Joint Meeting Neurotoxicity Society and

International Neurotoxicology Association

Hotel Slaviero Essential Florianópolis Ingleses – Acquamar Florianópolis, Brazil

Dear Conference Participants, Welcome to the 2017 Joint Meeting of the Neurotoxicity Society and the International Neurotoxicology Association. We value your participation in this meeting. Your contributions to the discussions of recent advancements in neurotoxicology. From such interactions and scientific exchanges across the two societies we hope to build upon the framework to chart the future of neurotoxicity research. We hope you enjoy and find intellectually fulfilling this confluence of scientists that have been brought together from around the world as we all learn of the latest research and advances in neurotoxicology. Many people have worked with considerable effort to bring us all together. We thank them all.

Best regards,

Gustavo Ferreira, Ph.D. Alexandra Latini, Ph.D. Co-Chair Conference Host Committee Co-Chair Conference Host Committee Universidade Federal do Rio de Janeiro Universidade Federal de Santa Catarina Rio de Janeiro, Brasil Florianópolis, SC, Brasil

Maria-Trinidad Herrero, MD, MPhil, Ph.D. Edward D. Levin, Ph.D. President, Neurotoxicity Society President, International Neurotoxicology Association University of Murcia, Spain Duke University, Durham, NC, USA

May 20 16:00-17:30 Registration Florianópolis Room 17:00-17:30: Opening remarks and welcome from the Presidents and Local Hosts 17:30-18:30: Jacob Hooisma Keynote Lecture: Parkinson’s disease: At the intersection of genes and environment

J. Timothy Greenamyre, M.D., Ph.D., University of Pittsburgh, PA, USA. jgreena@pitt.edu 18:30-19:30: Reception (ticket required)

May 21 Florianópolis Room

8:00-9:00: Workshop Agilent Technologies Workshop on Mitochondrial Bioenergetics

Carolyn Dazzo Gouchoe, Ph.D., Natalia Romero, Ph.D. Diets, Mitochondria and the Brain; Alicia J. Kowaltowski, M.D., Ph.D., University of São Paulo, São Paulo, Brazil.

9:10-10:30 Neuroinflammation and Neurodegeneration Chair: Patrícia F. Schuck Ph.D., Universidade do Extremo Sul Catarinense. Criciúma, Brazil. patischuck@gmail.com

Neuroinflammation in systemic inflammatory diseases Felipe Dal Pizzol, Ph.D., fdpizzol@gmail.com

Influence of a physiologically relevant brain oxygen tension on mitochondrial respiratory impairment in inflammatory microglia Evan Bordt, University of Maryland, Baltimore, MD, USA. ebordt@umaryland.edu

Administration of branched-chain amino acids alters the balance between pro- and anti-inflammatory cytokines, and induces cerebral oedema, and blood-brain barrier breakdown

Emilio Luis Streck, PhD - Universidade do Extremo Sul Catarinense. Criciúma, Brazil. emiliostreck@gmail.com Cognitive deficit and neuroinflammation in phenylketonuria: is there a link?

Patrícia F. Schuck Ph.D., Universidade do Extremo Sul Catarinense. Criciúma, Brazil. patischuck@gmail.com

10:30 – 11:00: Break

11:00-12:10: Neuroinflammation: Reaction and Regulation Chair: Rommy Von Bernhardi R., Ph.D., Pontificia Universidad Católica de Chile, Santiago, Chile. rvonb@med.puc.cl

Increased neuroinflammation and neurodegenerative changes secondary to age-associated changes of Scavenger-A as a novel pathophysiological mechanism for Alzheimer’s disease.

Rommy Von Bernhardi R., Ph.D., Pontificia Universidad Católica de Chile, Santiago, Chile. rvonb@med.puc.cl Inhibition of inflammasome activation by neopterin

Roberta de Paula Martins, Ph.D., Universidade Federal de Santa Catarina, Florianópolis, Brazil. robertamartinsss@gmail.com Can neurotoxic metals influence an inflammatory response or serve as an inflammasome trigger?

G. Jean Harry, Ph.D., NIEHS, Research Triangle Park, NC, USA. harry@niehs.nih.gov

12:10 – 13:10: Lunch

13:10-14:30: NeuroInflammation and Viral Infection in the Process of Neuropathology (Sponsored by International Society for Neurochemistry) Chairs: Italo Mocchetti, Ph.D., Georgetown University, Washington, DC, USA. moccheti@georgetown.edu

G. Jean Harry, Ph.D., NIEHS, Research Triangle Park, NC, USA. Mechanisms of Zika infection, toxicity, and pathogenesis within the human nervous system.

Eliseo Eugenin, Ph.D., Rutgers, The State University of New Jersey, Newark, NJ, USA. eugeniea@njms.rutgers.edu Retroviruses and neurodegeneration

Joseph Steiner Ph.D., National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. steinerjp@ninds.nih.gov Chemokines and neurodegeneration in HIV-1 infection

Marcus Kaul, Ph.D., University of California, San Diego, CA, USA. mkaul@sanfordburnham.org Neurotoxicity of HIV protein gp120

Italo Mocchetti, Ph.D., Georgetown University, Washington, DC, USA. moccheti@georgetown.edu

14:30 – 15:00: Break

15:00-16:00: Antibiotics Action In Neurological Diseases: In Vivo and In Vitro Advancing Mechanistic Understanding Chairs: Elaine Del-Bel, Ph.D., USP-Ribeirao Preto-Brazil, Sao Paulo, Brazil. eadelbel@forp.usp.br Rita Raisman-Vozari, Ph.D., INSERM Paris, Paris, France. ritaraisman@gmail.com

A study on the inflammatory reaction in the L-DOPA-induced dyskinesia in a Parkinson’s disease rat model Mariza Bortolanza, Ph.D., USP-Ribeirao Preto, Sao Paulo, Brazil. marizabortolanza@usp.br

A study on the protective role of doxycycline upon dopaminergic neurons in Parkinson’s Disease rodent model Elaine Del-Bel, Ph.D., USP-Ribeirao Preto-Brazil, Sao Paulo, Brazil. eadelbel@forp.usp.br

Role of doxycline in neuroinflammation and protein aggregation Rita Raisman-Vozari, Ph.D., INSERM Paris, Paris, France. ritaraisman@gmail.com

16:00 – 17:00: Regulated Necrosis and Associated Non-Apoptotic Mechanisms in Neurotoxicity Chair: Michael A. Collins, Ph.D. Loyola University Chicago, IL, USA. mcollin@luc.edu

Binge alcohol and brain neuronal necrosis Michael A. Collins, Ph.D., Stritch School of Medicine, Maywood IL, USA. mcollin@luc.edu

Programmed necrosis in photoreceptors: Implications for AMD and other retinal degenerations Demetrios G. Vavvas, M.D., Ph.D., Harvard Medical School, Boston MA, USA. demetrios_vavvas@meei.harvard.edu

Cellular senescence as an alternative programmed pathway in brain cells under stress: potential role in Parkinson’s Disease (PD). Julie K. Andersen, Ph.D., Buck Research Institute for Age Research, Novato CA, USA. jandersen@buckinstitute.org

May 21 Ingleses Room

9:10-10:30: Advances in the Neurotoxicology of Abused Drugs Chairs: Yousef Tizabi, Ph.D., Howard University. Washington, DC, USA. ytizabi@howard.edu

Emmanuel Onaivi, Ph.D., William Paterson University, Wayne NJ, USA. onaivie@wpunj.edu

Behavioral and neurobiological effects of low and high alcohol dose Yousef Tizabi, Ph.D., Howard University. Washington, DC, USA. ytizabi@howard.edu

Leading to drug addiction: participation of ethanol metabolizing enzymes in the increased voluntary ethanol intake in perinatally-lead-exposed rats

Miriam B Virgolini, Ph.D., Universidad Nacional de Córdoba. Argentina. miriam.virgolini@gmail.com 3,4-methylenedioxymethamphetamine: abuse potential and neurodegenerative effects

Nicola Simola, Ph.D., University of Cagliari, Cagliari, Italy. nicola.simola@gmail.com Neurobiology of compulsive behaviors: Translational tools in addiction

Emmanuel Onaivi, Ph.D., William Paterson University, Wayne, NJ, USA. onaivie@wpunj.edu

