Post on 23-Sep-2020
R.M. Kostrzewa, Ph.D.
January 2014
CURRICULUM VITA
Richard M. Kostrzewa, Ph.D.
Professor, Department of Biomedical Sciences
Quillen College of Medicine PH: +1 423 439-6321
East Tennessee State University FAX: +1 423 439-8044
P.O. Box 70,577 Email: kostrzew@etsu.edu
Johnson City, TN 37614-1708
Personal
United States Citizen
Married
Education/Degrees
Philadelphia College of Pharmacy & Science B.S. Chemistry 1965
Philadelphia College of Pharmacy & Science M.S. Pharmacology 1967
University of Pennsylvania, Philadelphia, PA Ph.D. Pharmacology 1971
Medical University of Silesia, Katowice, Poland Doctor Honoris Causa 2005
Positions
Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA, 1971-75
Adjunct Assistant Professor of Pharmacology, Tulane University Medical Center, New Orleans, LA,
1974-76; Adjunct Instructor, 1972-73
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans, LA,
1974-77
Assistant Professor of Physiology, Louisiana State University Medical Center, New Orleans, LA,
1975-78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee State
University, 1984- ; Associate Professor, 1978-84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003
Societies
Neurotoxicity Society, Founding Board, President (2001-03), Past-President (2003-05),
Treasurer (2005- Dec 2011), Council (2012-2014)
American Society of Pharmacology and Experimental Therapeutics (1975- present)
Federation of American Societies for Experimental Biology (1975-90)
Experimental Biology (1990- present)
Society for Neuroscience (1973- present); Int’l Brain Research Organization (1984- present)
Orthoquinone Club (1997- 2001)
Appalachian Chapter, Society for Neuroscience: Organizer (1979)
President-Elect (1986, 1988), President (1980, 1987, 1989-2003)
Southeastern Pharmacology Society (1986-96; Councilor, 1989-91; 1994-6)
Society of Toxicology (1994-99)
Greater New Orleans Chapter, Society for Neuroscience: Organizing Committee (1973), Secretary
(1976), President-Elect (1977), President (1978)
Histochemical Society (1980-89)
R.M. Kostrzewa, Ph.D.
TEACHING
Medical Pharmacology Course, East Tennessee State University (ETSU)
1980-present ; Course Director, 1985, -86, -87; -96, -97; 2005 & 2006; 2008, 2009.
Medical Neuroscience Course, ETSU College of Medicine, 2002-present
Medical Pharmacology Course, Medical University of Silesia, Katowice, Poland
approx. 10 lectures annually, 1997-2001
Nursing Pharmacology Course, ETSU, 1983-87
Clinical Pharmacology Course, ETSU, 1982-94
Graduate Biomedical Sciences Core Course, 2001-2004
Graduate Neurochemistry Course, ETSU, 1981, -83, -85, -87, -89
Graduate Neuropharmacology Course, ETSU
Course Director, 1982, -84, -86, -88, -90, -92, -94, -99, -01
Graduate Autonomic Pharmacology Course, ETSU, 1982, -87, -89, -91, -93, -96, -98
Graduate Pathophysiology Course, ETSU, lecturer, 2010, 2011
Graduate Toxicology Course, ETSU, 1983, -86, -90, -92, -95, -97
Pharmacology Journal Club, ETSU, 1985-present; Director, 1988-2003
Pharmacology Seminar, ETSU, 1972-present; Director, 1988-2001
Survival Skills and Ethics in Science, ETSU, Organizer, 1997; Director, 1998
Dental Physiology Course, Louisiana State Univ. Medical Ctr (LSUMC), 1975-78
Medical Pharmacology Course, LSUMC, 1976
Medical Pharmacology Course, Tulane Medical Center, 1973-75
Undergraduate Pharmacology Course, Tulane University, 1974
Graduate Pharmacology courses, Tulane and LSUMC, 1972-78
Undergraduate Psychology Course, University of New Orleans, 1975
GRADUATE ADVISING at ETSU
Dr. Ellen Kunkel-Bagden, Ph.D. Advisor, Dissertation defense, 1985
Ms. Teresa G. White, M.S. Advisor, Thesis defense, 1988
Dr. M. Iqbal Saleh, Ph.D. Advisor, Dissertation defense, 1988
Dr. Anwar Hamdi, Ph.D. Advisor, Dissertation defense, 1990
Dr. Li Gong, Ph.D. Advisor, Dissertation defense, 1993
Dr. Nuoyu Huang, Ph.D. Advisor, Dissertation defense, 1995
Thesis Advisory Committees for:
Dr. Tim A. Robert, 1978-80 Toh Gang, 2011-
Dr. Jacob Dunbar, 1987-92 Avinash Thirumalai, 2011-
Dr. T. Scott Thurmond, 1990-95 Joseph Wu, 2011-
Dr. Yu-Li Liu, 1993- 97 Ashley Brianna Sheppard, 2012-
Mr. Thomas Rudolph, 1995-96
Dr. Rachel Qualls, 1995-2000
Dr. Sandeep Saroch, 1996-7
Dr. Xuwan Liu, 1999-2003
Dr. David Burrows, 2002-04
Dr. X Xu, 2004-07
Kimberly Thompson, 2007-09
R.M. Kostrzewa, Ph.D.
RESEARCH ASSOCIATES
Dr. M. Blair Clark, NIH Postdoctoral Fellowship, 1977-79
Dr. Hideki Fukushima, Dept. Pediatrics, Tottori University, Japan, sabbatical 1978-80
Dr. Craig T. Harston, Postdoctoral Fellow, 1978-81
Dr. Dolores Klisans-Fuenmayor, Dept. Physiology, University of Venezuela, Caracas, Venezuela, sabbatical, 1982-83
Prof. Dr. Ryszard Brus, Chairman, Department of Pharmacology, Medical University of Silesia, Poland. Visiting
Scientist: 1981, -91, -92, -93, -94, -95, -96, -97
Prof. Dr. Andrzej Plech, Medical University of Silesia, Poland. Visiting Scientist, 1992
Ms. Tanisha Douglas, McNair Fellowship, 1992
Mr. Ed Abell, American Society of Pharmacology (ASPET) Fellowship, 1992
Dr. Dong Yugang, Sun Yat-sen University, China, sabbatical, 1997
Dr. Joanna Oswiecimska, Medical University of Silesia, Poland. Visiting Scientist, 2000
Ms. Salyka Sengsayadeth, ASPET Fellowship, 2001
Dr. Alexis Dagnino Subiabre, University of Chile, Santiago, Chile; Visiting student, 2002.
Dr. Przemyslaw Nowak, Department of Pharmacology, Medical University of Silesia, Poland.
Visiting Scientist: 1999; 2002; 2003; 2006; 2008
Dr. Roseanna Kostrzewa, ASPET Fellowship, 2003
UNIVERSITY COMMITTEES
Faculty Senate, ETSU, 1978-81; Faculty Senate Research Committee, ETSU, 1978-80
Faculty Senate ad hoc Committee on Curriculum, 1979
University Research Development Committee, 1978-85; Chairman, 1982-83
Institutional Self-Study Committee for the ETSU=s Quillen-Dishner College of Medicine 1980-81; Chairman,
Committee on Animal Care Facility, 1980-81
Research Committee on Institutional Self Study for ETSU, 1981-82; 1987-88
Search Committee for Director of Contracts and Grants, 1983
ETSU College of Medicine Student Promotions Committee, 1984-87; 1995-97; 2004-2006, 2008
ETSU Col. Medicine Faculty Advisory Council, 1986-92; 1998-2003; Chairman, 1987-88
Search Committee, Vice-President for Finance & Administration, 1988
Faculty Council ad hoc Committee on Grade Appeal, 1987; Chairman
Organizer of Faculty Forum at ETSU College of Medicine, 1987
Chairman, ETSU College of Medicine Faculty Forums (1988, 1989)
Ad hoc member, Search Committee for Director, Continuing Medical Education, 1990
Chairman, Research Forum Committee, 1990-91
Continuing Medical Education Committee, 1994-96
Graduate Program Review Committee, 1994-96
Graduate Coordinator, Department of Pharmacology (1994-2003)
Ad hoc Tenure Review Committee, 1997
Biomedical Sciences Graduate Committee, 2000-2003
Search Committee, Chairperson, Department of Pharmacology, ETSU College of Medicine, 2005
ETSU Col Medicine, Faculty Promotion and Tenure Committee, 2011- present
R.M. Kostrzewa, Ph.D.
JOURNAL AND BOOK EDITORIAL ACTIVITIES 1998 Founding Editor of the journal Neurotoxicity Research
1998-2017, Editor-in-Chief, Neurotoxicity Research. Impact Factor, 3.514 for 2011 (most recent yr) 2010 IF=3.014; 2009 IF=2.439; 2008 IF=2.828; 2007 IF=5.234
2003- present, Editorial Board, J. Neural Transmission
2012- present, Editorial Board, Neurochemical Research
2012-present, Editorial Board, Applied Cell Biology
1998- 2009, Editorial Board, Neurobiology Section of Amino Acids
2002, Guest co-Editor of Neurobiology issue of Amino Acids
1997 - 2001, Editorial Advisory Board, Nutritional Neuroscience
1980 - 2001, Associate Editor, Peptides
2010 – present, Editor-in-Chief, Handbook of Neurotoxicity, Springer Science, New York.
2010 - co-Editor-in-Chief (with Trevor Archer, Gőteborg Univ., Sweden), Springer Science Book series
on Current Topics in Neurotoxicity. Springer Science, New York.
1999 - 2003, Editor-in-Chief, FP Graham Biomedical Book Series
1996 - 1998, Editor-in-Chief, Sulzburger & Graham Biomedical Book Series
HONORS/AWARDS
2005 Doctor Honoris causa, Medical University of Silesia, Katowice, Poland.
2004, 2005 Gender Equity Award, Quillen College of Medicine, East Tennessee State Univ.
2001 Honorary Membership, Polish Pharmacological Society
1997-2003 Visiting Professorship, Medical University of Silesia, Zabrze, Poland
1996, 1999, 2000 Ad hoc reviewer, Grant Agency of Czech Republic Ministry of Health
1994, 1998 Dean’s Teaching Recognition Award
1996 Fellow of the Japan Society for the Promotion of Science
1994 Designation of the Pharmacological Reviews article, "Pharmacological Actions of 6-Hydroxydopamine"
(R.M. Kostrzewa and D.M. Jacobowitz) among the 400 most-cited articles in the life sciences
1993 Designation of the Pharmacol. Reviews article as a Citation Classic in Current Contents
1992 Fellow of the John E. Fogarty International Center
1990 Fellow of the John E. Fogarty International Center
1987 Invited Lecturer, 15th Intl Summer School of Brain Research, Amsterdam, The Netherlands
1981 Recipient, East Tennessee State University Foundation Research Award
GRANT REVIEWS, SITE TEAMS
1994 Site-team reviewer for NIMH at UCLA
2003 Site-team reviewer, Instituto de Ciencies Biomedica Facultad de Medicine, Universidad de
Chile in Santiago, Chile.
2008/July, External Reviewer for the Atlantic Canada Opportunities Agency (ACOA)
Atlantic Innovation Fund (AIF) Project
2010/Nov Review of a TEAM program grant application for the Fundacja na rzecz Nauki Polskiej
(i.e., Foundation for Polish Science).
Ad hoc JOURNAL REVIEWER, 2000- , >100 papers:
Amino Acids Comp. Biochem. Physiol. Neurochem. Res. Peptides
Brain Eur. J. Pharmacol. Neurosci. Lett. Pharmacological Reports
Brain Res. Eur. J. Neurosci. Neurotoxicity Res. Pol. J. Pharmacol.
Neuropharmacology Prog. NeuroPsychopharm. Biol Psychiatry
R.M. Kostrzewa, Ph.D.
GRANTS
Kostrzewa, R.M., Growth and Development of Monoaminergic Neurons, R01 NS 14797 NEUA,
06-01-75 to 12-31-78.
Kostrzewa, R.M., Adrenergic-Cholinergic Interactions in the Myocardium, Louisiana Heart
Association, 07-01-75 to 06-30-76.
Kostrzewa, R.M. and M.G. Levitzky, Paralytic Salivary Secretion and the Influence of Circulating
Catecholamines and Exogenous Sympathomimetic Amines, Louisiana State University School of
Dentistry, 07-01-76 to 06-30-77.
Kostrzewa, R.M., Determination of the Mechanisms of Anti-Parkinsonian Activity of L-prolyl-L-
leucyl-glycinamide, American Parkinson's Disease Association, 02-01-77 to 12-31-78.
Kostrzewa, R.M., Association of Neuronal Development with Regenerative Sprouting, National
Foundation March of Dimes, 07-01-77 to 06-30-79.
Kostrzewa, R.M., Sponsor for NIH Research Fellowship to M.B. Clark on Neuronal Development,
Regeneration and Sprouting, 07-01-77 to 06-30-79.
Kostrzewa, R.M., Growth and Development of Monoaminergic Neurons, R01 NS 14797 NEUA
(Supplement), 07-01-78 to 12-31-78.
Kostrzewa, R.M., Investigation of the Altered Mechanisms of Huntington's Chorea: A New
Approach Toward Treatment, East Tennessee State University Research Development Committee
Award, 07-01-78 to 06-30-79.
Kostrzewa, R.M., Growth and Development of Monoaminergic Neurons (Renewal), R01 NS 14797
NEUA (1A)ND, 07-01-78 to 06-30-82.
Kostrzewa, R.M., Influence of Purkinje Cells on Noradrenergic Neuronal Growth, NIH Biomedical
Research Support Grant, 07-01-80 to 03-31-81.
Kostrzewa, R.M., Highly Selective Neurotoxic Agents, 1 R01 NS 16887 NEUB (1A)ND,
Subcontractor with C.L. Blank of the University of Oklahoma, 07-01-81 to 06-30-85.
Kostrzewa, R.M., Topographical Changes in Noradrenergic Fibers Following Regenerative
Sprouting, ETSU Presidential Grant and Research Development Committee Award, 1984.
Kostrzewa, R.M., Description and Mapping of Dopaminergic Fibers to the Pyriform Cortex, East
Tennessee State University Research Development Committee Award, 01-01-85 to 06-30-86.
Kostrzewa, R.M., Peptide Modulation of Dopamine Receptors, East Tennessee State University
Research Development Committee Award, 01-01-87 to 12-31-87.
Kostrzewa, R.M., Neuropeptide Influence on Dopamine Receptor Populations, East Tennessee State
R.M. Kostrzewa, Ph.D.
University Presidential Grant, 1987.
Kostrzewa, R.M., Dopamine Receptor Coupling with Second Messenger Production, NIH
Biomedical Research Support Grant, 07-01-88 to 03-31-89.
Kostrzewa, R.M., Dopamine D1 and D2 Receptor Complex in Ontogenetically Altered Animal
Models, Scottish Rite Schizophrenia Research Program, 09-01-89 to 08-31-92.
Kostrzewa, R.M., Association of Behaviors with Dopamine Receptor Status in Animals with
Long-Term Changes in Dopamine D1 and D2 Receptors, Southern Regional Education Board, 1989.
Kostrzewa, R.M., Observation and Testing of Equipment to Digitize Oral Behavior, East Tennessee
State University Presidential Grant, 1990.
Kostrzewa, R.M., Dopamine Agonist-Induction of Stereotypic Behavior in Rats with Supersensitive
D1 and D2 Receptors, John E. Fogarty International Center for Advanced Study in the Health
Sciences, 1990.
Kostrzewa, R.M., Pharmacologic Study on Models of Tardive Dyskinesia, National Institute of
Neurological Disorders and Stroke, NS29505, 1991-95.
Kostrzewa, R.M., Characterization of Supersensitized Serotonin Receptors, East Tennessee State
University Research Development Committee, 1991.
Kostrzewa, R.M., Fellowship Award from the American Society for Pharmacology and Experimental
Therapeutics for sponsoring a summer research fellow, 1992.
Kostrzewa, R.M., Influence of Supersensitized Dopamine D1 and D2 Receptors on in vivo Dopamine
Turnover, John E. Fogarty International Center for Advanced Study in the Health Sciences, 1992.
Kostrzewa, R.M., Autoradiographic localization of 5-HT uptake sites in rat brain: relation to
dopamine receptors supersensitivity, ETSU Grant-in-Aid, 1993.
Kostrzewa, R.M., Use of specialized equipment and conduct of a pilot study on in vivo
microdialysis. Laboratory of R.W. Fuller and K.W. Perry at Eli Lilly Co. East Tennessee State
University Presidential Grant, 1993.
Kostrzewa, R.M., Association of dopamine D1 receptor supersensitivity with changes in the
expression of serotonin receptor mRNAs, NIH Biomedical Research Support Grant, 1994.
Kostrzewa, R.M., Neural involvement and interactions in dyskinetic motor patterns, Japan Society
for the Promotion of Science (JSPS)/Fogarty International Center, Research/Scholar Exchange
Grant, 1996.
Kostrzewa, R.M., Serotonin innervation and effects in coloboma hyperactive mice, ETSU Grant-in-
Aid, 1997-98.
R.M. Kostrzewa, Ph.D.
Breese, G.R. and R.M. Kostrzewa (Co-PI), Potential alleviation of oral dyskinesias by olanzepine in
an animal model of tardive dyskinesia. Eli Lilly Co., 1999-01.
Kostrzewa, R.M., Dopamine nerves suppress •OH formation in neostriatum. NINDS 1R15 NS
39272, 1999-2003.
Brown RD and Kostrzewa RM (Co-I), Eli Lilly study on olanzapine effect on impaired memory in
dopamine agonist-primed rats; 2003-04.
Brown RD and Kostrzewa RM (Co-I, 5%), Amphetamine sensitization in a model of
schizophrenia, NINDS, 1 R15 DA020481-01 2006-09.
Kostrzewa RM, ETSU Presidential Grant, Sept-Oct 2009. Project initiation with Prof. Rosario
Moratalla, Cajal Institute, Madrid, Spain.
Kostrzewa RM and R Brown, Preclinical Testing in an Animal Model of ADHD, Merz
Pharmaceutical Co., Frankfurt Germany, 2011-12.
Brown RD (PI) Nicotine and the roles of nicotinic receptors in a rodent model of schizophrenia.
NIH R15 grant application. Kostrzewa RM, collaborator.
Kostrzewa RM, Brown RW. Adolescent methylphenidate in rats: sex differences and brain
plasticity. NIH R15 grant application (submitted June 2012).
R.M. Kostrzewa, Ph.D.
SYMPOSIA/CONFERENCES
15
th International Summer School of Brain Research. Conference on Biochemical Basis of Functional
Neuroteratology. Invited Lecture: Neurochemistry of Functional Neuroteratology of Catecholaminergic Neurons.
Amsterdam, The Netherlands, 1987.
Organizer, symposium on The Basal Ganglia in Health and Disease: Perspectives on Future Treatment of
Parkinsonism, Psychosis and Tardive Dyskinesia. Lecture: Prolyl-leucyl-glycinamide Attenuation of Neuroleptic-
Iinduced Impairment of Dopamine D1 and D2 Receptor Ontogeny: Implication for Treatment of Tardive Dyskinesia.
Sponsor: Sandoz Pharmaceutical Co. East Tennessee State University, Johnson City, TN 1988.
Proceedings of the Society for Experimental Biology and Medicine, Southeastern Meeting. Lecture: Dopamine
Agonists Modify the Development of Dopamine D1 and D2 Receptor Responsiveness. Johnson City, TN, 1989.
11th Annual Meeting of the Southeastern Pharmacology Society. Organizer of the symposium Neural Adaptations to
Drugs of Abuse. Sponsors: Burroughs Wellcome Company, Upjohn Pharmaceutical Company, East Tennessee State
University, Johnson City, TN 1990.
11th Annual Meeting of the Southeastern Pharmacology Society. Organizer of the symposium Vistas for CNS Active
Drugs. Sponsors: Glaxo Pharmaceuticals, Eli Lilly Pharmaceutical Company, Parke-Davis Pharmaceutical Company,
Sandoz Pharmaceuticals; Somerset Pharmaceuticals; East Tennessee State University, 1990.
11th Annual Meeting of the Southeastern Pharmacology Society. Organizer of the Program for Graduate Students:
Careers in Pharmacology. Sponsors: Beecham Pharmaceutical Company, Upjohn Pharmaceutical Company, East
Tennessee State University, Johnson City, TN 1990.
1st International Conference on Botulinum and Tetanus Neurotoxins: Neurotrans-mission and Biomedical
Aspects. Invited Lecture: Altered Sensitivity of Recognition Sites for a Neurotransmitter in the Absence of Changes in
Receptor Binding Parameters: Co-Sensitization of an Alternate System. Madison, WI, 1992.
