 ml = 0,288 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-2
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
250,63270,68220,55
300,75180,45290,73
300,75200,50230,58
290,73260,63300,75
320,80270,68310,78
4, Perlakuan minggu ke-3
- Dosis 400 mg/ kg BB
C = 400 = 56,8 mg = 0,0568 g
C =
= 0,02272 g/ml x 5 ml = 0,1136 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 79,2 mg = 0,0792 g
C =
= 0,0792 g/ml x 5 ml = 0,1584 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 152,1 mg = 0,1521 g
C =
= 0,0507 g/ml x 5 ml = 0,2535 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-3
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
250,63250,63230,58
280,70220,55300,75
300,75260,65240,60
290,73270,68320,80
300,75320,80330,83
5, Perlakuan minggu ke-4
- Dosis 400 mg/ kg BB
C = 400 = 57,6 mg = 0,0576 g
C =
= 0,0576 g/ml x 5 ml = 0,1152 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 75,6 mg = 0,0756 g
C =
= 0,03024 g/ml x 5 ml = 0,1512 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 141,3 mg = 0,1413 g
C =
= 0,0471 g/ml x 5 ml = 0,2355 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-4
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
250,63240,60250,63
310,78220,55280,70
320,80260,65200,50
260,65250,63310,78
300,75290,73270,68
PERHITUNGAN DOSIS UJI KELOMPOK PERLAKUAN SATELIT
1, Perlakuan awal
- Dosis 400 mg/ kg BB
C = 400 = 55,2 mg = 0,0552 g
C =
= 0,02208 g/ml x 5 ml = 0,1104 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 72,6 mg = 0,0726 g
C =
= 0,02904 g/ml x 5 ml = 0,1452 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 111,6 mg = 0,1116 g
C =
= 0,04464 g/ml x 5 ml = 0,2232 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-0
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
240,60220,65280,70
280,70200,50290,73
350,88280,70220,55
270,68250,63240,60
240,60260,65210,53
2, Perlakuan minggu ke-1
- Dosis 400 mg/ kg BB
C = 400 = 52 mg = 0,052 g
C =
= 0,0208 g/ml x 5 ml = 0,104 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 67,2 mg = 0,0672 g
C =
= 0,02688 g/ml x 5 ml = 0,1344 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 107,1 mg = 0,1071 g
C =
= 0,04284 g/ml x 5 ml = 0,2142 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-1
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
250,63200,50240,60
250,63190,48250,63
320,80240,60220,55
250,63240,60230,58
230,58250,63250,63
3, Perlakuan minggu ke-2
- Dosis 400 mg/ kg BB
C = 400 = 56 mg = 0,056 g
C =
= 0,0224 g/ml x 5 ml = 0,112 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 72 mg = 0,072 g
C =
= 0,0288 g/ml x 5 ml = 0,144 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 94,5 mg = 0,0945 g
C =
= 0,04725 g/ml x 5 ml = 0,23625 g dalam 5 ml aquadest,
Tabel volume pemberian
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
260,65200,50310,78
260,65290,73250,63
290,73200,50200,50
340,85250,6300
250,63260,65290,73
4, Perlakuan minggu ke-3
- Dosis 400 mg/ kg BB
C = 400 = 58,8 mg = 0,0588 g
C =
= 0,02352 g/ml x 5 ml = 0,1176 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 68,4 mg = 0,0684 g
C =
= 0,02736 g/ml x 5 ml = 0,1368 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 99,9 mg = 0,0999 g
C =
= 0,04995 g/ml x 5 ml = 0,24975 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-3
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
270,53160,40230,58
270,50230,58230,58
300,73200,50200,50
330,85240,6000
300,73260,65250,63
5, Perlakuan minggu ke-4
- Dosis 400 mg/ kg BB
C = 400 = 53,2 mg = 0,0532 g
C =
