Post on 13-Jan-2016
International Partnership for International Partnership for MicrobicidesMicrobicides
International Partnership for International Partnership for MicrobicidesMicrobicides
Tessa Mattholie, European Liaison Officer, Tessa Mattholie, European Liaison Officer, BrusselsBrussels
IPM MissionIPM MissionIPM MissionIPM Mission
IPM’s mission is to prevent HIV transmission by accelerating the development and access of safe and effective microbicides for use by women in developing countries.
Pathway of Microbicide Pathway of Microbicide DevelopmentDevelopment
1. Assess and fundacross the microbicide
portfolio
4. Optimize clinical trialcapacity
2. Help develop the“next generation”of microbicides
3. Provide commoncapabilities or
supports for the field
5. Coordinate effortto ensure worldwide
access
DiscoveryBasicresearch
Pre-clinical
Clinicaltrials
Launch &Access
Multiple mechanisms/targets/products
Formulation capacityIn vitro and in vivo modelsRegulatoryManufacturing
IPM InfrastructureIPM InfrastructureIPM InfrastructureIPM Infrastructure
4 areas of initial focus were on the gaps/bottlenecks in microbicide development pathway:
Screening/activity testing Formulation NHP testing Clinical trials material manufacturing
IPM Clinical TrialsIPM Clinical TrialsIPM Clinical TrialsIPM Clinical Trials
Vaginal ring Phase I trial of TMC120 completed in Belgium
TMC120 Gel Phase I/II trial in Africa(Developing clinical trial sites)
Male tolerance of TMC120
IPM’s Approach to AccessIPM’s Approach to AccessIPM’s Approach to AccessIPM’s Approach to Access
Ensuring availability requires: Appropriate regulatory approval and licensing
infrastructure Manufacturing capability and sufficient capacity Logistics and delivery networks in-country
Ensuring adoption requires: End-user awareness about the product and its benefits Effective pricing and financing mechanisms to ensure
affordability Supportive social and policy environment (and the
research to generate this)
European advocacy activitiesEuropean advocacy activitiesEuropean advocacy activitiesEuropean advocacy activities
Aims: Increase political commitment for
microbicides Increase funding for R&D through
national research institutions and PPPs Advance policy environment for
development of, and acess to, microbicides
Current Donors to the IPMCurrent Donors to the IPMCurrent Donors to the IPMCurrent Donors to the IPM
Canada Denmark EC Gates Foundation Ireland Netherlands Norway
Rockefeller Foundation
Sweden UK UN US World Bank
How to Contact IPM?How to Contact IPM?How to Contact IPM?How to Contact IPM?
Visit our website at
www.ipm-microbicides.org
Email Tessa Mattholie at:
tmattholie@ipm-microbicide.org