VII International Symposium on Catecholamines. Invited Lecture: Persistent Changes in the Catecholaminergic
System Following Perinatal Insult. Co-chairman with J.W. Gibb of the symposium, Degeneration, Toxicity, Mechanisms
and Developmental Effects. Amsterdam, The Netherlands, 1992.
1st International Congress of the Polish Neuroscience Society. Invited Lecture: Serotonin Systems Mediate
Dopamine Receptor Supersensitivity. Session on APhysiology and Pharmacology of Neurotransmitters and their
Receptors@. Warsaw, Poland, 1992.
5th European Behavioral Pharmacology Society meeting. Organizer and Chairman of the symposium, Animal models
of tardive dyskinesia. Lecture: Interaction of Serotonin and Dopamine Neurotransmitters in the Genesis of Oral Activity.
Berlin, Germany, 1994.
2nd International Congress of the Polish Neuroscience Society. Co-Chairman with R. Brus of the Symposium,
Neuropharmacology I - Dopaminergic Transmission. Lecture: Sensitization to Dopamine and Serotonin Agonists is Not
Correlated with Alterations in Dopamine and Serotonin Contents of Neostriatum after Neonatal Intrastriatal 6-
Hydroxydopamine Injections in Rats. Cracow, Poland, 1995.
2nd International Congress of the Polish Neuroscience Society. Symposium, Neuropharmacology I - Dopaminergic
Transmission. Lecture: Nitric Oxide and Central Dopamine Receptor Reactivity in Rats. Cracow, Poland, 1995.
12th Congress of the Polish Pharmacology Society. Symposium, Dopamine and Motor Control. Lecture:
Complementarity of Dopamine and Serotonin Neurons in Regulating Motor Activity. Bydgoszcz, Poland, 1995.
5th International Congress on Amino Acids: Satellite meeting on Neurobiology. Organizer and Chairman of the
symposium, Neurotoxicity and Neurotoxic Potential of Amino Acids. Lecture: Destruction of Catecholamine-Containing
Neurons by 6-Hydroxydopa, an Endogenous Amine Oxidase Cofactor. Chalkidiki, Greece, 1997.
3rd International Congress of the Polish Neuroscience Society. Co-Organizer with J.Z. Nowak (Polish Academy of
R.M. Kostrzewa, Ph.D.
Sciences in d of the satellite symposium, Dopamine: New Trends in Receptor Research and Therapeutic
Implications. Lecture: Dopamine Receptor Supersensitivity. d, Poland, 1997.
13th
Polish Pharmacology Society Meeting. Co-Organizer with R. Brus (Silesian Academy of Medicine) of the satellite
symposium, Psychopharmacology of Coordinate Dopamine and Serotonin Neurochemistry: New Hypotheses and Impact
on Therapeutic Strategies. Lecture: Interactive Modulatory Roles of Dopamine and Serotonin Neurons on Sensitivity of
the Alternate Neurochemical System. Katowice, Poland, September 1998.
5th
Internet World Congress on Biomedical Sciences (INABIS99). Co-Organizer with J. Smythies (Univ. of San
Diego) of the symposium, Quinones and Other Reactive Oxygen Species in Neurobiologic, Apoptotic and Neurotoxic
Processes. McMaster University, Hamilton, Ontario, Canada, December 1998.
6th
International Congress on Amino Acids: Satellite meeting on Neurobiology. Symposium on Neurobiology of the
Ventral Basal Ganglia Loop. Lecture: Dopaminergic Denervation Enhances Susceptibility to Hydroxyl Radicals in Rat
Neostriatum. Bonn, Germany, August 1999.
4th
Polish International Neuroscience Meeting. Co-Organizer with R. Brus (Silesian Medical University) of the
symposium, New Therapeutic Strategies for Neurologic and Psychiatric Disorders. Lecture: Serotonin Mediates
Amphetamine-Attenuated Hyperlocomotor Activity in Rats. Gdansk, Poland, September 1999.
Fundación Cerebro y Mente International Meeting on Neurotoxicology, Degeneration and Protection in Brain
Disease States. Co-chair with E. Molina-Holgado (Instituto Cajal, Madrid, Spain) of the symposium, Neurotoxicological
Processes in Neuropsychiatry. Mojácar, Spain, October 1999.
Fundación Cerebro y Mente International Meeting on Neurotoxicology, Degeneration and Protection in Brain
Disease States. Co-chair with T. Palomo (Servicio de Psiquiatria, Hospital 12 de Octubre, Madrid, Spain) of the
symposium, The Essence of Protection in Neurodegenerative Disorders. Lecture: Neurotoxicity and Neurodegener-
ation: Among the Shifting Dunes of Protection. Mojácar, Spain, October 1999.
6th
Internet World Congress on Biomedical Sciences (INABIS2000). Co-Organizer with J. Callebert (Rene Descartes
Univ., Paris, France) of the symposium, Reactive Oxygen Species in Neurodegeneration. Presentation: Dopamine
Innervation and L-DOPA Treatment Suppress Hydroxyl Radical Formation in Rat Striatum. Madrid, Spain, February
2000.
Neurotoxicity as a Mechanism for Neurodegenerative Disorders: Basic and Clinical Aspects. Organizing
Committee. Lecture: Neurotoxic and Neuroprotective Properties of Dopamine: Relevance to Parkinson=s Disease.
Pucón, Chile, March 2001.
Neurotoxicity as a Mechanism for Neurodegenerative Disorders: Basic and Clinical Aspects. Chair, Symposium on
Neurotoxic Aspects of Antiparkinsonian Drugs, Pucón, Chile, March 2001.
10th
Neuropsychopharmacological Days. Lecture: Insidious Dopamine: Provocateur or Protectorate in Parkinson=s
Disease? Ustro, Jaszowiec, Poland, May 2001.
7th
International Congress on Amino Acids: Satellite meeting on Neurobiology. Symposium on Neural Mechanisms
Underlying Neurodegenerative Disorders. Lecture: Suppression of Spontaneous Hydroxyl Radical Formation in
Dopamine-Denervated Neostriatum, but Enhancement by Glutamate. Vienna, Austria, August 2001.
14th
Polish Pharmacology Society Meeting. Co-Organizer with Ryszard Brus (Silesian Medical Univ.) of the
symposium, Complimentary Neuroprotective Roles of Dopaminergic and Serotoninergic Neurons. Lecture: Involvement
of Dopaminergic Neurons in Generating and Sequestering Reactive Oxygen Species, Kraków, Poland, September 2001.
Fundación Cerebro y Mente International Meeting on Neurodevelopmental Liabilities in Brain Disease States.
Lecture: The Destructive Propensities of Perinatal Neurotoxins on Brain Development and Function. Mojácar, Spain,
October 2001.
Fundación Cerebro y Mente International Meeting on Neurodevelopmental Liabilities in Brain Disease States.
Chairman, symposium session on Risk Factors Affecting AVulnerability for Movement Disorders. Mojácar, Spain.
R.M. Kostrzewa, Ph.D.
11th
Neuropsychopharmacological Days. Lecture: Serotonin and Parkinson’s Disease. Ustron, Jaszowiec, Poland, May
2002.
1st Neurotoxicity Soc. Meeting: Mechanisms for Neurodegenerative Disorders. Lecture: Dopamine Receptor
Supersensitivity as an Index of Neurotoxicity. La Serena, Chile, April 24-27, 2003.
12th
Neuropsychopharmacological Days. Lecture: Priming as a process for producing dopamine D2 receptor
supersensitization: relevance in psychiatric disorders. Ustro, Jaszowiec, Poland, May 2003.
8th
International Congress on Amino Acids: Satellite meeting on Neurobiology. Lecture: L-DOPA elevates dopamine
in Parkinsonian rat striatal tissue and microdialysates without increasing hydroxyl radical production. Rome, Italy,
September 2003.
Fundación Cerebro y Mente International Meeting on Genes and Environment Interplay in Neuropsychiatric
Disorders. Lecture: Dopamine agonist priming in intact and dopamine-lesioned rats: implications for motor
dyskinesias. Mojácar, Spain, October 2003.
XV International Congress of the Polish Pharmacological Society. Co-Organizer with Ryszard Brus (Silesian
Medical Univ.) of the symposium, Neuropsychiatric and Neurodegenerative Disorders – Mechanisms and
Treatment. Lecture: In vivo Microdialysis Studies in an Animal Model of Parkinson’s Disease; Peculiarities of L-
DOPA Therapy, Poznan, Poland, 12-14 September 2004.
Satellite Meeting, Society for Neuroscience. Co-Chairman with J. Segura-Aguilar (Univ. Chile), Symposium on Iron
and Parkinson’s Disease. San Diego, CA, 22 October 2004. Introduction of Symposium by RM Kostrzewa.
2nd Neurotoxicity Soc. Meeting: Mechanisms for Neurodegenerative Disorders. Vice-Chair, Organizing
Committee. Lecture: L-DOPA Effects on Striatal Microdialysate Levels of Hydroxyl Radical in Parkinsonian Rats.
Viña del Mar, Chile, 8-10 April 2005.
14th
Neuropsychopharmacological Days. Member, Scientific Committee. Lecture: Modeling tardive dyskinesia:
predictive new treatment. Ustroń, Jaszowiec, Poland, May 2005.
16th International Congress on Parkinson’s Disease and Related Disorders. Co-Chair with M.B.H. Youdim
(Haifa Univ., Israel) of Symposium on “Controversies on new animal models of Parkinson’s disease: Pro and con.
Berlin, Germany, 5-9 June 2005.
Fundación Cerebro y Mente International Meeting on Implications of Comorbidity for Etiology and
Treatment of Neuropsychiatric Disorders. Lecture: Haloperidol-induced tardive dyskinesia in rats, its persistence
after discontinuation of haloperidol, and effective treatments. Mazagon (Huelva), Spain, October 2005.
Neurotoxicity Society Satellite Meeting, Society for Neuroscience. Organizer and Co-Chairman with J. Segura-
Aguilar (Univ. Chile): Dopamine Oxidation and Parkinson’s Disease. Georgetown University, Washington DC.
November 2005.
15th
Neuropsychopharmacological Days. Member, Organizing Committee. Lecture: Selective neurotoxins and
neuroscience – approaching the golden anniversary. Ustron, Jaszowiec, Poland, May 2006.
European Behavioral Pharmacology Soc. Workshop. Co-Chair with Prof. Ryszard Brus of the Symposium Basic
mechanisms of neurodegeneration and neuroprotection. Krakow, Poland, 02-04 September 2006.
Neurotoxicity Society Satellite Meeting, Society for Neuroscience. Organizer and Co-Chairman with L. Walker
(Emory Univ.): Neurotoxic Mechanisms in Alzheimer’s Disease. Emory University, Yerkes Primate Center, Atlanta,
GA. October 2006.
3rd
Neurotoxicity Society Meeting. Vice-Chair, Organizing Committee. Lecture: Serotonin in a Parkinsonian Rat.
Pucon, Chile, March 2007.
R.M. Kostrzewa, Ph.D.
Satellite of 3rd
Neurotoxicity Society Meeting. Organizer, Neurotoxins: Where we’ve been, where we are, where
we’re going. Patagonia, Chile, March 2007.
1st Int’l Congress on ADHD: from Childhood to Adult Disease. Co-Chair with M. Gerlach (Univ. Würzburg) of
the Plenary Session on Experimental Models of ADHD and Plenary Lecturer on Pharmacologic Models of ADHD.
Würzburg, Germany, 2-5 June 2007.
Recent Therapeutic Advances in Parkinson’s and Alzheimer’s Diseases Conference. Lecture: Serotonin and
Parkinson’s Disease; and Chair of the session, Parkinson’s Disease III: Therapeutic Iron Chelators. Technion-Israel
Institute of Technology, Haifa, Israel, 7-10 October 2007.
Fundación Cerebro y Mente International Meeting: ‘Beyond Neuropsychiatric Diagnostics: Symptoms not
Disorders’. Lecture: Dopamine receptor sensitivity and stereotypic / motor behaviours. Mazagon (Huelva), Spain,
18-21 October 2007.
Neurotoxicity Society/UCSD Shiley-Marcos Alzheimer’s Disease Research Center, Satellite Meeting, Society
for Neuroscience. Co-Organizer with J. Segura-Aguilar (Univ. Chile) and Eliezer Maslia (Univ. California in San
Diego): Protein Misfolding and Synaptic Toxicity. Speakers: Z Khachaturian, M Shelanski, DJ Selkow, B Hyman,
JQ Trojanowski, L Mucke, B Ghetti, Z Talloczy, H Ischiropoulos. University of California, San Diego, CA. CME
Accredited thru UCSD. 2 November 2007.
17th
Neuropsychopharmacological Days. Lecture: Advances in Dopamine Research: Success of Three Decades of
Research Collaboration Between the Medical University of Silesia in Poland and the Quillen College of Medicine at
East Tennessee State University in the USA. Ustron, Jaszowiec, Poland, May 2008.
Neurotoxicity Society Satellite Meeting, Society for Neuroscience. Chairman, session on Degeneration and
Neuroprotection of Dopaminergic Neurons. Georgetown University, Washington DC. November 14, 2008.
4th
Neurotoxicity Society Meeting. Vice-Chair, Organizing Committee; Lecture: Amourphous Selective
Neurotoxins; Chairman, Poster session. Arica, Chile, 24-26 April 2009.
Satellite of 4th
Neurotoxicity Society Meeting. Organizing Committee. Debate with Dr. Rosario Moratalla
(Instituto Cajal, Madrid, Spain): Serotonin & Parkinson Disease. Arica, Chile; Tacna, Peru, 27-30 April 2009.
Fundación Cerebro y Mente Intl Meeting: ‘Staging Neuropsychiatric Disorders: Implications for Etiopatho-
genesis & Treatment’. Lecture: Stereotypic Progressions in Psychotic Behaviour. Mojacar Spain, 14-18 Oct 2009.
CME Program on “ADHD: From Basic Science to Bench Side” at 10th
Annual Meeting of the Safety
Pharmacology Society. Lecture: Animal Models of ADHD. Boston, MA, 20-23 September 2010.
4th
Mediterranean Neuroscience Meeting. Co-Chair (with Wael Mohammad, Penn State Univ.) for the symposium
“Attention Deficit Hyperkinetic Disorder (ADHD) from Science to Treatment”, Istanbul, Turkey, Sept. 30-Oct. 3,
2012. [Scheduled in the program] – CANCELLED by RMK & WM
6th
Neurotoxicity Society Meeting. Invited Lecturer: The dopamine D2 agonist quinpirole as a non-
neurodegenerative neurotoxin. Valdivia, Chile, 21-24 March 2013.
XVIII International Congress of the Polish Pharmacological Society. Invited Lecture: “The Changing Face of
Neurotoxins”. Kazimierz Dolny, Poland, 22-25 May 2013.
11th
World Congress of Biological Psychiatry Meeting. Kostrzewa RM. Symposium: Dopamine D2 receptor
supersensitivity: impact on schizophrenia. Co-Chair: R Moratalla (Cajal Inst., Madrid, Spain). RM Kostrzewa
Lecture: Dopamine D2 Receptor Supersensitization – Effect on Dopamine Release and Actions. Other Speakers: R
Maggio (Univ. L’Aquila, Italy), Hiroyuki Nawa (Niigata Univ, Japan), P Sokoloff (Pierre Fabre Research Inst,
Castres, France). Kyoto, Japan. 23-27 June 2013.
11th
International Symposium on VIP, PACAP and Related Peptides. Invited Lecture on “Evolution of Selective
Neurotoxins”, in Neurotoxicity themed session. Pecs, Hungary, 26-31 August 2013.
R.M. Kostrzewa, Ph.D.
SCIENTIFIC COMMITTEES
Organizing Committee, 5th
Neurotoxicity Soc. Meeting, Uspallata, Mendoza, Argentina, 2011.
Vice-Chair, Organizing Com., 4th
Neurotoxicity Soc. Meeting, Arica, Chile, Apr. 2009.
Co-Organizer with J Segura-Aguilar (Univ. Chile); Program Chair, Satellite of 4th
Neurotoxicity Soc. Satellite Meeting,
Arica, Chile; Tacna, Peru, April 2009.
Co-Organizer with J Segura-Aguilar (Univ. Chile) and E Masliah (Univ Calif. San Diego) of the Neurotoxicity Society
meeting in San Diego; Symposia on Abnormal Intraneuronal Proteins & Alzheimer Disease, and Abnormal
Intraneuronal Proteins & Parkinson’s Disease, 3 November 2007.
Vice-Chair, Organizing Com., 3rd
Neurotoxicity Soc. Meeting, Pucon, Chile, Mar. 2007.
Vice-Chair, Organizing Com., 3rd
Neurotoxicity Soc. Satellite Meeting, Patagonia, Chile, Mar. 2007.
Co-Organizer with L. Walker of the Neurotoxicity Society meeting at Emory Univ. Yerkes Primate Research Center
in Atlanta; Symposium on Neurotoxic Mechanisms in Alzheimer’s Disease, October 2006.
Member, Scientific Com., Eur. Behav. Pharmacol. Soc. Workshop on Neurodegenerative Disorders, Krakow, Poland,
02-04 September 2006.
Member, Scientific Com., 15th
Neuropsychopharmacological Days, Ustrón, Poland, May 2006.
Co-Organizer with J. Segura-Aguilar of Satellite meeting for the 2005 Society for Neuroscience Meeting in
Washington DC; and symposium on Dopamine Oxidation and Parkinson’s Disease, 11 November 2005.
Member, Program Com., 9th
Intl Congress on Amino Acids, Neurobiology section, Vienna, Austria, August 2005.
Member, Scientific Com., 14th
Neuropsychopharmacological Days, Ustrón, Poland, May 2005.
Vice-Chair, Organizing Com., 2nd
Neurotoxicity Soc. Meeting, Viña del Mar, Chile, April 2005.
Co-Organizer with J. Segura-Aguilar of Satellite meeting for the 2004 Society for Neuroscience Meeting in San Diego,
CA; and symposium on Iron and Parkinson’s Disease, October 2004.
Member, Scientific Com., 15th Polish Pharmacological Congress, Poznan, Poland, Sept. 2004.
Member, Program Com., 8th
Intl Congress on Amino Acids and Proteins, Rome, Italy, Sept. 2003.
Vice-Chair, Organizing Com., 1st Neurotoxicity Soc. Meeting, La Serena, Chile, Apr. 2003.
Member, Program Com., 11th
Neuropsychopharmacological Days, Ustrón, Poland, May 2003.
Member, Organizing Com., Neurotoxicity Soc. Meeting, Pucon, Chile, March 2001.
Member, Scientific Com., 14th
Polish Pharmacological Congress, Krakow, Poland, Sept. 2001.
R.M. Kostrzewa, Ph.D.
SEMINARS/LECTURES (1990- )
Pharmacologic Modulation of Antipsychotic Actions by an Endogenous Neuropeptide. Department of Environmental
Practice, University of Tennessee School of Veterinary Medicine, Knoxville, TN, 1990.
Dopamine Agonists Sensitize D1 and D2 Receptors During Development. Department of Psychology, UCLA, Los
Angeles, CA, 1990.
Supersensitization of Brain Dopamine Receptors. Department of Pharmacology, Silesian Academy of Medicine,
Katowice, Poland, 1990.
Drug-Induced Alteration of the Development of Brain Dopamine Receptors. Department of Pharmacology, Silesian
Academy of Medicine, Zabrze, Poland, 1990.
Homologous Priming of Brain Dopamine Receptors. Institute of Pharmacological Sciences, Polish Academy of Sciences,
Cracow, Poland, 1990.
Pharmacological Treatment of Parkinsonism. Silesian Academy of Medicine lecture. Research in Medicine Orientation
Program for medical students. Jaszowiec, Poland, 1990.
Primed and Non-Primed Brain Dopamine Receptors. Department of Pharmacology, Lublin Academy of Medicine,
Lublin, Poland, 1990.
Supersensitization of Dopamine D1 Receptors. Department of Pharmacology and Physiology of the Nervous System,
Institute of Psychiatry and Neurology, Warsaw, Poland, 1990.
Production of Homologous and Heterologous Supersensitization of Dopamine Receptors: Models to Study Affective
Disorders. Department of Endocrinology, Louisiana State University School of Medicine, Pennington Biomedical
Research Center, Baton Rouge, LA, 1991.
Neonatal Destruction of Dopamine Neurons Supersensitizes Serotonin Receptors in Rats. Department of Biochemistry,
University of Tennessee, Knoxville, TN, 1992.
Dopamine Receptor Supersensitivity. Department of Pharmacology, Silesian Academy of Medicine, Zabrze, Poland,
1992.
Dopamine-Serotonin Interactions in the Central Nervous System. Department of Pharmacology, Silesian Academy of
Medicine, Zabrze, Poland, 1994.