10:30-11:00: Break

11:00-12:10: Neurotoxicity of New Psychoactive Substances: From molecular target to clinical toxicology Chairs: Laura Hondebrink, Ph.D., University Medical Center Utrecht. Utrecht, The Netherlands. L.Hondebrink@umcutrecht.nl

Remco H.S. Westerink, Utrecht University. Utrecht, The Netherlands. r.westerink@uu.nl

Introduction on new psychoactive substances (NPS): occurrence, prevalence of use and their primary mode of action Laura Hondebrink Ph.D., University Medical Center Utrecht. Utrecht, The Netherlands. L.Hondebrink@umcutrecht.nl

Neurotoxicity screening for acute effects of new psychoactive substances (NPS) on neuronal activity using cortical neurons and human iPSC-derived neurons grown on microelectrode array (mwMEA) plates

Remco Westerink Ph.D., Utrecht University, Utrecht, The Netherlands. r.westerink@uu.nl Overview of desired and unwanted (acute toxicity) effects following NPS exposure in humans

David Wood, MD, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, and School of Medicine and Life Sciences, King's College London, London, UK. David.Wood@gstt.nhs.uk

12:10 – 13:10 Lunch

13:10-14:30 Platform Session 1 Chair: Emilio Streck, Ph.D., UNESC emiliostreck@gmail.com

The place of epigenetics in the effect of alcohol on brain plasticity Laurence Lanfumey, Ph.D., Centre of Psychiatry and Neuroscience, Sainte Anne Hospital, Paris, France. laurence.lanfumey@inserum.fr

Cholesterol metabolism in adult neural stem cells: Impaired adult hippocampal neurogenesis in an animal model of familial hypercholesterolemia

Daiane F. Engel, Ph.D., Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil. daiane.engel01@gmail.com

Role of hypothalamic HIF-1 complex in the regulation of energy homeostasis Joana M. Gaspar, Ph.D., University of Campinas, Campinas, SP, Brazil. joanamgaspar@gmail.com

14:30-15:00: Break

15:00-15:40 Platform Session 1 (continued) Chair: Emilio Streck, Ph.D., UNESC emiliostreck@gmail.com Isovitexin rich fraction of Passiflora actinia extract provides cognitive improvement and neuroprotection after cerebral ischemia in mice

Simone Molz, Ph.D., Pharmacy School, Contestado University, Canoinhas, SC, Brazil. simonem@unc.br Restoration of cognitive performance in mice carrying a deficient allele of 8-oxoGuanine DNA glycosylase by x-ray irradiation

Tim Hofer, Ph.D., Norwegian Institute of Public Health, Oslo, Norway. tim.hofer@fhi.no 15:40-17:00: Different Aspects of Adverse Effects on the CNS of Stress-Related Factors Such as Glutamate and Ammonia Chairs: Marta C. Antonelli, Ph.D., Universidad de Buenos Aires. Buenos Aires, Argentina. mca@fmed.uba.ar

Arne Schousboe, D.Sc, University of Copenhagen. Copenhagen, Denmark. arne.schousboe@sund.ku.dk Hepatic encephalopathy and hyperammonemia lead to altered brain energy metabolism, GABAergic neurotransmission and behavioral deficits in the animal model of bile duct-ligation.

Renata Leke, Ph.D., University of Göteborg. Göteborg, Sweden. renata.leke@neuro.gu.se Metabotropic glutamate receptors and neurodegeneration

Ferdinando Nicoletti, M.D., University of Catania, Catania, Italy. nicoletti@neuromed.it Maternal behavior, glutamate and oxytocin balance in the perinatal stress rat model

Stefania Maccari, Ph.D., University of Lille 1, France, University of Rome, Italy. stefania.maccari@univ-lille1.fr Glutamate metabolism impairment in a rat model of prenatal restraint stress.

Marta C. Antonelli, Ph.D., Universidad de Buenos Aires, Buenos Aires, Argentina. mca@fmed.uba.ar

17:30 – 19:30: Poster Session (The listing of posters is at the end of the program.) 20:00 – 22:00: Dinner (ticket required)

May 22 Florianópolis Room 8:30-10:10: Emerging Neurotoxicological Mechanisms in Parkinsonian Neurodegeneration: Advances in Models and Concepts Chairs: Anumantha Kanthasamy Ph.D., Iowa State University, Ames, USA. akanthas@iastate.edu

Marcel Leist, Ph.D., University of Konstanz, Konstanz, Germany. marcel.leist@uni-konstanz.de Mechanisms of α-synuclein aggregation and cell-to-cell transmission of neurotoxic protein oligomers through the exosomal pathway

Anumantha Kanthasamy Iowa State University, Ames, USA. akanthas@iastate.edu Blocking mitochondrial fission is protective against dopaminergic neurodegeneration

Kim Tieu, Ph.D. Florida International University, USA. ktieu@fiu.edu Mechanisms of alpha-synuclein protein aggregates induced neuroinflammation in neurotoxicity models

Arthi Kanthasamy, Ph.D., Iowa State University, Ames, IA, USA. arthik@iastate.edu Impaired mitochondrial transport and proteasome function in human dopaminergic neurodegeneration

Marcel Leist, Ph.D., University of Konstanz, Konstanz, Germany. marcel.leist@uni-konstanz.de Dysregulation of metal transporters in dopaminergic neurodegeneration

Michael Aschner, Ph.D., Albert Einstein College of Medicine, New York, USA. Michael.aschner@einstein.yu.edu 10:10-10:40 Break 10:40-12:00: Mechanisms for Neurodegeneration, Neuroprotection and Treatment in Parkinson´s Disease: 1 Chair: Juan Segura-Aguilar, Ph.D., University of Chile. Santiago, Chile. jsegura@med.uchile.cl Aminochrome as preclinical model for Parkinson´s disease

Juan Segura-Aguilar, Ph.D., University of Chile. Santiago, Chile. jsegura@med.uchile.cl Epigenetic changes and brainstem dysfunction in neuropsychiatric disorders – AD/PD/Anx

Harry W.M. Steinbusch, Ph.D., Maastricht University, Maastricht, The Netherlands. h.steinbusch@maastrichtuniversity.nl Mechanisms of neuroprotection and immunomodulation of phytoestrogens: application for Parkinson disease in perspective

Silvia Costa, Federal University of Bahia, Bahia, Brazil. costasl2011@gmail.com Superimposed control by ATP and adenosine of behavioral dysfunction in animal models of Parkinson’s Disease

Rodrigo A. Cunha, M.D., University of Coimbra, Coimbra, Portugal. cunharod@gmail.com 12:00-13:00: Lunch 13:00-14:20 Mechanisms for Neurodegeneration, Neuroprotection and Treatment in Parkinson´s Disease: 2 Chairs: Rui Daniel Prediger, Ph.D., Universidade Federal de Santa Catarina. Florianópolis, Brazil. ruidsp@hotmail.com

Maria Trinidad Herrero, M.D., Ph.D., University of Murcia. Murcia, Spain. mtherrer@um.es Neuroprotective role of full--length human cerebral dopamine neurotrophic factor (CDNF) against α-synuclein oligomers

Débora Foguel, Ph.D., Universidade Federal do Rio de Janeiro, Rio de Janiero, Brazil. foguel@bioqmed.ufrj.br Physical activity improves the effects of antiinflammatory treatment in Parkinson’s Disease

María Trinidad Herrero, M.D., Ph.D., University of Murcia, Murcia, Spain. mtherrer@um.es Norepinephrine upregulates the expression of tyrosine hydroxylase and protection against 6-hydrodopamine toxicity in dopamine neurons.

