BIOGERONTOLOGY AND TRANSLATIONAL MEDICINE: HOW CAN WE REACH “OPTIMAL LONGEVITY”?

Emanuele Marzetti, MD, PhD

Dept. of Geriatrics, Neurosciences and Orthopedics Center for Geriatric Medicine (Ce.M.I.) Teaching Hospital “Agostino Gemelli”

Rome - Italy

Napoli, 30 novembre 2017

• Consultant for Novartis

• Consultant for Huron Consulting Group

• Consultant for Genactis

• Consultant for Nutricia

• Academic Leader of Work-Package 8 (analysis of results) of the SPRINTT Project (IMI–JU 115621)

CONFLICT OF INTEREST DISCLOSURE

NO END TO BAD NEWS…

• Which side effects? • Since senescence occurs differently across tissues and cell

types, how many drugs should one be taking? • To prove that senolytics prevent people from aging, enough

time needs to pass to show that they have not.

Laron syndrome: insensitivity to GH, very short stature, frequent obesity and dyslipidemia, reduced incidence of cancer and type II diabetes.

Roy Lee Walford

HARA HACHI BU

Targeting/Taming Aging With Metformin: the TAME study

Prof. Roberto Bernabei Prof. Francesco Landi Prof. Giulio Maccauro Dr. Riccardo Calvani Dr. Anna Picca Dr. Matteo Tosato

FUNDING Innovative Medicines Initiative – Joint Undertaking (IMI–JU 115621) Italian Ministry of Education and Research (D3.2 2013 and D3.2 2015) Achille and Linda Lorenzon Study Centre Fondazione Roma (NCDs call for proposals 2013)

emanuele.marzetti@policlinicogemelli.it

THANK YOU FOR YOUR ATTENTION!