Supersensitization of Dopamine Receptors is Mediated by Serotonin Neurons. Departments of Psychology and
Pharmacology, and Ohio State University Chapter of the Society for Neuroscience, Columbus, OH, 1995.
Persistent Spontaneous Oral Dyskinesias Induced by Long-Term Haloperidol Treatment of Dopamine-Lesioned Rats.
Department of Pharmacology, Silesian Academy of Medicine, Zabrze, Poland, 1995.
Serotonin Nerves Modulate the Motor Regulatory Actions of Dopamine. Department of Pharmacology, College of
Medicine, Howard University, Washington, D.C., 1995.
Dopamine Receptor Sensitivity is Regulated by Serotonin Neurochemistry. Department of Ophthalmology, Yamanashi
Medical University, Tamaho, Yamanashi, Japan, 1996.
Perplexities of Dopamine D2 Receptor Supersensitivity. Department of Pharmacology, Silesian Academy of Medicine,
Zabrze, Poland, 1996.
Role of Reactive Oxygen Species in Neurodegenerative Disorders. Department of Pharmacology, Silesian Academy of
Medicine, Zabrze, Poland, 1997.
Neurotoxicological Actions of 6-Hydroxydopa, an Endogenous Amine Oxidase Cofactor. Katowice Pharmacology
Society, Katowice, Poland, 1997.
Putative Mechanisms Underlying Oral Dyskinesias in an Animal Model of Tardive Dyskinesia. Department of
Chemistry, Virginia Polytechnic University, Blacksburg, VA, 1997.
Proposed Multineuronal Basis for Dopamine Receptor Supersensitivity. Department of Anatomy and Cell Biology, East
Tennessee State University, 1997.
Thirty Years of Highly Selective Neurotoxins: Chemical Tools to Probe the Mind. Department of Pharmacology, Silesian
Medical University, Zabrze, Poland, 1998.
Dopamine Receptor Supersensitivity, a Phenomenon Intricately Linked to Serotonin Receptor Sensitization. Department
of Physiology & Pharmacology, Karolinska Institute, Stockholm, Sweden, 1998.
Amphetamine=s Modulation of Hyperactivity May be Mediated by Serotonin, not Dopamine. Department of
Neurophysiology, Nencki Institute, Warsaw, Poland, 1998.
Duplicitous Dopamine: Pro- and Anti-Oxidant Actions Promote and Protect from Neuronal Necrosis and Apoptosis.
Silesian Medical University, Zabrze, Poland, 1999.
Genesis of Parkinson=s Disease: Apoptosis or Necrosis of Substantia Nigra? Impact on Therapeutic Strategies. Silesian
Medical University Lecture series in Progress in Medicine and Basic Science, Katowice, Poland, 2000.
Serotonin and Parkinson=s Disease. Department of Pharmacology, Medical University of Silesia, Zabrze, Poland, May
2002.
R.M. Kostrzewa, Ph.D.
Parkinson=s Disease. Medical student class, Medical University of Silesia, Zabrze, Poland, May 2002; 2003.
Neural Adaptations underlying L-DOPA Treatment in an Animal Model of Parkinson’s Disease. Department of
Pathology, Case Western Reserve University, Cleveland, OH, June 2004. Neural Adaptations underlying L-DOPA Treatment in an Animal Model of Parkinson’s Disease. Department of Internal
Medicine, East Tennessee State University, Nov 2004.
Peculiarities of L-DOPA Therapy of Parkinson’s Disease. Institute of Physiology, Academy of Sciences of the Czech
Republic, June 2005.
Serotonin Modulation of Dopamine Neurotransmission and Reactivity: Relevance to Parkinson’s Disease. Department
of Pharmacology, East Tennessee State University, Feb 2007.
Serotonin & Parkinson’s Disease. Merck-Serono Pharmaceutical Co., Geneva, Switzerland, October 2009.
Serotonin & Parkinson’s Disease. Department of Oncology and Neuroscience, University of Chieti-Pescara, via del
Vestini, 66100 Chiet. Invitation by Prof. Pio Conti. Date – October 14, 2010.
R.M. Kostrzewa, Ph.D.
PUBLICATIONS
1. Haugaard N, NH Lee, R Kostrzewa and ES Haugaard (1968) Effects of a disulfide (Ellman's reagent)
and thiols on oxidative phosphorylation and ion transport by rat liver mitochondria. Biochem.
Pharmacol. 18, 2385-2391.
2. Haugaard N, NH Lee, R Kostrzewa, RS Horn and ES Haugaard (1969) The role of sulfhydryl groups
in oxidative phosphorylation and ion transport by rat liver mitochondria. Biochem. Biophys. Acta.
172, 198-204.
3. Jacobowitz D and R Kostrzewa (1971) Selective action of 6-hydroxydopa on noradrenergic terminals:
Mapping of preterminal axons of the brain. Life Sci. 10, 1329-1341.
Kostrzewa R (1971) A biochemical and histofluorescent investigation of the central and peripheral
effects of 6-hydroxydopa on adrenergic and dopaminergic nerves. Doctoral Dissertation, Dissertation
Abstracts Intl. 32 (No.12), 1971. Advisor: David M Jacobowitz.
4. Kostrzewa R and D Jacobowitz (1972) The effect of 6-hydroxydopa on peripheral adrenergic neurons.
J. Pharmacol. Exp. Ther. 183, 284-297.
5. Kostrzewa R and D Jacobowitz (1973) Acute effects of 6-hydroxydopa on central monoaminergic
neurons. Europ. J. Pharmacol. 21, 70-80.
6. Kostrzewa RM and JW Harper (1974) Effects of 6-hydroxydopa on catecholamine-containing neurons
in brains of newborn rats. Brain Res. 69, 174-181.
7. Kostrzewa RM and DM Jacobowitz (1974) Pharmacological actions of 6-hydroxydopamine.
Pharmacol. Reviews 26, 199-288.
8. Fingerman M, WE Julian, MA Spirtes and RM Kostrzewa (1974) The presence of
5-hydroxytryptamine in the eyestalks and brain of the fiddler crab Uca pugilator, its quantitative
modification by pharmacological agents, and possible role as a neurotransmitter in controlling the
release of red pigment-dispersing hormone. Gen. Comp. Pharmacol. 5, 299-303.
9. Kostrzewa RM (1975) Effects of neonatal 6-hydroxydopa treatment on monamine content of rat brain
and peripheral tissues. Res. Commun. Chem. Pathol. Pharmacol. 11, 567-579.
10. Kostrzewa RM and JW Harper (1975) Comparison of the neonatal effects of 6-hydroxydopa and
6-hydroxydopamine on growth and development of noradrenergic neurons in the central nervous
system, in Chemical Tools in Catecholamine Research (T Malmfors, G Jonsson and C Sachs, Eds),
North Holland, Amsterdam, pp. 181-189.
11. Spirtes MA, RM Kostrzewa and AJ Kastin (1975) Effect of melanocyte stimulating hormone (MSH)
and MSH-release inhibiting factor on levels and synthesis of serotonin in various brain regions of
control and hypophysectomized rats. Pharmacol. Biochem. Behav. 3, 1011-1016.
12. Kostrzewa RM, AJ Kastin and MA Spirtes (1975) Effects of MSH and MIF-I on activity of
catecholamine-containing neurons in rat brain. Pharmacol. Biochem. Behav. 3, 1017-1023.
13. Kastin AJ, NP Plotnikoff, CA Sandman, MA Spirtes, RM Kostrzewa, SM Paul, LO Stratton, LH
Miller, F Labrie, AV Schally and H Goldman (1975) The effects of MSH and MIF on the brain, in
Anat. Neuroendocrinol., WE Stumpf and LD Grant, Eds), Karger, Basel, pp. 290-297.
R.M. Kostrzewa, Ph.D.
14. McLean JH, RM Kostrzewa and JG May (1976) Behavioral and biochemical effects of neonatal
treatment of rats with 6-hydroxydopa. Pharmacol. Biochem. Behav. 4, 601-607.
15. Kostrzewa RM and RE Garey (1976) Effects of 6-hydroxydopa on noradrenergic neurons in
developing rat brain. J. Pharmacol. Exp. Ther. 197, 105-118.
16. Klara PM, RM Kostrzewa and KR Brizzee (1976) Destructive action of systemically administered 6-
hydroxydopamine on the rat area postrema. Brain Res. 104, 187-192.
17. Christensen CW, CT Harston, AJ Kastin, RM Kostrzewa and MA Spirtes (1976) Investigation of α-
MSH and MIF-I effects on cyclic AMP levels in rat brain. Pharmacol. Biochem. Behav. 5, Suppl. 1,
117-120.
18. Spirtes MA, NP Plotnikoff, RM Kostrzewa, CT Harston, AJ Kastin and CW Christensen (1976)
Possible association of increased rat behavioral effects and increased striatal dopamine and
norepinephrine levels during the DOPA- potentiation test. Pharmcol. Biochem. Behav. 5, Suppl. 1,
121-124.
19. Kostrzewa RM, MA Spirtes, JW Klara, CW Christensen, AJ Kastin and TH Joh (1976) Effects of
L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons. Pharmacol. Biochem. Behav. 5,
Suppl. 1, 125-127.
20. McLean JH, RM Kostrzewa and JG May (1976) Minimal brain dysfunction: dopamine depletion?
Science 194, 451. [Letter]
21. Kostrzewa RM and RE Garey (1977) Sprouting of noradrenergic terminals in rat cerebellum following
neonatal treatment with 6-hydroxydopa. Brain Res. 124, 385-391.
22. Christensen CW, MA Spirtes, RM Kostrzewa and AJ Kastin (1978) Neuro- pharmacological aspects
of hypothalamic peptides and α-MSH, in Current Studies of Hypothalamic Functions, Vol. 1
Hormones (K Lederis and S Karger, Eds), Basel.
23. Kostrezewa RM, JW Klara, J Robertson and LC Walker (1978) Studies on the mechanism of
sprouting of noradrenergic terminals in rat and mouse cerebellum after neonatal 6-hydroxydopa. Brain
Res. Bull. 3, 525-531.
24. Kostrzewa RM, AJ Kastin and SK Sobrian (1978) Potentiation of apomorphine actions in rats by
L-prolyl-L-leucyl-glycine amide. Pharmacol. Biochem. Behav. 9, 375-378.
25. Kostrzewa RM, MB Clark and H Fukushima (1979) Regenerative sprouting of noradrenergic
terminals in the cerebellum, in Catecholamines: Basic and Clinical Frontiers, (E Usdin, IJ Kopin and
J Barchas, Eds) Pergamon Press, New York, pp. 797-799.
26. Clark MB, JC King and RM Kostrzewa (1979) Loss of nerve cell bodies in caudal locus coeruleus
following treatment of neonates with 6-hydroxydopa. Neurosci. Lett. 13, 331-336.
27. Kastin AJ, RH Ehrensing, DH Coy, AV Schally and RM Kostrzewa (1979) Behavioral effects of brain
peptides, including LH-RH, in Psychoneuroendocrin-ology in Reproduction (L Zichella and P
Pancheri, Eds), Elsevier, North Holland, pp. 69-80.
28. Morgan DN, JH McLean and RM Kostrzewa (1979) Effects of 6-hydroxy-dopamine and
6-hydroxydopa on development of behavior. Pharmacol. Biochem. Behav. 11, 309-312.
R.M. Kostrzewa, Ph.D.
29. Kostrzewa RM, J Hardin, RL Snell, AJ Kastin, DH Coy and F Bymaster (1979) MIF-I and
postsynaptic receptor sites for dopamine. Brain Res. Bull. 4, 657-662.
30. Kostrzewa RM, H Fukushima, CT Harston, KW Perry, RW Fuller and AJ Kastin (1979) Striatal
dopamine turnover and MIF-I. Brain Res. Bull. 4, 799-802.
31. Kastin AJ, AV Schally and RM Kostrzewa (1980) Possible aminergic mediation of MSH release and
of the CNS effects of MSH and MIF-I. Fed. Proc. 39, 2931-2936.
32. Harston CT, A Morrow and RM Kostrzewa (1980) Enhancement of sprouting and putative
regeneration of central noradrenergic fibers by morphine. Brain Res. Bull. 5, 421-424.
33. Kostrzewa RM, H Fukushima, A Morrow, P Cohenour, T Hsi, RE Lehr and CL Blank (1980) α-
Methyl-6-aminodopamine: Depletion of catecholamines in mouse brain and peripheral tissues. Life
Sci. 27, 2245-2250.
34. McLean JH, RS Glasser, RM Kostrzewa and JG May (1980) Effects of neonatal 6-hydroxydopa on
behavior in female rats. Pharmacol. Biochem. Behav. 13, 863-868.
35. Kastin AJ, RM Kostrzewa, AV Schally and DH Coy (1980) Neonatal administration of
met-enkephalin facilitates maze performance of adult rats. Pharmacol. Biochem. Behav. 13, 883-886.
36. Walker LC, AA Gerall and RM Kostrzewa (1980) Rostral midbrain lesions and copulatory behavior in
male rats. Physiol. Behav. 26, 349-353.
37. Harston CT, MB Clark, JC Hardin and RM Kostrzewa (1981) Opiate- enhanced toxicity and
noradrenergic sprouting in rats treated with 6-hydroxydopa. Europ. J. Pharmacol. 71, 365-373.
38. Harston CT, MB Clark, JC Hardin and RM Kostrzewa (1982) Developmental localization of
noradrenergic innervation to the rat cerebellum following neonatal 6-hydroxydopa and morphine
treatment. Dev. Neurosci. 5, 252-262.
39. Kostrzewa RM, CT Harston, H Fukushima and R Brus (1982) Noradrenergic fiber sprouting in the
cerebellum. Brain Res. Bull. 9, 509-517.
40. Kostrzewa RM and D Klisans-Fuenmayor (1984) Development of an opioid- specific action of
morphine in modifying recovery of neonatally-damaged noradrenergic fibers in rat brain. Res.
Commun. Chem. Pathol. Pharmacol. 46, 3-11.
41. Klisans-Fuenmayor D, CT Harston and RM Kostrzewa (1986) Alterations in noradrenergic
innervation of the brain following dorsal bundle lesions in neonatal rats. Brain Res. Bull. 16, 47-54.
42. Heydorn WE, KQ Nguyen, GJ Creed, RM Kostrzewa and DM Jacobowitz (1986) Effects of bilateral
lesion of the locus coeruleus and of neonatal administration of 6-hydroxydopamine on the
concentration of individual proteins in rat brain. Brain Res. 367, 31-38.
43. Kostrzewa RM and CT Harston (1986) Altered histofluorescent pattern of noradrenergic innervation
of the cerebellum of the mutant mouse Purkinje cell degeneration. Neuroscience 8, 809-815.
44. Kostrzewa RM, JC Hardin and DM Jacobowitz (1988) Destruction of cells in the midportion of the
locus coeruleus by a dorsal bundle lesion in neonatal rats. Brain Res. 442, 321-328.
R.M. Kostrzewa, Ph.D.
45. Kostrzewa RM (1988) Reorganization of noradrenergic neuronal systems following neonatal chemical
and surgical injury. Progr. Brain Res. 78, 405-423.
46. Saleh MI and RM Kostrzewa (1988) Impaired striatal dopamine receptor development: Differential
D-1 regulation in adults. Europ. J. Pharmacol. 154, 305-311.
47. Kostrzewa RM and MI Saleh (1989) Impaired ontogeny of striatal dopamine D1 and D2 binding sites
after postnatal treatment of rats with SCH-23390 and spiroperidol. Dev. Brain Res. 45, 95-101.
48. Saleh MI and RM Kostrzewa (1989) MIF-1 attenuates spiroperidol alteration of striatal dopamine D2
receptor ontogeny. Peptides 10, 35-40.
49. Kostrzewa RM (1989) Neurotoxins that affect central and peripheral catecholamine neurons, in
Neuromethods, vol. 12, Neuropharmacology Section, (AA Boulton, GB Baker and AV Juorio, Eds),
Humana Press, Totowa, NJ, pp. 1-48.
50. Kostrzewa RM, TG White, JE Zadina and AJ Kastin (1989) MIF-1 attenuates apomorphine
stereotypies in adult rats after neonatal 6-hydroxydopamine. Europ. J. Pharmacol. 163, 33-42.
51. Kostrzewa RM and MI Saleh (1989) Attenuation of SCH-23390-induced alteration of striatal
dopamine D-1 receptor ontogeny by prolyl-leucyl- glycinamide in the rat. Neuropharmacol. 28,
805-810.
52. Kostrzewa RM, A Hamdi and FP Kostrzewa (1990) Production of prolonged supersensitization of
dopamine D2 receptors. Europ. J. Pharmacol. 183, 1411-1412.
53. Arbogast LY, JK Neumann, RM Kostrzewa and BW Arbogast (1990) Decreased VLDL preventing
activity in response to a reverse mirror drawing stressor. SAAS Bull. Biochem. and Biotech. 3, 80-84.
54. Kostrzewa RM and A Hamdi (1991) Potentiation of spiroperidol-induced oral activity in rats after
neonatal 6-hydroxydopamine. Pharmacol. Biochem. Behav. 38, 215-218.
55. Neumann JK, DS Chi, BW Arbogast, RM Kostrzewa and LM Harvill (1991) Relationship between
blood groups and behavior patterns in men who have had myocardial infarction. Southern Med. J. 84,
214-218.
56. Kostrzewa RM (1991) Career planning for pharmacologist trainees. The Pharmacologist 33, 41-45.
57. Kostrzewa RM and R Brus (1991) Is dopamine-agonist induced yawning behavior a D3 mediated
event? Pharmacol. Lett. section of Life Sci. 48, PL-129.
58. Kostrzewa RM and R Brus (1991) Ontogenic homologous supersensitization of quinpirole-induced
yawning in rats. Pharmacol. Biochem. Behav. 39, 517-519.
59. Kostrzewa RM and L Gong (1991) Supersensitized D1 receptors mediate enhanced oral activity after
neonatal 6-OHDA. Pharmacol. Biochem. Behav. 39, 677-682.
60. Hamdi A and RM Kostrzewa (1991) Ontogenic homologous supersensitization of dopamine D1
receptors. Europ. J. Pharmacol. 203, 115-120.
61. Gong L, EA Daigneault, RV Acuff and RM Kostrzewa (1991) Vitamin E supplements fail to protect
mice from acute MPTP neurotoxicity. Neuroreport 2, 544-546.
R.M. Kostrzewa, Ph.D.
62. Kostrzewa RM, R Brus and J Kalbfleisch (1991) Ontogenetic homologous sensitization to the
antinociceptive action of quinpirole in rats. Europ. J. Pharmacol. 209, 157-161.
63. Gong L and RM Kostrzewa (1992) Supersensitized oral response to a serotonin agonist in neonatal 6-
OHDA treated rats. Pharmacol. Biochem. Behav. 41, 621-623.
64. Gong L, RM Kostrzewa, RW Fuller and KW Perry (1992) Supersensitization of the oral response to
SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system. J. Pharmacol.
Exp. Ther. 261, 1000-1007.
65. Kostrzewa RM, R Brus, DH Coy, H Criswell, PS Coogan and AJ Kastin (1992) D-Ala2,F5Phe
4-
dynorphin amide, an opiate with analgesic and lethal properties. Pol. J. Pharm. Pharmacol. 44, 109-
120.
66. Chi DS, L Gong, EA Daigneault and RM Kostrzewa (1992) Effects of MPTP and vitamin E
treatments on immune function in mice. Intl. J. Immunopharmacol. 14, 739-746.
67. Kostrzewa RM, L Gong and R Brus (1992) Serotonin (5-HT) systems mediate dopamine (DA)
receptor supersensitivity. Acta Neurobiol. Exp. 53, 31-41.
68. Kostrzewa RM, R Brus, M Rykaczewska and A Plech (1993) Low dose quinpirole ontogenically
sensitizes to quinpirole-induced yawning in rats. Pharmacol. Biochem. Behav. 44, 487-489.
69. Kostrzewa RM and D Neely (1993) Enhanced pilocarpine-induced oral activity responses in neonatal
6-OHDA-treated rats. Pharmacol. Biochem. Behav. 45, 737-740.
70. Kostrzewa RM and AJ Kastin (1993) Tyr-MIF-1 attenuates development of tolerance to spiperone-
induced catalepsy in rats. Brain Res. Bull. 31, 707-712.
71. Kostrzewa RM, J Guo and FP Kostrzewa (1993) Ontogenetic quinpirole treatments induce vertical
jumping activity in rats. Europ. J. Pharmacol. 239, 183-187.
72. Gong L, RM Kostrzewa, R Brus, RW Fuller and KW Perry (1993) Ontogenetic SKF 38393 treatments
sensitize dopamine D1 receptors in neonatal 6-OHDA-lesioned rats. Dev. Brain Res. 76, 59-65.