Meng-Yang Zhu, Ph.D., East Tennessee State University, Johnson City, TN, USA. zhum@etsu.edu Depression in Parkinson's disease: Neurobiology and new therapeutic agents

Rui Daniel Prediger, Ph.D., Federal de Santa Catarina, Florianópolis, Brazil. ruidsp@hotmail.com 14:20 – 15:40 Platform Session 2 Chair: Oddvar Myhre, Ph.D., Norwegian Institute of Public Health, Oslo, Norway. Oddvar.Myhre@fhi.no Molecular signatures of Parkinson’s, Alzheimer’s and bipolar diseases: Altered regulons, molecular targets and innovative therapeutic interventions

Fábio Klamt, Ph.D., Laboratory of Cellular Biochemistry, Federal University of Rio Grande do Sul, Brazil. 00025267@ufrgs.br Genetic susceptibility to neurodegeneration in Amazon: apolipoprotein E genotyping in vulnerable populations exposed to mercury

Maria Elena Crespo-López, Ph.D., Universidade Federal do Pará, Belém-PA, Brazil. maria.elena.crespo.lopez@gmail.com Color vision impairments at low-level methylmercury exposure of an Amazonian population at the Madeira River - Brazil

Cláudia Feitosa-Santana, Ph.D., Hospital Israelita Albert Einstein, São Paulo, Brazil. claudia@feitosa-santana.com Advances in Understanding the Mechanism of Dioxin Induced Neurotoxicity

Li Xu, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China. lixu@rcees.ac.cn

May 22 Ingleses Room 8:50-10:10 Developing an Integrated Testing Strategy Using In Vitro Data to Screen and Prioritize Compounds with High Throughput / High Content Methods: 1 Chairs: Tim Shafer, Ph.D., US-Environmental Protection Agency. Research Triangle Park, NC, USA. shafer.tim@epa.gov

David Reif, Ph.D., North Carolina State University, Raleigh, NC, USA. dmreif@ncsu.edu Analytical methods to distill useful information from high-throughput screening of chemicals

David Reif Ph.D., North Carolina State University, Raleigh, NC, USA. dmreif@ncsu.edu Screening the ToxCast Phase II library for acute neurotoxicity using cortical neurons grown on multi-well microelectrode array (mwMEA) plates

Jenna Strickland, Ph.D., Michigan State University, East Lansing, MI, USA. stric100@msu.edu Using developing cortical cultures on microelectrode arrays to identify and prioritize compounds based on changes in network formation

Tim Shafer, Ph.D., US-Environmental Protection Agency. Research Triangle Park, NC, USA. shafer.tim@epa.gov Towards in vitro DT/DNT testing: Assaying chemical susceptibility in early differentiating NT2 cells

Sepideh Abolpour Mofrad, Ph.D., Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. sepideh.abolpour@fau.de

10:10-10:40: Break 10:40-12:00 Developing an Integrated Testing Strategy Using In Vitro Data to Screen and Prioritize Compounds with High Throughput / High Content Methods: 2 Chair: Anna Price, Ph.D., Institute for Health and Consumer Protection, European Commission JRC, Ispra, Italy.

anna.price@ec.europa.eu Applications of human induced pluripotent stem cell (3D) models for neurotoxicity testing

Anke Tukker, MSc, Utrecht University, Utrecht, The Netherlands. a.m.tukker@uu.ul A 3D human brain organotypic model to study developmental neurotoxicology

David Pamies, Ph.D., Center for Alternatives to Animal Testing, John Hopkins University, Baltimore MD, USA. dpamies1@jhu.edu

Creating a developmental neurotoxicity (DNT) testing roadmap for regulatory purposes Anna Price, Ph.D., Institute for Health and Consumer Protection, European Commission JRC. Ispra, Italy. anna.price@ec.europa.eu

Discussion of Session 1 & 2: In vitro evaluations for neurotoxicity assessment and testing 12:00-13:00: Lunch 13:00-13:40: Platform Session 3 Chair: Julie Andersen, Buck Institute for Age Research, Novato CA, USA. jandersen@buckinstitute.org The role of chemical speciation for manganese disrupting cross-talking pathways in cerebellar granule cells and its implication for a putative adverse outcome pathways (AOP) relevant for manganese-induced neurotoxicity and neurodegeneration

Raúl Bonne Hernández, Ph.D., Federal University of São Paulo, Brazil. rara180206@gmail.com Biosafety assessment of nanostructured materials by using co-cultures of neurons and astrocytes

Christina Suñol, Ph.D., IIBB-CSIC-IDIBAPS-CIBERESP; 2ICMAB-CSIC. Barcelona. Spain. cristina.sunyol@iibb.csic.es 13:40-15:20 Physiological Assessment of Sensory Toxicity and the Role in Human Risk Assessment in the 21st Century Chairs: Jordi Llorens, Ph.D. Universitat de Barcelona, Barcelona, Spain. jllorens@ub.edu

William K. Boyes, Ph.D., US-Environmental Protection Agency, Research Triangle Park, USA. boyes.william@epa.gov Vestibular function assessment in humans and in animals exposed to ototoxic compounds

Jordi Llorens, Ph.D., Universitat de Barcelona, Barcelona, Spain. jllorens@ub.edu Membrane fluidity does not explain how solvents act on the middle-ear reflex. Physiological consequences for exposures to noise.

Pierre Campo, Ph.D., Institut National de Recherche et de Sécurté, Vandoeuvre-les-Nancy, France. pierre.campo@inrs.fr Visual impact of occupational exposure to mercury

Dora F. Ventura, Ph.D., Universidade de Sao Paulo, Sao Paulo, Brazil. dventura@usp.br Evaluating visual system toxicity in relation to human risk assessments in the 21st century.

William K. Boyes, Ph.D., US-Environmental Protection Agency, Research Triangle Park, USA. boyes.william@epa.gov

16:00-21:00: Florianópolis Tour and Dinner (ticket required)

May 23 Florianópolis Room 8:30-10:10: Mitochondria-related Metabolism Leading to Neurodegeneration and Neuroprotection Chair: Gustavo C. Ferreira, Ph.D., Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. gustavo.ferreira@bioqmed.ufrj.br

Arne Schousboe, D.Sc, University of Copenhagen. Copenhagen, Denmark. arne.schousboe@sund.ku.dk Mechanisms of neurotoxicity at physiological O2

Brian Polster, Ph.D., University of Maryland School of Medicine, Baltimore MD, USA. bpolster@anes.umm.edu Disruption of mitochondrial functions caused by the major fatty acids accumulating in long-chain fatty acid oxidation defects

Moacir Wajner, Ph.D., Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. mwajner@ufrgs.br Carnosine, a possible suppressor of neurotoxicity?

Alan Hipkiss, Ph.D., University of Birmingham, Birmingham, UK. alanandjill@lineone.net Astrocyte dysfunction in experimental models of glutaric acidemia type I

Silvia Olivera-Bravo, Ph.D, Instituto de Investigaciónes Biológicas Clemente Estable, Montevideo, Uruguay. solivera2011@gmail.com

Mitochondrial DNA damage as a peripheral biomarker for human rotenone exposure Laurie Sanders Ph.D., Duke University, Durham, NC, USA. laurie.sanders@duke.edu

10:10-10:30: Break 10:30-12:10: Neuroprotective and/or Neurotoxic Roles of SUMOylation in Neurodegenerative Diseases Chairs: Jeremy Henley, Ph.D., University of Bristol. Bristol, UK. J.M.Henley@bristol.ac.uk

Dean Pountney, Ph.D., Griffith University, Southport, Queensland, Australia. d.pountney@griffith.edu.au Mechanisms and consequences of neuronal protein SUMOylation in health and disease

Jeremy Henley, Ph.D., University of Bristol. Bristol, UK. J.M.Henley@bristol.ac.uk SUMO and mitochondrial dysfunction

Helena Cimarosti, Ph.D., University of Santa Catarina, Florianópolis, Brazil. helena.cimarosti@ufsc.br SUMOylation, aging and autophagy in neurodegeneration

Dean Pountney, Ph.D., Griffith University, Southport, Queensland, Australia. d.pountney@griffith.edu.au Exogenous guanosine to modify SUMOylation – focus on Alzheimer and Parkinson’s diseases

Camila Zanella, University of Santa Catarina, Florianópolis, Brazil. camila_z13@yahoo.com.br 12:10-13:30 Lunch and Business Meetings 13:30-15:00: Metabolic Derangements Predisposing to Neurotoxicity and Neurodegenerative Disease Chairs: Andreza Fabro de Bem, Ph.D., Federal University of Santa Catarina. Florianópolis, Brazil. andreza.bem@ufsc.br

Alexandra Latini, Ph.D., Federal University of Santa Catarina. Florianópolis, Brazil. a.latini@ufsc.br Hypothalamic dysfunction in obesity

Lício Velloso, Ph.D., University of Campinas, Campinas, Brazil. lavelloso.unicamp@gmail.com Hypercholesterolemia as a risk factor for neurocognitive impairments

Andreza Fabro de Bem, Ph.D., Federal University of Santa Catarina, Florianópolis, Brazil. andreza.bem@ufsc.br Chronic hyperglycemia promotes hippocampal REST epigenetic gene inactivation with cognitive impairment and neurotoxicity

Alexandra Latini, Ph.D., Federal University of Santa Catarina, Florianópolis, Brazil. a.latini@ufsc.br A single dose of glucocorticoid affects synaptic plasticity markers in the human limbic system

Roger Walz, M.D., Ph.D., Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. 15:00-15:30: Break 15:30 – 17:00: Joint Student Award Symposium Chair: Remco H.S. Westerink, Utrecht University. Utrecht, The Netherlands. r.westerink@uu.nl Hypoxia-inducible factor-1α (HIF-1α) binds to HIF-response elements on the promoter region of candidate genes in the genome rat under hypoxic conditions: A bioinformatics study

Emmanuel Casanova Ortiz, University of Chile, Santiago, Chile. emmanuel.casanovao@gmail.com Small molecules alter manganese toxicity in Caenorhabditis elegans

Tanara V. Peres, Albert Einstein College of Medicine, Bronx, NY, USA. tanara.peres-vieira@einstein.yu.edu The effects of early environmental enrichment and PACAP in a rat model of Parkinson’s disease.