= 0,02128 g/ml x 5 ml = 0,1064 g dalam 5 ml aquadest,
- Dosis 600 mg/ kg BB
C = 600 = 61,8 mg = 0,0618 g
C =
= 0,02472 g/ml x 5 ml = 0,1236 g dalam 5 ml aquadest,
- Dosis 900 mg/ kg BB
C = 900 = 81,9 mg = 0,0819 g
C =
= 0,04095 g/ml x 5 ml = 0,20475 g dalam 5 ml aquadest,
Tabel volume pemberian minggu ke-4
Dosis 400 mg/kg BBDosis 600 mg/kg BBDosis 900 mg/kg BB
Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)Berat badan (g)Volume (ml)
210,53160,40230,58
200,50230,58230,58
290,73200,50200,50
340,85240,6000
290,73260,65250,63
LAMPIRAN H
DATA PENIMBANGAN BERAT BADAN
BERAT BADAN KELOMPOK PERLAKUAN
Nomor kelompok mencitBerat badan
Perlakuan awalMinggu ke-1Minggu ke-2Minggu ke-3Minggu ke-4Sebelum bedah
Kontrol
1222425232323
2232732323233
3292825262726
4232230323334
5282527272729
Dosis 400 mg/ kg BB
1293025252526
226283028310
3282730303232
4252629292627
6222332303030
Dosis 600 mg/ kg BB
7242027252428
8262018222220
10322526262625
11312427272528
12342432322933
Dosis 900 mg/ kg BB
13252022232527
14222425302832
15252423242024
16252530323133
17302731332723
BERAT BADAN KELOMPOK SATELIT
Nomor kelompok mencitBerat badan
Perlakuan awalMinggu ke-1Minggu ke-2Minggu ke-3Minggu ke-4Sebelum bedah
Kontrol
1222425232323
2232732323233
3292825262726
4232230323334
5282527272729
Dosis 400 mg/ kg BB
19242526272129
2028252627200
2135322930290
22272534333437
23242325302930
Dosis 600 mg/ kg BB
2422202019160
25201929262325
26282420212024
27252425262426
2826252622260
Dosis 900 mg/ kg BB
29282431312325
20292525262325
31222220242030
3321252930250
34252529302525
LAMPIRAN I
DATA PENIMBANGAN BERAT ORGAN
Tabel berat organ mencit kelompok perlakuan
No, BBJantungParu-paruLimphaHeparGinjalOvarium
Kontrol negatif
1230,10500,31430,10961,05020,45430,3130
2330,10370,21360,18831,14880,36370,2172
3260,10250,20010,19701,33560,43730,0840
4340,15060,40000,16371,59670,67490,2595
5290,12200,19640,14541,45050,50330,1316
Dosis 400 mg/kg BB
1260,09490,16530,17921,22460,24470,1147
2310,12500,35050,50431,46000,35430,1563
3320,13460,26830,23871,80340,36460,1288
4270,14340,24880,22161,92140,47710,2143
6300,12850,31870,17481,58810,40460,2004
Dosis 600 mg/ Kg BB
7280,12720,21060,15241,49210,33840,0971
8200,10930,15460,14311,04120,28880,1498
10250,12560,30170,22381,65390,39640,2325
11280,10110,31700,19321,45900,33870,0892
12330,15280,34490,23551,64080,33770,1671
Dosis 900 mg/ Kg BB
13270,11050,33930,20851,63550,31120,1544
14320,10520,18700,15811,42870,30970,1414
15240,12000,16950,17041,24210,25530,1706
16330,14320,24030,27411,71460,40950,1023
17230,13010,20760,15041,58040,29550,1295
Tabel berat organ mencit kelompok satelit
No,BBJantungParu-paruLimphaHeparGinjalOvarium
Kontrol negatif
1230,10500,31430,10961,05020,45430,3130
2330,10370,21360,18831,14880,36370,2172
3260,10250,20010,19701,33560,43730,0840
4340,15060,40000,16371,59670,67490,2595
5290,12200,19640,14541,45050,50330,1316
Dosis 400 mg/kg BB
19290,15150,27220,19581,94440,39490,1322
20200,10850,25280,08751,00850,31650,0495
21290,16300,35900,12501,70900,21200,2560
22370,10650,26650,35471,91080,42320,0871
23300,15930,26240,11061,45770,34500,1859
Dosis 600 mg/ Kg BB
24160,11620,17660,19700,91550,29190,0560
25250,11560,30380,19051,26520,39160,1728
26240,09450,24190,18861,56850,28560,0828
27260,10600,29940,09721,22690,34290,2314
28260,38170,28270,12311,14880,33640,1103
Dosis 900 mg/ Kg BB
29250,12000,27070,11381,49880,29190,0560
20250,09360,17660,13981,35880,26540,1284
31300,16890,24220,26451,97010,40630,2075
33250,26760,23240,12310,91550,34300,1103
34250,38170,29270,25241,22560,47060,5064