73. Kostrzewa RM, R Brus, KW Perry and RW Fuller (1993) Age-dependence of a 6-hydroxydopamine
lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Dev.
Brain Res. 76, 87-93.
74. Gong L, RM Kostrzewa and J Kalbfleisch (1993) MIF-1 fails to modify agonist-induced oral activity
in neonatal 6-OHDA treated rats. Peptides 14, 1159-1164.
75. Kostrzewa RM (1993) Altered sensitivity of recognition sites for catecholamines in the absence of
changes in receptor binding parameters, in Botulinum and Tetanus Neurotoxins: Neurotransmission
and Biomedical Aspects (G DasGupta, Ed), Plenum Press, pp. 521-537.
76. Gong L, RM Kostrzewa, KW Perry and RW Fuller (1993) Dose-related effects of a neonatal 6-OHDA
lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats. Dev.
Brain Res. 76, 233-238.
Kostrzewa RM (1993) A Citation Classic: Pharmacology of 6-Hydroxydopamine, in Current
Contents Life Sciences vol. 36 (no. 32), p. 9. For the article by RM Kostrzewa and DM Jacobowitz,
Pharmacol. Reviews 26, 199-288, 1974. [590 citations through 1992].
R.M. Kostrzewa, Ph.D.
77. Arbogast BW, JK Newmann, LY Arbogast, SC Leeper and RM Kostrzewa (1994) Transient loss of
serum protective activity following short term stress: a possible chemical link between stress and
atherosclerosis. J. Psychosom. Res. 38, 871-884.
78. Huang N and RM Kostrzewa (1994) Enhanced oral activity response to A77636 in neonatal 6-
hydroxydopamine-lesioned rats. Europ. J. Pharmacol. 253, 163-166.
79. Kostrzewa RM, R Brus, JH Kalbflesich, KW Perry and RW Fuller (1994) Proposed animal model of
attention deficit hyperactivity disorder. Brain Res. Bull. 34, 161-167.
80. Gong L, RM Kostrzewa and C Li (1994) Neonatal 6-OHDA and adult SKF 38393 treatments alter
dopamine D1 receptor mRNA levels: Absence of other neurochemical associations with the enhanced
behavioral responses of lesioned rats. J. Neurochem. 63, 1282-1290.
The 1974 Pharmacol. Reviews article by RM Kostrzewa and DM Jacobowitz, `Pharmacological
Actions of 6-Hydroxydopamine' was ranked by Current Contents among the 400 most-cited articles in
the life sciences.
81. Brus R, RM Kostrzewa, KW Perry and RW Fuller (1994) Supersensitization of the oral response to
SKF 38393 in neonatal 6-hydroxydopamine-lesioned rats is eliminated by neonatal 5,7-
dihydroxytryptamine treatment. J. Pharmacol. Exp. Ther. 268, 231-237.
82. Huang N-Y and RM Kostrzewa (1994) Persistent oral dyskinesias in haloperidol-withdrawn neonatal
6-OHDA-lesioned rats. Europ. J. Pharmacol. 271, 433-437.
83. Kostrzewa RM (1995) Dopamine receptor supersensitivity. Neurosci. Biobehav. Reviews 19, 1-17.
84. Brus R, R Kostrzewa, W Felinska, A Plech, R Szkilnik and J Frydrych (1995) Ethanol inhibits
cadmium accumulation in brains of offspring of pregnant rats that consume cadmium. Toxicol. Lett.
76, 57-62.
85. Brus R, A Plech and RM Kostrzewa (1995) Enhanced quinpirole responses in rats lesioned neonatally
with 5,7-dihydroxytryptamine. Pharmacol. Biochem. Behav. 50, 649-653.
86. W Felinska, R Brus, R Szkilnik, M Rykaczewska, A Plech, RM Kostrzewa and J Frydrych (1995)
Cadmium modulates reactivity of central dopamine receptors in rats prenatally exposed to ethanol.
Pol. J. Environ. Studies 4, 31-36.
87. Jedrusiak J, R Brus, RM Kostrzewa and Z Sowinski (1995) Dopaminergic neuronal systems
modulate the central cardiovascular effects of TRH in rats. Pol. J. Pharmacol. 47, 43-52.
88. Brus R, W Felinska, M Rykaczewska, RM Kostrzewa, R Szkilnik and A Plech (1995) Prenatal ethanol
diminishes reactivity of presumed dopamine D3 receptors in rats. Pol. J. Pharmacol. 47, 109-114.
89. Plech A, R Brus, JH Kalbfleisch and RM Kostrzewa (1995) Enhanced oral activity responses to
intrastriatal SKF 38393 and m-CPP are attenuated by intrastriatal mianserin in neonatal 6-OHDA-
lesioned rats. Psychopharmacol. 119, 466-473.
90. Perry KW, RM Kostrzewa and RW Fuller (1995) Persistence of long-lasting serotonin depletion by p-
chloroamphetamine in rat brain after 6-hydroxydopamine lesioning of dopamine neurons. Biochem.
Pharmacol. 50, 1305-1307.
91. Brus R, R Szkilnik, RM Kostrzewa, A Plech, M Rykaczewska, P Nowak and J Shani (1995)
Reactivity of central dopamine receptors after an electric shock in male and female rats. Pharmacol.
Commun. 7, 79-86.
R.M. Kostrzewa, Ph.D.
92. Brus R, R Szkilnik, RM Kostrzewa, I Jedrusiak, J Konecki, M Glowacka and J Shani (1995)
Modulation of glucose uptake in rat brain after administration of quinpirole and SKF 38393, two
central dopamine-receptor agonists. Pharmacol. Commun. 7, 87-91.
93. Ma S, L Lin, R Rhagavan, P Cohenour, PYT Lin, J Bennett, RJ Lewis, EL Enwall, R Kostrzewa, RE
Lehr and CL Blank (1995) In vivo and in vitro studies on the neurotoxic potential of 6-
hydroxydopamine analogs. J. Med. Chem. 38, 4087-4097.
94. Brus R, R Szkilnik and RM Kostrzewa (1996) Nitric oxide (NO) and central dopamine (DA) D3
receptor reactivity in rats. Acta Neurobiol.Exp. 56, 15-19.
95. Kostrzewa RM, R Brus, KW Perry and RW Fuller (1996) Dopamine and 5-HT receptor sensitivity
does not correlate with neostriatal dopamine or 5-HT content. Acta Neurobiol. Exp. 56, 21-28.
96. Brus R, RM Kostrzewa, R Szkilnik, W Felinska and A Plech (1996) Prenatal ethanol exposure impairs
dopamine D2 and serotonin agonist effects in rats. Pharmacol. Reviews and Commun. 8, 285-290.
97. Huang N-Y, RM Kostrzewa, C Li, KW Perry and RW Fuller (1997) Persistent spontaneous oral
dyskinesias in haloperidol-withdrawn rats neonatally lesioned with 6-hydroxydopamine: Absence of
an association with the Bmax for [3H]raclopride binding to neostriatal homogenates. J. Pharmacol. Exp.
Ther. 280, 268-276.
98. Brus R, R Szkilnik and RM Kostrzewa (1997) Quinpirole-induced yawning behavior in rats neonatally
pretreated with 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (5,7-DHT). Med. Sci.
Monitor 3, 324-327.
99. Brus R, R Szkilnik, P Nowak and RM Kostrzewa (1997) Nitro-L-arginine attenuates SKF 38393-
induced oral activity in neonatal 6-hydroxydopamine-lesioned rats. Acta Neurobiol. Exp. 57, 283-287.
100. Brus R, R Szkilnik, I Popieuch, RM Kostrzewa and K Mengel (1997) Effect of aluminum exposure
on central serotonin and muscarine receptor reactivity in rats. Med. Sci. Monitor 3, 631-636.
101. Kostrzewa RM (1998) 6-Hydroxydopa, a catecholamine neurotoxin and endogenous excitotoxin at
non-NMDA receptors, in Highly Selective Neurotoxins: Basic and Clinical Applications (RM
Kostrzewa, Ed), Humana Press, Totowa, NJ, pp. 109-129.
102. Kostrzewa RM (1998) Observations relative to the neurotoxicity and neurotoxic potential of amino
acids. Amino Acids 13, 171-173.
103. Kostrzewa RM and R Brus (1998) Destruction of catecholamine-containing neurons by 6-
hydroxydopa, an endogenous amine oxidase cofactor. Amino Acids 14, 175-179.
104. Kostrzewa RM, TA Reader and L Descarries (1998) Serotonin neural adaptations to ontogenetic
loss of dopamine neurons in rat brain. J. Neurochem. 70, 889-898.
105. Brus R, R Szkilnik, P Nowak, A Kasperska, J Oswiecimska, RM Kostrzewa and J Shani (1998)
Locomotor sensitization of dopamine receptors by their agonists quinpirole and SKF-38393, during
maturation and aging in rats. Pharmacol. Reviews and Commun. 10, 25-30.
106. Brus R, R Szkilnik, P Nowak, R Kostrzewa and J Shani (1998) Sensitivity of central dopamine
receptors in rats to quinpirole and SKF-38393, administered at their early stages of ontogenicity,
evaluated by learning and memorizing a conditioned avoidance reflex. Pharmacol. Reviews and
Commun. 10, 31-36.
R.M. Kostrzewa, Ph.D.
107. Brus R, P Nowak, R Szkilnik, RM Kostrzewa and J Shani (1998) Induction of grooming behavior in
male rats by m-chlorophenylpiperazine, a central 5-hydroxytryptamine receptor agonist. Pharmacol.
Reviews and Commun. 10, 37-42.
108. Kostrzewa RM, R Brus and KW Perry (1999) Interactive modulation by dopamine and serotonin
neurons of receptor sensitivity of the alternate neurochemical system. Pol. J. Pharmacol. 5, 39-47.
109. Tizabi Y, RL Copeland Jr, R Brus and RM Kostrzewa (1999) Nicotine blocks quinpirole-induced
behavior in rats: psychiatric implications. Psychopharmacol. 145, 433-441.
110. Kostrzewa RM (1999) Editorial. Neurotoxicity Res. 1, 1-2.
111. Kostrzewa RM (1999) Selective neurotoxins, chemical tools to probe the mind: the first thirty years
and beyond. Neurotoxicity Res. 1, 3-25.
112. Kasperska A, R Brus, R Szkilnik, J Oswiecimska, RM Kostrzewa and J Shani (1999) Modulation of
central dopamine receptor reactivity in the rat, by nitric oxide donors and inhibitor: Behavioral studies.
Pharmacol. Rev. Commun. 10, 311-319.
113. Kasperska A, R Brus, A Sokoa, RM Kostrzewa and J Shani (1999) Sexual differentiation in the
central dopaminergic effect of nitric oxide donors and inhibitor on stereotype behavior changes
induced by amphetamine, but not by apomorphine. Pharmacol. Rev. Commun. 10, 329-339.
114. Kostrzewa RM, JP Kostrzewa and R Brus (2000) Dopaminergic denervation enhances susceptibility to
hydroxyl radicals in rat neostriatum. Amino Acids 19, 183-199.
115a. Kostrzewa RM (2000) Review on apoptosis vs. necrosis of substantia nigra pars compacta in
Parkinson’s disease. Neurotoxicity Res. 2, 239-250.
115b. Kostrzewa RM (2001) Review on apoptosis vs. necrosis of substantia nigra pars compacta in
Parkinson=s disease, in Strategies for Studying Brain Disorders 5: Neurodegenerative Brain
Disorders (T Palomo, T Archer and RJ Beninger, Eds), Fundacion Cerebro y Mente, Madrid, Spain,
Madrid, Spain, pp. 755-768.
116. Oswiecimska J, R Brus, R Szkilnik, P Nowak and RM Kostrzewa (2000) 7-OH-DPAT, unlike
quinpirole, does not prime a yawning response in rats. Pharmacol. Biochem. Behav.67, 11-15.
117. Kostrzewa RM (2000) Crucial role of iron in anesthesia. Commentary in Psycoloquy 11,
issue 032, article 3.
(http://www.cogsci.soton.ac.uk/psyc...article=11.032&submit=View+Article)
118. Beal MF, T Palomo, RM Kostrzewa and T Archer (2000) Neuroprotective and neurorestorative
strategies for neuronal injury. Neurotoxicity Res. 2, 71-84.
119. Archer T, T Palomo and RM Kostrzewa (2001) Neurotoxicity and substance abuse: further fuel for
regulatory dilemma. Neurotoxicity Res. 3, 1-6.
120. Kostrzewa RM (2001) Mechanisms of action of 6-hydroxydopamine, a dopaminergic neurotoxin, in
Mechanisms of Degeneration and Protection of the Dopaminergic System (Segura-Aguilar J, Ed), FP
Graham Publishing Co., New York, NY, pp. 85-104.
121. Palomo T, RJ Beninger, K Jhamandas, RM Kostrzewa, MF Beal and T Archer (2001) Protective and
Restorative Strategies in the Neurodegenerative Disorders, in Neurodegenerative Brain Disorders (T
Palomo, T Archer and RJ Beninger, Eds), Fundacion Cerebro y Mente, Madrid, Spain, pp. 481-500.
R.M. Kostrzewa, Ph.D.
122. Nowak P, R Brus and RM Kostrzewa (2001) Amphetamine-induced enhancement of neostriatal in
vivo microdialysate dopamine content in rats, quinpirole-primed as neonates. Pol. J. Pharmacol. 53,
319-329.
123. Oswiecimska J, R Brus, R Szkilnik, A Sokola, RM Kostrzewa and J Shani (2001) Sexual
differentiation in behavioral patterns of rats, pretreated with two central dopamine agonists: quinpirole
and 7-OH-DPAT. Pharmacol. Rev. Commun. 11, 203-213.
124. Kretschmer BD, WJ Schmidt, RM Kostrzewa and M Herrera-Marschitz (2002) Amino acids in
neurobiology: neuroprotective and neurotoxic aspects of amino acids involved in neurotransmission
and neuromodulation. Amino Acids 23, 1-7.
125. Kostrzewa RM, JP Kostrzewa and R Brus (2002) Novel roles of amino acids and analogues in
neurodegenerative disorders. Amino Acids 23, 55-56.
126. Kostrzewa RM, JP Kostrzewa and R Brus (2002) Neuroprotective and neurotoxic roles of levodopa
(L-DOPA) in neurodegenerative disorders relating to Parkinson’s disease. Amino Acids 23, 57-63.
127. Kostrzewa RM and J Segura-Aguilar (2002) Neurotoxicological and neuroprotective elements in
Parkinson=s disease. Neurotoxicity Res. 4, 83-86.
128. Brown RW, JT Gass and RM Kostrzewa (2002) Ontogenetic quinpirole treatments produce spatial
memory deficits and enhance skilled reaching in adult rats. Pharmacol. Biochem. Behav. 72, 591-600.
129. Brus R, P Nowak, A Sokola, RM Kostrzewa and J Shani (2002) Behavioral and biochemical effects of
new central dopamine D3 and D4 receptor antagonists in rats. Pharmacol. Rev. Commun. 12, 39-59.
130. Brus R, P Nowak, A Sokola, L Labus, J Oswiecimska, H. Winiarska, RM Kostrzewa and J Shani
(2002) Exposure of pregnant rats to manganese: effect on levels, turnover and release of biogenic
amines in brains of their offspring. Pharmacol. Rev. Commun. 12, 61-75.
131. Nowak P, R Brus, J Oswiecimska, A Sokola and RM Kostrzewa (2002) 7-Nitroindazole enhances
amphetamine-evoked dopamine release in rat striatum. An in vivo microdialysis and voltammetric
study. J. Physiol. Pharmacol. 53, 251-263.
Palomo T, T Archer, RJ Beninger and RM Kostrzewa (2002) Preface (to special journal edition on
substance abuse). Neurotoxicity Res. 4, iii.
132. Palomo T, T Archer, RJ Beninger and RM Kostrzewa (2002) Neurodevelopmental liabilities of
substance abuse. Neurotoxicity Res. 4, 267-279.
133. Palomo T, RM Kostrzewa, T Archer and RJ Beninger (2002) Neurodevelopmental liabilities in
schizophrenia and affective disorders. Neurotoxicity Res. 4, 397-408.
134. Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2003) Brain sites of movement disorder:
Genetic and environmental agents in neurodevelopmental perturbations. Neurotoxicity Res. 5, 1-26.
135. Kostrzewa RM, JP Kostrzewa and R Brus (2003) Dopamine receptor supersensitivity: an outcome and
index of neurotoxicity. Neurotoxicity Res. 5, 111-118.
R.M. Kostrzewa, Ph.D.
136. Brus R, RM Kostrzewa, P Nowak, KW Perry and JP Kostrzewa (2003) Ontogenetic quinpirole
treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-
lesioned rats. Neurotoxicity Res. 5(5), 329-338.
137. Kostrzewa RM and J Segura-Aguilar (2003) Novel mechanisms and approaches in the study of
neurodegeneration and neuroprotection. A review. Neurotoxicity Res. 5(6), 375-384.
138. Brown RW, KD Thompson, KN Thompson, JJ Ward, SK Thacker, ML Williams and RM Kostrzewa
(2004) Nicotine treatment in adulthood alleviates cognitive and skilled reaching impairments in rats
treated during early development with quinpirole: interactions of dopamine D2 receptor sensitivity,
acetylcholine function, and neurotrophic factor expression. Eur. J. Neurosci. 19(6), 1634-1642.
139. Moy SS, A Fernandes, Y Qian, DL Rotella, RM Kostrzewa and GR Breese (2004) Effect of acute
and chronic olanzapine treatment on phencyclidine-induced behavioral sensitization in rats with
neonatal dopamine loss. Pharmacol. Biochem. Behav. 78(1), 47-56.
140. Kostrzewa RM, P Nowak, JP Kostrzewa, RA Kostrzewa and R Brus (2004) Dopamine D2 agonist
priming in intact and dopamine-lesioned rats. Neurotoxicity Res. 6, 457-462.
141. Palomo T, T Archer, RM Kostrzewa and RJ Beninger (2004) Gene-environment interplay in
schizopsychotic disorders. Neurotoxicity Res. 6, 1-9.
142. Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2004) Gene-environment interplay in affect
and dementia: emotional modulation of cognitive expression in personal outcomes. Neurotoxicity Res.
6, 159-173.
143. Sieron A, L Labus, P Nowak, G Cieślar, H Brus, A Durczok, T Zagził, RM Kostrzewa and R Brus
(2004) Alternating extremely low frequency magnetic field increases turnover of dopamine and
serotonin in rat frontal cortex. Bioelectromagnetics 25, 426-430.
144. Brus R, P Nowak, R Szkilnik, U Mikołajun and RM Kostrzewa (2004) Serotoninergics attenuate
hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity. Neurotoxicity Res.
6, 317-325.
145. Palomo T, RM Kostrzewa, RJ Beninger and T Archer (2004) Gene-environment interplay in
alcoholism and other substance abuse disorders: expressions of heritability and factors influencing
vulnerability. Neurotoxicity Res. 6, 343-361.
146. Palomo T, T Archer, RJ Beninger and RM Kostrzewa (2004) Gene-environment interplay in
neurogenesis and neurodegeneration. Neurotoxicity Res. 6, 415-434. Review.
147. Segura-Aguilar J and RM Kostrzewa (2004) Neurotoxins and neurotoxic species implicated in
neurodegeneration. Neurotoxicity Res. 6, 615-630.
148. Herrera-Marschitz M, BD Kretschmer and RM Kostrzewa (2005) General Introduction: Neurobiology
at the 8th International Congress on Amino Acids and Proteins, Rome, Italy, September 2003. Amino
Acids 28(2), 119-121.
149. Kretschmer BD, RM Kostrzewa and M Herrera-Marschitz (2005) Introduction: Vulnerability of the
CNS to metabolic and drug-related insults. Amino Acids 28(2), 123-125.
R.M. Kostrzewa, Ph.D.
150. Durczok A, R Szkilnik, P Nowak, Ł Labus, J Dąbrowska, A Bortel, T Zagził, M Swoboda, W
Rycerski, H Winnicka, RM Kostrzewa and R Brus (2005) Effect of zinc on the central
dopaminergic system of rats prenatally exposed to cadmium. Pol. J. Environ. Studies (in press).
153. Kostrzewa RM, P Nowak, JP Kostrzewa, RA Kostrzewa and R Brus (2005) Peculiarities of L-
DOPA treatment of Parkinson's disease. Amino Acids 28(2), 157-164. Epub 2005 Mar 9.
Kostrzewa RM (2005) Mechanisms for neurodegenerative disorders. IDrugs 8(6), 469-471.
154. Nowak P, RM Kostrzewa, A Kwięcinski, A Bortel, Ł Labus and R Brus (2005) Neurotoxic action
of 6-hydroxydopamine on the nigrostriatal dopaminergic pathway in rats sensitized with D-
amphetamine. J. Physiol. Pharmacol. 56(2), 325-333.