Adel Jungling, University of Pecs Medical School, Pecs, Hungary. junglingadel@gmail.com 17:30-19:00: Soccer Game 19:30-24:00: Awards Dinner (ticket required)

May 23 Ingleses Room 8:30-10:10: Advancing Mechanistic Understanding of Neurotoxic Contributors to Autism (Sponsored by the National Institute for Environmental Health Sciences) Chair: Edward D. Levin, Ph.D., Duke University, Durham, NC, USA. edlevin@duke.edu What we have learned about mechanisms for ASD etiology by studying risk and protective factors

Rebecca J. Schmidt, Ph.D., University of California, Davis, CA, USA. rjschmidt@ucdavis.edu Developmental neurotoxicity of traffic-related air pollution: studies with diesel exhaust in mice

Rachel (Yu-Chi) Chang Ph.D., University of Washington, Seattle, WA, USA. ycc2@uw.edu Traffic related air pollution and autism spectrum disorder: A population based nested case-control study in Israel

Marc Weisskopf, Ph.D., Sc.D., Harvard University School of Public Health, Cambridge, MA, USA. mweissko@hsph.harvard.edu Environmental toxins and neural-glial interactions in autism

Staci Bilbo, Ph.D., Harvard University School of Medicine, Cambridge, MA, USA. sbilbo@mgh.harvard.edu Persisting impairment of neurobehavioral function in zebrafish caused by early developmental exposure to disrupting retinoic acid receptor and vitamin D signaling

Edward D. Levin, Ph.D., Duke University Medical Center, Durham, NC, USA. edlevin@duke.edu 10:10-10:30 Break 10:30-12:10: Long-lasting Effects of Early Development Challenge on Brain and Behavior Chairs: Sandra Ceccatelli, Ph.D., Karolinska Institutet, Stockholm, Sweden. Sandra.Ceccatelli@ki.se

Michael Aschner, Ph.D., Albert Einstein College of Medicine, Bronx, NY, USA. Michael.Aschner@einstein.yu.edu Developmental exposure to excess glucocorticoids alters neuronal differentiation and induces long-term behavioral changes

Sandra Ceccatelli, Ph.D., Karolinska Institutet, Stockholm, Sweden. Sandra.Ceccatelli@ki.se Long lasting neurotoxic effects of MDMA administration during adolescence

Micaela Morelli Ph.D., University of Cagliari, Cagliari, Italy. morelli@unica.it Interruption of oxygen at delivery and permanent vulnerability to recurrent metabolic insults: in vitro and in vivo experiments

Mario Herrera-Marschitz, Ph.D., University of Chile, Santiago, Chile. mh-marschitz@med.uchile.cl Low-level embryonic exposure to flame retardants and related compounds causes neurobehavioral impairment in larval and adult zebrafish

Lilah Glazer Ph.D., Duke University, Durham, NC, USA. lilah.glazer@duke.edu Lead exposure of children in China: Current status and prevention

Jingyuan Chen, M.D., Ph.D. School of Public Health, Fourth Military Medical University, Xi’an, China. jy_chen@fmmu.edu.cn 12:10-13:30: Lunch and Business Meetings 13:30-15:00: Neurodevelopmental Effects of Chemical Exposure Chair: Micaela Morelli Ph.D., University of Cagliari, Cagliari, Italy. Effects of developmental alcohol exposure on neuronal plasticity and multisensory integration in the cortex

Alexandre Medina de Jesus, University of Maryland Medical Center, Baltimore, MD, USA. amedina@peds.umaryland.edu Enduring neurotoxic effects of perinatal exposures to pesticides in mice

Marcelo Farina Ph.D., Universidade Federal de Santa Catarina, Florianópolis, Brazil. marcelo.farina@ufsc.br Exposure to domoic acid during a critical period of neurodevelopment alters myelin sheath formation and leads to behavioral deficits

J.M. Panlilio, Woods Hole Center for Oceans and Human Health, Woods Hole, MA, USA. panlilio@mit.edu Histopathological and behavioral alterations caused by chronic intrastriatal hypoxanthine administration in striatum of young rats

Helena Biasibetti-Brendler, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. helenabiasibetti@gmail.com

Poster Presentations 1 Vinpocetine, a phosphodiesterase inhibitor, mitigates hyperactivity and memory/ learning deficits in mice exposed to nicotine and ethanol during the period equivalent to human gestation

Yael Abreu-Villaça, Anna C. Carvalho-Graça, Gabriela Skinner, Bruna M. Lotufo, Vitor H. S. Duarte-Pinheiro, Alex C. Manhães and Claudio C. Filgueiras Laboratorio de Neurofisiologia, Departamento de Ciencias Fisiologicas, Universidade do Estado do Rio de Janeiro (UERJ), Brazil. yael_a_v@yahoo.com.br

2 Rifampicin suppresses alpha-synuclein induced microglial activation and improve neuron survival against inflammation

Leonardo Acuña1,2, Sabah Hamadat1, Natalia Corbalán3, Florencia González4, Jeremy Rocca1, Rosana Chehín4, Dulce Papy3, Patrick Michel1, Julia Sepúlveda1* and Rita Raisman1* 1Institut du Cerveau et de la Moelle Epinière-ICM, Hôpital de la Pitié-Salpêtrière. Paris France. 2Instituto de Patología Experimental (CONICET-UNSa). Salta, Argentina. 3Université Paris Est Créteil, Université Paris Est, Créteil, France. 4Instituto Superior de Investigaciones Biológicas (CONICET-UNT). Tucumán, Argentina. acunaleonardo@hotmail.com

3 Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells.

Syed Ali1*, H. Rosas-Hernandez1, E. Cuevas1, S.M. Lantz1, K.C. Rice2, B.M. Gannon3, W.E. Fantegrossi3 and M.G. Paule1 1National Center for Toxicological Research/FDA, Jefferson, AR, USA. 2NIDA/NIAAA, Bethesda, MD, USA. 3University of Arkansas Medical School, Little Rock, AR, USA. syed.ali@fda.hhs.gov

4 The flavonoid 4,5,7–trihydroxyflavone is a neuroprotective agent against neuroinflamation and dopaminergic degeneration induced by aminochrome

Fillipe M. de Araujo1, Rafael S. Ferreira1, Cleonice Creusa dos Santos1, Tácio L.R.S. Rodrigues1, Juliana Helena C. e Silva1, Juciano Gasparotto2, Daniel Pens Gelain2, Cleide S. Souza1, Ramon S. El-Bachá1, Maria de Fátima D. Costa1, José Claudio M. Fonseca2, Juan Segura-Aguilar3, Silvia L. Costa1 and Victor Diogenes A. Silva1 1Federal University of Bahia, Salvador, Bahia, Brazil. 2Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 3University of Chile, Santiago, Chile. fillipe_mendes@icloud.com

5 Isolated human populations and mercury exposure: blood mRNA of S100B protein as a possible biomarker of intoxication

Gabriela de Paula Fonseca Arrifano1, María Jiménez Moreno2, Rosa Del Carmen Rodriguez Martin-Doimeadios2, Marcus Augusto de Oliveira1, José Rogério Souza Monteiro1, Ricardo Souza Paraense1, Camila Rodrigues Machado1, Marcelo Farina3, Barbarella Macchi1, José Luiz Martins do Nascimento1 and Maria Elena Crespo Lopez1 1Universidade Federal do Pará, Brazil. 2Universidad de Castilla-La Mancha, España. 3Universidade Federal de Santa Catarina, Brazil. gabrielaarrifano@uol.com.br