LAMPIRAN J
DATA PERHITUNGAN INDEKS ORGAN
Tabel indeks organ mencit kelompok perlakuan
No, BBJantungParu-paruLimphaHeparGinjalOvarium
Kontrol negatif
1230,45651,36650,47654,56611,97521,3609
2330,31420,64730,57063,48121,10210,6582
3260,39420,76960,75775,13691,68190,3231
4340,44291,17650,48154,69621,98500,7632
5290,42070,67720,50145,00171,73550,4538
Dosis 400 mg/kg BB
1260,36500,63580,68924,71000,94120,4412
2310,40321,13061,62684,70971,14290,5042
3320,42060,83840,74595,63561,13940,4025
4270,53110,92150,82077,11631,76700,7937
6300,42831,06230,58275,29371,34870,6680
Dosis 600 mg/ Kg BB
7280,45430,75210,54435,32891,20860,3468
8200,54650,77300,71555,20601,44400,7490
10250,50241,20680,89526,61561,58560,9300
11280,36111,13210,69005,21071,20960,3186
12330,46301,04520,71364,97211,02330,5064
Dosis 900 mg/ Kg BB
13270,40931,25670,77226,05741,15260,5719
14320,32880,58440,49414,46470,96780,4419
15240,50000,70630,71005,17541,06380,7108
16330,43390,72820,83065,19581,24090,3100
17230,56570,90260,65396,87131,28480,5630
Tabel indeks organ mencit kelompok satelit
No, BBJantungParu-paruLimphaHeparGinjalOvarium
Kontrol negatif
1230,45651,36650,47654,56611,97521,3609
2330,31420,64730,57063,48121,10210,6582
3260,39420,76960,75775,13691,68190,3231
4340,44291,17650,48154,69621,98500,7632
5290,42070,67720,50145,00171,73550,4538
Dosis 400 mg/kg BB
19290,52240,93860,67526,70481,36170,4559
20200,54251,26400,43755,04251,58250,2475
21290,56211,23790,43105,89310,73100,8828
22370,28780,72030,95865,16431,14380,2354
23300,53100,87470,36874,85901,15000,6197
Dosis 600 mg/ Kg BB
24160,72631,10381,23135,72191,82440,3500
25250,46241,21520,76205,06081,56640,6912
26240,39381,00790,78586,53541,19000,3450
27260,40771,15150,37384,71881,31880,8900
28261,46811,08730,47254,41851,29380,4242
Dosis 900 mg/ Kg BB
29250,48001,08280,45525,99521,16760,2240
20250,37440,70640,55925,43521,06160,5136
31300,56300,80730,88176,56701,35430,6917
33251,07040,92960,49243,66201,37200,4412
34251,52681,17081,00964,90241,88242,0256
LAMPIRAN L
ANALISIS DATA INDEKS ORGAN
BERAT BADAN DAN JUMLAH JENGUKAN
1. Tabel analisis data indeks organ ginjal
Test of Homogeneity of Variances
organ_ginjal
Levene Statisticdf1df2Sig.
0.4116280.865
ANOVA
organ_ginjal
Sum of SquaresdfMean SquareFSig.
Between Groups1.0256.1712.144.080
Within Groups2.23128.080
Total3.25734
2. Tabel analisis data indeks organ jantung
Test of Homogeneity of Variances
organ_jantung
Levene Statisticdf1df2Sig.
6.357628.000
ANOVA
organ_jantung
Sum of SquaresdfMean SquareFSig.
Between Groups.6946.1161.705.157
Within Groups1.89828.068
Total2.59134
Kruskal-Wallis Test
Ranks
indeks organNMean Rank
organ_jantungkontrol negatif511.40
p1 400 mg513.20
p2 600 mg518.40
p3 900 mg516.40
s1 400 mg521.20
s2 600 mg520.40
s3 900 mg525.00
Total35
Test Statisticsa,b
organ_jantung
Chi-Square6.396
df6
Asymp. Sig..380
a. Kruskal Wallis Test
b. Grouping Variable: indeks organ
3. Analisis data indeks organ paru-paru
Test of Homogeneity of Variances
organ_paru_paru
Levene Statisticdf1df2Sig.
2.307628.062
ANOVA
organ_paru_paru
Sum of SquaresdfMean SquareFSig.
Between Groups.2246.037.741.621
Within Groups1.41328.050
Total1.63734
4. Analisis data indeks organ limpa
Test of Homogeneity of Variances
organ_limpha
Levene Statisticdf1df2Sig.
1.798628.136
ANOVA
organ_limpha
Sum of SquaresdfMean SquareFSig.
Between Groups.3706.062.946.479
Within Groups1.82528.065
Total2.19534
5. Analisis data indeks organ hepar
Test of Homogeneity of Variances
organ_hepar
Levene Statisticdf1df2Sig.