155. Kuballa G, P Nowak, Ł Labus, A Bortel, J Dąbrowska, M Swoboda, A Kwieciński, RM Kostrzewa
and R Brus (2005) Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats.
Comparison with haloperidol and clozapine. Pharmacol. Reports 57, 161-169.
156. Kostrzewa RM, JP Kostrzewa, R Brus, RA Kostrzewa and P Nowak (Sept. 2006) Proposed animal
model of severe Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic
innervation of striatum. J. Neural Transm. [Suppl.] 70, 277-279.
157. Nowak P, Ł Labus, RM Kostrzewa and R Brus (May 2006) DSP-4 prevents dopamine receptor
priming by quinpirole. Pharmacol. Biochem. Behav. 84, 3-7.
158. Nowak P, J Dąbrowska, A Bortel, B Izabela, RM Kostrzewa and R Brus (Nov 2006) Prenatal
cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatum.
Neurotoxicol. Teratol. 28, 563-572.
159. Kostrzewa RM, N-Y Huang, JP Kostrzewa, P Nowak and R Brus (2007) Modeling tardive
dyskinesia: predictive 5-HT2C receptor antagonist treatment. Neurotoxicity Res. 11(1), 41-50.
160. Nowak P, A Bortel, J Dąbrowska, J Oświęcimska, M Drosik, A Kwieciński, J Opara, RM
Kostrzewa and R Brus (Feb. 2007) Amphetamine and mCPP effects on dopamine and serotonin
striatal in vivo microdialysates in an animal model of hyperactivity. Neurotoxicity Res. 11(2), 131-
144.
161. Nowak P, J Dąbrowska, A Bortel, I Biedka, G Słomian, RM Kostrzewa and R Brus (Dec 2006)
Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-
lesioned rats occurs in an absence of change in microdialysate dopamine levels. Eur. J.
Pharmacol. 552(1-3), 46-54. Epub 2006 Sep 16.
162. Konecki J, G Bielaczyc, P Nowak, R Szkilnik, G Szczerbak, M Swoboda, A Kwieciński, RM
Kostrzewa and R Brus (2006) Effect of pre- and postnatal exposure to zinc on [3H]glucose uptake
in the brain and peripheral tissues of adult rats. Pol. J. Environ. Studies 15, 291-295.
163. Nowak P, T Zagził, J Konecki, G Szczerbak, R Szkilnik, J Niwiński, J Gorzałek, RM Kostrzewa
and R Brus (Oct 2006) Trimetazidine increases [3H]glucose uptake in rat brain. Pharmacol.
Reports 58, 559-561.
164. Nowak P, J Konecki, G Kuballa, R Szkilnik, A Kwieciński, G Szczerbak, M Drosik, J Gorzałek, J
Niwiński, Ł Noras, RM Kostrzewa and R Brus (2006) Effect of the dopamine D3 receptor
antagonist nafadotride on [3H]glucose uptake in the brain and peripheral tissues of rats –
R.M. Kostrzewa, Ph.D.
comparison with haloperidol and clozapine. Ann. Acad. Med. Silesia 60 (6), 269-273.
165. Kostrzewa RM (2008) Neurotoxins, In: New Encyclopedia of Neuroscience (Squire L, T Albright,
F Bloom, F Gage and N Spitzer, Eds.) (Elsevier:The Netherlands).
166. Xu X, CC Chua, J Kong, RM Kostrzewa, U Kumaraguru, RC Hamdy and BHL Chua (Dec 2007)
Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent
cell death in HT-22 cells. J. Neurochem.103(5), 2004-2014. Epub 2007 Aug 30.
167. Thacker SK, MK Perna, JJ Ward, TL Schaefer, MT Williams, RM Kostrzewa and RW Brown
(Oct 2006) The effects of adulthood olanzapine treatment on cognitive performance and
neurotrophic factor content in male and female rats neonatally treated with quinpirole. Eur. J.
Neurosci. 24(7), 2075-2083.
168. Szczerbak G, P Nowak, RM Kostrzewa and R Brus (Oct. 2007) Maternal lead exposure produces
long-term enhancement of dopaminergic reactivity in rat offspring. Neurochem. Res. 32, 1791-
1798.
Kostrzewa RM (2006) Therapeutic and neuroprotective strategies for neurodegenerative disorders.
Eur. Behav. Pharmacol. Soc. Workshop report. ID Drugs, September 2006.
Kostrzewa RM (2007) Mechanisms for Neurodegenerative disorders. III-Neurotoxicity Society
Meeting in Pucon, Chile. Meeting report. ID Drugs, April 2007.
169. Segura-Aguilar J and RM Kostrzewa (Dec 2006) Neurotoxins and neurotoxicity mechanisms.
Neurotoxicity Res. 10, 263-290.
170. Nowak P, G Szczerbak, I Biedka, M Drosik, RM Kostrzewa and R Brus (2006) Effect of
ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in
Parkinsonian rats. In vivo microdialysis study. J. Physiol. Pharmacol. 57, 583-597.
171. Nowak P, G Szczerbak, J Dąbrowska, A Bortel, I Biedka and RM Kostrzewa (Nov –Dec 2006)
Molecular mechanisms of levodopa action in animal models of Parkinson’s disease. Neurol
Neurochir Pol. (Pol. J. Neurol. Neurosurg.) 40, 517-525.
172. Sieroń A. H Brus, J Konecki, G Cieślar, R Szkilnik, P Nowak, Ł Noras, A Kwieciński, RM
Kostrzewa and R Brus (2007) Pol. J. Environ. Stud. 16, 309-312. Letter to Editor.
173. Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2007) Comorbidity implications in brain
disease: neuronal substrates of symptom profiles. Neurotoxicity Res. 12, 1-15.
174. Palomo T, RM Kostrzewa, RJ Beninger and T Archer (2007) Treatment consideration and
manifest complexity in comorbid neuropsychiatric disorders. Neurotoxicity Res. 12, 43-60.
175. Palomo T, RM Kostrzewa, RJ Beninger and T Archer (2007) Genetic variation and shared
biological susceptibility undrlying comorbidity in neuropsychiatry. Neurotoxicity Res. 12, 29-42.
176. Palomo T, T Archer, RM Kostrzewa and RJ Beninger (2007) Comorbidity of substance abuse with
other psychiatric disorders. Neurotoxicity Res. 12, 17-27.
177. Nowak P, M Swoboda, R Szkilnik, J Konecki, A Kwieciński, J Jośko, Ł Noras, K Sawczuk, RM
Kostrzewa and R Brus (Sep-Oct 2007) Nitric oxide (NO) modulates the amphetamine effect on
[3H]glucose uptake in the brain of rats prenatally exposed to lead. Pharmacol. Reports 59, 601-
R.M. Kostrzewa, Ph.D.
605.
178. Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, P Nowak and R Brus (Feb 2008) Pharmacological
models of ADHD. J. Neural Transm. 115, 287-298.
179. Kostrzewa RM (April 2007) The blood-brain barrier for catecholamines – revisited. Neurotox.
Res. 11, 261-271.
180. Kostrzewa RM, L Antkiewicz-Michaluk and F Fornai (2010) Dopaminergic nerves as targets for
neurotoxins, In: Neurotoxicology, Target Organ Toxicity Series, 3rd
Edition (Harry J and H Tilson,
Eds.) (Informa Health Care, New York, NY), pp. 112-137. [ISBN: 9781420054873]
181. Bortel A, D Nitka, L Słomian, P Nowak, E Korossy, R Brus and RM Kostrzewa. Neonatal
noradrenergic lesion with DSP-4 modifies the convulsant effect of bicuculine and
pentylenetetrazole in adult rats. Behavioral and biochemical studies. Ann. Acad. Med. Silesia
62(1), 46-52, 2008.
182. Bortel A, L Słomian, D Nitka, M Świerszcz, M Jaksz, P Nowak, RM Kostrzewa and R Brus (May-
June 2008) Neonatal DSP-4 treatment modifies the vulnerability to phenobarbital and ethanol
evoked sedative-hypnotic effects in adult rats. Pharmacological Reports 60(3), 331-338.
(submitted, September 2007).
183. Paris I, J Lozano, S Cardenas, C Periz-Pastene, K Saud, A Riveros, P Fuentes, P Caviedes, A
Dagnino-Subiabre, R Raisman-Vozari, T Shimahara, JP Kostrzewa, D Chi, RM Kostrzewa, P
Caviedes and J Segura-Aguilar (May/June 2008) The catecholaminergic RCSN-3 cell line: a
model to study dopamine metabolism. Neurotox. Res. 13(3,4), 219-228.
184. Nowak P, G Szczerbak, D Nitka, RM Kostrzewa and R Brus (Apr. 2008) Effect of prenatal lead
exposure on nigrostriatal neurotransmission and hydroxyl radical formation in rat neostriatum:
Dopaminergic-nitrenergic interaction. Toxicology 246, 83-89. Epub 2008 Jan 10.
185. Kostrzewa RM, JP Kostrzewa, R Brown, P Nowak and R Brus (Oct. 2008) Dopamine receptor
supersensitivity: development, mechanisms, presentation, and clinical applicability. Neurotox. Res.
14, 121-128.
186. Kostrzewa RM and J Segura-Aguilar (2007) Botulinum neurotoxin: evolution from poison, to
research tool – onto medicinal therapeutic and future pharmaceutical panacea. Neurotox. Res. 12,
275-290.
187. Kostrzewa RM (Jan 2009) Evolution of neurotoxins: from research modalities to clinical realities,
In Curent. Protocols in Neuroscience, Wiley Interscience. Chapter 1:Unit1.18, pp. 1.18.1-1.18.10.
[in Pub Med].
188. Nowak P, J Jochem, K Zwirska-Korczala, J Josko, L Noras, RM Kostrzewa and R Brus (2008)
Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats. Neurotox. Res. 13, 79-
83.
189. Nowak P, A Bortel, J Dąbrowska, I Biedka, G Slomian, W Roczniak, RM Kostrzewa and R Brus
(May/June 2008) Histamine H3 receptor ligands modulate L-dopa-evoked behavioral responses
and L-dopa-derived extracellular dopamine in dopamine-denervated rat striatum. Neurotox. Res.
13 (3,4), 231-240.
190. Nowak P, Ł Noras, J Jochem, R Szkilnik, H Brus, E Korossy, J Drab, RM Kostrzewa and R Brus
R.M. Kostrzewa, Ph.D.
(2009) Histaminergic activity in a rodent model of Parkinson’s disease. Neurotox. Res. 15(2), 246-
251. Neurotox Res. 15(3), 246-251. doi: 10.1007/s12640-009-9025-1. Epub 2009 Feb 28.
191. Nowak P, G Szczerbak, D Nitka, RM Kostrzewa, J Josko and R Brus (Sept-Oct 2008) Cortical
dopaminergic neurotransmission in rats intoxicated with lead during pregnancy. Nitric oxide and
hydroxyl radicals formation involvement. Neurotoxicol Teratol. 30, 428-432. E pub ahead of print,
Mar 2008.
192. Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Aug. 2008) Focusing on symptoms rather
than diagnoses in brain dysfunction: conscious and nonconscious expression in impulsiveness and
decision-making. Neurotox. Res. 14(1), 1-20.
193. Kostrzewa RM, RA Kostrzewa and JP Kostrzewa (March 2009) Botulinum toxin for restoration of
bladder control. The Female Patient 34, 20-23 (submitted Oct. 14, 2008; accepted Nov. 18, 2008).
194. Palomo T, RM Kostrzewa, RJ Beninger and T Archer (Oct. 2008) Schizopsychotic symptom-
profiles and biomarkers: beacons in diagnostic labyrinths. Neurotox. Res. 14(2,3), 79-96.
195. Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Oct. 2008) Affective status in relation to
impulsive, motor and motivational symptoms: personality, development and physical exercise.
Neurotox. Res. 14(2,3), 151-168.
196. Archer T, RM Kostrzewa, RJ Beninger and T Palomo (Oct. 2008) Cognitive symptoms
facilitatory for diagnoses in neuropsychiatric disorders: executive functions and locus of control.
Neurotox. Res. 14(2,3), 205-225.
197. Nowak P, J Oswiecimska, E Korossy, J Drab, A Kwiecinski, J Josko, RM Kostrzewa and R Brus
(2008) Altered functional response of dopamine D3-like receptors in neonatally 6-OHDA-lesioned
rats (rodent model of Parkinson’s disease. Ann. Acad. Med. Silesia 62(3-4), 46-55.
198. Kostrzewa RM (Feb. 2009) Editorial on ‘Neurotoxicity’. Neurotox. Res. 15(1), 1-2. DOI:
10.1007/s12640-009-9029-x.
199. Kostrzewa RM (2010) Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist
treatment, In: 5-HT2C Receptors in the Pathophysiology of CNS Disease (Di Giovanni G, E
Esposito, and V Di Matteo, Eds.) (Humana Press/ Springer Science+Business Media, New York),
pp. 383-393. ISBN: 978-1-60761-940-6. DOI: 10.1007/9780-1-60761-941-3.
200. Nowak P, D Nitka, A Kwieciński, J Jośko, J Drab, D Pojda-Wilczek, J Kasperski, RM Kostrzewa
and R Brus (April 2009) Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood
behavioral sensitization to dopamine D2 receptor agonists. Pharm. Rep. 61, 311-318.
201. Nowak P, RA Kostrzewa, D Skaba and RM Kostrzewa (April 2010) Acute L-DOPA effect on
hydroxyl radical- and DOPAC-levels in striatal microdialysates of Parkinsonian rats. Neurotox.
Res. DOI: 10.1007/s12640-009-9105-2. online, Sept. 4, 2009. Neurotox. Res. 17(3), 299-304.
207. Archer T and RM Kostrzewa (2010) Staging neurological disorders: expressions of cognitive and
motor disorder. DOI 10.1007/s12640-009-9134-x. [Editorial] online Nov 26, 2009. Neurotox. Res.
18(2), 107-111.
208. Archer T, Kostrzewa RM, Palomo T and Beninger RJ (Nov 2010) Clinical staging in the
pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment.
R.M. Kostrzewa, Ph.D.
Neurotox Res. 18(3-4):211-228. Epub 2010 Mar 17.
209. Nowak P, Bojanek K, Szkilnik R, Josko J, Boron D, Adwent M, Gorczyca P, Kostrzewa RM, Brus
R (May 2011) Ontogenetic exposure of rats to pre- and post-natal manganese enhances behavioral
impairments produced by perinatal 6-hydroxydopamine. Neurotox Res. 19(4):536-543. Epub 2010
Apr 6. PMID: 20369314. DOI: 10.1007/s126.
210. Archer T, Kostrzewa RM, Beninger RJ, Palomo T (Nov 2010) Staging perspectives in
neurodevelopmental aspects of neuropsychiatry: agents, phases and ages at expression. Neurotox.
Res. 18(3-4):287-305. Epub 2010 Mar 17.
211. Archer T, Beninger RJ, Palomo T, Kostrzewa RM (Nov 2010) Epigenetics and biomarkers in the
staging of neuropsychiatric disorders. Neurotox. Res. 18(3-4):347-366. Epub 2010 Mar 17.
212. Kostrzewa RM, Kostrzewa JP, Kostrzewa RA, Kostrzewa FP, Brus R, Nowak P (Feb 2011)
Stereotypic progressions in psychotic behavior. Neurotox. Res. 19: 243-252. DOI:
10.1007/s12640-010-9192-0
213. Archer T, Kostrzewa RM, Beninger RJ, Palomo T (Feb 2011) Staging neurodegenerative
disorders: structural, regional, biomarker and functional progressions. Neurotox. Res. 19: 211-234.
214. Jośko J, J Drab, P Nowak R Szkilnik, E Kőrőssy, D Boroń, H Brus, RM Kostrzewa, R Brus (July
2011) Thioperamide, an H3 receptor antagonist, prevents [3H]glucose uptake in adult rats lesioned
as neonates with 5,7-dihydroxytryptamine. Neurotox Res. 20(1): 93-96. Epub 2010 Sep 14. PMID:
20838953
215. Jośko J, J Drab, J Jochem, P Nowak, R Szkilnik, E Kőrőssy-Mruk, D Boroń, RM Kostrzewa, H
Brus, R Brus (Aug 2011) Ontogenetic serotoninergic lesioning alters histaminergic activity in rats
in adulthood. Neurotox. Res. 20(2):103-108. Epub 2010 Sep 14. PMID: 20838952. DOI:
10.1007/s12640-010-9217-8.
216. Archer T, A Fredriksson, E Szhulz, RM Kostrzewa (July 2011) Influence of physical exercise on
neuroimmunological functioning and health: aging and stress. Neurotox Res. 20(1):69-83. Epub
2010 Oct 15. DOI: 10.1007/s12640.010-9224-9. PMID: 20953749.
217. Brus R, J Jochem, P Nowak, M Adwent, D Boroń, H Brus, RM Kostrzewa (Feb 2012) Effect of
pre- and postnatal manganese exposure on brain histamine content in a rodent model of
Parkinson’s disease. Neurotox. Res. 21(2):143-148. Epub 2011 Aug 6. PMID: 21822760.
218. Archer T, Kostrzewa RM (Feb 2012) Physical exercise alleviates ADHD symptoms: regional
deficits and development trajectory. Neurotox Res. 21(2):195-209. Epub 2011 Aug 18. [Epub
ahead of print] PMID: 21850535.
219. Ferdyn-Drosik M, P Nowak, K Bojanek, M Bałasz, J Kasperski, D Skaba, R Muchacki, RM
Kostrzewa (Jul-Aug 2010) Neonatal DSP-4 treatment impairs 5-HT1B receptor reactivity in adult
rats. Behavioral and biochemical studies. Pharmacol. Rep. 62(4):608-20. PMID: 20885001.
220. Kostrzewa RM, FP Kostrzewa (Feb 2012) Neonatal 6-hydroxydopamine lesioning enhances
quinpirole-induced vertical jumping in rats that were quinpirole-primed during postnatal ontogeny.
DOI: 10.1007/s12640-011-9268-5. Neurotox Res. 21(2):231-235. Epub 2011 Aug 19. PMID:
21853388.
221. Korossy-Mruk E, Kuter K, Nowak P, Szkilnik R, Kostrzewa RM, Brus R (Jan 2013) Neonatal
R.M. Kostrzewa, Ph.D.
DSP-4 treatment modifies analgesic effect of methanandamide, a CB1 receptor agonist in adult
rats. Neurotox Res 23(1), 39–48. (in press, 28 March 2012).
222. Labus L, Nowak P, Szkilnik R, Kostrzewa RM, Boroń D, Brus R (2012) Neonatal DSP-4
lesioning of central noradrenergic neurons: a model for the study of interaction with other
neurotransmitter systems in the brain of adult rats. Annales Acad. Med. Silesiensis (in press).
223. Brown RW, Maple AM, Perna MK, Sheppard AB, Cope ZA, Kostrzewa, RM (2012)
Schizophrenia and substance abuse comorbidity: Nicotine addiction and the neonatal quinpirole
model. Dev Neurosci. 34(2-3), 140-151. Epub 2012 Jul 6. Review.
224. Kostrzewa RM, Kostrzewa JP, Brus R (2014) Tardive dyskinesia: Outcome of antipsychotic
treatment and brain damage? In Section on Diseases and Disorders Relevant to Neurotoxins, in
Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, pp 2315-2326. ISBN 978-
1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and
electronic bundle). DOI 10.1007/978-1-4614-5836-4_163.
225. Kostrzewa RM (2014) Survey of Selective Neurotoxins (chapter title), in Section on Selective
Neurotoxins, in Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, Heidelberg,
Dordrecht, London, 2014, pp 3-67. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook);
ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_53.
226. Archer T, Kostrzewa RM (Jan 2013) The inductive agency of stress: from perinatal to
adolescent induction, In: Laviola G, Macri S: Adaptive and Maladaptive Aspects of
Developmental Stress. Springer New York, pp 1-20. Galley proof, Nov. 12, 2012.
227. Archer T, Ricci S, Rapp-Ricciardi M, Kostrzewa RM (2013) “Polluting agents in Parkinsonism: I
Transition metals”. In Handbook of Neurotoxicity (Kostrzewa RM, Editor) (Springer, New York
NY), Section on Neurotoxicity in Psychiatric and Neurologic Disorders (T Archer and U Sailer,
Section Editors). Submitted September 2012.
228. Chen J, RM Kostrzewa, X Xu (Jan 2014) Necroptosis, a potential therapeutic target for
neurological disorders”. In Handbook of Neurotoxicity (Kostrzewa RM, Editor) (Springer, New York
NY), Section on Selective Neurotoxins (RM Kostrzewa, Section Editor), pp 69-93. . DOI
10.1007/978-1-4614-5836-4_166.