6 Atorvastatin-promoted neuroprotection against glutamate toxicity depends on GluN2B subunit of of N-methyl-D-aspartate receptors (NMDAR)

L.B. Binder, N.F. Marques, L.C. Constantino and C.I. Tasca Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. binder.luisa@gmail.com

7 Effects of combined exposure to low-frequency noise and CS2 on hearing and balance

Maria Carreres-Pons, Monique Chalansonnet, Thomas Venet, Aurélie Thomas, Jordi Llorens, Pierre Campo Institut National de Recherche et de Sécurité. Rue du Morvan. CS 60027. F-54519 Vandœuvre Cedex. France maria.carreres@inrs.fr

8 Chronic administration of L-tyrosine alters oxidative stress parameters in brain of rats supplemented with omega-3 fatty acids

Milena Carvalho-Silva1,2, Lara M. Gomes1,2, Letícia J. Teixeira1,2, Joyce Rebelo1,2, Fernanda Malgarin1, Maria L. Gomes1, Bruna K. Ferreira1,3, Patrícia F. Schuck1, Gustavo C. Ferreira3 and Emilio L. Streck1,2 1University of Southern Santa Catarina, Criciúma, S.C., Brazil. 2National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, R.S., Brazil. 3Federal University of Rio de Janeiro, Rio de Janeiro, R.J., Brazil. milena-cs@hotmail.com

9 Hypoxia-inducible factor-1α (HIF-1α) binds to HIF-response elements on the promoter region of candidate genes in the genome rat under hypoxic conditions: A bioinformatics study

Emmanuel Casanova Ortiz, Pablo Báez, Luis Valenzuela, Rodrigo Assar, Katherine Marcelain Cubillos and Mario Herrera-Marschitz University of Chile, Santiago, Chile. emmanuel.casanovao@gmail.com

10 Mechanisms mediating paraquat and maneb-induced toxicity in neural stem cells

Dirleise Colle1, Marilena Raciti2, Marcelo Farina1 and Sandra Ceccatelli2 1Federal University of Santa Catarina, Florianópolis, Brazil. 2Karolinska Institutet, Stockholm, Sweden. dirleise@yahoo.com.br

11 Poly [adp-ribose] polymerase-1 (parp-1) is important in adult brain neuroinflammation and neurotoxicity instigated by alcohol

M.A. Collins, D.E. Kouzoukas, N.F. Tajuddin, J.A. Schreiber, H.-Y. Kim*, S. Kaja and E.J. Neafsey Loyola University Chicago, Stritch School of Medicine, Maywood IL USA; and *NIAAA, Bethesda MD USA. mcollin@luc.edu

12 Antitumoral evaluation of triterpenes in glioblastoma cells

L.N. Comunello1, D. Diedrich1, S.C.B. Gnoatto1, M.S.L. Pereira²; D.L. de Oliveira² and G. Gosmann¹. 1Laboratório de Fitoquímica e Síntese Orgânica (LaFiS), Faculdade de Farmácia. Porto Alegre, RS, Brazil. 2Laboratório de Neuroquímica Celular (NeuroCell), Departamento de Bioquímica, UFRGS. Porto Alegre, RS, Brazil. maracomunello@hotmail.com

13 Involvement of GluN2B subunit containing N-Methyl-D-Aspartate (NMDA) receptors and phosphatidylinositol-3 kinase (PI3K) pathway in the mechanism of NMDA preconditioning

Leandra C. Constantino1, Fabiana K. Ludka2, Luisa Binder1, Samuel Vandresen-Filho3, Giordano G. Viola4 and Carla I. Tasca1 1Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. 2Curso de Farmácia, Universidade do Contestado, Canoinhas, SC, Brazil. 3Universidade Federal de Mato Grosso do Sul, Cuiabá, MT, Brazil. 4Universidade Federal de Sergipe, Campus São Cristóvão, Brazil. constantinolc@gmail.com

14 Motor deficits, loss of nigral dopaminergic neurons and gliosis in transgenic A53T +/- mice: role of Na+-Ca2+ exchanger isoforms

Giulia Costa1, Maria Josè Sisalli3, Katia Omura3, Rossana Sirabella3, Lucio Annunziato3, Antonella Scorziello3 and Micaela Morelli1,2 1University of Cagliari, Cagliari, Italy. 2 National Research Council of Italy, Institute of Neuroscience, Cagliari, Italy. 3School of Medicine, "Federico II" University of Naples, Italy. morelli@unica.it

15 Attenuation of sickness behavior and neuroinflammation and neuroplasticity improvement in the hippocampus of aged mice: The role of exercise training

Karine Mathilde Campestrini Dallagnol, Rodrigo Augusto da Silva, Aline Pertile Remor, Rui Prediger, Alexandra S Latini and Aderbal S Aguiar Jr. Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.. karine.chan04@gmail.com

16 Neurotoxic effect of As, Pb, and Mn – mixture developmental exposure: Impaired the learning and memory with NMDA receptor and postsynaptic signaling proteins in hippocampus of rats

Lalit P Chandravanshi, Anamika, Richa Gupta* and Surendra K Trigun Department of Zoology, Banaras Hindu University, Varanasi, India. *CSIR- Indian Institute of Toxicology Research, India. chandravanshi04@gmail.com

17 Methylmercury enhances SP1 nuclear localization concurrent with diminished Fyn gene expression in primary rat cortical astrocytes

Megan Culbreth and Michael Aschner Albert Einstein College of Medicine, Bronx, NY, USA. michael.aschner@einstein.yu.edu

18 Tributyltin (TBT) chronic exposure impairs object recognition memory in female mice

Igor Ferraz da Silva, Eduardo Merlo, Jones Bernardes Graceli and Lívia Carla de Melo Rodrigues. Federal University of Espírito Santo, Espírito Santo, Brasil. igor-sima@hotmail.com

19 GluN2B-containing NMDAR antagonism reduce short-term neurodegeneration and inflammation induced by early life status epilepticus

Natã Sehn da Rosa1, Cássio Morais Loss1, Régis Gemerasca Mestriner2, Léder Leal Xavier2 and Diogo Losch de Oliveira1 1Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil. 2Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. nata.sehn@gmail.com

20 C elegans as in vivo model for test quinolinic acid neurotoxic effects

Tássia L. da Silveira, Daniele C. Zamberlan, Marina L. Machado, Thayanara C. Silva, Leticia P. Arantes and Felix A. A. Soares. Federal University of Santa Catarina, Florianópolis, Brazil. felix@ufsm.br

21 The flavonoid 4,5,7–trihydroxyflavone is a neuroprotective agent against neuroinflamation and dopaminergic degeneration induced by aminochrome

Fillipe M. de Araujo1, Rafael S. Ferreira1, Cleonice Creusa dos Santos1, Tácio L.R.S. Rodrigues1, Juliana Helena C. e Silva1, Juciano Gasparotto2, Daniel Pens Gelain2, Cleide S. Souza1, Ramon S. El-Bachá1, Maria de Fátima D. Costa1, José Claudio M. Fonseca2, Juan Segura-Aguilar3, Silvia L. Costa1 and Victor Diogenes A. Silva1 1Federal University of Bahia, Salvador, Bahia, Brazil. 2Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 3University of Chile, Santiago, Chile. fillipe_mendes@icloud.com

22 Hospitalization rates for Parkinson’s disease and pesticide use in Brazil

Aline de Souza Espindola Santos1, Noa Krawczyk2, Jaime Lima3 and Armando Meyer4 1Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 2Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 3Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. armando@iesc.ufrj.br

23 Elucidation of the molecular signature of Parkinson's disease – altered regulons, molecular targets and innovative therapeutics interventions

Daiani Machado de Vargas, Marco Antônio De Bastiani and Fábio Klamt Universidade Federal do Rio Grande do Sul, Brazil. daianibio@yahoo.com.br

24 6-Hydroxydopamine decreases brain aldehyde dehydrogenase 2 (ALDH2) expression: Implications for neurotoxicity in a Parkinson´s disease model