.446628.842
ANOVA
organ_hepar
Sum of SquaresdfMean SquareFSig.
Between Groups3.5246.587.785.589
Within Groups20.95128.748
Total24.47534
6. Analisis data indeks organ ovarium
Test of Homogeneity of Variances
organ_ovarium
Levene Statisticdf1df2Sig.
1.818628.132
ANOVA
organ_ovarium
Sum of SquaresdfMean SquareFSig.
Between Groups.3476.058.437.848
Within Groups3.70628.132
Total4.05334
7. Analisis data berat badan mencit
Test of Homogeneity of Variances
Levene Statisticdf1df2Sig.
minggu_0.549628.767
minggu_1.616628.716
minggu_2.429628.853
minggu_31.365628.263
minggu_41.850628.125
sebelum_bedah4.578628.002
ANOVA
Sum of SquaresdfMean SquareFSig.
minggu_0Between Groups98.343616.3901.317.282
Within Groups348.4002812.443
Total446.74334
minggu_1Between Groups81.886613.6482.090.086
Within Groups182.800286.529
Total264.68634
minggu_2Between Groups85.086614.181.929.489
Within Groups427.2002815.257
Total512.28634
minggu_3Between Groups145.771624.2952.137.080
Within Groups318.4002811.371
Total464.17134
minggu_4Between Groups198.286633.0482.212.072
Within Groups418.4002814.943
Total616.68634
sebelum_bedahBetween Groups779.1436129.8571.029.427
Within Groups3532.40028126.157
Total4311.54334
Kruskal-Wallis Test
Ranks
perubahan_berat_badanNMean Rank
sebelum_bedah1523.40
2519.70
3519.60
4520.20
5518.70
659.90
7514.50
Total35
Test Statisticsa,b
sebelum_bedah
Chi-Square5.667
df6
Asymp. Sig..461
a. Kruskal Wallis Test
b. Grouping Variable: perubahan_berat_badan
Analisis jengukan mencit
Test of Homogeneity of Variances
jengukan_mencit
Levene Statisticdf1df2Sig.
2.4106189.029
ANOVA
jengukan_mencit
Sum of SquaresdfMean SquareFSig.
Between Groups242.214640.3693.604.002
Within Groups2116.78618911.200
Total2359.000195
Multiple Comparisons
jengukan_mencit
Tukey
jumlah_jengukan jumlah_jengukanMean Difference (I-J)Std. ErrorSig.95% Confidence Interval
Lower BoundUpper Bound
kontrol negatifp1-.821.894.969-3.491.84
p2-2.286.894.146-4.95.38
p3-2.929*.894.021-5.59-.26
s1-.250.8941.000-2.922.42
s2-.357.8941.000-3.022.31
s3.143.8941.000-2.522.81
p1kontrol negatif.821.894.969-1.843.49
p2-1.464.894.658-4.131.20
p3-2.107.894.224-4.77.56
s1.571.894.995-2.093.24
s2.464.894.999-2.203.13
s3.964.894.934-1.703.63
p2kontrol negatif2.286.894.146-.384.95
p11.464.894.658-1.204.13
p3-.643.894.991-3.312.02
s12.036.894.261-.634.70
s21.929.894.325-.744.59
s32.429.894.100-.245.09
p3kontrol negatif2.929*.894.021.265.59
p12.107.894.224-.564.77
p2.643.894.991-2.023.31
s12.679*.894.048.015.34
s22.571.894.067-.095.24
s33.071*.894.013.415.74
s1kontrol negatif.250.8941.000-2.422.92
p1-.571.894.995-3.242.09
p2-2.036.894.261-4.70.63
p3-2.679*.894.048-5.34-.01
s2-.107.8941.000-2.772.56
s3.393.894.999-2.273.06
s2kontrol negatif.357.8941.000-2.313.02
p1-.464.894.999-3.132.20
p2-1.929.894.325-4.59.74
p3-2.571.894.067-5.24.09
s1.107.8941.000-2.562.77
s3.500.894.998-2.173.17
s3kontrol negatif-.143.8941.000-2.812.52
p1-.964.894.934-3.631.70
p2-2.429.894.100-5.09.24
p3-3.071*.894.013-5.74-.41
s1-.393.894.999-3.062.27
s2-.500.894.998-3.172.17
*. The mean difference is significant at the 0.05 level.
LAMPIRAN M
TABEL CHI-SQUARE