229. Nowak P, Kowalińska-Kania M, Nowak D, Kostrzewa RM, Malinowska-Borowska J (Aug 2013)
Antinociceptive effects of H3 (R-methylhistamine) and GABAB (baclofen) -receptor ligands in an
orofacial model of pain in rats. Neurotox Res 24, 258-264. Epub 2013 Mar 6. Doi: 10.1007/s12640-
013-9385-4. PMID: 23463522.
230. Kostrzewa JP, RM Kostrzewa (2014?) p-Chloroamphetamine potentiated dopamine release into in
vivo microdialysates of partially serotonin-denervated neostriatum in an animal model of Parkinson’s
disease: implications for treatment of Parkinson’s disease. Neurochem Res. (to be submitted, Nov
2013).
231. Szkilnik R, R Brus, J Malinowska-Borowska, D Nowak, M Waliczek, RM Kostrzewa, P Nowak
(2014) Ontogenetic manganese exposure with perinatal 6-OHDA lesioning alters behavioral
responses of rats to dopamine D1 and D2 agonist treatments. Environ. Toxicol. Pharmacol. 37, 28-36.
232. Chandley MJ, A Szebeni, K Szebeni, JD Crawford, CA Stockmeier, G Turecki, RM Kostrzewa,
GA Ordway (submitted Oct 2013) Elevated gene expression of glutamate receptors in noradrenergic
R.M. Kostrzewa, Ph.D.
neurons from the locus coeruleus in major depression. Int J Neuropsychopharmacol (under review).
233. Bałasz M, R Szkilnik, R Brus, J Malinowska-Borowska, D Nowak, RM Kostrzewa, P Nowak
(2014?) Perinatal manganese exposure and hydroxyl radical formation in rat brain. In preparation.
R.M. Kostrzewa, Ph.D.
BOOKS
Kostrzewa RM (Author) Pharmacology, Blond’s Medical Guides, 398 pages, Sulzburger & Graham
Publishers, New York, N.Y. 1996. ISBN 0-945819-48-X
Kostrzewa RM (Editor) Highly Selective Neurotoxins: Basic and Clinical Applications, 404 pages, The
Humana Press, Totowa, N.J., 1998. ISBN 0-89603-465-8
Beninger RJ, T Palomo, RM Kostrzewa and T Archer (co-Editors), 762 pages, Neurodevelopmental
Liabilities in Brain Disease States, 762 pages, Fundación Cerebro y Mente, Madrid, Spain, 2003.
ISBN 84-921848-9-2
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors) Gene-Environment I-nterplay in Brain
Disease States, 575 pages, Fundación Cerebro y Mente, Madrid, Spain, 2005. ISBN 84-934250-1-X
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors), 698 pages, Implications of
Comorbidity for Etiology and Treatment of Neuropsychistric Disorders, Fundación Cerebro y Mente,
Madrid, Spain, 2007. ISBN 978-84-934250-0-5
Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors), 708 pages, Beyond Neuropsychiatric
Diagnostics: Symptoms not Disorders, Fundación Cerebro y Mente, Madrid, Spain, 2009. ISBN 978-
84-934250-4-3
Palomo T, RM Kostrzewa and RJ Beninger (co-Editors), 433 pages, Staging Neuropsychiatric Disorders:
Implications for Etiopathogenesis and Treatment, Fundación Cerebro y Mente, Madrid, Spain, 2013.
ISBN 978-1-4614-7263-6
Kostrzewa RM (Editor-in-Chief) Handbook of Neurotoxicity, Springer New York, Heidelberg, Dordrecht,
London, 2014. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-
4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4
Kostrzewa RM (Editor) The Process of Dopamine Receptor Supersensitivity, in the “The Receptor Series”
http://www.springer.com/series/7668 (Series Editor: G Di Giovanni, Univ Malta), Springer: Vienna.
Proposal submitted.
R.M. Kostrzewa, Ph.D.
ABSTRACTS AND PRESENTATIONS
Jacobowitz D and RM Kostrzewa (1971) The effect of 6-hydroxydopa on central and peripheral adrenergic neurons.
Satellite Symposium, Intl. Congress of Physiol. Soc., Warsaw, Poland.
Jacobowitz D and RM Kostrzewa (1971) The effect of 6-hydroxydopa on brain monoaminergic neurons. 22nd
Am.
Soc. Pharmacology & Exp. Ther. meeting, Burlington, VT.
Kostrzewa RM and D Jacobowitz (1971) The effect of 6-hydroxydopa on peripheral adrenergic neurons. 22nd
Am.
Soc. Pharmacology & Exp. Ther. meeting, Burlington, VT.
Teitelbaum P, E Satinoff, J Marshall, RM Kostrzewa and D Jacobowitz (1971) Disturbances in the regulation of
body temperature and food intake in rats caused by 6-hydroxydopa. 22nd
Am. Soc. Pharmacology & Exp. Ther.
meeting, Burlington, VT.
Kostrzewa RM (1972) Studies on the mechanism of action of 6-hydroxydopa. 56th
Federation Am. Soc. Exp. Biol.
Meeting, Atlantic City, NJ.
Kostrzewa RM and JW Harper (1973) Effects of 6-hydroxydopa on central mono- aminergic neurons in newborn
rats. 57th
Federation Am. Soc. Exp. Biol. Meeting, Atlantic City, NJ.
Kostrzewa RM (1974) Impaired development of noradrenergic neurons by 6-hydroxy-dopa in rat central nervous
system. 58th
Federation Am. Soc. Exp. Biol. Meeting, Atlantic City, NJ.
McLean JH, RM Kostrzewa and JG May (1974) Behavioral and biochemical effects of early injections of
6-hydroxydopa. 20th
Southeastern Psychological Assn. Meeting, El Paso, TX.
Kastin AJ, NP Plotnikoff, CA Sandman, MA Spirtes, RM Kostrzewa, SM Paul, LO Stratton, LH Miller, F Labrie,
AV Schally and H Goldman (1974) The effects of MSH and MIF on the brain. Intl. Conference on the
Neurobiology of CNS-Hormone Interactions, Chapel Hill, NC.
Kostrzewa RM, MA Spirtes and AJ Kastin (1974) Effects of melanocyte stimulating hormone (MSH) and
MSH-release inhibitory factor (MIF) on functional activity of central catecholamine-containing neurons. 25th
Am.
Soc. Pharmacology & Exp. Ther. Meeting, New Orleans, LA.
Spirtes MA, RM Kostrzewa and AJ Kastin (1974) Effects of melanocyte stimulating hormone (MSH) and
MSH-release inhibitory factor (MIF) on serotonin content and turnover in rat brain. 25th
Am. Soc. Pharmacology &
Exp. Ther. Meeting, New Orleans, LA.
Kostrzewa RM and JW Harper (1975) Comparison of the neonatal effects of 6- hydroxydopa and
6-hydroxydopamine on growth and development of noradrenergic neurons in the central nervous system. Intl.
Symposium on Chemical Tools in Catecholamine Research, Goteborg, Sweden.
Kostrzewa RM (1975) Age-related alterations in norepinephrine content by 6- hydroxydopa in regions of rat brain
receiving projections from the locus coeruleus. 6th
Intl Union of Pharmacology, Helsinki, Finland.
Spirtes MA, AJ Kastin and RM Kostrzewa (1975) Effects of melanocyte stimulating hormone (MSH) and
MSH-release inhibitory factor on serotonin turnover in hypophysectomized rats. 6th
Intl Union of Pharmacology,
Helsinki, Finland.
Spirtes MA, RM Kostrzewa, NP Plotnikoff and AJ Kastin (1975) Significant increases in dopamine and
norepinephrine levels after prolyl-leucyl-glycinamide in rats subjected to the behavioral dopa potentiation test. 5th
Soc. Neuroscience meeting, New York, NY.
Sweig R, JH McLean, RM Kostrzewa and JG May (1975) Behavioral and biochemical effects of neonatal
6-hydroxydopa. 5th
Soc. Neuroscience meeting, New York, NY.
Kostrzewa RM and RE Garey (1975) Investigation of the development of cerebellar noradrenegic neurons after
6-hydroxydopa. 5th
Soc. Neuroscience meeting, New York, NY.
Musgrave JB, JG May, R Sweig, JH McLean and RM Kostrzewa (1976) The effects of neonatal injections of
6-hydroxydopa on the habituation of a startle response in rats. 22nd
Southeastern Psychological Assn. meeting, New
Orleans, LA.
Kostrzewa RM and LC Walker (1976) Altered development of mouse central noradrenergic neurons following
prenatal treatment with 6-hydroxydopa. 60th
Federation Am. Soc. Exp. Biol. meeting, Anaheim, CA.
Kostrzewa RM, TH Joh, AJ Kastin, C Christensen and MA Spirtes (1976) Effects of L-prolyl-L-leucyl-glycine aide
(MIF-I) on dopaminergic neurons. Bicentennial Neuro-peptide Conference, Philadelphia, PA.
Spirtes MA, NP Plotnikoff, RM Kostrzewa, CT Harston, AJ Kastin and CW Christensen (1976) Possible
association of increased rat behavioral effects and increased striatal dopamine and norepinephrine levels during the
DOPA- potentiation test. Bicentennial Neuropeptide Conference, Philadelphia, PA.
Christensen CW, CT Harston, AJ Kastin, RM Kostrzewa and MA Spirtes (1976) Preliminary investigations on
α-MSH and MIF-I. Effects on cyclic nucleotide levels in rat brain. Bicentennial Neuropeptide Conference,
Philadelphia, PA.
Kostrzewa RM (1977) Sprouting of noradrenergic terminals in rat cerebellum after 6-hydroxydopa. 8th
Am. Soc.
Neurochemistry meeting, Denver, CO.
R.M. Kostrzewa, Ph.D.
Morgan D, JH McLean and RM Kostrzewa (1977) Comparison of 6-hydroxydopamine and 6-hydroxydopa on the
development of behavior. American Psychological Assn. meeting, San Francisco, CA.
Kostrzewa RM, AJ Kastin and S Sobrian (1978) Studies on the antiparkinsonian activity of a naturally-occurring
tripeptide, L-prolyl-L-leucyl-glycinamide. 62nd
Federation Am. Soc. Exp. Biol. meeting, Atlantic City, NJ.
Kostrzewa RM and MB Clark (1978) Stimulation of regenerative sprouting in the central nervous system by nerve
growth factor. 7th
Int=l Union of Pharmacology, Paris, France.
Kostrzewa RM and MB Clark (1978) Regenerative sprouting of noradrenergic terminals in the cerebellum. IV Int'l.
Catecholamine Symposium, Pacific Grove, CA.
Kostrzewa RM, SK Sobrian, H Fukushima and AJ Kastin (1978) Actions of L-prolyl-L-leucyl-glycine amide on
striatal enzyme activities. Huntington's Disease Symposium, San Diego, CA.
Robert TA, RL Snell and RM Kostrzewa (1978) Similarity in structure between MIF-I and dopamine: Reason for
anti-parkinsonian activity? 8th
Soc. Neuroscience Meeting, St. Louis, MO.
Clark MB, RM Kostrzewa and J King (1978) Loss of locus coeruleus perikarya following treatment of newborn rats
with 6-hydroxydopa. Anatomy Meeting, Vancouver, Canada.
Kastin AJ, RH Ehrensing, DH Coy, AV Schally and RM Kostrzewa (1979) Behavioral effects of brain peptides,
including LH-RH. 2nd
Intl. Symposium on Clinical Psycho-Neuro Endocrinology in Reproduction. Venice, Italy.
Kastin AJ, AV Schally and RM Kostrzewa (1979) Possible aminergic mediation of MSH release and of the CNS
effects of MSH and MIF-I. Am. Physiological Soc. meeting, East Lansing, MI.
Harston CT, JC Hardin and RM Kostrzewa (1979) Morphine-enhanced regeneration of central noradrenergic nerves
following 6-hydroxydopa treatment of rat pups. 9th
Soc. Neuroscience meeting, Atlanta, GA.
Kostrzewa RM and H Fukushima (1979) Growth of axonal processes from in vivo transplants of rat locus coeruleus.
9th
Soc. Neuroscience meeting, Atlanta, GA.
Kostrzewa RM, CT Harston, JC Hardin and E Kunkel-Bagden (1980) Enhanced regeneration of noradrenergic fibers
in rat cerebellum by nerve growth factor. 26th
Histochemistry Soc. meeting, New Orleans, LA.
Harston CT and RM Kostrzewa (1980) Noradrenergic sprouting in the cerebellum of "Purkinje cell degeneration"
mutant mice. 10th
Soc. Neuroscience meeting, Cincinnati, OH.
McLean JH, DN Morgan and RM Kostrzewa (1980) Behavioral effects of amphetamine in animals treated
neonatally with 6-hydroxydopa or 6-hydroxydopamine. 10th
Soc. Neuroscience meeting, Cincinnati, OH.
McLean JH, SB Hutson, BM King and RM Kostrzewa (1981) Behavioral effects of norepinephrine and/or dopamine
depletions. 11th
Soc. Neuroscience meeting, Los Angeles, CA.
Kostrzewa RM, H Fukushima and CT Harston (1982) Collateral sprouting of noradrenergic fibers in rat cerebellum
after a midbrain lesion at birth. 6th
Federation Am. Soc. Exp. Biol. meeting, New Orleans, LA.
Kunkel-Bagden E and RM Kostrzewa (1982) Influence of nerve growth factor (NGF) on growth of noradrenergic
fibers into rat cerebellum. 3rd
Southeastern Pharmacological Society meeting, Oxford, MS.
Kostrzewa RM (1982) Naloxone-reversible morphine-induced sprouting of noradren-ergic fibers in the cerebellum
of 6-hydroxydopa-treated neonatal rats. 3rd
Southeastern Pharmacological Society meeting, Oxford, MS.
Kostrzewa RM and D Klisans-Fuenmayor (1983) Naloxone-reversible morphine- enhanced sprouting of
noradrenergic fibers in rat brainstem and cerebellum. 34th
Am. Soc. Pharmacology & Exp. Ther. meeting,
Philadelphia, PA.
Kostrzewa RM and D Klisans-Fuenmayor (1983) Collateral sprouting of noradrenergic fibers in rat brainstem and
cerebellum after dorsal lesions in neonatal rats; failure of 6-hydroxydopa to modify the response. 13th
Soc.
Neuroscience meeting, Boston, MA.
Kunkel-Bagden E and RM Kostrzewa (1984) Morphine-induced alterations of development of noradrenergic fiber
projections in rat brain following a dorsal bundle lesion. 68th
Federation Am. Soc. Exp. Biol. meeting, St. Louis,
MO.
Kostrzewa RM, D Klisans-Fuenmayor and JC Hardin (1984) Naloxone-reversible morphine-induced destruction of
coeruleus cells accompanies enhanced recovery of noradrenergic fibers in brains of rats treated as neonates with
6-hydroxydopa. 9th
Int=l Union of Pharmacology, London, England.
Hsi T, D Liu, P Cohenour, R Rhagavan, L Lin, P Lin, R Kostrzewa, RE Lehr and CL Blank (1984) Improved selectivity
in the chemical destruction of noradrenergic neurons. 9th
Int=l Union of Pharmacology, London, England.
Lin P, R Rhagavan, RE Lehr, RM Kostrzewa, S Sasa and CL Blank (1984) 5-Amino- 2,4-dihydroxy-α-
methylphenethylamine provides more selective noradrenergic destruction than 6-hydroxydopamine. 14th
Soc.
Neuroscience meeting, Anaheim, CA.
Kostrzewa RM, D Klisans-Fuenmayor and JC Hardin (1984) Naloxone-reversible morphine-induced destruction of
coeruleus cells accompanies enhanced recovery of noradrenergic fibers in brains of rats treated as neonates with
6-hydroxydopa. Southeast section, Soc. Toxicology Meeting, Johnson City, TN.
Kunkel-Bagden E and RM Kostrzewa (1985) Opioids fail to alter recovery from a dorsal bundle lesion. 16th
Am.
Soc. Neurochemistry meeting, Baltimore, MD.
R.M. Kostrzewa, Ph.D.
Kostrzewa RM, D Klisans-Fuenmayor and JC Hardin (1986) Opioid-induced destruction of locus coeruleus cells in
6-hydroxydopa-treated neonatal rats. 16th
Soc. Neuroscience meeting, Washington, DC.
White TG and RM Kostrzewa (1987) Transient reduction of 3H-spiroperidol (
3H-SP) binding to striatal tissue
following chronic administration of prolyl-leucyl- glycinamide (PLG) in MPTP-treated mice. 71st Federation Am.
Soc. Exp. Biol. meeting, Washington, DC.
Kostrzewa RM, AJ Kastin, DH Coy, R Brus, H Criswell and PS Coogan (1987) [D-ALA2,F5-PHE
4]-dynorphin
amide, an opioid analgesic with lethal properties. 17th
Soc. Neuroscience meeting, New Orleans, LA.
Kostrzewa RM and MI Saleh (1988) Attenuation of SCH 23390-induced ontogenic impairment of rat striatal
dopamine D-1 receptors by L-prolyl-l-leucyl- glycinamide (PLG). 18th
Soc. Neuroscience meeting, Toronto.
Saleh MI and RM Kostrzewa (1988) Attenuation of spiroperidol-induced impairment of rat striatal dopamine D-2
receptors by L-prolyl-l-leucyl-glycinamide (PLG). 18th
Soc. Neuroscience meeting, Toronto.
Gong L, DS Chi, EA Daigneault and RM Kostrzewa (1989) Inhibitory effects of MPTP and vitamin E on
interleukin-2 (IL-2) production in mice. 10th
Southeastern Pharmacological Society meeting, Augusta, GA.
Hamdi A and RM Kostrzewa (1989) Enhanced yawning response to the dopamine D-2 agonist, LY171555, in adult
rats that were treated in development with LY171555. 10th
Southeastern Pharmacological Society meeting,
Augusta.
Hamdi A and RM Kostrzewa (1989) Enhanced yawning response to the dopamine D-2 agonist, LY171555, in adult
rats that were treated in development with LY171555. 19th
Soc. Neuroscience meeting, Phoenix, AZ.
Kostrzewa RM and A Hamdi (1989) Enhanced stereotypic responses to dopamine agonists in adult rats that were
treated in development with SKF38393. 19th
Soc. Neuroscience meeting, Phoenix, AZ.
Kostrzewa RM (1989) Dopamine agonists modify the development of brain D1 and D2 receptor responsiveness.
Plenary Session, 14th Southeast Section, Soc. Exp. Biol. Med. meeting, Johnson City, TN.
Hamdi A and RM Kostrzewa (1990) Enhanced stereotypic responses to dopamine agonists in adult rats that were
treated in development with both SKF38393 and 6-OHDA. 14th
Southeast Section, Soc. Exp. Biol. Med. meeting,
Johnson City, TN, 1989; Proc. Soc. Exp. Biol. Med. 194, 375.
Gong L, DS Chi, EA Daigneault and RM Kostrzewa (1990) Effects of MPTP and vitamin E on interleukin-2 (IL-2)
production in mice. 14th
Southeast Section, Soc. Exp. Biol. Med. meeting, Johnson City, TN, 1989; Proc. Soc. Exp.
Biol. Med. 194, 378.
Arbogast LY, JK Neumann, RM Kostrzewa and BW Arbogast (1990) Response of toxicity preventing activity levels
to psychological stress. 14th
Southeast Section, Soc. Exp. Biol. Med. meeting, Johnson City, TN, 1989; Proc. Soc.
Exp. Biol. Med. 194, 378.
Neumann JK, DS Chi, BW Arbogast, RM Kostrzewa and LM Harvill (1990) Relation-ship of blood groups to
self-reported behavior patterns in MI patients. 14th
Southeast Section, Soc. Exp. Biol. Med. meeting, Johnson City,
TN, 1989; Proc. Soc. Exp. Biol. Med. 194, 379.
Arbogast LY, JK Neumann, RM Kostrzewa and BW Arbogast (1990) Decreased VLDL toxicity preventing activity
in response to a reverse mirror drawing stressor. Southern Association of Agricultural Scientists, Little Rock, AK.
Chi DS, L Gong, EA Daigneault and RM Kostrzewa (1990) Effects of MPTP and vitamin E (VE) on immune
functions. Joint meeting, Am. Soc. Biochem. Molec. Biol. and Am. Assn. Immunology meeting, New Orleans, LA.
Kostrzewa RM, A Hamdi and FP Kostrzewa (1990) Production of prolonged super-sensitization of dopamine D2
receptors. 11th Int=l Union of Pharmacology, Amsterdam, The Netherlands.
Gong L, EA Daigneault, DS Chi, RW Acuff and RM Kostrzewa (1991) The effective-ness of neurotoxin MPTP in
mice treated with alpha-tocopherol. Joint 11th
Southeastern Pharmacological Society and 2nd
Am. College of
Clinical Pharmacology meeting, Johnson City, TN, 1990; J. Clin. Pharmacol. 31, 276.