Romina Deza-Ponzio1*, Macarena L. Herrera1*, Natalia A. Marchese1, Osvaldo M. Basmadjian1, María José Bellini2, Víctor A. Molina1, Miriam B. Virgolini1 and Claudia B. Hereñú1 *Equally contribution 1Depto. Farmacología-FCQ-UNC-CONICET-Córdoba, Córdoba, Argentina. 2Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP)- FCM-UNLP-CONICET-La Plata, Buenos Aires, Argentina. rdezaponzio@fcq.unc.edu.ar

25 Prenatal hypoxia-ischemia causes loss of retinal ganglion cells followed by pupillary light reflex alteration in rats

G.M. Diniz-Taveira; Fonseca, L.S.; Oliveira, M.H.N.; Tenorio, F.; Barradas, P.C. and Krahe, T.E. Rio de Janeiro State University, Rio de Janeiro, Brazil. taveiragdm@gmail.com

26 Methylmercury induces oxidative stress and rock-1 activation in primary astroglial cells

Alessandra Antunes dos Santos1, Aaron B. Bowman2 and Michael Aschner1 1Albert Einstein College of Medicine, New York, USA. 2Vanderbilt University Medical School, Nashville, TN, USA. Michael.Aschner@einstein.yu.edu

27 Agmatine improves behavioral impairments observed in an animal model of the attention deficit hyperactivity disorder

Angela P. França, Marissa G. Schamne, Bruna S. de Souza, Thiago Corrêa, José E. da Silva Santos, Geison S. Izídio and Rui D. Prediger. Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. angels_franca@me.com

28 Evaluation of neurochemical, inflammatory and behavioral parameters in hyperphenylananic female rats

Maria Luiza Gomes1; Jotele Fontana Agostini1; Michele Garcez¹; Monique Michels¹; Franciele Vuolo¹; Felipe Dal Pizzol¹; Josiane Budni¹; Gustavo da Costa Ferreira2; Emilio Luis Streck¹; Patrícia Fernanda Schuck¹

¹Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; 2Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. gomesmluiza@gmail.com

29 Prenatal infection affects inhibitory synaptic function and plasticity: role of endocannabinoids

Zhiling Guo1,2, Bin Zhao1

1Chinese Academy of Sciences, Beijing, China. 2McGill University, Montreal, QC, Canada. sxxy.1987@163.com

30 Cognitive impairment in an experimental model of Parkinson´s Disease

Macarena Lorena Herrera1*, Romina Deza-Ponzio1*, Osvaldo M. Basmadjian1, Victoria B. Occhieppo1, Victor A.Molina1, María José Bellini2, Claudia B. Hereñú1 *equally contribution 1Instituto de Farmacología Experimental de Córdoba (IFEC)- Depto. Farmacología-FCQ-UNC-CONICET-Córdoba, Argentina. 2Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP)- FCM-UNLP-CONICET-La Plata, Buenos Aires, Argentina. macarenalherrera@hotmail.com

31 Repeated 5-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse cognitive effects

Tim Hofer1, Dag Marcus Eide1, Synne Kleiven2, Hans Christian Utkilen2 and Oddvar Myhre1 1Norwegian Institute of Public Health, Oslo, Norway. 2University College of Southeast Norway, Bø, Norway. tim.hofer@fhi.no

32 Effects of postnatal enriched environment in a model of Parkinson’s disease in adult rats

Adel Jungling, Dora Reglodi, Zsofia Nozomi Karadi, Gabor Horvath and Jozsef Farkas, Balazs Gaszner and Andrea Tamas University of Pecs Medical School, Pecs, Hungary. junglingadel@gmail.com

33 The effects of early environmental enrichment and PACAP in aging rat model of Parkinson’s disease

Adel Jungling1, Dora Reglodi1, Gabor Maasz2, Gabor Horvath1, Zsolt Priger2 and Andrea Tamas1 1University of Pecs Medical School, Pecs, Hungary. 2Balaton Limnological Institute, MTA-CER, Tihany, Hungary. junglingadel@gmail.com

34 Protein SUMOylation in models of Parkinson’s disease

Stella C. Junqueira1, Ana C. Guerra de Souza1, Izi I. Floriano1, Kevin A. Wilkinson2, Jeremy M. Henley2, Rui D. Prediger1 and Helena Cimarosti1 1Federal University of Santa Catarina, Florianópolis, Brazil. 3University of Bristol, UK. stellacjunqueira@gmail.com

35 Novel non-estrogenic endpoints of phenolic metabolites toxicity in fish: Using zebrafish as a model for study

Nessrin Kheirallah and Tamer El-Sayed Ali

Alexandria University, Alexandria, Egypt. tameraly@yahoo.com

36 Assessing the role of the intermediate filament (nanofilament) protein nestin in poststroke plasticity

Renata Leke1, Ulrika Wilhelmsson1, Andras Nagy2 and Milos Pekny1 1University of Gothenburg, Sweden. 2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. renata.leke@neuro.gu.se

37 Correlation between oxide nitric synthase and catalase in neonatal brain exposed to perinatal asphyxia

Lespay-Rebolledo C; Perez-Lobos R; Tapia-Bustos A; Vío V; Bustamante D; Morales P and Herrera-Marschitz M University of Chile, Santiago, Chile. carolynelespay@gmail.com

38 Persisting effects of separate and combined nicotine and benzo-a-pyrene exposure during gestation on motor, emotional and cognitive functions in rats

Edward D. Levin, Marty Cauley, Andrew Hawkey, Corrine Wells, Shaqif Junaid, Leah Yao and Zachary Spiera Duke University, Durham, NC, USA. edlevin@duke.edu

39 Impairment of spatial working memory and biochemical changes induced by direct crack-cocaine inhalation and cocaine pyrolysis product, anhydroecgonine methyl ester (AEME)

Ingryd FS Lipaus1, Elisa F Gomes1, Thais B Oliveira1, Cleciane W Martins1, Andrezza M Araújo1, Evandro C Lebarch2, Josideia B Mendonça2, Fabricio S Pelição2, Patrícia F Schuck3, Fernanda Malgarin3, Ester M Nakamura-Palacios1 and Lívia CM Rodrigues1 1Universidade Federal do Espírito Santo, Brazil. 2Polícia Civil do Estado do Espírito Santo, Brazil. 3Universidade do Extremo Sul Catarinense, Brazil. susuvi@gmail.com

40 Molecular mechanisms of neurotoxicity induced by chlorpyrifos and chlorpyrifos-oxon in HT22 cells

Mark William Lopes, Aline Aita Naime, Dirleise Colle and Marcelo Farina Federal University of Santa Catarina, Florianópolis, Brazil. mark.william@hotmail.com

41 Influence of early life NMDAR antagonism and early life GluN2B-containing NMDAR antagonism on adult behavior: Interaction with rearing environments

Cássio Morais Loss, Natã Sehn da Rosa, Natividade de Sá Pereira, Fabrício Figueiró, Giordano Gubert Viola and Diogo Losch de Oliveira Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil. cassio.m.loss@gmail.com

42 Triton WR-1339 exerts cellular impairment and depressive-like behavior

Fabiana Kalyne Ludka, Andreia Gapski, Amanda Catarina Borba, Idilaine Custódio and Simone Molz Universidade do Contestado, Canoinhas, Brazil. fabianakalyne@hotmail.com

43 Guanosine prevents olfactory impairment and mitochondrial disruption induced by intranasal MPTP infusion

N.F. Marques, T.B. Sampaio, L.B. Binder, L.C. Constantino, J.M. Mack, R.D. Prediger and C.I. Tasca Federal University of Santa Catarina, Florianópolis, Brazil. n.fmarques@yahoo.com.br

44 Intranasal administration of sodium dimethyldithiocarbamate induces persistent motor deficits related to Parkinson’s disease in mice that are prevented by melatonin treatment

Josiel Mileno Mack, Tainara de Menezes Moura, Débora Lanznaster, Carla Inês Tasca, Alcir Luiz Dafre and Rui Daniel Prediger. Universidade Federal de Santa Catarina, Florianópolis, Brazil. josielmack1@gmail.com

45 Short-time forebrain glutamate uptake impairment related to reduction of GFAP expressing cells after kainic acid induced epileptic seizures in adult zebrafish.

