Post on 26-Dec-2015
Outline
1) Introduction
2) Case Study 1 : Selenol Project
3) Case Study 2 : DeltaG Nutraceutical
4) Case Study 3 : Joomo
5) Case Study 4 : Coffee Metabolites
6) Case Study 5 : Polymeric drug delivery system
iPRD : innovative Process Research and Development
Specialise in all aspects of process development ranging from:
1. Route design
2. Reaction scaling
3. Process engineering
4. Formulation
Introduction
Selenol Project
Background
Selenol and diselenides have a wide application in high end electronics and are known to be used in photovoltaic cells found in solar panels.
Synthesis of Selenols on scale can be problematic with associated odours, toxicity and the tendency of Selenols to undergo rapid oxidative dimerisation in the presence of O2.
Original Process
Number of problems : Poor Yield (40 – 50 %) and subsequent selenium waste. Highly Toxic H2Se byproduct
Case Study 1
Case Study 1
New Process
1. The new process produces almost quantitative yield of the desired selenol.
2. Removes the formation of the toxic malodourous H2Se.
3. Intermediate deselenide is a distillable stable liquid; allowing storage.
TΔS – Nutraceutical
Background
Product is a high value nutraceutical in human trials based on the science of ketone-bodies in human nutrition. Ketone-bodies have a key role in nutrition as highly efficient 'brain and muscle food'. TΔS have identified proprietary precursors that, for the first time, enable the amounts of ketones in our bodies to be elevated, bringing a range of benefits.
Current Process
The original batch process was catalysed by a heterogeneous catalyst for 5 days.
Issues :
1. Extended reaction times produced various impurities2. Scale up with current catalyst loading was prohibitively expensive
Case Study 2
Moving to a continuous system :
1. Reduced reactions times from 5 days to 1 h
2. Shorter reaction times produced fewer impurities
3. Reduced catalyst loading required for 50 kg batch - from 12 kg to 100 g of catalyst.
Overall this produced significant cost savings by making the process much more efficient.
Case Study 2
http://www.tdeltas.com/index.htm
Case Study 3
JOOMO : Natural face cream
Background
Start-up company with an new skincare product required large batch for further trials but no in-house capabilities
Original process
Initial product formulation led to variance in product homogeneity caused by frothing.
http://www.joomo.coop/
Original formulation
Case Study 3
After two week exploratory work to ensure successful manufacture we delivered two 20 kg batches on time and to customer specifications
This enabled distribution of free product samples during the Christmas shopping period.
New formulation
Case Study 4
Coffee Metabolites Study
Background
We were asked to synthesise a variety of coffee metabolites recently identified in human plasma and urine after consumption of coffee.
Summary
We produced multigram quantities of these metabolites for use as analytical standards in a food science study.
*Barron, D, et al.; Org. Biomol. Chem., 2010, 8, 5199–5211
Case Study 5
Polymeric drug delivery
Background
We were contracted to synthesise a variety of polymeric backbones for use as novel drug delivery systems. These particular systems have been successful in delivering various drug payloads including chemotherapy treatments.
Summary
We have successfully scaled the polymer synthesis to produce multigrams of the desired polymer backbone. We are in the process of grafting a fluorescence stains to allow visual monitoring of the polymer during ex vivo studies.
Chen, R.; Eccleston, M.; Yuec, Z.; Slater, N.;*, J. Mater. Chem., 2009, 19, 4217–4224
Summary
We have a broad skill base ranging from chemical synthesis to process design and engineering. Our facilities allows to produce materials ranging from grams for use as analytical samples up to kilos of material for more extensive testing.
Acknowledgements
Prof. John BlackerProf. Philip Kocienski
Prof. Frans MullerDr. John Cooksey
Susan PollardJanet Welch