Trial Innovation NetworkHub Liaison Team Meeting

April 4, 2017

Trial Innovation NetworkWebsite & Communications

Paul Harris, Julia DunagunApril 4, 2017

Trial Innovation NetworkUpcoming Events & News

• Announcements and access to key information

Trial Innovation Network

Resource Page for Trial Innovation Network Information

Trial Innovation NetworkCTSA Program Hub Liaison Teams

All CTSA Sites have established Hub Liaison Teams

305 Hub Liaison Team Members

36 CTSA Sites have completed the FDP-CTSA Trial Innovation Network Standard Agreement

Trial Innovation Network

Short announcements/notifications sent via email

Trial Innovation NetworkWebsite Metrics – Since launch on 10/26/2016

Website Traffic

Top 3 pages visited (excluding homepage):• Submit A Proposal• Webinars• Preparing To Submit A Proposal

Webinars -

Hosted 6 with 325 attendees

170 Unique Attendees71 Institutions

Key Message & Call To Action

Introduction to site – What is this about?

Key Element Site Navigation – “Command Central”

News & Upcoming Events – With Archives

Subscribe To Keep In Touch

Command Central

Navigation

Command Central Navigation For All

Key Elements

Brief introduction to page About section

Page Title with corresponding key element

icon highlighted

Key content area(s)

Page navigation –other information

related to key element

Navigation links from “toolbox” will change

content in the key content area while keeping the overall framework of the page the same

Key content sections can be expanded to include more information without navigating away from page

Trial Innovation NetworkDevelopment Projects & Updates: Shared Toolkit

Automated notification sent for a light touch

review of submission

Approve or Reject Triggers automated publishing to library

Intake form on Trial Innovation Network Website

https://trialinnovationnetwork.org/recruitment-retention-toolkit/

Trial Innovation NetworkDevelopment Projects & Updates: Shared Toolkit

6 months from the date of publishing:• Listed contact for resource will

receive an automated email notification with a link to published information and associated metrics with the options to:

• Keep resource as published

• Edit published information• Remove resource

Trial Innovation NetworkEngaging Hub Liaison Teams

APRIL 4, 2017

Trial Innovation Network Communications with Hub Liaison Teams

• How to best communicate information to the Hub Liaison Teams and CTSA Hub PIs?

• What information do you need to help you better organize your Hub Liaison Teams?

• What suggestions do the Hub Liaison Teams have to improve communications about the Proposal Process CIRB Process

• What suggestions do the Hub Liaison Teams have about the Trial Innovation Network Website

Trial Innovation Network Engaging Hub Liaison Teams

• How do we get direct feedback from the Hub Liaison Teams and CTSA Hub PIs on TIN processes and workflows?

• How do engage the Hub Liaison Teams in generating ideas for the Network?

• What does the group think about a Hub Liaison Team WG with ~10-15 Hub Liaison Team members?

Trial Innovation Network Key ElementRecruitment

Rhonda Kost / Mary Stroud / Paul HarrisApril 04, 2017

What the Research Says….

• 1% of US population participates in health studies

• nearly 1 in 5 trials either terminated for failed accrual, or completed with <85% of the expected enrollment.

• Less than 10% of clinical studies are completed on time

• Reports of clinical trials consistently state that initial approaches to recruitment are rarely successful, take longer than planned and the pool of participants is overestimated.

Vision and PurposeOur goal is to positively impact human health by improving participant enrollment and retention in multi-center clinical trials.

Achieving this goal will require sophisticated informatics-based recruitment tools and novel engagement approaches to accelerate recruitment and retention.