Luana Moro1, Ben Hur Marins Mussulini1, Adriana Vizuete1, Suelen Baggio1, Emerson Santos1, Gabriela Lazzarotto1, Letícia Pettenuzzo1, Renato Dutra Dias1, Maria Elisa Calcagnotto1, Diogo Losch de Oliveira1, Diogo Onofre Gomes de Souza1, Javier S. Burgos2 and Eduardo Pacheco Rico3. 1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. 2Parque Tecnológico de Ciencias de la Salud, Granada, Spain. 3Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. luanamoro222@gmail.com

46 Brain metabolic preference shifts under prolonged epileptic seizure episodes in adult zebrafish pentylenetetrazole model

Ben Hur Marins Mussulini, Gabriela Lazzarotto, Ivi Juliana Bristot, Renato Dutra Dias and Fabio Klamt, Diogo Losch de Oliveira. Federal University of Rio Grande do Sul, , Porto Alegre, RS, Brazil. ben_hurmussulini@yahoo.com.br

47 Neurotoxicity in rats exposed to exhaust emissions from biodiesel fuels – the FuelHealth project

Oddvar Myhre2, Pål Amdal Magnusson2, Johan Øvrevik2, Joanna Gromadzka-Ostrowska3, Anna Lankoff4,5 and Renate Valand1,2

1Oslo and Akershus University College of Applied Sciences, Norway. 2Norwegian Institute of Public Health, Norway. 3Warsaw University of Life Sciences, Poland. 4Center for Radiobiology and Biological Dosimetry, Poland. 5Jan Kochanowski University, Poland. oddvar.myhre@fhi.no

48 Effects of flavonoid agathisflavone on differentiation of rat bone marrow mesenchymal stem cells

Ravena Nascimento¹ ² and Silvia Lima Costa² ¹ Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil. ²Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil. ravenanascimentoufba@gmail.com

49 New insights in neuronal protection against methylmercury-induced cytotoxicity and proposed new targets for upcoming research

Nair Olguín, Marie-Lena Müller, Eduard Rodríguez-Farré and Cristina Suñol IIBB-CSIC-IDIBAPS-CIBERESP, Barcelona, Spain. cristina.sunyol@iibb.csic.es

50 Monocrotaline pyrrole from Crotalaria retusa induces glial response and behavioral changes in adult Wistar rats

Joana L. Oliveira1, Adriana L. Silva1, Roberto F. Almeida2, Rejane Santana1, Eduardo Moreira Trindade1, Adriano M. Assis2, Diogo Onofre G. Souza2, Victor Diogenes A. Silva1 and Silvia L. Costa1

1Federal University of Bahia, Salvador, Bahia, Brazil. 3Federal University of Rio Grande do Sul, Porto Alegre, Brazil. joanabioquimica@gmail.com

51 Towards new solutions against mercury intoxication in Amazon: Pre-clinical results of Euterpe oleracea (açaí)

Ricardo O. Paraense1, Ericks Soares1, José Rogério Souza-Monteiro1, Gabriela Arrifano1, Camila R. Machado1, Luciana C. Imbiriba1, Cristiane do Socorro Ferraz Maia1, Hervé Rogez1, Marcelo Lima2 and Maria Elena Crespo Lopez1 1Universidade Federal do Pará, Brazil. 2Instituto Evandro Chagas, Brazil. pos_ricardo@hotmail.com

52 Involvement of the endocannabinoid system on neuroinflammation in the prefrontal cortex and hippocampus of adolescent rats submitted to chronic binge alcohol

Renan Pelição¹, Paula MQ Bellozzi2, Isabel VA Lima2, Soraya W Saliba2, Ester M Nakamura-Palacios¹, Antonio Carlos Pinheiro Oliveira2, Alline C Campos2, Antonio L Teixeira2, Lívia CM Rodrigues¹. 1Universidade Federal do Espírito Santo, Brazil. 2Universidade Federal de Minas Gerais, Brazil. susuvi@gmail.com

53 Small molecules alter manganese toxicity in Caenorhabditis elegans

Tanara V. Peres1, Kyle Horning2, Aaron B. Bowman2 and Michael Aschner1

1Albert Einstein College of Medicine, Bronx, NY, USA. 2Vanderbilt University Medical Center and Vanderbilt University, Nashville, TN, USA. tanara.peres-vieira@einstein.yu.edu

54 The effects of guanosine in neural proliferation, neurogenesis and antidepressant-like behavior in adult mice

Tetsade Piermartiri, Beatriz Santos, Fernanda Barros, Rui D Prediger and Carla I Tasca

Universidade Federal de Santa Catarina, Florianópolis, Brazil. tetsade@yahoo.com.br

55 Interruption of oxygen at delivery and permanent vulnerability to recurrent metabolic insults: In vitro and in vivo experiments

R. Perez-Lobos, C. Lespay-Rebolledo, E. Palacios, A. Tapia-Bustos, V Vío, D Bustamante, P. Morales and M. Herrera-Marschitz. University of Chile, Santiago, Chile. ronald.perezlobos@gmail.com

56 Vulnerability of basal ganglia to metabolic insults following perinatal asphyxia: Metabolic impairment and nicotinamide protection

R. Pérez-Lobos R1,2, C. Lespay-Rebolledo1, A. Tapia-Bustos1, V. Vío1, D. Bustamante1, P. Morales1 and M. Herrera-Marschitz.1 1University of Chile; Santiago, Chile. 2Universidad Andrés Bello, Santiago, Chile. ronald.perezlobos@gmail.com

57 Alteration of the PAC1 receptor expression in the basal ganglia of MPTP-induced parkinsonian macaque monkeys

D. Reglodi1, M. Feher1,2, A. Tamas1, A.L. Gil-Martinez3, E. Fernandez-Villalba3, M.T. Herrero3 and B. Gaszner1 1University of Pecs, Pecs, Hungary. 2"Kaposi Mór" Teaching Hospital, Kaposvar, Hungary. 3University of Murcia, Murcia, Spain. dora.reglodi@aok.pte.hu

58 Effects of sulfasalazine administration on nociceptive responses in rats following intranasal MPTP administration, an animal model of Parkinson´s disease

Katiane Roversi, Sérgio J. Macedo-Júnior, Juliano Ferreira, Alexandra Latini and Rui D. Prediger Universidade Federal de Santa Catarina, Florianópolis, Brazil. katianeroversi@gmail.com

59 Noradrenaline replacement in prefrontal cortex restores both short- and long-term recognition memory impairments induced by locus coeruleus lesion in rats

Tuane Bazanella Sampaio, Marina Aparecida Magnini Portes, Tayná Schuh and Rui Daniel Prediger. Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. tuanebs@gmail.com

60 Aminochrome induces glial activation and neuronal degeneration in primary culture from rat CNS

Cleonice C. Santos1, Fillipe M. Araújo1, Rafael S. Ferreira1, Vanessa B. Silva1, Juliana H. C. Silva1, Maria S. Grangeiro1, Érica Patricia L. Pereira1, Cleide S. Souza1, Silvia L. Costa1, Juan Segura-Aguilar2 and Victor Diogenes A. Silva1 1Federal University of Bahia, Salvador, Bahia, Brazil. 2University of Chile, Santiago, Chile. cleonicemev@gmail.com

61 Agmatine reverses emotional impairments in the intranasal MPTP model of Parkinson’s disease – the role of neurotrophic factors and neuroinflammation

Marissa G. Schamne, Bruna Soares de Souza, Tainara Menezes Moura and Rui Daniel Prediger Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. maschamne@gmail.com

62 Levodopa improves fatigue tolerance in reserpine-treated mice – an animal model of Parkinson disease

Débora da Luz Scheffer1, Roberta de Paula Martins1, Catherine Ward2 Nick Andrews2 Aderbal Silva Aguiar Junior1 and Alexandra Latini1 1Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. 2Harvard Medical School, Boston, USA. deborascheffer@hotmail.com

63 SUMOylation profiles in an animal model of epilepsy

Leticia Coelho Silva, Mark W. Lopes, Roger Walz and Helena Cimarosti Federal University of Santa Catarina, Florianópolis, Brazil. leticiacoelhoo13@gmail.com

64 Neural cell death induced by piperidine alkaloids from Prosopis juliflora (Mesquite) leaves involves programmed cell death via caspase-9 activation and autophagy

Victor Diogenes A. Silva1, Carlos Cuevas2, Patricia Muñoz2, Cleonice Creusa dos Santos1, Fillipe M. de Araujo1;