Kostrzewa RM, A Hamdi and L Gong (1991) Enhanced spiperone- and SKF 38393- induced oral activity in rats
after neonatal intracerebroventricular treatment with 6-hydroxydopamine. Joint 11th
Southeastern Pharmacological
Society and 2nd
Am. College of Clinical Pharmacology meeting, Johnson City, TN 1990; J. Clin. Pharmacol. 31,
264.
Kostrzewa RM, R Brus and J Guo (1991) Production of supersensitized D2 and/or D3 receptors in rats. 21st Soc.
Neuroscience meeting, New Orleans, LA.
Gong L, EA Daigneault and RM Kostrzewa (1991) Mediation of enhanced SKF 38393-induced oral activity by a
serotonin system. 21st Soc. Neuroscience meeting, New Orleans, LA.
Arbogast BW, JK Neumann, RM Kostrzewa, LY Arbogast and SC Leeper (1992) Effect of acute psychological
stress on serum VLDL protective activity. 25th
Lofland Conference, Boston, MA.
Brus R, R Kostrzewa, R Szkilnik and A Plech (1992) Effect of quinpirole, a dopamine D2 receptor agonist, on
learning and memory of conditioned avoidance reflex (CAR) in rats. 11th
Congress of the Polish Pharmacological
Society, Gdansk, Poland. Pol. J. Pharmacol. 44 (Suppl.), 105-106.
Jdrusiak J, RM Kostrzewa and R Brus (1992) Influence of dopamine receptor agonists and antagonists on the
cardiovascular actions of TRH in rats. 11th
Congress of the Polish Pharmacological Society, Gdansk, Poland. Pol.
J. Pharmacol. 44 (Suppl.), 148-149.
R.M. Kostrzewa, Ph.D.
Kostrzewa RM, L Gong and R Brus (1992) Serotonin (5-HT) systems mediate dopamine (DA) receptor
supersensitivity. 1st Intl Congress of the Polish Neuroscience Society, Warsaw, Poland. Acta Neurobiol. Exp. 52,
126.
Gong L, RM Kostrzewa, RW Fuller and KW Perry (1992) Ontogenic supersensitization of dopamine D1 receptors.
13th
Southeastern Pharmacological Society meeting, Charleston, SC.
Leeper SC, JK Neumann, LY Arbogast, RM Kostrzewa and BW Arbogast (1992) Effect of stress on the ability of
human serum to protect against VLDL injury of aortic endothelial cells in culture. 65th
American Heart Assn.
meeting, New Orleans, LA.
Arbogast BW, JK Neumann, LY Arbogast, SC Leeper and RM Kostrzewa (1993) Transient loss of serum protective
activity following short term stress: a possible biochemical link between stress and atherosclerosis. Experimental
Biology meeting, New Orleans, LA.
Brus R, RM Kostrzewa, M Rykaczewska and A Plech (1993) Nadwrazliwosc osrodkowych receptorow
dopaminergicznych: badania behawioralne. [Supersensitivity of central dopamine receptors: a behavioral study].
2nd
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland.
Feliska W, R Brus, M Rykaczewska, A Plech, RM Kostrzewa and R Szkilnik (1993) Wplyw ethanolu stosowanego
w okresie prenatalnym na readtywnosc osrodkowych receptorow dopaminergicznych u szczurow. [Effect of
prenatal ethanol on reactivity of central dopaminergic receptors in rats]. 2nd
Neuropsychopharmacological Days,
Ustro, Jaszowiec, Poland.
Brus R, W Feliska, RM Kostrzewa, M Rykaczewska, A Plech, R Szkilnik and H Jakrzewska (1993) Cadmium
modulates reactivity of central dopamine receptors to agonists in rats prenatally exposed to ethanol. Conference of
the Polish Pharmacological Society and Polish Toxicological Society, Bialowieza, Poland.
Brus R, R Szkilnik, RM Kostrzewa, M Rykaczewska, A Plech, P Nowak and H Jakrzewska (1993) Effect of electric
foot shock on reactivity of central dopaminergic receptors to agonists in rats. 19th
Congress of the Polish
Physiological Society, Toru, Poland.
Kostrzewa RM, R Brus, KW Perry and RW Fuller (1993) 5,7-Dihydroxytryptamine destruction of serotonin fibers
eliminates the enhanced oral activity response to SKF 38393 in neonatal 6-hydroxydopamine-lesioned rats. 23rd
Soc. Neuroscience meeting, Washington, DC.
Gong L, RM Kostrzewa, R Brus, EA Daigneault, RW Fuller and KW Perry (1993) Ontogenetic supersensitization of
dopamine D1 receptors occurs without a change in D1 high affinity sites. 23rd
Soc. Neuroscience Meeting,
Washington, DC.
Huang N-Y, RM Kostrzewa and MD Miyamoto (1993) Chronic haloperidol treatment greatly increases spontaneous
oral activity in neonatal 6-hydroxydopamine-lesioned rats. 23rd
Soc. Neuroscience meeting, Washington, DC.
Brus R, RM Kostrzewa, KW Perry and RW Fuller (1994) Serotonin fibers and central dopamine D1 receptor
supersensitivity. 3rd
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland.
Plech A, R Brus and RM Kostrzewa (1994) Enhanced oral activity responses to intrastriatal SKF-38393 and m-CPP
are attenuated by intrastriatal mianserin in neonatal 6-OHDA-lesioned rats. 3rd
Neuropsychopharmacological Days,
Ustro, Jaszowiec, Poland.
Kostrzewa RM, L Gong, N-Y Huang and R Brus (1994) Serotonin-dopamine interactions in the genesis of oral
activity. 5th
Eur. Behav. Pharmacological Soc. meeting, Berlin, Germany. Behav. Pharmacol. 5, Suppl. 1, 11.
Brus R, RM Kostrzewa, R Szkilnik, M Rykaczewska, A Plech, P Nowak and H Jakrzewska (1994) Electric foot
shock stress and reactivity of central dopamine (D1, D2) receptors to agonists in male and female rats. 5th
Eur.
Behav. Pharmacological Soc. Meeting, Berlin, Germany. Behav. Pharmacol. 5, Suppl. 1, 110-111.
Brus R, RM Kostrzewa, R Szkilnik, W Feliska, A Plech, M Rykaczewska and H Jakrzewska (1994) Reactivity of
the central dopamine (D1, D2) receptors to agonists in rats prenatally exposed to ethanol and cadmium. 5th
Eur.
Behav. Pharmacological Soc. Meeting, Berlin, Germany. Behav. Pharmacol. 5, Suppl. 1, 126.
Brus R, R Szkilnik, W Feliska, RM Kostrzewa, A Plech and H Jakrzewska (1994) Prenatal exposure to ethanol and
reactivity of central dopaminergic, serotoninergic and muscarinic receptors in rat offspring. 4th
Joint Meeting of
Hungarian, Italian and Polish Pharmacological Societies, Poznan, Poland. Pol. J. Pharmacol. 46, 218-219.
Brus R, RM Kostrzewa, R Szkilnik, I Jdrusiak, J Konecki and M Gowacka (1994) Dopaminergic neuronal system
and glucose metabolism in the rat brain. 4th Joint Meeting of Hungarian, Italian and Polish Pharmacological
Societies, Poznan, Poland. Pol. J. Pharmacol. 46, 283.
Kostrzewa RM, R Brus, RW Fuller and KW Perry (1995) 5,7-Dihydroxytryptamine (5,7-DHT) lesions of serotonin
(5-HT) fibers alter dopamine (DA) agonist-induced behaviors in rats. 34th
Soc. Toxicology Meeting, Baltimore,
MD. The Toxicologist 15, 246.
Huang N-Y and RM Kostrzewa (1995) Enhanced oral activity persists in neonatal 6-hydroxydopamine (6-OHDA)-
lesioned rats withdrawn from long-term haloperidol treatment. 34th
Soc. Toxicology Meeting, Baltimore, MD. The
Toxicologist 15, 246.
R.M. Kostrzewa, Ph.D.
Kostrzewa RM, R Brus, KW Perry and RW Fuller (1995) Sensitization to dopamine (DA) and 5-hydroxytryptamine
(5-HT) agonists is not correlated with alterations in DA and 5-HT contents of neostriatum after neonatal
intrastriatal 6-hydroxydopamine injections in rats. 2nd
Int=l Congress of the Polish Neuroscience Society, Cracow,
Poland. Acta Neurobiol. Exp. 55 (Suppl.), 13.
Brus R, R Szkilnik, P Nowak and RM Kostrzewa (1995) Nitric oxide (NO) and central dopamine (DA) receptor
supersensitivity in rats. 2nd
Int=l Congress of the Polish Neuroscience Society, Cracow, Poland. Acta Neurobiol.
Exp. 55 (Suppl.), 13.
Brus R, RM Kostrzewa, I Jdrusiak, R Szkilnik and L Wojtowicz (1995) In vivo voltammetric determination of
enhanced spiperone-induced release of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) in neostriatum
of rats with supersensit-ized DA D2-receptors.' 2nd
Int=l Congress of the Polish Neuroscience Society, Cracow,
Poland. Acta Neurobiol. Exp. 55 (Suppl.), 59.
Kostrzewa RM and R Brus (1995) Complementarity of dopamine and serotonin neurons in regulating motor activity.
12th
Congress of the Polish Pharmacological Society, Bydgoszcz, Poland. Pol. J. Pharmacol. 47 (Suppl.), 17-18.
Brus R, R Szkilnik, P Nowak and RM Kostrzewa (1995) Effect of NAME and arginine on central dopamine receptor
reactivity in rats. 12th
Congress of the Polish Pharmacological Society, Bydgoszcz, Poland. Pol. J. Pharmacol. 47
(Suppl.), 54.
Brus R, P Nowak, R Szkilnik and RM Kostrzewa (1995) Effect of mCPP, a 5HT2C central receptor agonist, on
grooming behavior in male and female rats after neonatally induced chemical serotoninectomy. 12th
Congress of the
Polish Pharmacological Society, Bydgoszcz, Poland. Pol. J. Pharmacol. 47 (Suppl.), 54.
Brus R, R Szkilnik, P Nowak and RM Kostrzewa (1996) Effect of m-CPP, a 5-HT2 central receptor agonist, on
grooming behavior in male and female rats after neonatally induced chemical serotoninectomy. 20th
Congress of the
Polish Physiological Society, Wrocaw, Poland.
Brus R, R Szkilnik, P Nowak and RM Kostrzewa (1996) Effect of NAME and arginine on central dopamine receptor
reactivity in rats. 20th
Congress of the Polish Physiological Society, Wrocaw, Poland.
Brus R, R Szkilnik, RM Kostrzewa, U Mikoajun and W Tramer (1996) 6-Hydroxydop-amine, 5,7-
dihydroxytryptamine and reactivity of the central dopamine D3 receptor to quinpirole. 20th
Congress of the Polish
Physiological Society, Wrocaw, Poland.
Kostrzewa RM, R Brus, KW Perry and RW Fuller (1996) Enhanced quinpirole-induced oral activity in rats lesioned
with 6-hydroxydopamine during ontogeny and with 5,7-dihydroxytryptamine during adulthood. 26th
Soc.
Neuroscience Meeting, Washington, DC.
Kostrzewa RM and N-Y Huang (1997) Serotonin antagonists attenuate oral dyskinesia in 6-hydroxydopamine-
lesioned rats during withdrawal from chronic haloperidol. Am. Soc. Pharmacology & Exp. Ther. Meeting, San
Diego, CA, 1997. The Pharmacologist 39, 120.
Kostrzewa RM (1997) Observations relative to the neurotoxicity and neurotoxic potential of amino acids. In the
symposium Neurotoxicity and Neurotoxic Potential of Amino Acids. 5th
Int=l Congress on Amino Acids,
Chalkidiki, Greece.
Kostrzewa RM and R Brus (1997) Destruction of catecholamine-containing neurons by 6-hydroxydopa, an
endogenous amine oxidase cofactor. In the symposium Neuro-toxicity and Neurotoxic Potential of Amino Acids. 5th
Int=l Congress on Amino Acids, Chalkidiki, Greece. Amino Acids 13, 60.
Brus R, R Szkilnik, A Kasperska, J Owicimska and R.M. Kostrzewa.(1997) Effect of the amino acid L-arginine
and its analog nitro-L-arginine methyl ester HCl (L-NAME) on central dopamine (DA) receptor reactivity. 5th
Int=l
Congress on Amino Acids, Chalkidiki, Greece, 1997. Amino Acids 13, 29.
Brus R, R Szkilnik, A Kasperska, J Owicimska and RM Kostrzewa (1997) Effect of the aminoacid L-arginine and
its analog nitro-L-arginine methyl ester HCl (L-NAME) on central dopamine (DA) receptor reactivity. 3rd
Intl
Congress of the Polish Neuroscience Society, d, Poland. Acta Neurobiol. Exp. 57, 22.
Kostrzewa RM and R Brus (1997) Dopamine receptor supersensitivity. In Satellite Symposium Dopamine: New
Trends in Receptor Research and Therapeutic Implications 3rd
Int=l Congress of the Polish Neuroscience Society,
d, Poland. Acta Neurobiol. Exp. 57, 3.
Kostrzewa RM, R Brus and KW Perry (1997) Ontogenetic intrastriatal 6-OHDA lesions enhance m-
chlorophenylpiperazine- (m-CPP-) induced vacuous chewing in rats. 27th
Soc. Neuroscience Meeting, New
Orleans, LA.
Brus R, J Owicimska, L Glenn and RM Kostrzewa (1997) Quinpirole, but not 7-OH-DPAT, induces oral activity
and locomotor activity in rats. 27th
Soc. Neuroscience Meeting, New Orleans, LA.
Brus R, J Owicimska and RM Kostrzewa (1998) Comparison of some behavioral and biochemical effects of two
central dopamine agonists (Quinpirole and 7-OHDPAT) in rats. XIII Int=l Union of Pharmacology Congress,
Munich, Germany. Naunyn-Schmiedeberg=s Arch. Pharmacol. 358, suppl. 1, R96.
R.M. Kostrzewa, Ph.D.
Brus R, A Kasperska, P Nowak, R Szkilnik and RM Kostrzewa (1998) Effects of nitric oxide donor (L-Arginine)
and nitric oxide synthase inhibitor (L-NAME) on reactivity of central dopamine receptors in rats. XIII Int=l Union
of Pharmacology Congress, Munich, Germany. Naunyn-Schmiedeberg=s Arch. Pharmacol. 358, suppl. 1, R95.
Kostrzewa, R.M. and R. Brus. Coordinate dopamine and serotonin neurochemical actions: relevance to drug actions.
XIII Polish Pharmacological Society Congress, Katowice, Poland, September 1998.
Kasperska A, R Brus, R Szkilnik and RM Kostrzewa (1998) Effect of the nitric oxide (NO) synthase inhibitor (L-
NAME) and NO donors (L-ARGININE, MOLSIDOMINE) on amphetamine-induced stereotypy behavior in rats.
XIII Polish Pharmacological Society Congress, Katowice, Poland.
Owicimska J, R Brus and RM Kostrzewa (1998) Comparison of some behavioral effects of two central dopamine
(DA) agonists: Quinpirole and 7-OH-DPAT in male and female rats. XIII Polish Pharmacological Society
Congress, Katowice, Poland.
Tizabi Y, VA Louis, RL Copeland Jr, R Brus and RM Kostrzewa (1998) Nicotinic cholinergic systems mediate
quinpirole-induced behavior in rats. 28th
Soc. Neuroscience Meeting, Los Angeles, CA.
Tizabi Y and RM Kostrzewa (1998) Involvement of nicotinic cholinergic system in quinpirole-induced behaviors.
Soc. Biol. Psychiatry, Washington, DC.
Kostrzewa RM, JP Kostrzewa and R Brus (1999) Susceptibility of neostriatal dopamine nerve terminals to oxidative
injury by L-DOPA. In the symposium Neurobiology of the ventral basal ganglia loop. 6th
Int=l Congress on Amino
Acids: Satellite meeting on Neurobiology, Bonn, Germany. Amino Acids 17:12.
Brus R, A Kasperska, A Sokoa and RM Kostrzewa (1999) Effect of the aminoacid L-arginine and its analog nitro
L-arginine methyl ester (L-NAME) on amphetamine and apomorphine induced stereotyped behavior and DOPAC
release in the striatum of rats. 6th
Int=l Congress on Amino Acids: Satellite meeting on Neurobiology, Bonn,
Germany. Amino Acids 17:19.
Brus R, J Owicimska, R Szkilnik, A Sokola dnd RM Kostrzewa (1999) Discrimination between dopamine (DA)
D2 and D3 receptor-mediated events: DOPAC release in the striatum and some behavioral effects of quinpirole and
7-OH-DPAT in rats. 30th
Am. Soc. Neurochemistry meeting, New Orleans, LA, USA, March 1999. J. Neurochem.
72 Suppl., p. S77.
Kostrzewa RM, R Brus and J Owicimska (1999) Insights on neurochemical mechanisms of hyperactivity and
potentially new therapeutic strategies. In the symposium, New Therapeutic Strategies for Neurologic and
Psychiatric Disorders. 4th
Polish Int=l Neuroscience Meeting, Gdansk, Poland. Acta Neurobiol. Exp. 59:217.
Kasperska A, R Brus, A Sokoa and RM Kostrzewa (1999) Effect of L-arginine and nitro-L-arginine methyl ester
(L-NAME) on amphetamine and apomorphine induced stereotyped behavior and DOPAC release in the striatum of
rats. 4th
Polish Int=l Neuroscience Meeting, Gdansk, Poland. Acta Neurobiol. Exp. 59:235.
Brus R, J Owicimska, R Szkilnik, A Sokoa and RM Kostrzewa (1999) Comparison of DOPAC release in the
striatum and some behavioral effects of quinpirole and 7-OH-DPAT, dopamine D2/D3 receptor agonists in rats. 4th
Polish Int=l Neuroscience Meeting, Gdansk, Poland. Acta Neurobiol. Exp. 59:235.
Brus R, P Nowak, R Szkilnik, RM Kostrzewa and W Kiszka (1999) Catecholamine levels in rat brain prenatally
exposed to mercury. Polish Toxicological Society Meeting, Augustow, Poland.
Kostrzewa RM, JP Kostrzewa and R Brus (1999) Neurotoxicity and neurodegeneration: Among the shifting sand
dunes of protection. Fundación Cerebro y Mente Intl meeting on Neurotoxicology, Degeneration and Protection in
Brain Disease States, Mojácar (Almeria) Spain.
Kostrzewa RM, JP Kostrzewa and R Brus (1999) Suppression of hydroxyl radical by dopaminergic innervation.
Fundación Cerebro y Mente Intl meeting on Neurotoxicology, Degeneration and Protection in Brain Disease
States, Mojácar (Almeria) Spain.
Kostrzewa JP, RM Kostrzewa and R Brus (2000) Dopamine innervation and L-DOPA treatment suppress hydroxyl
radical formation in rat striatum. 6th
Internet World Congress on Biomedical Sciences, Madrid, Spain.
Kostrzewa JP, RM Kostrzewa and R Brus (2000) Suppression of hydroxyl radical by dopaminergic innervation. East
Tennessee State University, 16th
annual Student Research Forum, Johnson City, TN.
Owicimska J, P Nowak, U Mikoajun, R Szkilnik, R Brus and RM Kostrzewa (2000) Effects of the central
serotonin receptor agonists on locomotor activity in animal model of attention deficit hyperactivity disorder
(ADHD). 9th
Neuropsychopharmacological Days, Ustro-Jaszowiec, Poland. Pol. J. Pharmacol. 52: 152.
Owicimska J, P Nowak, R Szkilnik, R Brus and RM Kostrzewa (2000) Comparison of behavioral effects induced
by two central dopamine D3 receptor agonists: 7-OH-DPAT and quinpirole in neonatally 6-OHDA-lesioned male
and female rats. 9th
Neuro-psychopharmacological Days, Ustro-Jaszowiec, Poland. Pol. J. Pharmacol. 52:152-
153.
Kostrzewa JP, RM Kostrzewa and R Brus (2000) Suppression of hydroxyl radical by dopaminergic innervation.
Joint Am. Soc. Biochem. Molec. Biol. and Am. Soc. Pharmacology & Exp. Ther. meeting, Boston.
R.M. Kostrzewa, Ph.D.
Kostrzewa RM, JP Kostrzewa and R Brus (2001) Neurotoxic and neuroprotective properties of dopamine: relevance
to Parkinson=s Disease. Int=l Congress on Neurotoxicity as a Mechanism for Neurodegenerative Disorders: Basic
and Clinical Aspects. Pucón, Chile.