Participant Trial

Trial Innovation Network – Recruitment Guiding Principles

• Respecting CTSA autonomy and diversity• A focus on minority and underserved populations• Making the most of electronic health records• Preserving a disease neutral approach• Focus on cost efficiency• Respecting and returning value to participants• Build on best practice (avoid reinventing the wheel)• Evidence based…. What works? (test bed)• Finite resources – scalability / tools• Home for recruitment experts (across + beyond CTSA)

Trial Innovation Network – Recruitment

1.Create a national home for the creation, storing and sharing of recruitment education, programs and best practices

2.Catalyze enrollment by developing and disseminating novel approaches to support researchers in recruiting

3.Enhance national awareness of research through patient education and facilitate patient participation with online patient facing tools

4.Conduct studies on methods to enhance recruitment efficacy and efficiency

Trial Innovation Network – RecruitmentRIC Services

1. Consultation2. Community

Engagement Studios3. Feasibility Analysis4. Recruitment Plan

Consultation5. Recruitment Materials6. EHR Based Cohort

Assessment

Trial Innovation Network

• Initial consultations make up 80% of requests for support from the RIC.

• Majority of consults are TIC led.

RIC Recruitment Consultations

Consultations are provided in order to trouble shoot and provide advice, guidance and recommendations.

Hub liaison team representatives:• Part of the initial consult;• Help problem solve;• Shape recommendations.

Trial Innovation Network – RecruitmentRIC Consultation – Feasibility

RIC will consider ways to improve the feasibility of a study. As part of the consultation, the RIC will:

• Comprehensively review the details of your study with a focus on focusing on timeline, targets and cost.

• Assess the likelihood of meeting predefined recruitment and retention goals;

• Provide tailored advice on how you can enhance the feasibility of your study overall.

Trial Innovation Network – Recruitment RIC Consultation – Recruitment Plan

• Comprehensively review your recruitment plan in the context of your study;

• Assess the likelihood of meeting predefined recruitment and retention goals

• Give tailored advice and recommendations on the most appropriate recruitment strategies to deploy when engaging participants from any community.

Trial Innovation Network – Recruitment RIC Consultation – Recruitment Materials

• Review your recruitment material needs including any dissemination plans;

• Provide advice, recommendations and templates in order to improve the recruitment of potential participants for specific studies;

• Share best practice.

Trial Innovation Network – Recruitment RIC Consultation – EHR-Based Cohort Assessment

• Explore ways that Electronic Health Record data may be leveraged to inform study design and potential site selection.

• You can expect expert clinical and technical review of a study’s goal recruitment population and a high level assessment of computable phenotyping.

• Funded projects may also petition and receive support required to organize distribution of phenotype algorithms to potential CTSA hubs and collation of results.

Trial Innovation Network – RecruitmentRIC Consultation: EHR Based Feasibility Assessment

EHR-Based FeasibilityAssessment

Informatics / PlatformsEHR-Based FeasibilityAssessment

Informatics / PlatformsEHR-Based FeasibilityAssessment

RIC Teams

Infor

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latfo

rms

Trial Innovation Network – Recruitment Toolkit• Community engagement

toolkit • ResearchMatch/TrialFinder

collaboration• Share recruitment resources• Give a webinar

Coming soon…..• Feasibility• Compensation guidance• Template recruitment

materials https://trialinnovationnetwork.org/resources/tools/

THREE Immediate Opportunities

Share materials, tools, best practices, …

THREE Immediate Opportunities

Give a webinar

On Deck:

Recent offerings (video available)

THREE Immediate Opportunities

Be an earlyAdopter/Collaborator

Search

Review Act

Can easily be extended for this …

In summary…

The RIC is a place where you can….

1. Find tools & resources that work2. Discover best practices3. Seek expert advice and support4. Expect recognition – please join us as a

collaborator

Recruitment Innovation CenterContact Information

Paul HarrisPaul.Harris@vanderbilt.edu

Laura YearsleyResearch Programs Manager

Laura.j.Yearsley@Vanderbilt.edu

For sharing tools/best practice:

Leslie BooneLeslie.Boone@Vanderbilt.edu

Put yourself forward for a webinar!

Bridget SwindellBridget.swindell@Vanderbilt.edu

Trial Innovation NetworkChat Box Discussion: Q&A

Trial Innovation NetworkNext Meeting: May 2, 2017, 3-4:30PM ET