Rafael S. Ferreira1, Juliana Helena C. e Silva1, Érica N. Soares1, Eudes S. Velozo1, Juan Segura-Aguilar2 and Silvia L. Costa1. 1Federal University of Bahia, Salvador, Bahia, Brazil. 2University of Chile, Santiago, Chile. vdsilva@ufba.br

65 Physical exercise attenuates cortical neuroinflammation induced by lipopolysaccharide in mice

Ananda Staats, Roberta de Paula Martins, Lívia Maria, Karina Ghisoni, Lucila Silv1, Rui Daniel Prediger, Alexandra Latini and Aderbal Aguiar Jr. Federal University of Santa Catarina, Florianópolis, Brazil. anandastaats@hotmail.com

66 Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters

Emilio L. Streck1,2, Luciane Taschetto1,2, Giselli Scaini1,2, Hugo G. Zapelini1, Ândrea C. Ramos1, Monique Michels3, Felipe Dal-Pizzol3, Patrícia F. Schuck1 and Gustavo C. Ferreira3 1University of Southern Santa Catarina, Criciúma, SC, Brazil. 2National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil. 3Federal University of Rio de Janeiro, Rio de Janeiro, R.J., Brazil. emiliostreck@gmail.com

67 Perinatal asphyxia induces changes in oligodendrocytes phenotype in telencephalon of rat brain

A. Tapia-Bustos1, R. Perez-Lobos1, C. Lespay-Rebolledo1, V. Vío1, D. Bustamante1, A. Lamaison, B. Villafranca. F. Ezquer2, M. Herrera-Marschitz1 and P. Morales1. 1University of Chile, Santiago, Chile. 2Universidad del Desarrollo, Santiago, Chile. ac.tapiabustos@gmail.com

68 Metabotropic glutamate receptors as prognostic markers in Glioblastomas

Chairini C. Thome, Mery S. L. Pereira., Marco A. Debastiani., Fábio Klamt. and Diogo L. de Oliveira. Federal University of Rio Grande do Sul, Porto Alegre, Brazil. chairini.thome@gmail.com

69 Effects of hearing isolation on the development of ultrasonic vocalization in rat pups

Hiromi Wada, Ph.D. Hokkaido University, Sapporo, Japan. wada@let.hokudai.ac.jp

70 Effect of acute and chronic administration of L-tyrosine on working memory in young rats

Leticia B. Wessler1, Milena Carvalho-Silva1,2, Lara M. Gomes1,2, Letícia J. Teixeira1,2, Joyce Rebelo1,2, Gislaine Z. Reús1, Airam B. Moura1, Danyela Matos1, João Quevedo1, Patrícia F. Schuck1, Emilio L. Streck1,2 1University of Southern Santa Catarina, Criciúma, SC, Brazil. 2National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, R.S, Brazil. leticia.wessler@hotmail.com

71 Antidyskinetic effect of acute guanosine administration in reserpinized mice.

Massari, C.M.1; Lanznaster, D.2; Tasca C.I.1,2. 1Programa de Pós-Graduação em Bioquímica, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brasil; 2Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, Brasil;

72 Alterations on the gene expression on cerebellar thyroid hormone homeostasis in perinatally rats exposed by glyphosate-based herbicide

Costa Reis LT; Souza JS; Romano RM; Romano AR; Chiamolera MI; Giannocco G; Dias da Silva MR; Amaral da Silva VD; Costa SL; Cunha Lima ST. Universidade Federal da Bahia, Laboratório de Biotecnologia e Bioprospecção, Instituto de Biologia, Salvador, Bahia, Brazil. Laboratório de Endocrinologia Molecular e Translacional, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. Departamento de Farmácia, Universidade Estadual do Centro-Oeste, Guarapuava Paraná, Brazil. Laboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

73 Brain bioenergetics in rats with acute hyperphenylalaninemia

Agostini JF; Dimer NW; Ferreira BK; Gomes ML; Kist LW; Malgarin F; Carvalho-Silva M; Gomes LM; Rebelo J; Silva Frederico MJ; Mena Barreto Silva FR; Rico ER; Bogo MR; Streck EL; Ferreira GC; Schuck PF. Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

74 Carnosine alters redox homeostasis in cultured primary cortical astrocytes

Ferreira BK; Diniz FC; Oliveira-Bravo S; Barbeito L; Streck EL; Shuck PF; Melo Reis RA; Ferreira GC. Laboratório de Neuroenergética e Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Cellular and Molecular Neurobiology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Montevideo, Uruguay. Neurodegeneration Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay. Laboratório de Bioenergética, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. Laboratório de Erros Inatos do Metabolismo, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil. Laboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro , Rio de Janeiro, Brazil.

75 Colonic inflammation is accompanied by glial alterations in 6-OHDA mouse model of Parkinson’s disease

Thomasi B; Valdetaro L; Mussauer A; Nascimento G; Fernandes AC; Serfaty CA; Campello P; Melibeu A; Ribeiro MG; Moura Neto V; Tavares Gomes AL. UFF (Universidade Federal Fluminense), Instituto de Biologia; Departamento de Neurobiologia Laboratório da Interação Neuro-Glial. UFRJ (Universidade Federal do Rio de Janeiro), Instituto de Ciências Biomédicas, Laboratório de morfogênese celular. Instituto Estadual do Cérebro Paulo Niemeyer.

76 Doxycycline can efficiently switch alpha-synuclein early aggregation oligomers into non-toxic species: repurposing an old drug as neuroprotector

Lizarraga FG; Socias B; Avila C; Barbosa L; Andres B; Diaz JS; Elaine DB; Fernandez C; Papy-Garcia D; Chehin R; Raisman-Vozari R. Universidad Nacional de Tucuman/CONICET, INSIBIO, S.M. de Tucuman, Argentina. Instituto de Física da Universidade de São Paulo, IFUSP, São Paulo, Brazil. Max Planck Laboratory for Structural Biology- Chemistry and Molecular Biophysics of Rosario, MPLbioR- UNR-MPIbpC, Rosario, Argentina. Institut Du Cerveau Et De La Moelle Epinière ICM and CNRS- Unité Mixte De Recherche- Sorbonne Universités, ICM-CNRS, Paris, France. Faculty of Odontology of Ribeirão Preto, USP, Ribeirão Preto-, Brazil. Laboratoire Croissance- Réparation et Régénération Tissulaires CRRET, Université Paris Est Créteil-CRRET, Créteil, France.

77 Effect of nanocapsules with naringin and naringenin against brain damage induced by streptozotocin in mice

Budel RG; Ferreira CF; Guerino BC; Biacchi KB; Borin DB; Raffin RP; Boeck CR. Postgraduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria – RS, Brazil.

78 NAC decreases both dopaminergic cell death and inflammatory changes in old-Parkinsonian mice

Gil-Martinez AL; Cuenca L; Estrada C; Fernandez-Villalba E; Trinidad Herrero M. Clinical & Experimental Neuroscience, School of Medicine, Institute of Aging Research. University of Murcia, Murcia, Spain.

79 Opposing roles for ascorbic acid and glutathione in the chick embryonic retina

Freitas HR; Faria RX; Braga Ferreira LG; Cussa Kubrusly RC; Ferreira GC; Melo Reis RA. Laboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Laboratory of Toxoplasmosis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. Laboratory Neuropharmacology, Dept. Physiology and Pharmacology, Federal Fluminense University, Niterói, Brazil. Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

80 Running for REST: the effects of exercise in the hippocampus of aged mice

Campestrini Dallagnol KM; Silva RA; Remor AP; Prediger R; Latini AS; Aguiar Junior AS. Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, CCB – UFSC, Florianópolis – SC. Laboratório Experimental de Doenças Neurodegenerativas (LEXDON).

81 Tnf-alpha plays a role in neuroplasticity mediated by microglia activation after monocular enucleation

Chagas LS; Trindade P; Serfaty CA. Instituto de Biologia, Universidade Federal Fluminense. D’or Institute for Research and Education, Brasil.

82 Toxicity evaluation of nanoparticles with simvastatin in hippocampal slices from rats and C. elegans

Guerino BC; Moreira MP; Machado ML; Antunes Soares FA; Ourique AF; Boeck CR.

We appreciate the support of the meeting from: Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) National Institute for Environmental Health Sciences International Society for Neurochemistry American Society for Neurochemistry Springer Publishing Company Agilent/Seahorse Elsevier Axion BioSystems Cellular Dynamics International Mimetas Alesco Axol Bioscience