Brus R and RM Kostrzewa (2001) Receptor sensitization as a manifestation of neurotoxicity. Int=l Congress on
Neurotoxicity as a Mechanism for Neurodegenerative Disorders: Basic and Clinical Aspects. Pucón, Chile.
Kostrzewa RM, R Brus and JP Kostrzewa (2001) Insidious dopamine: Provocateur or protective agent in
Parkinson=s disease. 10th
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland. Pol. J. Pharmacol.
53(2): 165-166.
Kostrzewa RM, JP Kostrzewa and R Brus (2001). Suppression of spontaneous hydroxyl radical formation in
dopamine-denervated neostriatum, but enhancement by glutamate. 7th
Int=l Congress on Amino Acids and Proteins,
Vienna, Austria. Amino Acids 21(1): 39.
Kostrzewa RM, JP Kostrzewa and R Brus. Involvement of dopaminergic neurons in generating and sequestering
reactive oxygen species. In the symposium Complementary Neuroprotective Roles of Dopaminergic and
Serotonergic Neurons, XIV Int=l Congress of the Polish Pharmacological Society, Kraków, Poland, September
2001. Pol. J. Pharmacol. 53 (suppl.): 49-50, 2001.
Brus R, P Nowak, A Sokoa, RM Kostrzewa and J Shani (2001) Behavioral and biochemical effects of new central
dopamine D3 (U-99194A) and D4 (U-101958) receptor antagonists in rats. 5th
Int=l Congress of the Polish
Neuroscience Society, Toru, Poland. Acta Neurobiol. Exp. 61: 197.
Nowak P, R Brus, R Szkilnik and RM Kostrzewa (2001) Effects of the central dopamine and serotonin receptor
agonists on biogenic amines release in rats= brain with experimental model of attention deficit hyperactivity
disorder (ADHD). In vivo brain microdialysis study. 5th
Int=l Congress of the Polish Neuroscience Society, Toru,
Poland. Acta Neurobiol. Exp. 61: 199.
Brus R, P Nowak, R Szkilnik and RM Kostrzewa (2001) Effect of amphetamine and quinpirole on dopamine and its
metabolites release in the brain of neonatal quinpirole-primed rats. An in vivo microdialysis study. XIV Congress
of the Polish Pharmacological Society, Cracow, Poland. Pol. J. Pharmacol. 53 (suppl.): 107, 2001.
Szkilnik R, R Brus, P Nowak, A Sokoa, Labus, RM Kostrzewa and J Shani (2001) Effect of prenatal manganese
exposure on behavior, biogenic amine levels and their release in the brain of adult rats. XIV Congress of the Polish
Pharmacological Society, Cracow, Poland.
Kostrzewa RM, JP Kostrzewa and R Brus (2001) Destructive propensities of perinatal neurotoxins on brain
development and function. Fundación Cerebro y Mente International Meeting on Neurodevelopmental Liabilities in
Brain Disease States. Mojácar, Spain.
Brown RW, JT Gass, IA Click, SK Thacker, RL Norris and RM Kostrzewa. Ontogenetic quinpirole treatment
produces spatial memory deficits and reaching accuracy enhancement in adult rats. 31st Society for Neuroscience
Meeting, San Diego, CA, 2001.
Nowak P, R Brus and RM Kostrzewa. Determination of hydroxyl radical from in vivo microdialysates of the rat
neostriatum: methodological aspects and preliminary findings. 11th
Neuropsychopharmacological Days, Ustro-
Jaszowiec, Poland. Pol. J. Pharmacol. 54(2): 198, 2002.
Kostrzewa RM and R Brus. Serotonin and Parkinson=s disease. 11th
Neuropsycho-pharmacological Days, Ustro-
Jaszowiec, Poland. Pol. J. Pharmacol. 54(2): 178-179, 2002.
Brown RW, KD Thompson, KL Thompson, JJ Ward, SK Thacker and RM Kostrzewa. Nicotine alleviates cognitive
and motor deficits produced by ontogenetic quinpirole treatments. 32nd
Soc. Neurosci. Meeting, Orlando, FL, 2002.
Soc. Neurosci. Abstr. 305.2.
Thompson KD, DS White, JJ Ward, R Kostrzewa and RW Brown (2002) Ontogenetic quinpirole treatments produce
behavioral deficits that are alleviated by nicotine. Southeastern Psychol. Assn., Orlando, FL.
Brus R, P Nowak and RM Kostrzewa. Co-morbid ontogenetic effects of cadmium and ethanol in rats evidenced by
altered in vivo microdialysate levels of striatal dopamine, DOPAC and HVA after amphetamine or haloperidol.
32nd
Soc. Neurosci. Meeting, Orlando, FL, 2002. Soc. Neurosci. Abstr. 606.18.
Kostrzewa RM, JP Kostrzewa and R Brus. Dopamine receptor supersensitivity as an index of neurotoxicity. 1st
Neurotoxicity Soc. Meeting, La Serena, Chile, April 2003.
Kostrzewa RM, JP Kostrzewa, P Nowak and R Brus. Priming as a process for producing dopamine D2 receptor
supersensitization: relevance in psychiatric disorders. 12th Neuropsychopharmacological Days, Ustro-Jaszowiec,
Poland, May 2003. Pol. J. Pharmacol. 55, 281-284, 2003.
Kostrzewa RM, JP Kostrzewa, R Brus and P Nowak. L-Dihydroxyphenylalanine treatment reduces hydroxyl radical
levels in tissue and microdialysates of dopamine-denervated rat striatum. 8th
Int=l Congress on Amino Acids and
Proteins, Rome, Italy. September 2003. Amino Acids 25(2), 157, 2003.
Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, P Nowak and R Brus. Dopamine agonist priming in intact and
dopamine-lesioned rats: implications for motor dyskinesias. Fundación Cerebro y Mente International Meeting on
Genes and Environment Interplay in Neuropsychiatric Disorders, Mojácar, Spain, October 2003.
R.M. Kostrzewa, Ph.D.
Kostrzewa RM, P Nowak, R Brus, RA Kostrzewa and JP Kostrzewa. Peculiarities of Parkinson's disease and L-DOPA
therapy. Studies in an animal model of Parkinson’s disease. XV International Congress of the Polish Pharmacological
Society, Poznan, Poland, September 2004.
Nowak P, A Bortel, J Dąbrowska, Ł Labus, R Brus and RM Kostrzewa. Effect of neonatal DSP-4 administration on
biogenic amine levels and amphetamine-induced release into microdialysates of adult rat frontal cortex. XV
International Congress of the Polish Pharmacological Society, Poznan, Poland, September 2004.
Brus R, P Nowak, Ł Labus, A Bortel, J Dąbrowska and RM Kostrzewa. Neonatal lesion of noradrenergic neurons in rat
brain: interaction with the dopaminergic system. XV International Congress of the Polish Pharmacological Society,
Poznan, Poland, September 2004.
McCoy MT, KG Becker, WH Wood 3rd, DR Teichberg, RW Brown, RM Kostrzewa and JL Cadet. Differential
quinpirole-induced transcriptional responses in the rat striatum and nucleus accumbens: evidence from microarray
analysis. Society for Neuroscience, San Diego, CA, October 2004.
Thacker SK, MK Perna, KS Smith, RM Kostrzewa and RW Brown. Chronic olanzapine treatment eliminates D2
supersensitization and cognitive deficits produced by neonatal quinpirole treatment. Intl. Soc. Behav. Neurosci., Key
West, FL, June 2004.
Thacker SK, MK Perna, KS Smith, RM Kostrzewa and RW Brown. Chronic olanzapine treatment eliminates D2
supersensitization and cognitive deficits produced by neonatal quinpirole treatment. Society for Neuroscience, San
Diego, CA, October 2004.
Kostrzewa RM, JP Kostrzewa, P Nowak, RA Kostrzewa and R Brus. Serotonin systems mediate and modulate
dopamine in a Parkinsonian rodent model. Viña del Mar, Chile, April 2005. Neurotox. Res. 8(3,4), 319.
Kostrzewa JP and RM Kostrzewa. p-Chloroamphetamine enhances dopamine release (striatal in vivo
microdialysates) after 5-HT lesion of Parkinsonian rats. Viña del Mar, Chile, April 2005. Neurotox. Res. 8(3,4),
321.
Nowak P, Ł Labus, A Bortel, J Dąbrowska, R Szkilnik, RM Kostrzewa and R Brus. Simultaneous neonatal lesion of
noradrenergic and serotoninergic neurons in rat brain: interaction with the dopaminergic system. 14th
Neuropsychopharmacological Days, Ustro-Jaszowiec, Poland, May 2005. Pol. J. Pharmacol. 57, x-y, 2005.
Brus R, P Nowak, Ł Labus, A Bortel, J Dąbrowska and RM Kostrzewa. Neonatal lesion of noradrenergic neurons in
rat brain: interaction with the dopaminergic system. II Neurotoxicity Society meeting, Viña del Mar, Chile, April
2005.
Nowak P, A Bortel, J Dąbrowska, Ł Labus, R Brus and RM Kostrzewa. Effect of neonatal DSP-4 administration on
biogenic amine levels and amphetamine-induced release into microdialysates of adult rat frontal cortex. II Neurotoxicity
Society meeting, Viña del Mar, Chile, April 2005.
Nowak P, Ł Labus, A Bortel, J Dąbrowska, R Szkilnik, RM Kostrzewa and R Brus (2005) Simultaneous neonatal
lesion of noradrenergic and serotonergic neurons in rat brain: interaction with the dopaminergic system. 14th
Neuropsychopharmacological Days, Ustro-Jaszowiec, Poland, May 2005. Pharmacological Reports 57, 260-261,
2005.
Kostrzewa RM and R Brus. Modeling tardive dyskinesia: predictive new treatment. 14th
Neuropsychopharmacological Days, Ustro-Jaszowiec, Poland, May 2005. Pharmacological Reports 57, 262-264,
2005.
Nowak P, L Labus, RM Kostrzewa and R Brus (2005) Central noradrenergic system lesion by DSP-4 prevents quinpirole
ontogenic sensitization to quinpirole-induced yawning in rats. Pharmacological Reports 57, 316, 2005.
Kostrzewa RM, JP Kostrzewa, R Brus, RA Kostrzewa and P Nowak (2005) Proposed animal model of severe
Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. 16th
Int’l
Congress on Parkinson’s Disease and Related Disorders, Berlin, Germany, June 5-9, 2005.
Kostrzewa RM and R Brus (2005) Persistent vacuous chewing and treatment strategy in a model of tardive
dyskinesia. Fundación Cerebro y Mente International Meeting on Implications of Comorbidity for Etiology and
Treatment of Neuropsychiatric Disorders, Mojácar, Spain, October 2005.
Brown RW, SK Thacker, MK Perna, KJ Smith, JJ Ward, TL Schaefer, MT Williams and RM Kostrzewa (2005) Chronic
adulthood olanzapine treatment eliminates D2 receptor priming and cognitive deficits produced by neonatal quinpirole
treatment. Society for Neuroscience, Washington DC, November 2005.
Kostrzewa RM and R Brus (2006) Selective neurotoxins and neuroscience – approaching the golden anniversary,
15th
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland, May 2006.
Kostrzewa RM, JA Correll, KN Thompson, ID Longacre, D Yin, ML Woodruff and RW Brown (2006) Nicotine
sensitization in adolescent beta arrestin-2 knockout mice. Society for Neuroscience, Atlanta, GA, October 2006.
Nowak P, R Szkilnik, A Bortel, J Niwinski, G Szczerbak, M Drosik, L Noras, A Kwiecinski, RM Kostrzewa and R
Brus (2007) Revelation of ‘dysplacement’ functions of monoaminergic nerves after lesions. III Neurotoxicity
Society Meeting, Pucon Chile, March 2007.
R.M. Kostrzewa, Ph.D.
Nowak P, A Bortel, J Jochem, K Zwirska-Korczala, J Niwinski, M Drosik, L Noras, RM Kostrzewa and R Brus
(2007) Ontogenetic noradrenergic lesion alters histaminergic activity in adult rats. III Neurotoxicity Society
Meeting, Pucon Chile, March 2007.
Nowak P, A Bortel, Ł Noras, G Szczerbak, J Gorzałek, A Kwieciński, R Szkilnik, M Drosik, RM Kostrzewa and R
Brus (2007) Effect of dual ontogenetic lesions of noradrenergic and dopaminergic neurons on biogenic amine
levels in rat brain, and reactivity of serotonin and dopamine receptors. Neurotoxicity Society Meeting, Pucon,
Chile, March 2007.
Kostrzewa RM, JP Kostrzewa, P Nowak and R Brus (2007) Serotonin in a Parkinsonian rat. III Neurotoxicity
Society Meeting, Pucon Chile, March 2007.
Kostrzewa RM and J Segura-Aguilar (2007) Neurotoxins: Where we’ve been, where we are, where we’re going.
Satellite of the III Neurotoxicity Society Meeting, Patagonia, Chile, March 2007.
Kostrzewa RM (2007) Pharmacological models of ADHD. 39th
Int’l Danube Symposium for Neurological Sciences
and Continuing Education & 1st Int’l Congress on ADHD: from Childhood to Adult Disease, Wűrzburg, Germany,
2-5 June 2007. J. Neural Transm. 114(4):XLVII, 2007.
Nowak P, J Jochem, K Zwirska-Korczala, Ł Noras, M Drosik, A Kwiecinski, RM Kostrzewa and R Brus (2007)
Effect of noradrenergic neurons lesion as neonates on histamine level in the brain and reactivity of the central
histamine receptors in adult rats. Polish Pharmacological Congress, Wrocław, Poland, Sept. 2007. Pharmacol.
Reports 59 suppl. 1, 47.
Nowak P, M Swoboda, R Szkilnik, G Szczerbak, J Josko, J Gorzałek, A Kwiecinski, RM Kostrzewa and R Brus
(2007) Nitric oxide modulates the amphetamine effect on [3H]glucose uptake in the brain of rats prenatally exposed
to lead. Polish Pharmacological Congress, Wrocław, Poland, Sept. 2007. Pharmacol. Reports 59 suppl. 1, 53-54.
Nowak P, G Szczerbak, RM Kostrzewa and R Brus (2007) Effect of prenatal lead exposure on nigrostriatal
neurotransmission and hydroxyl radicals formation in rat neostriatum. Dopaminergic-nitrenergic interaction.
Society for Neuroscience, San Diego, CA, 3-7 Nov. 2007.
Kostrzewa RM, JP Kostrzewa, R Brown and R Brus (2007) Dopamine receptor sensitivity and stereotypic / motor
behaviours. Fundación Cerebro y Mente International Meeting, Beyond Neuropsychiatric Diagnostics: Symptoms
Not Disorders. Lecture: Mazagon (Huelva), Spain, 17-21 October 2007.
Kostrzewa RM (2008) Advances in Dopamine Research: Success of Three Decades of Research Collaboration
Between the Medical University of Silesia in Poland and the Quillen College of Medicine at East Tennessee State
University in the USA. 17th
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland, 25-29 May 2008.
Pharmacol. Rep. 60: 254, 2008.
Nowak P, J Jochem, E Kőrössy, Ł Noras, RM Kostrzewa and R Brus (2008) Histamine level in the brain of
neonatally 6-OHDA-lesioned rats (rodent model of Parkinson’s disease). 17th
Neuropsychopharmacological Days,
Ustro, Jaszowiec, Poland, 25-29 May 2008. Pharmacol. Rep. 60: 288, 2008.
Nowak P, R Szkilnik, E Kőrössy, Ł Noras, RM Kostrzewa and R Brus (2008) Effect of histamine receptor
antagonists on oral activity and stereotyped behaviors in neonatally 6-OHDA-lesioned rats (rodent model of
Parkinson’s disease). 17th
Neuropsychopharmacological Days, Ustro, Jaszowiec, Poland, 25-29 May 2008.
Pharmacol. Rep. 60: 288-289, 2008.
Nowak P, J Jochem, R Szkilnik, A Plech, E Korossy, L Noras, RM Kostrzewa and R Brus (2008) Histamine level in
the brain of rats with rodent model of Parkinson’s disease. Acta Biochimica Polonica 55 Suppl. 3, 195. From 43rd
Congress of Biochemistry and Cell Biology, Olsztyn, Poland, Sept. 7-11, 2008.
Nowak P, A Kwiecinski, RM Kostrzewa and R Brus (2009) Prenatal manganese and perinatal 6-hydroxydopamine
alter adulthood [3H]glucose uptake in rat brain. 4th
Neurotoxicity Society meeting, Arica, Chile, 24-26 April, 2009.
Nowak P, J Jochem, R Szkilnik, J Drab, RM Kostrzewa and R Brus (2009) Histaminergic activity in adult rats neonatally
lesioned with neurotoxins: DSP-4, 5,7-DHT and 6-OHDA. 4th Neurotoxicity Society meeting, Arica, Chile, 24-26 April,
2009.
Nowak P, J Jochem, R Szkilnik, E Kőrőssy, J Drab, K Bojanek, RM Kostrzewa and R Brus (2009) Histaminergic activity
in adult rats neonatally lesioned with neurotoxins: DSP-4, 5,7-DHT and 6-OHDA. 18th
Neuropsychopharmacological
Days, Ustroń, Jaszowiec, Poland 25-27 May, 2009.
Nowak P, J Jochem, R Szkilnik, E Kőrőssy, J Drab, K Bojanek, RM Kostrzewa and R Brus (2009) Histaminergic activity
in adult rats neonatally lesioned with neurotoxins: DSP-4, 5,7-DHT and 6-OHDA (rodent model of Parkinson’s
disease). 18th
Neuropsychopharmacological Days, Ustroń, Jaszowiec, Poland 25-27 May, 2009.
Nowak P, J Drab, R Szkilnik, E Kőrőssy, J Konecki, K Bojanek, RM Kostrzewa and R Brus (2009) Thioperamide
effect on [3H]glucose uptake in the brain of adult rats neonatally lesioned with 5,7-dihydroxytryptamine. 18
th
Neuropsychopharmacological Days, Ustroń, Jaszowiec, Poland 25-27 May, 2009.
Kostrzewa RM, R Brus, P Nowak, JP Kostrzewa (2009) Stereotypic progressions in psychotic behaviour. Fundacion
Cerebro y Mente meeting on ‘Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and
Treatment’, Mojacar, Spain, October 2009.
R.M. Kostrzewa, Ph.D.
Szkilnik R, P Nowak, K Bojanek, RM Kostrzewa, R Brus (2010) Ontogenetic exposure of rats to pre- and post-natal
manganese enhances behavioral impairments produced by perinatal 6-hydroxydopamine. XVIIth International
Congress of the Polish Pharmacological Society, Krynica Zdrój, Poland, 16-18 Sept. 2010. Pharm. Reports 52
Suppl, p. 64.
Brus R, P Nowak, R Szkilnik, J Jochem, RM Kostrzewa (2010) Histaminergic activity in adult rats with neonatally
lesioned central noradrenergic, serotoninergic and dopaminergic (rodent model of Parkinson’s disease) systems.
XVIIth International Congress of the Polish Pharmacological Society, Krynica Zdrój, Poland, 16-18 Sept. 2010.
Pharm. Reports 52 Suppl, p. 107.
Kostrzewa RM (2010) Animal Models of ADHD, CME Program on “ADHD: From Basic Science to Bench Side” at
10th
Annual Meeting of the Safety Pharmacology Society. Boston, MA, 20-23 September 2010.
Brus R, J Jochem, P Nowak, R Szkilnik, RM Kostrzewa (May 2011) Histamine content in rat brains with rodent
model of Parkinson’s disease exposure to manganese during pre- and postnatal development. 20th
Neuropsychopharmacological Days, Ustroń, Jaszowiec, Poland. Pharmacol. Rep. 63: 589.
Kostrzewa RM, P Nowak, R Brus, RA Kostrzewa, JP Kostrzewa (Oct 2012) Hydroxyl radicals in striatum of
parkinsonian rats. Society for Neuroscience meeting, New Orleans LA, 13-17 Oct 2012.
Kostrzewa RM (March 2013) The dopamine D2 agonist quinpirole as a non-neurodegenerative neurotoxin. VI
Neurotoxicity Society meeting, Valdivia, Chile, 20-24 March, 2013.
Kostrzewa RM (May 2013) The changing face of neurotoxins. XVIII International Congress of the Polish
Pharmacological Society, Kazimierz Dolny, Poland, 22-25 May 2013.
Kostrzewa RM (June 2013) Dopamine D2 receptor supersensitization – effect on dopamine release and actions. 11th
World Congress of Biological Psychiatry, Kyoto, Japan. 23-27 June 2013.
Kostrzewa RM (August 2013) Amorphous Selective Neurotoxins. 11th International Symposium on VIP, PACAP
and Related Peptides, Pecs, Hungary, 26-31, 2013.