Intro-BIOL318 Immunology

Instructor: Dr. Kathy Szick-MirandaOffice: Science I 316Phone: 654-6165Email: kszick-miranda@csub.edu Web: www.csub.edu/~kszick_mirandaOffice hours: M 10-12; T 3:30-5; W 10-11:30Lecture and Discussion: T R 10:00-11:40am, Sci II 180

Intro-BIOL318 ImmunologyCourse Objectives: Upon completion of this course students will be expected to: •Describe the various cells and organs of the immune system, including the role of each during the immune response.•Compare and contrast innate and acquired immunity, including their specific components and effector mechanisms.•Describe antigens and antibodies and their interactions.•Discuss the immune response to specific pathogens.

Intro-BIOL318 Immunology

Assignment Point Values:Exam I 100ptsExam II 100ptsFinal Exam (Exam III) 100ptsQuizzes (top 5 scores) 50ptsTOTAL 350pts

Historical PerspectiveImmunity - state of protection from an infectious disease.

430 BC – Greek historian Thucydides - Athenian plague

15th century – Chinese attempts to induce immunity

1718 – Mary Wortley Montagu – innoculated her children

1798 – Edward Jenner – milkmaids and cowpox/smallpox

Historical Perspective

early 1880’s – Cholera and chickens

Attenuation hypothesis

1881 – Testing the hypothesis with anthrax and sheep

1885 – Rabies vaccine

Louis Pasteur

Historical Perspective1890 - Behring and Kitasato – link serum to immunity

1883 – Metchnikoff – links cells (phagocytes) to immunity

early 1900’s – many functions of immune serum

1930’s – Kabat - immunoglobulin/antibodies

1950’s – Glick – two types of lymphocytes

Historical Perspective

1900 – Paul Ehrlich – Selective theory

1950’s – Jerne, Talmadge and Burnet – clonal selection theory

Historical Perspective

Infection and Immunitypathogens – organisms causing disease

pathogenesis – the means by which disease-causing organisms attach a host.

Innate and Adaptive Immunity

Innate

1st line of defense

Non-specific mechanisms

Phagocytes and recognition molecules

Adaptive

2nd line of defense

Highly specific mechanisms

Lymphocytes, antigen specific

receptors, antibodies

Components of Adaptive Immunity

T Lymphocytes

Innate and Adaptive Immunity

Innate and Adaptive Immunity

Immune Dysfunction

Allergies and asthma

Graft rejection

Autoimmune disease

Immunodeficiency